公开(公告)号：US5434289A

公开(公告)日：1995-07-18

申请号：US208379

申请日：1994-03-10

申请人： Koichi Mikami ,  Satoru Matsukawa ,  Masaki Shimizu ,  Masahiro Terada ,  Noboru Sayo

发明人： Koichi Mikami ,  Satoru Matsukawa ,  Masaki Shimizu ,  Masahiro Terada ,  Noboru Sayo

IPC分类号： B01J31/22 ,  C07B53/00 ,  C07B61/00 ,  C07C45/51 ,  C07C45/67 ,  C07C67/333 ,  C07C67/343 ,  C07C67/38 ,  C07C69/675 ,  C07C69/708 ,  C07C69/712 ,  C07C69/732 ,  C07C69/734 ,  C07C319/20 ,  C07C323/22 ,  C07C327/28 ,  C07C327/32 ,  C07C327/00 ,  C07C45/00 ,  C07C69/76

CPC分类号： C07C327/32 ,  C07C327/28 ,  C07C45/511 ,  C07C67/343

摘要： A process for producing an optically active .beta.-hydroxyketone represented by formula (I): ##STR1## by catalytic asymmetrical aldol reaction is disclosed, comprising reacting a silyl-enol ether represented by formula (II): ##STR2## with a substituted aldehyde represented by formula (III):R.sup.5 CHO (III)in the presence of a binaphthol-titanium complex represented by formula (IV): ##STR3## An optically active .beta.-hydroxyketone is efficiently produced with diastereo-specificity and enantio-specificity.

摘要翻译： 公开了由式（I）表示的光学活性β-羟基酮：通过催化不对称醛醇缩合反应制备的光学活性β-羟基酮的方法，包括使由式（II）表示的甲硅烷基烯醇醚： ）与由式（III）表示的取代的醛：R5CHO（III）在由式（IV）表示的联萘酚 - 钛络合物的存在下：以非对映特异性和对映体特异性有效地产生。

公开(公告)号：US08901082B2

公开(公告)日：2014-12-02

申请号：US13002629

申请日：2009-07-10

申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

IPC分类号： A61K38/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/00 ,  A61P35/00 ,  C07K14/47 ,  A61K31/711 ,  A61K39/00 ,  G01N33/574

CPC分类号： C07K14/47 ,  A61K31/711 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/55566 ,  G01N33/57415 ,  G01N33/57426

摘要： An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo can be used for therapy and/or prophylaxis of cancer: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in the odd number IDs of SEQ ID NOs:3 to 95 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof. Further, since the above polypeptide(s) react(s) with antibodies existing specifically in serum of a cancer patient, it is possible to detect cancer in a living body by measuring the antibodies in a sample.

摘要翻译： 一种免疫诱导剂，其包含选自以下多肽的至少一种多肽，具有免疫诱导活性/活性的多肽或作为有效成分的重组载体（s）的有效成分 ），其可以用于治疗和/或预防癌症：（a）基本上包含编码多肽并且能够在体内表达多肽的多核苷酸的多核苷酸 在SEQUENCE LISTING中SEQ ID NO：3至95的奇数ID中显示的任何一个氨基酸序列中不少于7个连续氨基酸; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽。 此外，由于上述多肽与癌症患者的血清中特异性存在的抗体反应，因此可以通过测量样品中的抗体来检测活体中的癌症。

公开(公告)号：US08454968B2

公开(公告)日：2013-06-04

申请号：US13056122

申请日：2009-08-05

申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/04 ,  C12N15/00

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K38/19 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C12N5/0634 ,  C12N5/0636 ,  A61K2300/00

摘要： The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.

