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公开(公告)号：US4006057A
公开(公告)日：1977-02-01
申请号：US628840
申请日：1975-11-04
申请人： Konosuke Sano , Keizo Matsuda , Koji Mitsugi , Kazuhiko Yamada , Fumihide Tamura , Naohiko Yasuda , Ichiro Noda
发明人： Konosuke Sano , Keizo Matsuda , Koji Mitsugi , Kazuhiko Yamada , Fumihide Tamura , Naohiko Yasuda , Ichiro Noda
CPC分类号： C12P13/12 , Y10S435/824 , Y10S435/829 , Y10S435/833 , Y10S435/84 , Y10S435/847 , Y10S435/859 , Y10S435/874 , Y10S435/881
摘要： A method for producing L-cysteine and/or L-cystine which comprises:A. holding 2-amino-thiazoline-4-carboxylic acid in an aqueous solution at a pH of 5 to 11 in the presence of an effective amount of enzyme produced by a microorganism; said enzyme being capable of converting the 2-amino-thiazoline-4-carboxylic acid to L-cysteine and/or L-cystine, and said microorganism being capable of growing in a medium containing 2-amino-thiazoline-4-carboxylic acid as a nitrogen source; andB. recovering the L-cysteine and/or L-cystine formed from said aqueous solution.
摘要翻译： 一种L-半胱氨酸和/或L-胱氨酸的制造方法，其特征在于：
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公开(公告)号：US4016037A
公开(公告)日：1977-04-05
申请号：US622519
申请日：1975-10-15
申请人： Koji Mitsugi , Konosuke Sano , Kenzo Yokozeki , Kazuhiko Yamada , Ichiro Noda , Teruhiko Kagawa , Chikahiko Eguchi , Naohiko Yasuda , Fumihide Tamura , Kazushi Togo
发明人： Koji Mitsugi , Konosuke Sano , Kenzo Yokozeki , Kazuhiko Yamada , Ichiro Noda , Teruhiko Kagawa , Chikahiko Eguchi , Naohiko Yasuda , Fumihide Tamura , Kazushi Togo
CPC分类号： C12P13/04 , C12N9/86 , Y10S435/85
摘要： L-amino acids are produced by fermenting a hydantoin compound with Flavobacterium aminogenes or its enzymes.
摘要翻译： L-氨基酸是通过用氨溴青霉素或其酶发酵乙内酰脲化合物来生产的。
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3.发明授权
公开(公告)号：US4072687A
公开(公告)日：1978-02-07
申请号：US737781
申请日：1976-11-01
申请人： Kazushi Togo , Fumihide Tamura , Naohiko Yasuda , Takehiko Ichikawa , Konosuke Sano , Keizo Matsuda , Koji Mitsugi
发明人： Kazushi Togo , Fumihide Tamura , Naohiko Yasuda , Takehiko Ichikawa , Konosuke Sano , Keizo Matsuda , Koji Mitsugi
IPC分类号： C07D277/18 , C12P13/12
CPC分类号： C12P13/12 , C07D277/18
摘要： 2-Amino-(2)-thiazoline-4-carboxylic acid is prepared by dehydrochlorinating S-(.beta.-carboxy-.beta.-chloroethyl) isothiourea by adding it to an aqueous medium maintained at a pH ranging from 5.5 to 7.5 with an alkali.
摘要翻译： 通过将S-（β-羧基-β-氯乙基）异硫脲通过用碱保持在5.5至7.5的pH范围的水性介质中脱氯化氢来制备2-氨基 - （2） - 噻唑啉-4-羧酸。
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公开(公告)号：US3930948A
公开(公告)日：1976-01-06
申请号：US492906
申请日：1974-07-29
申请人： Konosuke Sano , Keizo Matsuda , Hidetsugu Nakazawa , Koji Mitsugi
发明人： Konosuke Sano , Keizo Matsuda , Hidetsugu Nakazawa , Koji Mitsugi
IPC分类号： C12P13/00 , C07C209/68 , C07D209/16 , C12N9/88 , C12P13/22 , C12D13/00
CPC分类号： C07C209/68 , C07D209/16 , C12N9/88 , Y10S435/859
摘要： A decarboxylase in cells of Micrococcus strains converts tryptophan, phenylalanine, and substitution products thereof to the corresponding phenyl- and indolylethylamines. The enzyme can be recovered in pure state from the microorganisms, but cells and cell material are effective enzyme sources in the decarboxylation reaction.
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公开(公告)号：US4371613A
公开(公告)日：1983-02-01
申请号：US930046
申请日：1978-08-01
申请人： Takashi Utagawa , Takeshi Miyoshi , Hirokazu Morisawa , Akihiro Yamazaki , Fumihiro Yoshinaga , Koji Mitsugi
发明人： Takashi Utagawa , Takeshi Miyoshi , Hirokazu Morisawa , Akihiro Yamazaki , Fumihiro Yoshinaga , Koji Mitsugi
摘要： Purine-arabinosides and a method for making purine-arabinosides are disclosed. The method comprises contacting an arabinose donor and a purine source in the presence of an effective amount of enzyme produced by a bacterium and capable of transarabinosylation from the arabinose donor to the purine source, whereby a 9-(.beta.-D-arabinofuranosyl)-purine is produced.
