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1.发明授权Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration 失效用于神经治疗和再生的可生物降解和生物可吸收的引导通道
公开(公告)号：US5735863A
公开(公告)日：1998-04-07
申请号：US104025
申请日：1994-05-24
IPC分类号： A61L31/00 , A61B17/11 , A61F2/00 , A61F2/02 , A61F2/04 , A61L31/04 , A61L31/12 , A61L31/14 , A61L31/16 , A61B17/00
CPC分类号： A61L31/148 , A61L31/042 , A61L31/129 , A61B17/1128 , A61F2/0077 , A61F2/04 , A61F2210/0004 , A61L2430/32
摘要： The present invention is drawn to medical devices comprised of biodegradable guide channels for use in repair and regeneration of nerve tissue. The guide channels are comprised of threads embedded in a matrix and coextruded with active factors wherein both the matrix and the threads are comprised of biocompatible and bioabsorbable esters of hyaluronic acid.
摘要翻译： PCT No.PCT / EP92 / 00285 Sec。 371日期：1994年5月24日 102（e）日期1994年5月24日PCT提交1992年2月10日PCT公布。 出版物WO92 / 13579 日本1992年8月20日本发明涉及由可用于修复和再生神经组织的生物可降解导向通道构成的医疗器械。 引导通道由嵌入基质中的螺纹组成并与活性因子共挤出，其中基质和螺纹均由透明质酸的生物相容性和生物可吸收的酯组成。
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2.发明授权Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts 失效生物相容性穿孔膜，其制备方法，它们作为上皮细胞体外生长中的载体的用途，以这种方式获得的人造皮肤及其在皮肤移植物中的用途
公开(公告)号：US5658331A
公开(公告)日：1997-08-19
申请号：US478541
申请日：1995-06-07
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterized by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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3.发明授权Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions 失效盐和透明质酸与药物活性物质的混合物，含有它们的药物组合物以及用于施用这些组合物的方法
公开(公告)号：US5442053A
公开(公告)日：1995-08-15
申请号：US931949
申请日：1992-08-19
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02 , C07H5/04
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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公开(公告)号：US5424294A
公开(公告)日：1995-06-13
申请号：US138184
申请日：1993-10-20
CPC分类号： C07H15/10
摘要： N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at least one of the two acyl groups is not aliphatic, and their preparation are disclosed. Also disclosed is the preparation of the esters, inner esters, amides and hydroxy peracylates of these compounds and salts thereof. These compounds are useful in the treatment of pathologies of the central and peripheral nervous systems.
摘要翻译： N-酰基-N，N'-二溶菌索双胞苷，N'-酰基-N，N'-二溶菌索双胍和N，N'-二酰基-N，N'-二赖藻糖苷，其中酰基衍生 来自脂族，芳族，芳脂族，脂环族或杂环系列的有机酸，其中两个酰基中的至少一个不是脂族的，并且其公开。 还公开了这些化合物的酯，内酯，酰胺和羟基过酰基化物及其盐的制备。 这些化合物可用于治疗中枢和周围神经系统的病理。
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公开(公告)号：US5336668A
公开(公告)日：1994-08-09
申请号：US722398
申请日：1991-06-20
IPC分类号： A23L29/00 , A61K8/00 , A61K8/30 , A61K8/64 , A61K8/72 , A61K8/73 , A61K9/00 , A61K47/00 , A61K47/36 , A61K47/48 , A61L15/00 , A61L15/16 , A61L15/28 , A61L17/00 , A61L17/10 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/04 , C11D3/48 , A61K9/70 , A61K31/725 , C07H1/00
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L15/28 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total and partial esters of alginic acid which possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
摘要翻译： 藻酸的全部和部分酯具有重要的生物塑料和药物特性，可用于包括医疗，外科，化妆品和食品在内的各个领域。
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公开(公告)号：US4849413A
公开(公告)日：1989-07-18
申请号：US95223
申请日：1987-09-11
IPC分类号： C07H3/00 , A61K31/70 , A61K31/7028 , A61K31/715 , A61K35/30 , A61P25/00 , C07C68/00 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/10 , C08G18/08 , C08G18/18
CPC分类号： C07H15/10
摘要： New functional ganglioside derivatives comprising ester, amide and peracylated derivatives of gangliosides, preparation procedures therefor, pharmaceutical preparations containing the same, and the therapeutic use of the derivatives.
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7.发明授权
公开(公告)号：US4736024A
公开(公告)日：1988-04-05
申请号：US847632
申请日：1986-04-03
IPC分类号： A61K9/00 , A61K20060101 , A61K9/06 , A61K9/08 , A61K31/05 , A61K31/16 , A61K31/195 , A61K31/22 , A61K31/27 , A61K31/335 , A61K31/34 , A61K31/40 , A61K31/415 , A61K31/46 , A61K31/495 , A61K31/505 , A61K31/51 , A61K31/52 , A61K31/57 , A61K31/635 , A61K31/70 , A61K31/715 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61K45/06 , A61K45/08 , A61K47/00 , A61K47/36 , A61K47/48 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C01F20060101 , C08B37/08 , F17C1/02
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K9/0048 , C08B37/0072
摘要： Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
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8.发明授权Pharmaceutical compositions and method for preparing phosphatidylserine compositions useful in treating central nervous system disorders without effects on blood coagulation 失效制备用于治疗中枢神经系统疾病而不影响血液凝固的磷脂酰丝氨酸组合物的药物组合物和方法
公开(公告)号：US4595680A
公开(公告)日：1986-06-17
申请号：US599341
申请日：1984-04-12
CPC分类号： A61K31/685 , A23J7/00 , A61K9/127
摘要： A phospholipid composition comprised of a mixture of phosphatidylserine and phosphatidylethanolamine in a specified ratio having activity against disorders of the central nervous system but without secondary haematic coagulation effects. Particularly useful compositions comprise from 60 to 75% by weight of phosphatidylserine and from 40 to 25% by weight of phosphatidylethanolamine.
摘要翻译： 一种由磷脂酰丝氨酸和磷脂酰乙醇胺的混合物组成的磷脂组合物，其特定比例具有抗中枢神经系统疾病的活性，但没有次要的血液凝固作用。 特别有用的组合物包含60至75重量％的磷脂酰丝氨酸和40至25重量％的磷脂酰乙醇胺。
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9.发明授权
公开(公告)号：US5650164A
公开(公告)日：1997-07-22
申请号：US209626
申请日：1994-03-14
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500 .mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000 .mu., separated from each other by a constant distance of between 50 and 1000 .mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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公开(公告)号：US5147861A
公开(公告)日：1992-09-15
申请号：US761511
申请日：1991-09-18
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total esters of alginic acid with aliphatic and araliphatic alcohols possess important bioplastic and pharmaceutical qualities and are useful in various fields including the sanitary and surgical fields.
摘要翻译： 藻酸与脂肪族和芳脂肪醇的总酯具有重要的生物塑料和药物特性，可用于包括卫生和外科领域在内的各个领域。
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