摘要翻译： 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。

公开(公告)号：US08167451B2

公开(公告)日：2012-05-01

申请号：US12438510

申请日：2007-09-10

申请人： Masaki Shimizu

发明人： Masaki Shimizu

IPC分类号： F21V33/00

CPC分类号： G02F1/133604 ,  F21V19/0085 ,  F21V19/009 ,  G02F1/133608 ,  G02F2001/133612

摘要： A fluorescent tube is prevented from being wrongly attached and broken when being attached, and luminance nonuniformity of backlight due to luminance difference generated in the tube axis direction of the fluorescent tube is reduced. In a backlight device (2), a plurality of fluorescent tube sets, each of which is composed of four fluorescent tubes (21) having electrodes (211) at the both ends and a pair of lamp holders (5) storing portions close to the both electrodes at the both ends of the four fluorescent tubes (21), and the fluorescent tube sets are driven by a pair of inverter circuit board. The backlight device (2) is provided with a power transmitting member (10), which is connected to electrodes (211) at the ends on one side of the two fluorescent tubes (21), for every two adjacent fluorescent tubes configuring the fluorescent tube set, gathers wirings (9) from the electrodes (211) at the ends and transmits power; and a conduction member (7), which is connected to the electrodes (211) on the other side of the two fluorescent tubes and permits a current to flow between the electrodes at the other ends. In the lamp holder (5), the power transmitting members (10) and the conductive members (7) are alternately arranged.

摘要翻译： 防止荧光灯在安装时被错误地安装和断开，并且由于在荧光管的管轴方向上产生的亮度差导致的背光源的亮度不均匀性降低。 在背光装置（2）中，多个荧光管组由荧光灯管（21）和两个荧光管（21）构成，所述荧光管具有在两端具有电极（211）和一对灯座（5） 四个荧光管（21）的两端的两个电极和荧光管组由一对逆变器电路板驱动。 背光装置（2）具有电力传输构件（10），其连接到两个荧光管（21）的一侧上的端部处的电极（211），对于构成荧光管的每两个相邻的荧光管 设置，在端部从电极（211）收集布线（9）并传输电力; 和连接到两个荧光管的另一侧上的电极（211）的导电构件（7），并允许电流在另一端的电极之间流动。 在灯座（5）中，动力传递部件（10）和导电部件（7）交替布置。

公开(公告)号：US07786681B2

公开(公告)日：2010-08-31

申请号：US11855536

申请日：2007-09-14

申请人： Yutaka Inoue ,  Masaki Shimizu ,  Shuhki Ohtani

发明人： Yutaka Inoue ,  Masaki Shimizu ,  Shuhki Ohtani

IPC分类号： H05B41/24 ,  H05B39/00

CPC分类号： H05B41/2821 ,  G09G3/3406 ,  H05B41/2822 ,  Y02B20/185

摘要： A driving apparatus and a driving method are disclosed that are capable of uniformly lighting each entire fluorescent tube irrespective of the length or number of fluorescent tubes when simultaneously driving a plurality of fluorescent tubes in a fluorescent tube lighting apparatus. When two inverter circuits having respective transformers are provided at both ends of a fluorescent tube to light the fluorescent tube by push-pull driving, feedback windings of transformers not used in self-excited oscillation of each inverter circuit are connected together, with the transformer connection that connects together the feedback windings being either in-phase or in opposite phase, and the method of connection for fluorescent tubes connecting to secondary windings of each transformer can be changed in accordance with that connection method.

公开(公告)号：US20100182514A1

公开(公告)日：2010-07-22

申请号：US12666736

申请日：2008-03-24

申请人： Yasumori Kuromizu ,  Masashi Yokota ,  Masaki Shimizu

发明人： Yasumori Kuromizu ,  Masashi Yokota ,  Masaki Shimizu

IPC分类号： H04N5/44 ,  F21V1/00 ,  G02F1/13357

CPC分类号： G02F1/133604 ,  G02F1/133605 ,  G02F1/133611 ,  G02F2001/133613

摘要： The present invention includes a plurality of linear sources 17 arranged parallel to one another, and a light reflecting member 40 arranged on the side of the linear light sources 17 that corresponds to the opposite side of the light emitting side. The linear light sources 17 are arranged so that a narrow-interval area 17A where the arrangement interval thereof is relatively narrow and a wide-interval area 17B where the arrangement interval is relatively wide are provided. The light reflecting member 40 includes an opening section 50 located directly below the linear light sources 17. The opening section 50 is provided so that the opening ratio as a ratio between a total area of the light reflecting member 40 and areas of the opening section 50 is higher at an area of the light reflecting member 40 corresponding to the narrow-interval area 17A than at an area of the light reflecting member 40 corresponding to the wide-interval area 17B.

