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34 条记录 (耗时 0.035 秒)

    Flurbiprofen analogs and methods of use in treating cancer
    1.
    发明授权
    Flurbiprofen analogs and methods of use in treating cancer 有权
    氟比洛芬类似物和治疗癌症的方法

    公开(公告)号：US08575170B2

    公开(公告)日：2013-11-05

    申请号：US13035834

    申请日：2011-02-25

    申请人： Lajos Gera ,  Daniel C. Chan ,  Robert S. Hodges ,  Paul A. Bunn

    发明人： Lajos Gera ,  Daniel C. Chan ,  Robert S. Hodges ,  Paul A. Bunn

    IPC分类号： A61K31/495 ,  A61K31/4453 ,  C07D295/15

    CPC分类号： A61K31/19

    摘要： Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells in vitro and inhibiting the growth of cancers in viva. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of lung, pancreatic and head and neck cancers.

    摘要翻译： 在氟比洛芬链烷羧酸衍生化并终止于酯或酰胺基团的具有氨基酸的氟比洛芬类似物化合物在体外抑制癌细胞并抑制血液中癌症的生长是有效的。 含有它们的化合物和药物组合物特别可用于治疗肺，胰腺和头颈部癌症。

    Antimicrobial peptides
    2.
    发明授权
    Antimicrobial peptides 有权
    抗菌肽

    公开(公告)号：US09352015B2

    公开(公告)日：2016-05-31

    申请号：US12793666

    申请日：2010-06-03

    申请人： Robert S. Hodges ,  Ziqing Jiang

    发明人： Robert S. Hodges ,  Ziqing Jiang

    IPC分类号： A61K38/16

    CPC分类号： A61K38/16

    摘要： Disclosed are antimicrobial peptides with useful or superior properties such as antimicrobial activity, desirable levels of hemolysis, and advantageous therapeutic index against various microorganisms, especially Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus. Also provided are methods of to control microbial growth and pharmaceutical compositions to treat or prevent microbial infections. Certain peptides are disclosed utilizing a structure-based rational modification of antimicrobial peptide D1, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face, or peptides with one or more amino acids in the D configuration, and peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation. Compositions disclosed herein are useful as antibiotics, including as broad spectrum antibiotics.

    摘要翻译： 公开了具有有用或优异性质的抗微生物肽，例如抗微生物活性，期望的溶血水平，以及针对各种微生物，特别是铜绿假单胞菌，鲍氏不动杆菌和金黄色葡萄球菌的有利治疗指数。 还提供了控制微生物生长和药物组合物以治疗或预防微生物感染的方法。 公开了利用基于结构的抗微生物肽D1的合理修饰，在非极性或极性表面上的肽中心附近或附近具有单个D- / L-氨基酸置换或带电残基取代的某些肽，或具有一个或多个 D构型中更多的氨基酸，以及D构型中所有氨基酸的肽。 本文中修饰的肽类似物可以证明一种或多种性质，例如改善的抗微生物活性，特异性和抗降解性。 本文公开的组合物可用作抗生素，包括作为广谱抗生素。

    Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity
    3.
    发明申请
    Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity 审中-公开
    Sars冠状病毒感染的修饰和预防的组合物和方法

    公开(公告)号：US20080027006A1

    公开(公告)日：2008-01-31

    申请号：US10597914

    申请日：2005-02-14

    申请人： Brian Tripet ,  Robert S. Hodges

    发明人： Brian Tripet ,  Robert S. Hodges

    IPC分类号： A61K38/10 ,  A61P31/00 ,  C07K7/08 ,  C12Q1/70

    CPC分类号： A61K38/162 ,  G01N33/68 ,  G01N2333/165

    摘要： The invention relates to diseases of coronaviruses, particularly severe acute respiratory syndrome (SARS). Compositions and methods in connection with peptide-based compounds are described relating to inhibition or prevention of coronavirus activity including that of SARS coronavirus and the ability of its S protein to achieve fusion with and entry into a target cell.

    摘要翻译： 本发明涉及冠状病毒，特别是严重急性呼吸综合征（SARS）的疾病。 关于与肽类化合物有关的组合物和方法涉及抑制或预防包括SARS冠状病毒在内的冠状病毒活性以及其S蛋白与靶细胞融合和进入靶细胞的能力。

    Pseudomonas exoenzyme S peptide composition and method
    10.
    发明授权
    Pseudomonas exoenzyme S peptide composition and method 失效
    PSEUDOMONAS EXOENZYME S PEPTIDE COMPOSITION AND METHOD

    公开(公告)号：US5223604A

    公开(公告)日：1993-06-29

    申请号：US721759

    申请日：1991-06-25

    申请人： Robert S. Hodges ,  Randall T. Irvin ,  William Paranchych ,  Pamela A. Sokol ,  Donald E. Woods

    发明人： Robert S. Hodges ,  Randall T. Irvin ,  William Paranchych ,  Pamela A. Sokol ,  Donald E. Woods

    IPC分类号： A61K39/00 ,  C07K14/21 ,  C12N9/10

    CPC分类号： C07K14/21 ,  C12N9/1077 ,  A61K39/00

    摘要： A peptide having a sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseusdomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms.

    摘要翻译： 公开了具有对应于蛋白质外切酶S中抗原性位点的序列的肽，其与铜绿假单胞菌菌毛蛋白质的C末端部分具有抗原性。 该肽与某些细菌和真菌微生物中存在的表面肽具有交叉反应性，并且有效抑制这些生物体与目标上皮细胞的结合。 肽也可以用于疫苗组合物中，用于产生针对这种交叉反应性微生物的免疫。