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公开(公告)号：US07993583B2
公开(公告)日：2011-08-09
申请号：US12574095
申请日：2009-10-06
IPC分类号： G01N21/00 , G01N33/543 , C12M3/00 , G01N33/53 , C40B60/12
CPC分类号： G01N35/00069 , B01L3/5023 , B01L3/502746 , B01L2200/027 , B01L2300/069 , B01L2300/0803 , B01L2300/0864 , B01L2400/0406 , G01N21/253 , G01N2021/0346
摘要： A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a multiplicity of array windows, and a transport section or sections for transporting the sample from the sample loading section to the array windows. The microfluidic array card reader includes a housing, a receiving section for receiving the microfluidic array card, a viewing section, and a light source that directs light to the array window of the microfluidic array card and to the viewing section.
摘要翻译： 用于分析样品的微流体阵列卡和读取器系统。 微流体阵列卡包括用于将样品加载到微流体阵列卡上的样品加载部分，多个阵列窗口，以及用于将样品从样品加载部分运送到阵列窗口的传送部分或部分。 微流体阵列读卡器包括壳体，用于接收微流体阵列卡的接收部分，观察部分和将光引导到微流体阵列卡的阵列窗口和观察部分的光源。
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公开(公告)号：US20100105577A1
公开(公告)日：2010-04-29
申请号：US12574095
申请日：2009-10-06
IPC分类号： C40B60/12
CPC分类号： G01N35/00069 , B01L3/5023 , B01L3/502746 , B01L2200/027 , B01L2300/069 , B01L2300/0803 , B01L2300/0864 , B01L2400/0406 , G01N21/253 , G01N2021/0346
摘要： A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a multiplicity of array windows, and a transport section or sections for transporting the sample from the sample loading section to the array windows. The microfluidic array card reader includes a housing, a receiving section for receiving the microfluidic array card, a viewing section, and a light source that directs light to the array window of the microfluidic array card and to the viewing section.
摘要翻译： 用于分析样品的微流体阵列卡和读取器系统。 微流体阵列卡包括用于将样品加载到微流体阵列卡上的样品加载部分，多个阵列窗口，以及用于将样品从样品加载部分运送到阵列窗口的传送部分或部分。 微流体阵列读卡器包括壳体，用于接收微流体阵列卡的接收部分，观察部分和将光引导到微流体阵列卡的阵列窗口和观察部分的光源。
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公开(公告)号：US07901623B2
公开(公告)日：2011-03-08
申请号：US11528286
申请日：2006-09-26
申请人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
发明人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
IPC分类号： G01N33/00
CPC分类号： G01N33/558
摘要： A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.
摘要翻译： 一种侧流条测定装置，包括壳体; 所述外壳中的横向流动条，所述横向流动带具有接收部分; 样本收集单元; 和试剂储存器。 使用样品收集单元从个体收集唾液和/或颊细胞。 样品收集单元浸入试剂容器中。 横向流动条的尖端浸入储存器中，并将试剂/样品混合物吸入侧流条中以进行测定。
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公开(公告)号：US08428398B2
公开(公告)日：2013-04-23
申请号：US12826215
申请日：2010-06-29
申请人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
发明人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
IPC分类号： G06K9/22
摘要： A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.
摘要翻译： 用于生物检测的手持便携式微阵列读取器包括被设计为足够小以用于便携式应用的微阵列读取器。 本发明包括发射激发光的大功率发光二极管，定位成接收激发光的激发滤光器，滑块，用于定位滑块以接收来自激发滤光器的激发光的滑块保持器组件，发射滤光片 定位成接收来自滑块的激发光，定位成接收来自发射滤光器的激发光的透镜，以及定位成接收来自透镜的激发光的CCD照相机。
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公开(公告)号：US20110188782A1
公开(公告)日：2011-08-04
申请号：US12826215
申请日：2010-06-29
申请人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
发明人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
摘要： A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.
摘要翻译： 用于生物检测的手持便携式微阵列读取器包括被设计为足够小以用于便携式应用的微阵列读取器。 本发明包括发射激发光的大功率发光二极管，定位成接收激发光的激发滤光器，滑块，用于定位滑块以接收来自激发滤光器的激发光的滑块保持器组件，发射滤光片 定位成接收来自滑块的激发光，定位成接收来自发射滤光器的激发光的透镜，以及定位成接收来自透镜的激发光的CCD照相机。
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公开(公告)号：US20080200342A1
公开(公告)日：2008-08-21
申请号：US12031625
申请日：2008-02-14
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译： 提供耦合到捕获分子的装置和阵列。 具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。 装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。 该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。
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公开(公告)号：US07585815B2
公开(公告)日：2009-09-08
申请号：US10884783
申请日：2004-07-01
CPC分类号： G01N33/6803
摘要： Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.
摘要翻译： 提供了用于无细胞生产和分析蛋白质的方法，组合物和试剂盒。 本发明允许从原核序列或真核序列生产蛋白质，包括使用PCR和IVT方法的人cDNA，并通过荧光或免疫印迹技术检测蛋白质。 本发明可用于鉴定优化的PCR和WT条件，密码子用途和突变。 该方法易于自动化，可用于蛋白质表达水平，相互作用和功能状态的高通量分析。
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公开(公告)号：US20080076169A1
公开(公告)日：2008-03-27
申请号：US11528286
申请日：2006-09-26
申请人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
发明人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
IPC分类号： G01N33/558 , C12M1/34
CPC分类号： G01N33/558
摘要： A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.
摘要翻译： 一种侧流条测定装置，包括壳体; 所述外壳中的横向流动条，所述横向流动带具有接收部分; 样本收集单元; 和试剂储存器。 使用样品收集单元从个体收集唾液和/或颊细胞。 样品收集单元浸入试剂容器中。 横向流动条的尖端浸入储存器中，并将试剂/样品混合物吸入侧流条中以进行测定。
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公开(公告)号：US20150087543A1
公开(公告)日：2015-03-26
申请号：US14465796
申请日：2014-08-21
IPC分类号： G01N33/543 , B01J19/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译： 提供耦合到捕获分子的装置和阵列。 具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。 装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。 该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。
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公开(公告)号：US08821860B2
公开(公告)日：2014-09-02
申请号：US12852358
申请日：2010-08-06
CPC分类号： A61K38/50 , A61K45/06 , C12P1/04 , C12Q1/18 , C12Y305/01028 , G01N2333/32 , G01N2333/914
摘要： Targeted antimicrobials are described and related, compositions, methods and systems.
摘要翻译： 有针对性的抗微生物剂被描述和相关，组合物，方法和系统。
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