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1.发明授权Magnetic particles comprising an organic polymer layer and method for producing the same 有权包含有机聚合物层的磁性颗粒及其制备方法公开(公告)号：US07713627B2
公开(公告)日：2010-05-11
申请号：US11688653
申请日：2007-03-20
申请人： Kouji Tamori , Tetsuo Fukuta , Satoshi Katayose , Masaru Ueno , Mitsuhiro Murata
发明人： Kouji Tamori , Tetsuo Fukuta , Satoshi Katayose , Masaru Ueno , Mitsuhiro Murata
IPC分类号： B32B5/16
CPC分类号： G01N33/5434 , G01N33/54393 , Y10S525/921 , Y10T428/2991 , Y10T428/2998
摘要： Magnetic particles comprising a group shown by the following formula (1): wherein R1 and R2 individually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that R1 and R2 are not both hydrogen atoms, wherein R3 represents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and wherein R4 is a hydrogen atom or an alkyl group.
摘要翻译： 包含由下式（1）表示的基团的磁性颗粒：其中R1和R2各自表示羟基，下式（2）表示的基团或下式（3）所示的基团，条件是R1 并且R 2不是氢原子，其中R 3表示具有2至6个碳原子的直链，支链或环状亚烷基或亚芳基，并且其中R4是氢原子或烷基。
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2.发明授权公开(公告)号：US08703289B2
公开(公告)日：2014-04-22
申请号：US11588388
申请日：2006-10-27
申请人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
发明人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
CPC分类号： G01N33/54326 , C08F8/36 , C08F8/42 , C08F8/44 , C08F220/26 , C08F220/32 , C08F222/1006 , C08F257/02 , C08F265/04 , C08F291/00 , C08F2810/20 , C08L25/04 , C08L33/066 , C08L51/003 , G01N33/5434 , H01F1/0054 , Y10T428/2991 , Y10T428/2998 , C08L2666/06 , C08L2666/02 , C08F8/12 , C08F2220/325 , C08F2220/1825 , C08F2222/1013 , C08F212/08 , C08F212/36 , C08F220/14 , C08F2222/1026 , C08F2220/281 , C08F2220/282
摘要： The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5° to 60°. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.
摘要翻译： 有机聚合物颗粒包含羧基和2,3-二羟基丙基，用于诊断的磁性颗粒包括细小的磁性材料颗粒和含有亲水性聚合物部分和交联聚合物部分的聚合物部分，从水中获得的干燥涂膜 其与水的接触角为5°至60°的分散体。 制备含羧基颗粒的方法包括通过使具有羟基的有机聚合物颗粒中的羟基与羧酸酐反应而产生酯键的步骤。 有机聚合物颗粒包含源自2,3-二羟基丙基和聚氧乙烯基团的羟基。
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公开(公告)号：US20070224424A1
公开(公告)日：2007-09-27
申请号：US11688653
申请日：2007-03-20
申请人： Kouji TAMORI , Tetsuo Fukuta , Satoshi Katayose , Masaru Ueno , Mitsuhiro Murata
发明人： Kouji TAMORI , Tetsuo Fukuta , Satoshi Katayose , Masaru Ueno , Mitsuhiro Murata
IPC分类号： B32B5/16
CPC分类号： G01N33/5434 , G01N33/54393 , Y10S525/921 , Y10T428/2991 , Y10T428/2998
摘要： Magnetic particles comprising a group shown by the following formula (1): wherein R1 and R2 individually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that R1 and R2 are not both hydrogen atoms, wherein R3 represents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and wherein R4 is a hydrogen atom or an alkyl group.
