-
公开(公告)号：US5108894A
公开(公告)日：1992-04-28
申请号：US376160
申请日：1989-07-05
CPC分类号： C07K14/315 , A61M1/3687 , A61K38/00
摘要： A hybrid DNA molecule is disclosed by this invention capable of cellular expression comprising the DNA sequence for protein G. Said DNA sequence has substantially the same IgC binding properties as naturally occurring protein G. The molecule may be comprised of DNA sequences coding for fragments of protein G. Moreover, said DNA sequence may code for both fragments of protein G and protein G. The DNA sequence can be isolated from streptococcal DNA.
摘要翻译： 本发明公开了能够包含蛋白G的DNA序列的细胞表达的杂交DNA分子。所述DNA序列具有与天然存在的蛋白G基本上相同的IgC结合特性。该分子可以由编码蛋白质片段的DNA序列组成 G.此外，所述DNA序列可以编码蛋白G和蛋白G的两个片段.DNA序列可以从链球菌DNA中分离。
-
公开(公告)号：US4948874A
公开(公告)日：1990-08-14
申请号：US311446
申请日：1989-02-15
申请人： Goran Kronvall , Lars Bjorck
发明人： Goran Kronvall , Lars Bjorck
IPC分类号： C12P21/00 , C07K1/14 , C07K1/22 , C07K1/36 , C07K14/005 , C07K14/195 , C07K14/41 , C07K14/705 , C07K14/735 , C12R1/46 , C07K15/04 , C07K3/12 , C07K15/00
CPC分类号： C07K14/70535 , C07K1/36 , Y10S435/82 , Y10S530/82 , Y10S530/825
摘要： A process is disclosed for recovering a cell wall protein, particularly a Fc-receptor, from streptococcal bacteria. In the process, streptococcal bacteria are treated with at least one proteolytic enzyme to solubilize the cell wall protein. A process is also disclosed for recovering Fc-receptor type III (protein G) having selective IgG-binding capability (i.e., no albumin-binding capability) from streptococcal bacteria by pretreating these bacteria with enzymes prior to said enzymatic solubilization.
摘要翻译： 公开了从链球菌细菌中回收细胞壁蛋白，特别是Fc受体的方法。 在此过程中，用至少一种蛋白水解酶处理链球菌细菌以溶解细胞壁蛋白。 还公开了一种用于通过在所述酶促溶解之前用酶预处理这些细菌来从链球菌中回收具有选择性IgG结合能力（即不具有白蛋白结合能力）的Fc受体III型（蛋白G）的方法。
-
公开(公告)号：US20080085853A1
公开(公告)日：2008-04-10
申请号：US11705352
申请日：2007-02-12
CPC分类号： C12N15/90 , A61K48/00 , Y10S530/82
摘要： A nuclear delivery construct comprises (i) protein H or a fragment or derivative thereof that is capable of being targeted to the nucleus of a eukaryotic cell; and associated therewith (ii) one or more other components whose targeting to the nucleus of the eukaryotic cell is desired.
摘要翻译： 核递送构建体包含（i）能够靶向真核细胞核的蛋白H或其片段或衍生物; 并与其相关联（ii）期望靶向真核细胞核的一种或多种其它成分。
-
公开(公告)号：US5278297A
公开(公告)日：1994-01-11
申请号：US961390
申请日：1992-10-15
申请人： Hideyuki Gomi , Tatsunobu Hozumi , Shizuo Hattori , Chiaki Tagawa , Fumitaka Kishimoto , Lars Bjorck
发明人： Hideyuki Gomi , Tatsunobu Hozumi , Shizuo Hattori , Chiaki Tagawa , Fumitaka Kishimoto , Lars Bjorck
IPC分类号： G01N33/53 , A61K38/00 , C07K14/005 , C07K14/195 , C07K14/315 , C07K14/41 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/46 , G07H17/00
CPC分类号： C07K14/315 , A61K38/00
摘要： A gene coding for Protein H, which is capable of binding specifically to human IgG of all subclasses, was isolated from Streptococcus sp. AP1 and expressed in host cells, E. coli to produce the Protein H.
