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1.发明授权Processes for making spinal intervertebral implant, interconnections for such implant 有权制造脊柱椎间植入物的过程，用于这种植入物的互连公开(公告)号：US07726002B2
公开(公告)日：2010-06-01
申请号：US10964113
申请日：2004-10-13
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/4611 , A61F2002/30009 , A61F2002/30059 , A61F2002/30125 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30168 , A61F2002/30205 , A61F2002/30266 , A61F2002/30331 , A61F2002/30403 , A61F2002/30448 , A61F2002/30492 , A61F2002/30599 , A61F2002/30604 , A61F2002/30785 , A61F2002/30904 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0043 , A61F2230/0067 , A61F2230/0082 , A61F2250/0028 , A61F2250/0063 , A61F2310/00017 , Y10S623/919 , Y10T29/49947 , Y10T403/75
摘要： A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form offset configurations in place of the offset bores for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.
摘要翻译： 皮质骨植入物由两个或更多个骨板形成，其与一个或多个偏移销连接。 销可以是插入到相应的偏移孔中的右圆柱体，其偏移弯曲插入的销。 弯曲在销中产生压缩和拉伸载荷，这种负载在通过摩擦将它们连接到销上的板条产生摩擦压缩力。 销可以具有不同的形状以形成偏移构造来代替用于摩擦附接到木板的偏移孔。 植入物可以由形成为包括互锁装置的其它形状的扁平或L形板或骨形成。 公开了用于形成销，木板和植入物的工艺和固定装置。 公开了销，板，植入物和工艺的各种实施例。
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2.发明授权Spinal intervertebral implant, interconnections for such implant and processes for making 有权脊椎椎间植入物，这种植入物的互连和制造过程公开(公告)号：US06855167B2
公开(公告)日：2005-02-15
申请号：US10005238
申请日：2001-12-05
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/4611 , A61F2002/30009 , A61F2002/30059 , A61F2002/30125 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30168 , A61F2002/30205 , A61F2002/30266 , A61F2002/30331 , A61F2002/30403 , A61F2002/30448 , A61F2002/30492 , A61F2002/30599 , A61F2002/30604 , A61F2002/30785 , A61F2002/30904 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0043 , A61F2230/0067 , A61F2230/0082 , A61F2250/0028 , A61F2250/0063 , A61F2310/00017 , Y10S623/919 , Y10T29/49947 , Y10T403/75
摘要： A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form the offsets and different configurations for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.
摘要翻译： 皮质骨植入物由两个或更多个骨板形成，其与一个或多个偏移销连接。 销可以是插入到相应的偏移孔中的右圆柱体，其偏移弯曲插入的销。 弯曲在销中产生压缩和拉伸载荷，这种负载在通过摩擦将它们连接到销上的板条产生摩擦压缩力。 销可以具有不同的形状以形成用于摩擦附着到木板的偏移和不同构造。 植入物可以由形成为包括互锁装置的其它形状的扁平或L形板或骨形成。 公开了用于形成销，木板和植入物的工艺和固定装置。 公开了销，板，植入物和工艺的各种实施例。
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公开(公告)号：US06530955B2
公开(公告)日：2003-03-11
申请号：US09861369
申请日：2001-05-18
申请人： John W. Boyle , Lawrence A. Shimp , David R. Kaes , John W. Morris , Erik O. Martz , Todd M. Boyce , Mark Daugherty
发明人： John W. Boyle , Lawrence A. Shimp , David R. Kaes , John W. Morris , Erik O. Martz , Todd M. Boyce , Mark Daugherty
IPC分类号： A61F244
CPC分类号： A61F2/4611 , A61F2/28 , A61F2/30771 , A61F2/30965 , A61F2/442 , A61F2/4465 , A61F2/447 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/30112 , A61F2002/30115 , A61F2002/30131 , A61F2002/30153 , A61F2002/30158 , A61F2002/3023 , A61F2002/30235 , A61F2002/30238 , A61F2002/30266 , A61F2002/3028 , A61F2002/30324 , A61F2002/30772 , A61F2002/30774 , A61F2002/30785 , A61F2002/30789 , A61F2002/3082 , A61F2002/30836 , A61F2002/30843 , A61F2002/30904 , A61F2002/30952 , A61F2002/4623 , A61F2002/4627 , A61F2002/4649 , A61F2230/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0036 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00359
摘要： A ramp-shaped intervertebral implant is disclosed. The implant has a body having a first end, a second end, a top surface and a bottom surface. At least one of the top and bottom surfaces is tapered and converges towards the second end of the body. An opening extends through the body and has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.