摘要翻译： 包含由下式（1）表示的基团的磁性颗粒：其中R 1和R 2各自表示羟基，由下式（2）表示的基团， 或下式（3）所示的基团，条件是R 1和R 2不都是氢原子，其中R 3， 表示具有2〜6个碳原子的直链，支链或环状亚烷基或亚芳基，其中R 4为氢原子或烷基。
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4.发明申请公开(公告)号：US20070099814A1
公开(公告)日：2007-05-03
申请号：US11588388
申请日：2006-10-27
申请人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
发明人： Kouji Tamori , Tetsuo Fukuta , Mitsuhiro Murata , Masaru Ueno , Satoshi Katayose , Eiji Takamoto , Kiyoshi Kasai
IPC分类号： C11D17/00
CPC分类号： G01N33/54326 , C08F8/36 , C08F8/42 , C08F8/44 , C08F220/26 , C08F220/32 , C08F222/1006 , C08F257/02 , C08F265/04 , C08F291/00 , C08F2810/20 , C08L25/04 , C08L33/066 , C08L51/003 , G01N33/5434 , H01F1/0054 , Y10T428/2991 , Y10T428/2998 , C08L2666/06 , C08L2666/02 , C08F8/12 , C08F2220/325 , C08F2220/1825 , C08F2222/1013 , C08F212/08 , C08F212/36 , C08F220/14 , C08F2222/1026 , C08F2220/281 , C08F2220/282
摘要： The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5° to 60°. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.
摘要翻译： 有机聚合物颗粒包含羧基和2,3-二羟基丙基，用于诊断的磁性颗粒包括细小的磁性材料颗粒和含有亲水性聚合物部分和交联聚合物部分的聚合物部分，从水中获得的干燥涂膜 其与水的接触角为5°至60°的分散体。 制备含羧基颗粒的方法包括通过使具有羟基的有机聚合物颗粒中的羟基与羧酸酐反应而产生酯键的步骤。 有机聚合物颗粒包含源自2,3-二羟基丙基和聚氧乙烯基团的羟基。
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5.发明授权Polymer-coated magnetic particles comprising a 2,3-hydroxypropyl group, and probe-bonded particles 有权包含2,3-羟丙基的聚合物涂覆的磁性颗粒和探针结合的颗粒公开(公告)号：US07732051B2
公开(公告)日：2010-06-08
申请号：US11772616
申请日：2007-07-02
申请人： Kouji Tamori , Eiji Takamoto , Masaru Ueno , Tetsuo Fukuta , Tomohiro Uetsuhara , Mitsuhiro Murata
发明人： Kouji Tamori , Eiji Takamoto , Masaru Ueno , Tetsuo Fukuta , Tomohiro Uetsuhara , Mitsuhiro Murata
IPC分类号： B32B5/16
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/86 , Y10S525/902 , Y10T428/2998
摘要： A method for producing magnetic particles includes forming a hydrophobic first polymer layer on the surface of a mother particle containing superparamagnetic particles, forming a second polymer layer having glycidyl groups at least on its surface on the first polymer layer, and introducing a polar group containing one or more of at least one atom selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom by chemically modifying the glycidyl groups.
摘要翻译： 制造磁性粒子的方法包括在含有超顺磁性粒子的母粒子的表面形成疏水性第一聚合物层，在第一聚合物层上至少在其表面上形成具有缩水甘油基的第二聚合物层，并引入含有一个 或更多的选自氧原子，氮原子和硫原子的至少一个原子，通过化学改性缩水甘油基。
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6.发明申请公开(公告)号：US20080026222A1
公开(公告)日：2008-01-31
申请号：US11772616
申请日：2007-07-02
申请人： Kouji TAMORI , Eiji Takamoto , Masaru Ueno , Tetsuo Fukuta , Tomohiro Uetsuhara , Mitsuhiro Murata
发明人： Kouji TAMORI , Eiji Takamoto , Masaru Ueno , Tetsuo Fukuta , Tomohiro Uetsuhara , Mitsuhiro Murata
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/86 , Y10S525/902 , Y10T428/2998
摘要： A method for producing magnetic particles includes forming a hydrophobic first polymer layer on the surface of a mother particle containing superparamagnetic particles, forming a second polymer layer having glycidyl groups at least on its surface on the first polymer layer, and introducing a polar group containing one or more of at least one atom selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom by chemically modifying the glycidyl groups.