摘要翻译： 从链球菌中分离出能够特异性结合所有亚类的人IgG的蛋白H编码基因。 AP1并在宿主细胞中表达，大肠杆菌产生蛋白H。
-
公开(公告)号：US20050119464A1
公开(公告)日：2005-06-02
申请号：US10499143
申请日：2002-12-17
IPC分类号： A61K38/00 , A61K39/00 , C07K14/36 , C12N9/64 , C12N15/57 , C07K14/195 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C12N9/52 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/36 , C12N9/641
摘要： A polypeptide isolated from S. pyogenes is described, having IgG cysteine protease activity. The protease is designated IdeS, Immunoglobulin G-degrading enzyme of S. pyogenes. A polypeptide comprises SEQ ID NO: 1 and variants and fragments thereof having IgG cysteine protease activity or the ability to generate an immune response against S. pyogenes in an individual. Polynucleotides encoding these polypeptides and the polypeptides may be used in generating an immune response in an individual. IdeS protease inhibitors may be used in the treatment of S. pyogenes infection.
摘要翻译： 描述了从化脓性链球菌分离的多肽，其具有IgG半胱氨酸蛋白酶活性。 蛋白酶被命名为化脓性链球菌的IdeS，免疫球蛋白G降解酶。 多肽包含SEQ ID NO：1及其具有IgG半胱氨酸蛋白酶活性的变体和片段或在个体中产生抗化脓性链球菌的免疫应答的能力。 编码这些多肽和多肽的多核苷酸可用于在个体中产生免疫应答。 IdeS蛋白酶抑制剂可用于治疗化脓性链球菌感染。
-
公开(公告)号：US5965390A
公开(公告)日：1999-10-12
申请号：US795475
申请日：1997-02-11
申请人： Lars Bjorck , Ulf Sjobring
发明人： Lars Bjorck , Ulf Sjobring
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P37/00 , C07H21/04 , C07K14/195 , C07K14/315 , C07K14/33 , C07K14/41 , C07K14/47 , C07K16/00 , C07K19/00 , C12N1/19 , C12N1/21 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/865 , C12N15/63
CPC分类号： C07K14/315 , C07K14/33 , A61K38/00 , C07K2319/034 , C07K2319/705 , Y10S435/975
摘要： The invention relates to sequences of protein L which bind to light chains of immunoglobulins. The invention also relates to hybrid proteins thereof which are able to bind to both light and heavy chains of immunoglobulin G, in particular protein LG. The invention also relates to DNA-sequences which code for the proteins, vectors which include such DNA-sequences, host cells which have been transformed with the vectors, methods for producing the proteins, reagent appliances for separation and identification of immunoglobulins, compositions and pharmaceutical compositions and pharmaceutical compositions which contain the proteins.
摘要翻译： 本发明涉及结合免疫球蛋白轻链的蛋白L的序列。 本发明还涉及其能够结合免疫球蛋白G，特别是蛋白质LG的轻链和重链的杂交蛋白。 本发明还涉及编码蛋白质的DNA序列，包括这些DNA序列的载体，已经用载体转化的宿主细胞，用于产生蛋白质的方法，用于分离和鉴定免疫球蛋白的试剂装置，组合物和药物 组合物和含有蛋白质的药物组合物。
-
公开(公告)号：US5180810A
公开(公告)日：1993-01-19
申请号：US376641
申请日：1989-07-07
申请人： Hideyuki Gomi , Tatsunobu Hozumi , Shizuo Hattori , Chiaki Tagawa , Fumitaka Kishimoto , Lars Bjorck
发明人： Hideyuki Gomi , Tatsunobu Hozumi , Shizuo Hattori , Chiaki Tagawa , Fumitaka Kishimoto , Lars Bjorck
IPC分类号： G01N33/53 , A61K38/00 , C07K14/005 , C07K14/195 , C07K14/315 , C07K14/41 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/46
CPC分类号： C07K14/315 , A61K38/00
摘要： A gene coding for Protein H, which is capable of binding specifically to human IgG of all subclasses, was isolated from Streptococcus sp. APl and expressed in host cells, E. coli to produce the Protein H.
-
8.发明申请USE OF THE ENDOGLYCOSIDASE ENDOS FOR TREATING IMMUNOGLOBULIN G MEDIATED DISEASES 有权内酰胺多糖内毒素治疗免疫球蛋白G介导性疾病的应用公开(公告)号：US20100135981A1
公开(公告)日：2010-06-03
申请号：US12518855
申请日：2007-12-12
申请人： Lars Bjorck , Mattias Collin , Arne Olsen , Rikard Holmdahl , Kutty Selva Nandakumar , Oonagh Shannon
发明人： Lars Bjorck , Mattias Collin , Arne Olsen , Rikard Holmdahl , Kutty Selva Nandakumar , Oonagh Shannon
IPC分类号： A61K38/47 , A61K31/7052 , C12N5/00 , A61P37/06 , A61P7/04
CPC分类号： A61K38/47 , A61K48/005
摘要： The invention provides use of an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies.
