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1.发明申请公开(公告)号：US20090143456A1
公开(公告)日：2009-06-04
申请号：US11884165
申请日：2006-02-13
IPC分类号： A61K31/409 , A61K31/132 , A61P43/00
CPC分类号： A61K31/137 , Y02A50/401
摘要： This disclosure relates to methods of inhibiting cell motility or cell migration, and of treating diseases involving cell migration or cell motility, using polyamine analogs, such as conformationally restricted polyamine analogs. The diseases to be treated include immune disorders, inflammatory conditions, infection, abnormal immune responses, undesired angiogenesis, tumor cell metastasis or invasion, atherosclerosis, vascular graft occlusion, transplant rejection, other complications of transplants, glomerulonephritis, arthritis, inflammatory responses subsequent to stroke or ischemia, and asthma.
摘要翻译： 本公开涉及使用多胺类似物如构象限制性多胺类似物来抑制细胞运动或细胞迁移以及涉及细胞迁移或细胞运动的疾病的方法。 待治疗的疾病包括免疫疾病，炎症状况，感染，免疫反应异常，不希望的血管生成，肿瘤细胞转移或侵袭，动脉粥样硬化，血管移植物阻塞，移植排斥反应，其他移植并发症，肾小球肾炎，关节炎，中风后炎症反应 或缺血和哮喘。
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2.发明申请NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES 审中-公开新型聚氨酯类似物和喹诺酮类似物作为癌症和前列腺疾病的治疗方案公开(公告)号：US20080194697A1
公开(公告)日：2008-08-14
申请号：US11868910
申请日：2007-10-08
IPC分类号： A61K31/132 , A61P35/00
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/13 , C07C211/18 , C07C2601/02 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Peptide conjugates in which cytostatic and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
摘要翻译： 提供了其中细胞抑制剂和细胞抑制剂如多胺类似物或萘醌与与诸如前列腺特异性抗原（PSA）和组织蛋白酶B之类的酶识别和切割的多肽缀合的肽缀合物，以及包含这些缀合物的组合物。 还提供了使用这些缀合物治疗前列腺疾病的方法。
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公开(公告)号：US20090124832A1
公开(公告)日：2009-05-14
申请号：US12357323
申请日：2009-01-21
申请人： Benjamin Frydman , Linda Clifford , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu , Laurence J. Marton , Venodhar K. Reddy
发明人： Benjamin Frydman , Linda Clifford , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu , Laurence J. Marton , Venodhar K. Reddy
IPC分类号： C07C237/06
CPC分类号： C07C215/18 , C07C211/14
摘要： Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
摘要翻译： 提供具有抗癌和抗增殖活性的寡胺化合物，以及制备和使用该化合物的方法。 该化合物显示出对前列腺癌细胞系和抗小鼠前列腺癌肿瘤的活性。 该化合物也可用于治疗乳腺癌和其它癌症。
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公开(公告)号：US07026347B2
公开(公告)日：2006-04-11
申请号：US10606016
申请日：2003-06-24
申请人： Benjamin Frydman , Aldonia L. Valasinas , Venodhar K. Reddy , Hirak S. Basu , Aparajita Sarkar , Subhra Bhattacharya , Yu Wang , Laurence J. Marton , Andrei V. Blokhin
发明人： Benjamin Frydman , Aldonia L. Valasinas , Venodhar K. Reddy , Hirak S. Basu , Aparajita Sarkar , Subhra Bhattacharya , Yu Wang , Laurence J. Marton , Andrei V. Blokhin
IPC分类号： A61K31/40 , A61K31/555 , A61B5/055 , A61B10/00 , C07B47/00
CPC分类号： C07D487/22
摘要： Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.
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公开(公告)号：US07253207B2
公开(公告)日：2007-08-07
申请号：US10909978
申请日：2004-08-02
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： A61K31/35 , C07D311/92
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译： 提供了新的醌，以及包含这些新型醌的组合物。 还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。
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公开(公告)号：US06982351B2
公开(公告)日：2006-01-03
申请号：US10313530
申请日：2002-12-06
申请人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
发明人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
IPC分类号： C07C211/17
CPC分类号： A61K31/132 , C07C211/18 , C07C2601/02
摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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公开(公告)号：US06482943B1
公开(公告)日：2002-11-19
申请号：US09562980
申请日：2000-04-27
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： C07B4700
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译： 提供了新的醌，以及包含这些新型醌的组合物。 还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。
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公开(公告)号：US07235695B2
公开(公告)日：2007-06-26
申请号：US11205341
申请日：2005-08-16
申请人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
发明人： Benjamin Frydman , Aldonia L. Valasinas , Andrei V. Blokhin , Aparajita Sarkar , Hirak S. Basu , Venodhar K. Reddy , Laurence J. Marton , Yu Wang
IPC分类号： C07C209/24 , C07C209/28 , C07C211/17
CPC分类号： A61K31/132 , C07C211/18 , C07C2601/02
摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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公开(公告)号：US07186825B2
公开(公告)日：2007-03-06
申请号：US10873100
申请日：2004-06-21
申请人： Benjamin Frydman , Laurence J. Marton , Venodhar K. Reddy , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu
发明人： Benjamin Frydman , Laurence J. Marton , Venodhar K. Reddy , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu
IPC分类号： C07C47/00
CPC分类号： C07C211/09 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/18 , C07C211/22 , C07C211/23 , C07C211/36 , C07C215/14 , C07C257/18 , C07C2601/04 , C07C2601/08 , C07D207/34 , C07D219/10 , C07D235/18 , C07D295/185 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D487/22 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
摘要翻译： 提供新颖的构象限制性多胺类似物，以及包含这些新型多胺类似物的组合物。 还提供了将新型多胺类似物用于治疗诸如癌症的疾病的方法。 还提供了通过将多胺类似物共价连接到卟啉化合物以及新型多胺 - 卟啉共价缀合物将这些类似物特异性递送至肿瘤细胞的方法。
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公开(公告)号：US06809176B2
公开(公告)日：2004-10-26
申请号：US10139978
申请日：2002-05-06
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： C07K200
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译： 提供了新的醌，以及包含这些新型醌的组合物。 还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。
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