公开(公告)号：US20100323724A1

公开(公告)日：2010-12-23

申请号：US12438775

申请日：2007-08-22

申请人： Klaus Balschat ,  Pascal Kopperschmidt ,  Reiner Spickermann

发明人： Klaus Balschat ,  Pascal Kopperschmidt ,  Reiner Spickermann

IPC分类号： H04W4/12 ,  H04B7/00

CPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/168 ,  A61M1/1682 ,  A61M1/34 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/60 ,  A61M2205/70

摘要： The present invention relates to an extracorporeal blood treatment device comprising a treatment unit and a device for controlling the treatment unit for preparing and carrying out the blood treatment. The blood treatment device also comprises an internal communication unit for communicating with an external communication unit. In order to the prepare the device blood treatment, the patient sends an initiation code by means of an external communication unit to the internal communication device. Routines required for preparing the blood treatment are then started. One main advantage is that the patient, for example during home dialysis, does not need to be present when the device is preparing for dialysis and the dialysis preparation can be started when the patient thinks of returning home in time for the beginning of the preparation phase.

摘要翻译： 本发明涉及一种体外血液处理装置，其包括处理单元和用于控制用于制备和进行血液处理的处理单元的装置。 血液处理装置还包括用于与外部通信单元通信的内部通信单元。 为了准备用于血液处理的装置，患者通过外部通信单元向内部通信装置发送启动代码。 然后开始准备血液处理所需的程序。 一个主要的优点是，例如在家庭透析期间，当设备正在进行透析时，患者不需要存在患者，并且当患者认为在准备阶段开始时及时回家时可以开始透析准备 。

公开(公告)号：US08315654B2

公开(公告)日：2012-11-20

申请号：US12438775

申请日：2007-08-22

申请人： Klaus Balschat ,  Pascal Kopperschmidt ,  Reiner Spickermann

发明人： Klaus Balschat ,  Pascal Kopperschmidt ,  Reiner Spickermann

IPC分类号： H04W4/12

CPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/168 ,  A61M1/1682 ,  A61M1/34 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/60 ,  A61M2205/70

摘要： The present invention relates to an extracorporeal blood treatment device comprising a treatment unit and a device for controlling the treatment unit for preparing and carrying out the blood treatment. The blood treatment device also comprises an internal communication unit for communicating with an external communication unit. In order to the prepare the device blood treatment, the patient sends an initiation code by means of an external communication unit to the internal communication device. Routines required for preparing the blood treatment are then started. One main advantage is that the patient, for example during home dialysis, does not need to be present when the device is preparing for dialysis and the dialysis preparation can be started when the patient thinks of returning home in time for the beginning of the preparation phase.

摘要翻译： 本发明涉及一种体外血液处理装置，其包括处理单元和用于控制用于制备和进行血液处理的处理单元的装置。 血液处理装置还包括用于与外部通信单元通信的内部通信单元。 为了准备用于血液处理的装置，患者通过外部通信单元向内部通信装置发送启动代码。 然后开始准备血液处理所需的程序。 一个主要的优点是，例如在家庭透析期间，当设备准备透析时，患者不需要存在患者，并且当患者认为在准备阶段开始时及时回家时可以开始透析准备 。

公开(公告)号：US20100130906A1

公开(公告)日：2010-05-27

申请号：US12312040

申请日：2007-10-22

申请人： Klaus Balschat ,  Reiner Spickermann

发明人： Klaus Balschat ,  Reiner Spickermann

IPC分类号： A61M1/34

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/342 ,  A61M1/3441 ,  A61M1/3465 ,  A61M2205/50 ,  A61M2205/70

摘要： The invention relates to the field of equipment for renal replacement therapy. It is based on the observation that connections (14, 15, 101) already present in a hemodialysis machine or hemodiafiltration machine (10) may also be used directly for sampling for the connection to a hemodialyzer or for providing replacement fluid, as is required for regular microbiological testing. The invention does not require any additional components on the equipment or any complex hygiene measures to prevent secondary contamination. By connecting an inventive sterile sampling set, samples can easily be taken. On the equipment end, one need only to program the control unit (26) to implement the inventive method by means of corresponding control of the closing means (20, 21, 103) and the pumping mechanisms (17, 18) as part of a sampling control program.