摘要翻译： 本发明包括彼此平行布置的多个线性源17和布置在线性光源17的对应于发光侧的相对侧的一侧的光反射部件40。 线性光源17被布置成使得其布置间隔相对窄的窄间隔区域17A和布置间隔相对较宽的宽间隔区域17B。 光反射部件40具有位于线状光源17的正下方的开口部50.开口部50的开口率成为光反射部件40的总面积与开口部50的面积之比 在对应于窄间隔区域17A的光反射构件40的区域处比对应于宽间隔区域17B的光反射构件40的区域高。

公开(公告)号：US20080067958A1

公开(公告)日：2008-03-20

申请号：US11979039

申请日：2007-10-30

申请人： Yutaka Inoue ,  Masaki Shimizu ,  Shuhki Ohtani

发明人： Yutaka Inoue ,  Masaki Shimizu ,  Shuhki Ohtani

IPC分类号： H05B37/00

CPC分类号： H05B41/2821 ,  G09G3/3406 ,  H05B41/2822 ,  Y02B20/185

摘要： A driving apparatus and a driving method are disclosed that are capable of uniformly lighting each entire fluorescent tube irrespective of the length or number of fluorescent tubes when simultaneously driving a plurality of fluorescent tubes in a fluorescent tube lighting apparatus. When two inverter circuits having respective transformers are provided at both ends of a fluorescent tube to light the fluorescent tube by push-pull driving, feedback windings of transformers not used in self-excited oscillation of each inverter circuit are connected together, with the transformer connection that connects together the feedback windings being either in-phase or in opposite phase, and the method of connection for fluorescent tubes connecting to secondary windings of each transformer can be changed in accordance with that connection method.

摘要翻译： 公开了一种驱动装置和驱动方法，其能够在荧光管照明装置中同时驱动多个荧光管时，与荧光管的长度或数量无关地均匀地点亮每个荧光管。 当在荧光管的两端设置具有各自变压器的两个逆变器电路，以通过推挽驱动来对荧光管进行点亮时，不用于每个逆变器电路的自激振荡的变压器的反馈绕组连接在一起，变压器连接 将反馈绕组连接在一起的同相或相反相，并且可以根据该连接方法改变连接到每个变压器的次级绕组的荧光管的连接方法。

公开(公告)号：US07338630B2

公开(公告)日：2008-03-04

申请号：US10963492

申请日：2004-10-11

申请人： Takashi Kano ,  Yasuhiro Hazama ,  Junya Asaoka ,  Masaki Shimizu ,  Katsumi Mori ,  Hisashi Endo

发明人： Takashi Kano ,  Yasuhiro Hazama ,  Junya Asaoka ,  Masaki Shimizu ,  Katsumi Mori ,  Hisashi Endo

IPC分类号： C22C38/02 ,  C22C38/04 ,  C22C38/06 ,  C22C38/14

CPC分类号： C22C38/22 ,  C22C38/02 ,  C22C38/04 ,  F02M55/025 ,  F02M61/168 ,  F02M2200/8069

摘要： The present invention is to provide a free-cutting steel capable of suppressing production of coarse inclusions, and having a high fatigue strength and a desirable machinability. The free-cutting steel aimed at solving the foregoing problems consists essentially of, in % by mass, C: 0.1-0.5%, Si: 0.05-2.5%, Mn: 0.1-3.5%, S: 0.0005-0.004%, Al: 0.01-0.06%, Ti: 0.003-0.01%, O: up to 0.0015%, N: 0.003-0.01%, Bi: 0.015-0.025%, and the balance of Fe and inevitable impurities, wherein the formula (1) below is satisfied: −4.8≦log(([N]−0.0015)×[Ti]0.98)≦−4.3.   formula (1)