摘要翻译： 制造磁性粒子的方法包括在含有超顺磁性粒子的母粒子的表面形成疏水性第一聚合物层，在第一聚合物层上至少在其表面上形成具有缩水甘油基的第二聚合物层，并引入含有一个 或更多的选自氧原子，氮原子和硫原子的至少一个原子，通过化学改性缩水甘油基。
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7.发明申请Carrier Polymer Particle, Process for Producing the Same, Magnetic Particle for Specific Trapping, and Process for Producing the Same 审中-公开载体聚合物颗粒，其制备方法，用于特定捕集的磁性颗粒及其生产方法公开(公告)号：US20090014682A1
公开(公告)日：2009-01-15
申请号：US11914986
申请日：2006-05-17
申请人： Masayuki Takahashi , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
发明人： Masayuki Takahashi , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
CPC分类号： C08G63/91 , B32B5/16 , G01N33/53 , G01N33/5434 , G01N33/54353 , Y10T428/2982 , Y10T428/2998
摘要： Carrier polymer particles comprising organic polymer particles having a particle diameter of 0.1 to 20 micrometers and a saccharide with which the surface of the organic polymer particles is covered, the organic polymer particles and the saccharide being chemically bonded.
摘要翻译： 包含粒径为0.1-20微米的有机聚合物颗粒的载体聚合物颗粒和被覆盖有机聚合物颗粒的表面的糖类，有机聚合物颗粒和化学键合的糖类。
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8.发明申请CARRIER POLYMER PARTICLE, PROCESS FOR PRODUCING THE SAME, MAGNETIC PARTICLE FOR SPECIFIC TRAPPING, AND PROCESS FOR PRODUCING THE SAME 审中-公开载体聚合物颗粒，其制造方法，用于特定捕获的磁性颗粒及其生产方法公开(公告)号：US20110184155A1
公开(公告)日：2011-07-28
申请号：US13025273
申请日：2011-02-11
申请人： Masayuki TAKAHASHI , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
发明人： Masayuki TAKAHASHI , Tetsuo Fukuta , Kiyoshi Kasai , Toshihiro Ogawa , Satoshi Katayose , Kouji Tamori , Kinji Yamada
CPC分类号： C08G63/91 , B32B5/16 , G01N33/53 , G01N33/5434 , G01N33/54353 , Y10T428/2982 , Y10T428/2998
摘要： Carrier polymer particles comprising organic polymer particles having a particle diameter of 0.1 to 20 micrometers and a saccharide with which the surface of the organic polymer particles is covered, the organic polymer particles and the saccharide being chemically bonded.
摘要翻译： 包含粒径为0.1-20微米的有机聚合物颗粒的载体聚合物颗粒和被覆盖有机聚合物颗粒的表面的糖类，有机聚合物颗粒和化学键合的糖类。
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9.发明申请公开(公告)号：US20100105879A1
公开(公告)日：2010-04-29
申请号：US12529824
申请日：2008-03-04
IPC分类号： C07K1/04
CPC分类号： C07K17/06 , G01N33/543 , G01N33/54353
摘要： A method of producing a protein-immobilized support includes immobilizing a protein having a tag sequence on a support, the tag sequence including a sequence that includes three or more consecutive basic amino acids.
摘要翻译： 制备蛋白质固定化载体的方法包括将具有标签序列的蛋白质固定在载体上，所述标签序列包括包含三个或更多个连续碱性氨基酸的序列。
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公开(公告)号：US08846877B2
公开(公告)日：2014-09-30
申请号：US13121124
申请日：2009-09-24
申请人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yuusuke Okano , Masaki Momiyama , Takahiro Kawai
发明人： Kouji Tamori , Tetsuo Fukuta , Masaaki Miyaji , Yong Wang , Takayoshi Abe , Yuusuke Okano , Masaki Momiyama , Takahiro Kawai
IPC分类号： C07K1/14 , G01N33/544 , G01N33/547 , B01J20/32 , C07K1/22 , B01J20/286
CPC分类号： C07K1/22 , B01J20/286 , B01J20/321 , B01J20/3219 , B01J20/3274 , Y10T428/29
摘要： An affinity chromatography packing material includes porous mother particles that include a copolymer of a monomer mixture including a crosslinkable vinyl monomer and an epoxy group-containing vinyl monomer, a ligand being bound to the porous mother particles, and the porous mother particles including a ring-opening epoxy group produced by ring-opening of the epoxy group included in the porous mother particles.
摘要翻译： 亲和层析填充材料包括多孔母体颗粒，其包括包含可交联乙烯基单体和含环氧基的乙烯基单体的单体混合物的共聚物，与多孔母体颗粒结合的配体，以及多孔母体颗粒， 开环环氧基，其由包含在多孔母体颗粒中的环氧基开环制得。
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