摘要翻译： 本发明涉及用于肾替代治疗的设备领域。 基于以下观察，已经存在于血液透析机或血液透析滤器（10）中的连接（14,15,101）也可以直接用于取样连接到血液透析器或用于提供置换液体，如 定期进行微生物检测。 本发明不需要设备上的任何附加部件或任何复杂的卫生措施来防止二次污染。 通过连接本发明的无菌取样装置，可以容易地取样。 在设备端，仅需要对控制单元（26）进行编程，以通过对闭合装置（20,21,103）和泵机构（17,18）的相应控制来实现本发明的方法，作为 抽样控制程序。

公开(公告)号：US08676512B2

公开(公告)日：2014-03-18

申请号：US12809791

申请日：2008-12-17

申请人： Klaus Balschat ,  Alfred Gagel ,  Michael Kulz ,  Reiner Spickermann

发明人： Klaus Balschat ,  Alfred Gagel ,  Michael Kulz ,  Reiner Spickermann

IPC分类号： A61M1/34 ,  G06F19/00 ,  G06F17/40

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/36 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50

摘要： A method and device are provided for determining the transmembrane pressure during an extracorporeal blood treatment in which blood flows at a defined blood flow rate through an arterial blood conduit of an extracorporeal blood circuit into the inlet of a first chamber of a dialyzer, which is divided by a semipermeable membrane into the first chamber and a second chamber, and flows through a venous blood conduit from the outlet of the first chamber of the dialyzer, while dialysis liquid flows through a dialysis liquid supply conduit into the inlet of the second chamber of the dialyzer and flows through a dialaysis liquid discharge conduit from the outlet of the second chamber of the dialyzer. The method and the device for determining the transmembrane pressure are such that the pressure on the blood side and on the dialysis liquid side of the dialyzer is measured with relatively little technical outlay, specifically with fewer than four pressure sensors, and a preliminary uncorrected value is calculated for the transmembrane pressure and is thereafter corrected by a correction variable that is dependent on a variable correlating with the viscosity of the blood.

摘要翻译： 提供了一种用于在体外血液处理期间确定跨膜压力的方法和装置，其中血液以限定的血液流量通过体外血液回路的动脉血管流入到透析器的第一腔室的入口中，该第一腔室被分开 通过半透膜进入第一腔室和第二腔室，并且从透析器的第一腔室的出口流过静脉血液导管，同时透析液体流过透析液体供应管道进入第二腔室的入口 透析器，并从透析器的第二腔室的出口流过拨号液体排出导管。 用于确定跨膜压力的方法和装置使得透析器的血液侧和透析液体侧的压力以相对较少的技术支出来测量，特别是使用少于四个的压力传感器，初步未校正的值是 计算跨膜压力，然后通过依赖于与血液粘度相关的变量的校正变量进行校正。

公开(公告)号：US08518258B2

公开(公告)日：2013-08-27

申请号：US12312040

申请日：2007-10-22

申请人： Klaus Balschat ,  Reiner Spickermann ,  Josef Winter

发明人： Klaus Balschat ,  Reiner Spickermann ,  Josef Winter

IPC分类号： C02F1/44 ,  A61M37/00

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/342 ,  A61M1/3441 ,  A61M1/3465 ,  A61M2205/50 ,  A61M2205/70

摘要： A hemodialysis machine or hemodiafiltration machine is provided that may be used directly for sampling for the connection to a hemodialyzer or for providing replacement fluid, as is required for regular microbiological testing. The machine does not require any additional components or any complex hygiene measures to prevent secondary contamination. By connecting an inventive sterile sampling set, samples can easily be taken. Closing elements and pumping mechanisms are controlled by a control unit as part of a sampling control program.