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公开(公告)号：US06277149B1
公开(公告)日：2001-08-21
申请号：US09328242
申请日：1999-06-08
申请人： John W. Boyle , Lawrence A. Shimp , David R. Kaes , John W. Morris , Erik O. Martz , Todd M. Boyce , Mark Daugherty
发明人： John W. Boyle , Lawrence A. Shimp , David R. Kaes , John W. Morris , Erik O. Martz , Todd M. Boyce , Mark Daugherty
IPC分类号： A61F244
CPC分类号： A61F2/4611 , A61F2/28 , A61F2/30771 , A61F2/30965 , A61F2/442 , A61F2/4465 , A61F2/447 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/30112 , A61F2002/30115 , A61F2002/30131 , A61F2002/30153 , A61F2002/30158 , A61F2002/3023 , A61F2002/30235 , A61F2002/30238 , A61F2002/30266 , A61F2002/3028 , A61F2002/30324 , A61F2002/30772 , A61F2002/30774 , A61F2002/30785 , A61F2002/30789 , A61F2002/3082 , A61F2002/30836 , A61F2002/30843 , A61F2002/30904 , A61F2002/30952 , A61F2002/4623 , A61F2002/4627 , A61F2002/4649 , A61F2230/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0036 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00359
摘要： A ramp-shaped intervertebral implant is disclosed. The implant has a body having a first end, a second end, a top surface and a bottom surface. At least one of the top and bottom surfaces is tapered and converges towards the second end of the body. An opening extends through the body and has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.
摘要翻译： 公开了一种斜坡状椎间植入物。 植入物具有具有第一端，第二端，顶表面和底表面的主体。 顶表面和底表面中的至少一个是锥形的并且朝向身体的第二端会聚。 开口延伸穿过主体并且在植入物的顶表面上具有一个端部开口，并且另一端开口延伸到植入物的底表面上。 植入物可以由长骨的骨干或干be形成，其中长骨的髓内管限定开口。 或者，植入物可以由具有必要强度要求的任何生物相容性材料制成。
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公开(公告)号：US07448264B2
公开(公告)日：2008-11-11
申请号：US10884097
申请日：2004-07-02
IPC分类号： G01M19/00
CPC分类号： G01N33/4833 , G01N2203/0089
摘要： A non-destructive method for evaluating the strength of cancellous bone includes the steps of performing at least two of the following tests on each cancellous bone of a population of cancellous bones: a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and, eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.
摘要翻译： 用于评价松质骨强度的非破坏性方法包括以下步骤：对松质骨群体的每个松质骨执行以下测试中的至少两项：手动压缩试验，表观密度试验和外观试验; 基于所进行的两次测试确定每个松质骨的抗压强度; 将每个松质骨的确定的抗压强度与预定的抗压强度要求进行比较; 并且从松质骨群体中消除松质骨的子集，松质骨的哪一个子组不能满足预定的抗压强度要求。
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公开(公告)号：US06368322B1
公开(公告)日：2002-04-09
申请号：US09542556
申请日：2000-04-03
申请人： Howard J. Luks , John W. Boyle , Lawrence A. Shimp , David R. Kaes , John W. Morris , Erik O. Martz , Daniel E. Rosenthal
发明人： Howard J. Luks , John W. Boyle , Lawrence A. Shimp , David R. Kaes , John W. Morris , Erik O. Martz , Daniel E. Rosenthal
IPC分类号： A61B1786
CPC分类号： A61B17/864 , A61B17/861 , A61B17/8645 , A61B17/866 , A61B17/8877 , Y10S606/91
摘要： An interference screw suitable for surgical use is provided. The interference screw is constructed from bone and includes an elongated body having an outer threaded surface, a tapered insertion end and a central throughbore. Insertion tool engaging structure is formed along the walls defining the throughbore. The insertion tool engaging structure extends from the proximal end of the elongated body over a substantial portion of the length of the elongated body. The insertion tool engaging structure functions to distribute the forces required to insert the interference screw throughout the body of the interference screw to prevent fracturing of the interference screw during insertion into bone.
