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公开(公告)号:US06916833B2
公开(公告)日:2005-07-12
申请号:US10793296
申请日:2004-03-04
IPC分类号: A61P35/00 , C07D211/52 , C07D211/96 , A61K31/445 , C07D211/40 , C07D211/42 , C07D211/50
CPC分类号: C07D211/52 , C07D211/96
摘要: The present invention provides compounds having formula (I): and formula (II): wherein X, n, and R1-R12 are defined herein, or a pharmaceutically acceptable salt thereof. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound represented by formula (I) or (II) and a pharmaceutically acceptable carrier or excipient. The invention further provides a method for treating cancer comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound represented by formula (I) or (II).
摘要翻译: 本发明提供具有式(I):和式(II)的化合物:其中X,n和R 1 -R 12在本文中定义,或药学上可接受的 的盐。 本发明还提供了包含治疗有效量的由式(I)或(II)表示的化合物和药学上可接受的载体或赋形剂的药物组合物。 本发明还提供了一种治疗癌症的方法,包括向需要这种治疗的患者施用治疗有效量的由式(I)或(II)表示的化合物。
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公开(公告)号:US07060713B2
公开(公告)日:2006-06-13
申请号:US11083750
申请日:2005-03-18
IPC分类号: A61K31/445 , C07D211/40 , C07D211/44
CPC分类号: C07D211/52 , C07D211/96
摘要: The present invention provides compounds having formula (II): wherein X, n, R1–R12 are defined herein, or a pharmaceutically acceptable salt thereof. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound represented by formula (II) and a pharmaceutically acceptable carrier or excipient. The invention further provides a method for treating cancer comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound represented by formula (II).
摘要翻译: 本发明提供具有式(II)的化合物:其中X,n,R 1 -R 12在本文中定义,或其药学上可接受的盐。 本发明还提供了包含治疗有效量的由式(II)表示的化合物和药学上可接受的载体或赋形剂的药物组合物。 本发明还提供了一种治疗癌症的方法,包括向需要这种治疗的患者施用治疗有效量的由式(II)表示的化合物。
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公开(公告)号:US07803816B2
公开(公告)日:2010-09-28
申请号:US11526523
申请日:2006-09-25
申请人: Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
发明人: Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
IPC分类号: A61K31/454 , C07D403/02
CPC分类号: C07D401/04 , C07D401/14 , C07D471/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗肥胖,食欲过盛,焦虑,抑郁和相关疾病和疾病。
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公开(公告)号:US08765730B2
公开(公告)日:2014-07-01
申请号:US13180574
申请日:2011-07-12
申请人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
发明人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号: A61K31/4409 , C07D401/10
CPC分类号: C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
摘要: This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula wherein R1 to R10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译: 本发明涉及下式的新颖的1-肟基-3-苯基 - 丙烷,其中R 1至R 10如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂,可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号:US20120232051A1
公开(公告)日:2012-09-13
申请号:US13406572
申请日:2012-02-28
申请人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
发明人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号: C07D213/72 , C07D401/04 , A61K31/496 , A61P3/10 , A61K31/444 , C07D413/12 , A61K31/5377 , A61K31/4427 , A61K31/4418 , A61K31/501
CPC分类号: C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
摘要: This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译: 本发明涉及下式的新的3-氨基吡啶类,其中B1,B2和R1至R6如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂,可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号:US08188098B2
公开(公告)日:2012-05-29
申请号:US12433921
申请日:2009-05-01
申请人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人: Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US20120010190A1
公开(公告)日:2012-01-12
申请号:US13180574
申请日:2011-07-12
申请人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
发明人: Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号: A61K31/4409 , C07D401/10 , A61K31/506 , C07D413/10 , A61P3/10 , A61K31/4427 , C07D417/10 , A61P3/00 , A61P29/00 , C07D213/53 , A61K31/5377
CPC分类号: C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
摘要: This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula wherein R1 to R10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译: 本发明涉及下式的新颖的1-肟基-3-苯基 - 丙烷,其中R 1至R 10如说明书和权利要求书中所定义,以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂,可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号:US20090062276A1
公开(公告)日:2009-03-05
申请号:US12259737
申请日:2008-10-28
申请人: Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
发明人: Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
IPC分类号: A61K31/519 , C07D471/04 , A61P3/10 , A61K31/5377
CPC分类号: C07D471/04
摘要: The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要翻译: 本发明包括通式I的吡啶并嘧啶二胺化合物:本发明的化合物是PTP1B的有效抑制剂。 因此,本发明还包括治疗或预防PTP-1B介导的疾病(包括糖尿病,肥胖症和糖尿病相关疾病)的药物组合物和方法。
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公开(公告)号:US20120191832A1
公开(公告)日:2012-07-26
申请号:US13061408
申请日:2011-01-24
申请人: Kyungjin Kim , Kiwon Lee , Sungil Cho , Jiyoung Hong , Sungeun Kim
发明人: Kyungjin Kim , Kiwon Lee , Sungil Cho , Jiyoung Hong , Sungeun Kim
IPC分类号: G06F15/173
CPC分类号: H04L65/403 , H04L12/2812 , H04L67/36 , H04M1/7253
摘要: Data sharing between networked smart devices is disclosed. One embodiment of the present disclosure pertains to a method for data sharing with one or more associated smart devices via a network. The method comprises displaying, on a display unit of the smart device, an image for each one of the associated smart devices within coverage of the network and an image of shared data. The method also comprises effecting a change in a first image for a first smart device of the associated smart devices when the first smart device is targeted as a target device for the data sharing. The method further comprises communicating the shared data with the first smart device via the network when, on the display unit, the image of the shared data is moved to or from a domain of the first image of the first smart device.
摘要翻译: 公布了网络智能设备之间的数据共享。 本公开的一个实施例涉及一种用于经由网络与一个或多个相关联的智能设备进行数据共享的方法。 该方法包括在智能设备的显示单元上显示针对网络覆盖范围内的相关智能设备中的每一个的图像和共享数据的图像。 该方法还包括当将第一智能设备定位为用于数据共享的目标设备时,对相关智能设备的第一智能设备的第一图像进行改变。 该方法还包括当在显示单元上将共享数据的图像移动到第一智能设备的第一图像的域或从第一智能设备的第一图像的域移动时,经由网络将共享数据与第一智能设备通信。
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公开(公告)号:US20100280021A1
公开(公告)日:2010-11-04
申请号:US12837558
申请日:2010-07-16
申请人: Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
发明人: Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
IPC分类号: A61K31/541 , C07D471/04 , A61K31/519 , A61K31/5377 , A61P3/10
CPC分类号: C07D471/04
摘要: The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要翻译: 本发明包括通式I的吡啶并嘧啶二胺化合物:本发明的化合物是PTP1B的有效抑制剂。 因此,本发明还包括治疗或预防PTP-1B介导的疾病(包括糖尿病,肥胖症和糖尿病相关疾病)的药物组合物和方法。
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