Method of producing a polyether antibiotic from actinomadura fibrosa sp.
nov. NRRL 18348 and actinomadura sp. NRRL 18880
    6.
    发明授权
    Method of producing a polyether antibiotic from actinomadura fibrosa sp. nov. NRRL 18348 and actinomadura sp. NRRL 18880 失效
    从放线菌纤维菌中生产聚醚抗生素的方法 nov。 NRRL 18348和放线菌属 NRRL 18880

    公开(公告)号:US5278053A

    公开(公告)日:1994-01-11

    申请号:US760640

    申请日:1991-09-16

    申请人: LaVerne D. Boeck

    发明人: LaVerne D. Boeck

    摘要: Improved processes for producing a polyether antibiotic compound represented by A82810 comprising: (1) cultivating Actinomadura fibrosa sp. nov. NRRL 18348 or Actinomadura sp. NRRL 18880, (2) feeding acid hydrolyzed casein at a rate from about 2.50-7.50 gm/L/day, (3) feeding glucose at a rate from about 2.50-7.50 gm/L/day, and (4) feeding propionate at a rate from about 0.50-1.5 gm/L/day to the appropriate culture medium during fermentation, are provided.

    摘要翻译: 用于生产由A82810代表​​的聚醚抗生素化合物的改进方法包括:(1)培养放线菌(Actinomadura fibrosa sp。 nov。 NRRL 18348或Actinomadura sp。 NRRL 18880,(2)以约2.50-7.50gm / L /天的速率喂食酸水解酪蛋白,(3)以约2.50-7.50gm / L /天的速率喂食葡萄糖,和(4)将丙酸盐 提供了在发酵期间从约0.50-1.5gm / L /天到合适培养基的速率。

    Antibiotic A-28086 recovery process
    10.
    发明授权
    Antibiotic A-28086 recovery process 失效
    抗生素A-28086恢复过程

    公开(公告)号:US4009262A

    公开(公告)日:1977-02-22

    申请号:US569712

    申请日:1975-04-21

    IPC分类号: C07G11/00 A61K35/00

    CPC分类号: C07G11/00

    摘要: Recovery of an antibiotic selected from the group consisting of antibiotic A-28086 factor A, antibiotic A-28086 factor B, antibiotic A-28086 factor D, and salinomycin by acidifying the fermentation broth in which said antibiotic is produced to about pH 2.0-4.0 and separating the antibiotic with the culture solids.