摘要翻译： 提供适合于外科手术的干涉螺钉。 干涉螺钉由骨构成并且包括具有外螺纹表面，锥形插入端和中心穿透孔的细长主体。 插入工具接合结构沿着限定穿透孔的壁形成。 插入工具接合结构在细长体的长度的大部分上从细长体的近端延伸。 插入工具接合结构用于分配将干涉螺钉插入干涉螺钉的整个主体所需的力，以防止在插入骨中时干扰螺钉的断裂。
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公开(公告)号：US08425893B2
公开(公告)日：2013-04-23
申请号：US13181715
申请日：2011-07-13
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译： 生物基聚氨酯及其制备方法。 聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。 形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。
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公开(公告)号：US08672980B2
公开(公告)日：2014-03-18
申请号：US12861902
申请日：2010-08-24
申请人： John W. Morris , Lawrence A. Shimp , David R. Kaes
发明人： John W. Morris , Lawrence A. Shimp , David R. Kaes
IPC分类号： A61B17/70
CPC分类号： A61B17/7059 , A61B17/80 , A61B17/86 , A61B2017/00831 , A61F2/28 , A61F2/30749 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/447 , A61F2002/2817 , A61F2002/30794 , A61F2220/0008 , A61F2310/00179 , A61F2310/00359
摘要： There is provided an implant retaining device, which has the effect of preventing an intervertebral implant from jutting out of the receiving bed. The implant retaining device generally includes a plate having at least one throughbore to receive a screw, and a screw for securing the plate to the vertebrae. The plate may be dimensioned to cover a portion of the opening of a receiving bed, and thus, need only be secured to a single vertebral body. In an alternate embodiment, the plate may be used during bone fracture correction procedures to prevent a bone screw from backing out of engagement with adjacent bone sections. A method of retaining an intervertebral implant using the device is also provided.
摘要翻译： 提供了一种植入物保持装置，其具有防止椎间植入物从接受床突出的作用。 植入物保持装置通常包括具有至少一个通孔以容纳螺钉的板和用于将板固定到椎骨的螺钉。 该板的尺寸可以确定为覆盖接收床的开口的一部分，因此仅需要固定到单个椎体。 在替代实施例中，可以在骨折矫正程序期间使用该板，以防止骨螺钉脱离与相邻骨段的接合。 还提供了使用该装置保持椎间植入物的方法。
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公开(公告)号：US08562648B2
公开(公告)日：2013-10-22
申请号：US12914051
申请日：2010-10-28
IPC分类号： A61B17/70
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
摘要翻译： 在手术中使用的植入单元具有由成骨可植入材料制成的主体，并且包括植入部分和保持部分，该部分与植入部分相连并横向延伸。 保持部分附接到邻接的椎体或哺乳动物骨的侧壁，以防止植入部分相对于椎体或哺乳动物骨骼移位，并加速其间的融合。
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公开(公告)号：US09034356B2
公开(公告)日：2015-05-19
申请号：US11625086
申请日：2007-01-19
申请人： Lawrence A. Shimp , John Winterbottom , David R. Kaes , Ryan M. Belaney , Subhabrata Bhattacharyya
发明人： Lawrence A. Shimp , John Winterbottom , David R. Kaes , Ryan M. Belaney , Subhabrata Bhattacharyya
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
摘要： The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
摘要翻译： 本发明涉及用于骨缺损部位以促进新骨生长的多孔复合材料。 本发明的多孔复合材料包括生物相容性聚合物和多种骨源材料，无机材料，骨替代材料或复合材料的颗粒。 在某些实施方案中，使用包括超临界流体（例如超临界二氧化碳）处理的方法制备多孔复合材料。 本发明还公开了使用这些复合材料作为骨空隙填料的方法。
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