摘要翻译： 公开了嘌呤 - 阿拉伯糖苷和制备嘌呤 - 阿拉伯糖苷的方法。 该方法包括在有效量的由细菌产生并能够从阿拉伯糖供体转运到嘌呤源的阿拉伯糖基化反应的存在下使阿拉伯糖供体和嘌呤源接触，由此将9-（β-D-阿拉伯呋喃糖基） - 嘌呤 生产。
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公开(公告)号：US4228241A
公开(公告)日：1980-10-14
申请号：US889877
申请日：1978-03-24
申请人： Hirofumi Hiraga , Ryuichi Miyajima , Koji Mitsugi
发明人： Hirofumi Hiraga , Ryuichi Miyajima , Koji Mitsugi
CPC分类号： C12N9/48 , A23L27/50 , Y10S435/913 , Y10S435/918
摘要： A method is provided for producing a peptidase capable of substantially completely hydrolyzing protein into its constituent amino acids which comprises culturing a strain of filamentous fungus, belonging to one of the species Aspergillus oryzae and Aspergillus soyae and characterized in that said strain is capable of producing said peptidase, in a nutrient culture medium containing at least one substrate selected from the group consisting of a fatty acid having 14, 16, 18 or 20 carbon atoms and a derivative of said fatty acid, and recovering said peptidase from said culture medium. It is particularly effective to use a combination of a sugar ester of a fatty acid and a vegetable oil as substrates in a liquid culture medium.
摘要翻译： 提供了一种生产能够将蛋白质基本上完全水解成其组成氨基酸的肽酶的方法，其包括培养属于米曲霉和大豆曲霉之一的丝状真菌菌株，其特征在于所述菌株能够产生所述 肽酶，在含有选自具有14,16,18或20个碳原子的脂肪酸和所述脂肪酸的衍生物的至少一种底物的营养培养基中，并从所述培养基中回收所述肽酶。 在液体培养基中使用脂肪酸的糖酯和植物油的组合物作为底物是特别有效的。
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公开(公告)号：US4071405A
公开(公告)日：1978-01-31
申请号：US696398
申请日：1976-06-15
申请人： Kenji Soda , Hidehiko Tanaka , Hidetsugu Nakazawa , Koji Mitsugi
发明人： Kenji Soda , Hidehiko Tanaka , Hidetsugu Nakazawa , Koji Mitsugi
CPC分类号： C12P13/12 , C12P13/04 , Y10S435/842 , Y10S435/849 , Y10S435/874
摘要： Method for the production of substituted sulfur containing L-amino acids by contacting .beta.- or .gamma.-substituted amino acids in an aqueous medium containing methioninase together with the precursor of the substituent.
摘要翻译： 通过使含有蛋氨酸酶的水性介质中的β-或γ-取代的氨基酸与取代基的前体接触来生产含有L-氨基酸的取代的硫的方法。
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公开(公告)号：US4211840A
公开(公告)日：1980-07-08
申请号：US897003
申请日：1978-04-17
IPC分类号： C07D233/72 , C12P13/04 , C12P13/24
CPC分类号： C12P13/04
摘要： D-.alpha.-amino acids are produced by contacting a 5-substituted hydantoin with an effective amount of an enzyme capable of converting the 5-substituted hydantoin to the D-.alpha.-amino acid produced by a microorganism in an aqueous medium at a pH in the range of 4 to 9, the microorganism being capable of utilizing the D-isomer of the 5-substituted hydantoin as the sole nitrogen source, but substantially incapable of utilizing the L-isomer of the 5-substituted hydantoin as the nitrogen source and the substituent of the 5-position being such that upon reaction with the enzyme, an optically active D-.alpha.-amino acid isomer is produced; and recovering the D-.alpha.-amino acid which accumulates in the aqueous medium.
摘要翻译： D-α-氨基酸是通过使5-取代的乙内酰脲与有效量的能够将5-取代的乙内酰脲转化为由微生物在水性介质中产生的D-α-氨基酸的酶在pH值 范围为4至9，微生物能够利用5-取代乙内酰脲的D-异构体作为唯一的氮源，但基本上不能利用5-取代的乙内酰脲的L-异构体作为氮源， 5位的取代基使得当与酶反应时，产生光学活性的D-α-氨基酸异构体; 并回收积聚在水性介质中的D-α-氨基酸。
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公开(公告)号：US4022666A
公开(公告)日：1977-05-10
申请号：US70656
申请日：1970-09-09
CPC分类号： C12N9/2417 , Y10S435/839
摘要： Alpha-amylases which have optimum activity between pH 6.5 to 8 and between pH 9.0 to 11.5 at 40.degree. C are produced by culturing strains of Bacillus subtilis on a nutrient medium under aerobic conditions. Some of the alpha amylases are effective in hot and alkaline detergent solutions containing chelating agents.
摘要翻译： 通过在有氧条件下在营养培养基上培养枯草芽孢杆菌菌株，产生在pH6.5〜8和pH9.0〜11.5之间具有最佳活性的α-淀粉酶。 一些α-淀粉酶在含有螯合剂的热和碱性洗涤剂溶液中是有效的。
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公开(公告)号：US4789658A
公开(公告)日：1988-12-06
申请号：US873302
申请日：1986-06-09
申请人： Ryota Yoshimoto , Nobukazu Kashima , Junji Hamuro , Koji Mitsugi
发明人： Ryota Yoshimoto , Nobukazu Kashima , Junji Hamuro , Koji Mitsugi
IPC分类号： C12N15/02 , A61K35/12 , A61K35/14 , A61K35/28 , A61K36/06 , A61K38/00 , A61K38/16 , A61K38/18 , A61P35/00 , C07K14/52 , C07K14/54 , C07K14/55 , C07K14/555 , C07K14/56 , C12P21/00 , A61K37/00
CPC分类号： C07K14/55 , A61K31/716 , A61K38/21 , A61K38/00
摘要： An immunopropylactic and immunotherapeutic agent comprising human interleukin 2 of human cellular origin is disclosed along with a method of producing the agent.
摘要翻译： 公开了包含人细胞来源的人白细胞介素2的免疫性丙立体和免疫治疗剂及其制备方法。
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