摘要翻译： 本发明提供一种能够抑制粗大夹杂物的生产，并且具有高疲劳强度和期望的切削性能的自由切削钢。 旨在解决上述问题的自由切削钢基本上以质量％计含有C：0.1-0.5％，Si：0.05〜2.5％，Mn：0.1-3.5％，S：0.0005〜0.004％，Al： 0.01-0.06％，Ti：0.003-0.01％，O：至多0.0015％，N：0.003-0.01％，Bi：0.015-0.025％，余量为Fe和不可避免的杂质，其中下式（1） 满足：<？in-line-formula description =“In-line formula”end =“lead”？> - 4.8 <= LOG（（[N] -0.0015）x [Ti] <0.98 <= - 4.3。 公式（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>

公开(公告)号：US20080037250A1

公开(公告)日：2008-02-14

申请号：US11882917

申请日：2007-08-07

申请人： Masaki Shimizu ,  Tsutomu Tsuji ,  Takaharu Kikuchi

发明人： Masaki Shimizu ,  Tsutomu Tsuji ,  Takaharu Kikuchi

IPC分类号： F21V21/00

CPC分类号： F21V19/009 ,  G02F1/133604 ,  G02F1/133608

摘要： A lamp supporting device for supporting a plurality of lamps so as to be juxtaposed includes the first and second mounting holes for mounting the first lamp holding member having a plurality of holding parts for holding middle parts of the lamps and the second lamp holding member having a holding part of the number different from that of the holding parts of the first lamp holding member; and identifying means for identifying positions to which the first and second lamp holding members are mounted.

摘要翻译： 用于支撑多个灯以并列的灯支撑装置包括用于安装第一灯保持构件的第一和第二安装孔，其具有用于保持灯的中间部分的多个保持部分，并且第二灯保持构件具有 保持与第一灯保持构件的保持部的数量不同的一部分; 以及用于识别安装第一和第二灯保持构件的位置的识别装置。

公开(公告)号：US20080012500A1

公开(公告)日：2008-01-17

申请号：US11855536

申请日：2007-09-14

申请人： Yutaka Inoue ,  Masaki Shimizu ,  Shuhki Ohtani

发明人： Yutaka Inoue ,  Masaki Shimizu ,  Shuhki Ohtani

IPC分类号： H05B41/36

CPC分类号： H05B41/2821 ,  G09G3/3406 ,  H05B41/2822 ,  Y02B20/185

摘要： A driving apparatus and a driving method are disclosed that are capable of uniformly lighting each entire fluorescent tube irrespective of the length or number of fluorescent tubes when simultaneously driving a plurality of fluorescent tubes in a fluorescent tube lighting apparatus. When two inverter circuits having respective transformers are provided at both ends of a fluorescent tube to light the fluorescent tube by push-pull driving, feedback windings of transformers not used in self-excited oscillation of each inverter circuit are connected together, with the transformer connection that connects together the feedback windings being either in-phase or in opposite phase, and the method of connection for fluorescent tubes connecting to secondary windings of each transformer can be changed in accordance with that connection method.

摘要翻译： 公开了一种驱动装置和驱动方法，其能够在荧光管照明装置中同时驱动多个荧光管时，与荧光管的长度或数量无关地均匀地点亮每个荧光管。 当在荧光管的两端设置具有各自变压器的两个逆变器电路，以通过推挽驱动来对荧光管进行点亮时，不用于每个逆变器电路的自激振荡的变压器的反馈绕组连接在一起，变压器连接 将反馈绕组连接在一起的同相或相反相，并且可以根据该连接方法改变连接到每个变压器的次级绕组的荧光管的连接方法。