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1.发明申请Methods for the identification of inhibitors of amidophosphoribosyltransferase as antibiotics 审中-公开用于鉴定作为抗生素的酰胺磷酰基转移酶抑制剂的方法公开(公告)号：US20050221409A1
公开(公告)日：2005-10-06
申请号：US10969709
申请日：2004-10-20
申请人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
发明人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
摘要： The present inventors have discovered that amidophosphoribosyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of amidophosphoribosyltransferase gene expression in fungi results in drastically reduced pathogenicity. Thus, amidophosphoribosyltransferase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit amidophosphoribosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，酰胺磷酸核糖基转移酶对于正常的真菌致病性是必需的。 具体地，抑制真菌中酰胺磷酰基转移酶基因表达导致致病性急剧下降。 因此，酰胺磷酰基糖基转移酶可以用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制酰胺磷酰基转移酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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2.发明申请Methods for the identification of inhibitors of mannosyltransferase as antibiotics 审中-公开用于鉴定作为抗生素的甘露糖基转移酶抑制剂的方法公开(公告)号：US20050042705A1
公开(公告)日：2005-02-24
申请号：US10874708
申请日：2004-06-23
申请人： Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer
发明人： Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer
IPC分类号： A61K31/4709 , A61K31/496 , A61K31/704 , C12Q20060101 , C12Q1/48 , G01N33/94
CPC分类号： G01N33/9446
摘要： The present inventors have discovered that mannosyltransferase is essential for normal fungal growth and pathogenicity. Specifically, the inhibition of mannosyltransferase gene expression in fungi results in drastically reduced growth and pathogenicity. Thus, mannosyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit mannosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，甘露糖基转移酶对于正常的真菌生长和致病性是必需的。 具体地说，抑制真菌中的甘露糖基转移酶基因表达导致生长和致病性急剧下降。 因此，甘露糖基转移酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制甘露糖基转移酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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3.发明申请Methods for the identification of inhibitors of ornithine carbamoyltransferase as antibiotics 审中-公开用于鉴定鸟氨酸氨基甲酰基转移酶抑制剂作为抗生素的方法公开(公告)号：US20050019846A1
公开(公告)日：2005-01-27
申请号：US10849985
申请日：2004-05-20
申请人： Matthew Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Jeffrey Shuster
发明人： Matthew Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Jeffrey Shuster
IPC分类号： A61K38/00 , C12N20060101 , C12Q1/00 , C12Q1/18 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/48 , C12Q1/68 , G01N33/53 , G01N33/569 , G01N33/573
CPC分类号： G01N33/573 , C07K14/37
摘要： The present inventors have discovered that ornithine carbamoyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of ornithine carbamoyltransferase gene expression in fungi eliminates pathogenicity. Thus, ornithine carbamoyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit ornithine carbamoyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现鸟氨酸氨基甲酰基转移酶对于正常的真菌致病性是必需的。 具体地说，抑制鸟氨酸氨基甲酰转移酶基因在真菌中的表达消除了致病性。 因此，鸟氨酸氨基甲酰基转移酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了用于鉴定抑制鸟氨酸氨基甲酰基转移酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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4.发明申请Methods for the identification of inhibitors of cyclic nucleotide phosphodiesterase as antibiotics 审中-公开用于鉴定环核苷酸磷酸二酯酶抑制剂作为抗生素的方法公开(公告)号：US20050233404A1
公开(公告)日：2005-10-20
申请号：US11041553
申请日：2005-01-24
申请人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
发明人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
摘要： The present inventors have discovered that a cyclic nucleotide phosphodiesterase is essential for normal fungal pathogenicity. Specifically, the inhibition of PDE2 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, PDE2 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit PDE2 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides.
