公开(公告)号：US20170219603A1

公开(公告)日：2017-08-03

申请号：US15352607

申请日：2016-11-16

申请人： Lei Han ,  Xiaohui Zhou ,  Yuyan Zhou ,  Li Zhou ,  Guohua Li ,  Yongzhen Li

发明人： Lei Han ,  Xiaohui Zhou ,  Yuyan Zhou ,  Li Zhou ,  Guohua Li ,  Yongzhen Li

IPC分类号： G01N33/68 ,  C07K16/28 ,  C07K14/47

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K14/705 ,  G01N33/6872 ,  G01N2800/342

摘要： A TRPM8 related peptide fragment, comprising amino acid sequence as shown in SEQ ID No: 1-18 is provided. Furthermore, application of TRPM8 protein, TRPM8 related peptide fragment and their antibodies in preparing diagnostic reagent for chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is provided. By detecting level of TRPM8 protein molecule, TRPM8 related peptide fragment and their antibodies, the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is effectively diagnosed, and the present invention is capable of effectively making a distinction between CP/CPPS and other diseases of prostate. In addition, by intravenously or subcutaneously injecting 1˜30000 IU TRPM8 protein or TRPM8 related polypeptide fragments with or without combining nanoparticles for desensitization therapy, or monoclonal or polyclonal antibodies of the TRPM8 protein or polypeptide fragments, the present invention is capable of curing or significantly relieve clinical symptoms of the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) and having an therapeutic effect.

公开(公告)号：US11175289B2

公开(公告)日：2021-11-16

申请号：US15352607

申请日：2016-11-16

申请人： Lei Han ,  Xiaohui Zhou ,  Yuyan Zhou ,  Li Zhou ,  Guohua Li ,  Yongzhen Li

发明人： Lei Han ,  Xiaohui Zhou ,  Yuyan Zhou ,  Li Zhou ,  Guohua Li ,  Yongzhen Li

IPC分类号： C07K14/705 ,  G01N33/564 ,  C07K16/28

摘要： A TRPM8 related peptide fragment, comprising amino acid sequence as shown in SEQ ID No: 1-18 is provided. Furthermore, application of TRPM8 protein, TRPM8 related peptide fragment and their antibodies in preparing diagnostic reagent for chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is provided. By detecting level of TRPM8 protein molecule, TRPM8 related peptide fragment and their antibodies, the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is effectively diagnosed, and the present invention is capable of effectively making a distinction between CP/CPPS and other diseases of prostate. In addition, by intravenously or subcutaneously injecting 1˜30000 IU TRPM8 protein or TRPM8 related polypeptide fragments with or without combining nanoparticles for desensitization therapy, or monoclonal or polyclonal antibodies of the TRPM8 protein or polypeptide fragments, the present invention is capable of curing or significantly relieve clinical symptoms of the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) and having an therapeutic effect.

公开(公告)号：US20170105675A1

公开(公告)日：2017-04-20

申请号：US15394852

申请日：2016-12-30

申请人： Xiaohui Zhou

发明人： Xiaohui Zhou ,  Lei Han ,  Yuyan Zhou ,  Li Zhou ,  Guohua Li ,  Yongzhen Li

IPC分类号： A61B5/00 ,  A61B5/0402 ,  A61B5/0205 ,  A61B5/01 ,  A61N1/362 ,  A61B5/02 ,  A61N2/00 ,  A61H9/00 ,  A61M5/31 ,  A61M39/10 ,  A61N2/02 ,  A61B5/145

CPC分类号： A61B5/4836 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0432 ,  A61B5/14503 ,  A61B5/14539 ,  A61H9/00 ,  A61M1/106 ,  A61M1/1068 ,  A61M1/122 ,  A61M5/31 ,  A61M39/10 ,  A61N1/0597 ,  A61N1/362 ,  A61N2/002

摘要： A surface attached cardiac function monitor and/or intervention system comprises of a cardiac support device, a cardiac function monitor device and/or intervention device. Cardiac support device is attached on an external or internal surface of a cardiac chamber and supports it. The cardiac function monitor device is connected with a biochemical and physiological sensor. The physiological and biochemical sensor transmits variations of biochemical and physiological parameters that are received by the cardiac function monitor device. The intervention device has at least one member selected from pressure intervention device, an electrical/magnetic stimulation intervention device and a medicine intervention device. This medical system of the present invention could help in diagnosis as well as treatment of the heart failure and other myocardial diseases to improve the condition of patient. It could also be helpful for the monitoring, diagnosis and treatment of diseases of lungs, kidney, liver, spleen, stomach and bladder, etc.