摘要翻译： 提供血液透析机或血液透析滤过机，其可以直接用于取样以连接血液透析器或提供替代液体，如常规微生物测试所要求的。 机器不需要任何额外的部件或任何复杂的卫生措施来防止二次污染。 通过连接本发明的无菌取样装置，可以容易地取样。 关闭元件和泵送机构由控制单元控制，作为采样控制程序的一部分。

公开(公告)号：US08104348B2

公开(公告)日：2012-01-31

申请号：US11921624

申请日：2006-04-15

申请人： Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

发明人： Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

IPC分类号： G01H3/12

CPC分类号： G01N29/032 ,  A61M1/3626 ,  G01N2291/02433 ,  G01N2291/02466 ,  G01N2291/02854

摘要： The present invention relates to a method and a device for monitoring a flowing medium, in particular the blood flowing in an extracorporeal blood circulation, for the presence of air, in particular micro-bubbles. A sequence of signal pulses or a continuous signal is injected into the flowing medium, and the signal pulses or continuous signal leaving the flowing medium are received. To detect micro-bubbles, a signal pattern that is characteristic of the variation over time of the received signal pulses or the continuous signal in a predetermined period of time is extracted from the signal received. The characteristic signal pattern is compared with one or more characteristic reference patterns, and the presence of air bubbles is determined if the characteristic signal pattern deviates from the characteristic reference pattern by a predetermined amount. Statistical characteristic variables, in particular the variance, are preferably determined from the signal patterns and compared with one another.

摘要翻译： 本发明涉及用于监测流动介质，特别是在体外血液循环中流动的血液，用于存在空气，特别是微气泡的方法和装置。 信号脉冲序列或连续信号被注入到流动介质中，并且接收离开流动介质的信号脉冲或连续信号。 为了检测微气泡，从接收到的信号中提取出在接收到的信号脉冲或连续信号随时间变化的特征的信号模式。 将特征信号图案与一个或多个特征参考图案进行比较，并且如果特征信号图案偏离特征参考图案预定量，则确定气泡的存在。 统计特征变量，特别是方差，优选地根据信号图案确定并相互比较。

公开(公告)号：US20090205426A1

公开(公告)日：2009-08-20

申请号：US11921624

申请日：2006-04-15

申请人： Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

发明人： Klaus Balschat ,  Tobias Fritsche ,  Alfred Gagel ,  Steffen Kirchner ,  Hans-Joachim Muench ,  Olaf Nicholas ,  Jochen Schneider ,  Reiner Spickermann ,  Santer Zur Host-Meyer

IPC分类号： G01N29/032

CPC分类号： G01N29/032 ,  A61M1/3626 ,  G01N2291/02433 ,  G01N2291/02466 ,  G01N2291/02854

摘要： The present invention relates to a method and a device for monitoring a flowing medium, in particular the blood flowing in an extracorporeal blood circulation, for the presence of air, in particular micro-bubbles. A sequence of signal pulses or a continuous signal is injected into the flowing medium, and the signal pulses or continuous signal leaving the flowing medium are received. To detect micro-bubbles, a signal pattern that is characteristic of the variation over time of the received signal pulses or the continuous signal in a predetermined period of time is extracted from the signal received. The characteristic signal pattern is compared with one or more characteristic reference patterns, and the presence of air bubbles is determined if the characteristic signal pattern deviates from the characteristic reference pattern by a predetermined amount. Statistical characteristic variables, in particular the variance, are preferably determined from the signal patterns and compared with one another.

摘要翻译： 本发明涉及用于监测流动介质，特别是在体外血液循环中流动的血液，用于存在空气，特别是微气泡的方法和装置。 信号脉冲序列或连续信号被注入到流动介质中，并且接收离开流动介质的信号脉冲或连续信号。 为了检测微气泡，从接收到的信号中提取出在接收到的信号脉冲或连续信号随时间变化的特征的信号模式。 将特征信号图案与一个或多个特征参考图案进行比较，并且如果特征信号图案偏离特征参考图案预定量，则确定气泡的存在。 统计特征变量，特别是方差，优选地根据信号图案确定并相互比较。

公开(公告)号：US06804991B2

公开(公告)日：2004-10-19

申请号：US10342851

申请日：2003-01-14

申请人： Klaus Balschat ,  Helmuth Ender ,  Alfred Gagel ,  Reiner Spickermann

发明人： Klaus Balschat ,  Helmuth Ender ,  Alfred Gagel ,  Reiner Spickermann

IPC分类号： G01M304

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/50

摘要： In order to detect a leakage in a fluid system of a blood treatment apparatus having an extracorporeal blood circuit, the pressure in the fluid system is measured continuously during a predetermined period of the duration of treatment, and the leak rates are calculated from the change in the pressure at predetermined time intervals of the predetermined period of the duration of treatment. The leakage volume in the predetermined period of the duration of treatment is calculated from the leak rates, and the leakage volume is compared with a predetermined limit value. If the leakage volume is greater than the limit value, this indicates a possible loss of leaktightness in the system. This can be verified with a conventional pressure-holding test. The method and device are characterized by the fact that it is not necessary in principle to interrupt the blood treatment in order to detect a loss of leaktightness.