摘要翻译： 本发明人已经发现环状核苷酸磷酸二酯酶对于正常的真菌致病性是必需的。 具体来说，稻瘟病菌中PDE2基因表达的抑制严重降低了真菌的致病性。 因此，PDE2可用作鉴定抗生素，优选杀真菌剂的靶标。 因此，本发明提供了鉴定抑制PDE2表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选杀真菌剂。
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5.发明申请Methods for the identification of inhibitors of histidinol dehydrogenase as antibiotics 审中-公开用于鉴定作为抗生素的组氨醇脱氢酶抑制剂的方法公开(公告)号：US20050227304A1
公开(公告)日：2005-10-13
申请号：US11076770
申请日：2005-03-10
申请人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
发明人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
IPC分类号： C12Q1/18 , C12Q1/32 , C12Q1/68 , G01N33/53 , G01N33/569
CPC分类号： C12Q1/32 , C12Q1/18 , G01N2500/04
摘要： The present inventors have discovered that a histidinol dehydrogenase (HIS4) is essential for normal fungal pathogenicity, Specifically, the inhibition of HIS4 gene expression in Magnaportha grisea severely reduces the pathogenicity of the fungus. Thus, HIS4 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit HIS4 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides.
摘要翻译： 本发明人已经发现，组氨醇脱氢酶（HIS4）对于正常的真菌致病性是必需的。具体而言，稻瘟病菌中HIS4基因表达的抑制严重降低了真菌的致病性。 因此，HIS4可用作鉴定抗生素，优选杀真菌剂的目标。 因此，本发明提供了用于鉴定抑制HIS4表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选杀真菌剂。
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6.发明申请Methods for the identification of inhibitors of porphobilinogen deaminase as antibiotics 审中-公开用于鉴定胆色素脱氨酶抑制剂作为抗生素的方法公开(公告)号：US20050042706A1
公开(公告)日：2005-02-24
申请号：US10803132
申请日：2004-03-17
申请人： Matthew Tanzer , Jeffrey Shuster , Todd DeZwaan , Amy Covington , Maria Montenegro-Chamorro , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Rex Tarpey , Lisbeth Hamer , Kiichi Adachi , Sze-Chung Lo , Blaise Darveaux
发明人： Matthew Tanzer , Jeffrey Shuster , Todd DeZwaan , Amy Covington , Maria Montenegro-Chamorro , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Rex Tarpey , Lisbeth Hamer , Kiichi Adachi , Sze-Chung Lo , Blaise Darveaux
IPC分类号： A61K38/00 , C12N20060101 , C12N1/14 , C12N9/00 , C12N9/88 , C12Q1/18 , C12Q1/34 , C12Q1/37 , C12Q1/48 , C12Q1/68
CPC分类号： C12N9/88 , C12Q1/18 , G01N2333/988 , G01N2500/02 , G01N2500/04
摘要： The present inventors have discovered that porphobilinogen deaminase (PBG) is essential for normal fungal pathogenicity. Specifically, the inhibition of porphobilinogen deaminase gene expression in fungi abolishes pathogenicity. Thus, porphobilinogen deaminase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit porphobilinogen deaminase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，胆色素原脱氨酶（PBG）对于正常的真菌致病性是必需的。 具体来说，抑制胆色素脱氨酶基因在真菌中的表达可以消除致病性。 因此，胆色素原脱氨酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制胆色素原脱氨酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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7.发明申请Methods for the identification of inhibitors of fumarate reductase as antibiotics 审中-公开用于鉴定富马酸盐还原酶抑制剂作为抗生素的方法公开(公告)号：US20050026237A1
公开(公告)日：2005-02-03
申请号：US10864701
申请日：2004-06-09
申请人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
发明人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , C12Q1/18 , G01N33/573 , G01N2333/90206
