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    BILE DUCT CHIP AND USE THEREOF
    1.
    发明公开
    BILE DUCT CHIP AND USE THEREOF 审中-公开

    公开(公告)号：US20240150691A1

    公开(公告)日：2024-05-09

    申请号：US18280659

    申请日：2022-03-09

    Applicant: Kyoto University ,  OSAKA UNIVERSITY

    Inventor： Kazuo TAKAYAMA ,  Yusuke TORISAWA ,  Kenji OSAFUNE ,  Maki KOTAKA ,  Sayaka DEGUCHI ,  Hiroyuki MIZUGUCHI

    IPC: C12M3/00 ,  C12M1/00 ,  C12M3/06

    CPC classification number: C12M21/08 ,  C12M23/16 ,  C12M29/04

    Abstract: There is provided a bile duct chip that is a bile duct chip (200) including a membrane (210) through which substances are movable from one surface to the other surface, a first substrate (221) having a recessed part that forms a first flow path (220), and a second substrate (231) having a recessed part that forms a second flow path (230), in which the first substrate (221), the membrane (210), the second substrate (231) are stacked in this order, the recessed part of the first substrate (221) has an opening portion facing the one surface of the membrane (210), the recessed part of the second substrate has an opening portion facing the other surface of the membrane (210), the one surface of the membrane (210) forms a part of the first flow path (220), the other surface of the membrane (210) forms a part of the second flow path (230), the first flow path (220) and the second flow path (230) communicate with each other through the membrane (210), and bile duct epithelial cells (222) are disposed on a surface of an inner wall of the first flow path (220) to form a tube.

    METHOD FOR INDUCING URETERIC BUD-LIKE TISSUE
    4.
    发明申请
    METHOD FOR INDUCING URETERIC BUD-LIKE TISSUE 有权

    公开(公告)号：US20210009960A1

    公开(公告)日：2021-01-14

    申请号：US16763875

    申请日：2018-11-16

    Applicant: Kyoto University

    Inventor： Kenji OSAFUNE ,  Shinichi MAE ,  Makoto RYOUSAKA

    IPC: C12N5/071

    Abstract: An object of the present application is to provide a method for inducing the differentiation from pluripotent stem cells, particularly iPS cells and ES cells, into ureteric bud cells. Another object of the present application is to provide a system for producing ureteric bud-like tissue from pluripotent stem cells through each stage of differentiations, i.e. anterior primitive streak cells, anterior intermediate mesoderm cells and Wolffian duct cells. Yet another object of the present application is to provide a method for maintaining ureteric bud-like organoids. Another object of the present application is to provide a method for expansion-culturing ureteric bud-like tip tissue.

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