摘要翻译： 为了检测具有体外血液回路的血液处理装置的流体系统的泄漏，在治疗期间的预定期间内连续地测量流体系统中的压力，并且根据变化计算泄漏率 在治疗持续时间的预定时间段的预定时间间隔的压力。 根据泄漏率计算处理持续时间的规定期间的泄漏量，将泄漏量与规定的极限值进行比较。 如果泄漏量大于极限值，则表示系统中可能会有泄漏密封损失。 这可以通过常规的压力保持测试来验证。 该方法和装置的特征在于，原则上不需要中断血液处理以检测泄漏密度的损失。

公开(公告)号：US6080321A

公开(公告)日：2000-06-27

申请号：US923245

申请日：1997-09-04

申请人： Reiner Spickermann

发明人： Reiner Spickermann

IPC分类号： A61M1/14 ,  A61M1/16 ,  B01D61/30 ,  F04C13/00 ,  F04C14/00 ,  F04C14/08 ,  B01D61/32 ,  B01D65/00 ,  B01D65/06

CPC分类号： F04C14/00 ,  A61M1/1607 ,  A61M1/1656 ,  A61M1/169 ,  B01D61/30 ,  F04C13/001 ,  F04C14/08 ,  A61M1/1692 ,  A61M2205/702 ,  A61M2205/707 ,  F04C2210/10 ,  F04C2210/1016 ,  F04C2270/08 ,  F04C2270/10

摘要： A dialysis machine for the removal of toxic substances from biological fluids with agents for the decalcification of a dialysis liquid circulation is disclosed. The dialysis machine allows measurement of the degree of calcification of the dialysis liquid through the use of a blood leak detector or by measuring the dialysis machine pump flow or pump voltage. The invention also includes a process for automatically decalcifying the dialysis liquid circulation when a predetermined degree of calcification of the dialysis machine is measured.

摘要翻译： 公开了一种用于从生物流体中除去有毒物质的透析机与用于透析液体循环脱钙的试剂。 透析机允许通过使用血液泄漏检测器或通过测量透析机泵流量或泵电压来测量透析液的钙化程度。 本发明还包括当测量透析机的预定程度的钙化时自动脱钙透析液体循环的方法。

公开(公告)号：US20100049114A1

公开(公告)日：2010-02-25

申请号：US12312604

申请日：2007-11-19

申请人： Gail-Suzanne Brown ,  Reiner Spickermann

发明人： Gail-Suzanne Brown ,  Reiner Spickermann

IPC分类号： A61M1/14 ,  G06F12/00

CPC分类号： A61M1/16 ,  A61M1/1698 ,  A61M1/3679 ,  A61M1/38 ,  A61M2205/3569 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/59

摘要： The present invention relates to the field of blood treatment machines such as hemodialysis machines. The object of this invention is to improve upon a generic blood treatment machine such that a certain individualization of the treatment station with little or no expenditure of materials is made possible in order to make the treatment environment more pleasant for the patient to be treated on the machine. The inventive blood treatment machine (10) therefore includes a control unit (16) that is configured so that image files transmitted and/or indexed via a data interface (15) can be displayed on the display screen (13) of the blood treatment machine during a blood treatment. The present invention also includes an external memory means (20) for connection to the data interface (15) and a combination consisting of the blood treatment machine (10) and the external memory means (20).

摘要翻译： 本发明涉及血液透析机等血液处理机领域。 本发明的目的是改进一般的血液处理机，使得能够很少或根本没有材料消耗的治疗台的某些个体化成为可能，以便使治疗环境对患者进行治疗更加愉快 机。 因此，本发明的血液处理机（10）包括控制单元（16），其被配置为使得经由数据接口（15）发送和/或索引的图像文件可以显示在血液处理机的显示屏幕（13）上 在血液治疗期间。 本发明还包括用于连接到数据接口（15）的外部存储装置（20）和由血液处理机（10）和外部存储装置（20）组成的组合。