摘要： The present inventors have discovered that fumarate reductase is essential for normal fungal pathogenicity. Specifically, the inhibition of fumarate reductase gene expression in fungi results in drastically reduced pathogenicity. Thus, fumarate reductase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit fumarate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，富马酸盐还原酶对于正常的真菌致病性是必需的。 具体来说，真菌中富马酸还原酶基因表达的抑制导致致病性急剧下降。 因此，富马酸盐还原酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制富马酸酯还原酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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8.发明申请Methods for the identification of inhibitors of adenylosuccinate synthase as antibiotics 审中-公开用于鉴定作为抗生素的腺苷酸琥珀酸合酶抑制剂的方法公开(公告)号：US20050227305A1
公开(公告)日：2005-10-13
申请号：US11034798
申请日：2005-01-13
申请人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Kiichi Adachi
发明人： Matthew Tanzer , Jeffrey Shuster , Lisbeth Hamer , Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Kiichi Adachi
摘要： The present inventors have discovered that adenylosuccinate synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of adenylosuccinate synthase gene expression in fungi results in drastically reduced pathogenicity. Thus, adenylosuccinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit adenylosuccinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现腺苷酸琥珀酸合成酶对于正常的真菌致病性是必需的。 具体地说，在真菌中抑制腺苷酸琥珀酸合酶基因表达导致致病性急剧下降。 因此，腺苷酸琥珀酸合酶可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制腺苷酸琥珀酸合酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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9.发明申请Methods for the identification of inhibitors of acetolactate synthase as antibiotics 审中-公开鉴定乙酰乳酸合酶抑制剂作为抗生素的方法公开(公告)号：US20050048593A1
公开(公告)日：2005-03-03
申请号：US10877284
申请日：2004-06-25
申请人： Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Jeffrey Shuster , Matthew Tanzer , Lisbeth Hamer , Kiichi Adachi
发明人： Todd DeZwaan , Sze-Chung Lo , Maria Montenegro-Chamorro , Blaise Darveaux , Sheryl Frank , Ryan Heiniger , Sanjoy Mahanty , Huaqin Pan , Amy Covington , Rex Tarpey , Jeffrey Shuster , Matthew Tanzer , Lisbeth Hamer , Kiichi Adachi
IPC分类号： A61K20060101 , C12Q1/18 , C12Q1/48 , C12Q1/527
CPC分类号： C12Q1/18 , C12Q1/527 , G01N2500/00
摘要： The present inventors have discovered that ALS catalytic and regulatory subunits are essential for normal fungal pathogenicity. Specifically, the inhibition of either ALS catalytic or regulatory subunit gene expression in fungi severely reduces growth and pathogenicity. Thus, ALS catalytic and regulatory subunits are useful as targets for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit ALS catalytic or regulatory subunit expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人发现ALS催化和调控亚基对于正常的真菌致病性是必需的。 具体来说，ALS催化或调节亚基基因在真菌中的表达的抑制严重降低了生长和致病性。 因此，ALS催化和调控亚基可用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制ALS催化或调节亚基表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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10.发明授权Methods for the identification of inhibitors of threonine synthase as antibiotics 失效鉴定苏氨酸合酶抑制剂作为抗生素的方法公开(公告)号：US06806060B2
公开(公告)日：2004-10-19
申请号：US10011106
申请日：2001-12-07
申请人： Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo
发明人： Maria Victoria Montenegro-Chamorro , Sheryl Frank , Blaise Darveaux , Sanjoy Mahanty , Ryan Heiniger , Amy Skalchunes , Huaqin Pan , Rex Tarpey , Jeffrey Shuster , Matthew M. Tanzer , Lisbeth Hamer , Kiichi Adachi , Todd DeZwaan , Sze-Chung Lo
IPC分类号： C12Q118
摘要： The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
摘要翻译： 本发明人已经发现，苏氨酸合成酶对于真菌致病性是必需的。 具体地说，抑制真菌中的苏氨酸合成酶基因表达没有导致成功感染或病变的迹象。 因此，苏氨酸合成酶可以用作鉴定抗生素，优选抗真菌剂的靶标。 因此，本发明提供了鉴定抑制苏氨酸合成酶表达或活性的化合物的方法。 本发明的方法可用于鉴定抗生素，优选抗真菌剂。
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