摘要翻译： 本发明提供EndoS多肽或编码EndoS多肽的多核苷酸在制备用于治疗或预防由IgG抗体介导的疾病或病症的药物中的用途。
-
公开(公告)号：US20070237784A1
公开(公告)日：2007-10-11
申请号：US11730659
申请日：2007-04-03
IPC分类号： A61K39/09 , A61K38/16 , C07K14/315
CPC分类号： C12N9/52 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/36 , C12N9/641
摘要： A polypeptide isolated from S. pyogenes is described, having IgG cysteine protease activity. The protease is designated IdeS, Immunoglobulin G-degrading enzyme of S. pyogenes. A polypeptide comprises SEQ ID NO: 1 and variants and fragments thereof having IgG cysteine protease activity or the ability to generate an immune response against S. pyogenes in an individual. Polynucleotides encoding these polypeptides and the polypeptides may be used in generating an immune response in an individual. IdeS protease inhibitors may be used in the treatment of S. pyogenes infection.
摘要翻译： 描述了从化脓性链球菌分离的多肽，其具有IgG半胱氨酸蛋白酶活性。 蛋白酶被命名为化脓性链球菌的IdeS，免疫球蛋白G降解酶。 多肽包含SEQ ID NO：1及其具有IgG半胱氨酸蛋白酶活性的变体和片段或在个体中产生抗化脓性链球菌的免疫应答的能力。 编码这些多肽和多肽的多核苷酸可用于在个体中产生免疫应答。 IdeS蛋白酶抑制剂可用于治疗化脓性链球菌感染。
-
公开(公告)号：US07335355B2
公开(公告)日：2008-02-26
申请号：US10333319
申请日：2001-07-17
申请人： Lars Bjorck , Inga-Maria Frick , Artur Schmidtchen
发明人： Lars Bjorck , Inga-Maria Frick , Artur Schmidtchen
IPC分类号： G01N33/53 , G01N33/567 , G01N33/554 , G01N33/569 , C08B37/00 , A61K38/47
CPC分类号： C12Q1/18 , A61K31/721 , A61K31/722 , A61K31/785 , A61K38/02 , G01N2400/40 , A61K2300/00
摘要： A method of identifying an agent that enhances the anti-microbial activity of cationic anti-microbial peptides by blocking the inhibitory effects of the proteinase/glycosaminoglycan pathway, which method comprises: (i) providing, as a first component, a cationic anti-microbial peptide; (ii) providing, as a second component, bacteria; (iii) providing, as a third component, part of all of the components of a proteinase/glycosaminoglycan pathway such that the third component reduces the antimicrobial effect of the first component, for example, a glycosaminoglycan or bacteria or bacteria and a proteoglycan or a bacterial proteinase or a bacterial proteinase and a proteoglycan; (iv) contacting the first, second and third components with a test agent under conditions that would permit the killing of the bacteria by the antimicrobial agent in the absence of the third component, and that would permit the inhibition of the anti-microbial activity of the first component by the third component in the absence of the test agent; (v) monitoring the survival of the bacterial culture thereby determining whether the test agent is capable of enhancing anti-microbial activity wherein a test agent capable of enhancing anti-microbial activity promotes killing of the bacterial culture. Agents identified by such a method are useful in the therapy of acute and chronic infections, particularly in the treatment of ulcers and in the promotion of wound healing.
摘要翻译： 鉴定通过阻断蛋白酶/糖胺聚糖途径的抑制作用来增强阳离子抗微生物肽的抗微生物活性的试剂的方法，该方法包括：（i）提供阳离子抗微生物 肽; （ii）作为第二组分提供细菌; （iii）提供蛋白酶/糖胺聚糖途径的所有组分的一部分作为第三组分，使得第三组分降低第一组分例如糖胺聚糖或细菌或细菌的抗微生物作用，以及蛋白聚糖或 细菌蛋白酶或细菌蛋白酶和蛋白多糖; （iv）在允许在不存在第三组分的情况下允许由抗微生物剂杀死细菌的条件下将第一，第二和第三组分与测试试剂接触，并且这将允许抑制抗微生物活性 在没有测试代理的情况下第三个组分的第一个组分; （v）监测细菌培养物的存活，从而确定测试剂是否能够增强抗微生物活性，其中能够增强抗微生物活性的测试剂促进细菌培养物的杀死。 通过这种方法鉴定的药物可用于治疗急性和慢性感染，特别是治疗溃疡和促进伤口愈合。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.02 秒)