公开(公告)号：US20130074202A1

公开(公告)日：2013-03-21

申请号：US13470467

申请日：2012-05-14

申请人： Thomas Adams ,  Ameeta K. Agarwa ,  Jeffrey Ahrens ,  James A. Ball ,  Amarjit Basra ,  Erin Bell ,  Terry L. Bradshaw ,  Paul S. Chomet ,  James H. Crowley ,  Jill Deikman ,  Molian Deng ,  Meghan Donnarummo ,  Kimberly Faye Zobrist Duff ,  Stephen Duff ,  Michael D. Edgerton ,  Banu Gopalan ,  Xiaoping He ,  Mackenzie Heal ,  Brendan S. Hinchey ,  Shihshieh Huang ,  Richard G. Johnson ,  Vincent Jung ,  Keith Kretzmer ,  Lucille B. Laccetti ,  Chao Qiang Lai ,  Garrett J. Lee ,  Michael H. Luethy ,  Timothy J. Leland ,  Jingdong Liu ,  Bin Lu ,  Adrian A. Lund ,  Linda L. Madson ,  Kathleen P. Malloy ,  Marcus Paul McNabnay ,  Manchikanti Padmavati ,  Thomas Ruff ,  William Start ,  Daniel Tennessen ,  Carl P. Urwin ,  Gabriela Vaduva ,  K. R. Vidya ,  Steven Thomas Voss ,  Christine Voyles ,  Zhango Xin ,  Nanfei Xu ,  Qingzhang Xu ,  Qiang Zhang ,  Yajuan Zhao ,  Li Zhou

发明人： Thomas Adams ,  Ameeta K. Agarwa ,  Jeffrey Ahrens ,  James A. Ball ,  Amarjit Basra ,  Erin Bell ,  Terry L. Bradshaw ,  Paul S. Chomet ,  James H. Crowley ,  Jill Deikman ,  Molian Deng ,  Meghan Donnarummo ,  Kimberly Faye Zobrist Duff ,  Stephen Duff ,  Michael D. Edgerton ,  Banu Gopalan ,  Xiaoping He ,  Mackenzie Heal ,  Brendan S. Hinchey ,  Shihshieh Huang ,  Richard G. Johnson ,  Vincent Jung ,  Keith Kretzmer ,  Lucille B. Laccetti ,  Chao Qiang Lai ,  Garrett J. Lee ,  Michael H. Luethy ,  Timothy J. Leland ,  Jingdong Liu ,  Bin Lu ,  Adrian A. Lund ,  Linda L. Madson ,  Kathleen P. Malloy ,  Marcus Paul McNabnay ,  Manchikanti Padmavati ,  Thomas Ruff ,  William Start ,  Daniel Tennessen ,  Carl P. Urwin ,  Gabriela Vaduva ,  K. R. Vidya ,  Steven Thomas Voss ,  Christine Voyles ,  Zhango Xin ,  Nanfei Xu ,  Qingzhang Xu ,  Qiang Zhang ,  Yajuan Zhao ,  Li Zhou

IPC分类号： C12N15/82 ,  A01D45/00

CPC分类号： C12N15/8279 ,  A01D45/00 ,  A01N25/34 ,  A01N31/16 ,  A01N41/10 ,  A01N43/40 ,  A01N43/653 ,  A01N43/78 ,  A01N43/80 ,  A01N55/02 ,  C07K14/415 ,  C12N9/0071 ,  C12N15/8241 ,  C12N15/8243 ,  C12N15/8247 ,  C12N15/8251 ,  C12N15/8261 ,  C12N15/8271 ,  C12N15/8273 ,  C12N15/8274 ,  C12N15/8275 ,  C12Y114/12017 ,  A01N25/10 ,  A01N25/02 ,  A01N2300/00

摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

公开(公告)号：US20120244583A1

公开(公告)日：2012-09-27

申请号：US13071126

申请日：2011-03-24

申请人： Yuanfa Liu ,  Kangyi Zhang ,  Xingguo Wang ,  Xiangyun Qian ,  Li Zhou ,  Zhihua Song

发明人： Yuanfa Liu ,  Kangyi Zhang ,  Xingguo Wang ,  Xiangyun Qian ,  Li Zhou ,  Zhihua Song

IPC分类号： C12P13/00

CPC分类号： C12P9/00 ,  C12P13/001

摘要： Disclosed is a method for preparing L-α-Glycerylphosphorylcholine with high yields and purity. The method uses phospholipase A1-based enzymatic hydrolysis, ion-exchange resin purification and silica gel column chromatography to prepare L-α-glycerylphosphorylcholin with purity up to 99.8% and a final yield up to 78.4%. The method disclosed is simple, cost-effective, environmentally friendly, and adaptable to industrial applications.

摘要翻译： 公开了以高产率和纯度制备L-α-甘油基磷酰胆碱的方法。 该方法采用磷脂酶A1酶水解，离子交换树脂纯化和硅胶柱色谱法制备纯度高达99.8％的L-α-甘油基磷酰胆碱，最终产率高达78.4％。 所公开的方法简单，成本效益高，环保，适用于工业应用。

公开(公告)号：US20110258734A1

公开(公告)日：2011-10-20

申请号：US13046601

申请日：2011-03-11

申请人： Thomas Adams ,  Ameeta K. Agarwa ,  Jeffrey Ahrens ,  James A. Ball ,  Amarjit Basra ,  Erin Bell ,  Terry L. Bradshaw ,  Paul S. Chomet ,  James H. Crowley ,  Jill Deikman ,  Molian Deng ,  Meghan Donnarummo ,  Kimberly Faye Zobrist Duff ,  Stephen Duff ,  Michael D. Edgerton ,  Banu Gopalan ,  Xiaoping He ,  Mackenzie Heal ,  Brendan S. Hinchey ,  Shihshieh Huang ,  Richard G. Johnson ,  Vincent Jung ,  Keith Kretzmer ,  Lucille B. Laccetti ,  Chao Qiang Lai ,  Garrett J. Lee ,  Michael H. Luethy ,  Timothy J. Leland ,  Jingdong Liu ,  Bin Lu ,  Adrian A. Lund ,  Linda L. Madson ,  Kathleen P. Malloy ,  Marcus Paul McNabnay ,  Manchikanti Padmavati ,  Thomas Ruff ,  William Start ,  Daniel Tennessen ,  Carl P. Urwin ,  Gabriela Vaduva ,  K.R. Vidya ,  Steven Thomas Voss ,  Christine Voyles ,  Zhango Xin ,  Nanfei Xu ,  Qingzhang Xu ,  Qiang Zhang ,  Yajuan Zhao ,  Li Zhou

发明人： Thomas Adams ,  Ameeta K. Agarwa ,  Jeffrey Ahrens ,  James A. Ball ,  Amarjit Basra ,  Erin Bell ,  Terry L. Bradshaw ,  Paul S. Chomet ,  James H. Crowley ,  Jill Deikman ,  Molian Deng ,  Meghan Donnarummo ,  Kimberly Faye Zobrist Duff ,  Stephen Duff ,  Michael D. Edgerton ,  Banu Gopalan ,  Xiaoping He ,  Mackenzie Heal ,  Brendan S. Hinchey ,  Shihshieh Huang ,  Richard G. Johnson ,  Vincent Jung ,  Keith Kretzmer ,  Lucille B. Laccetti ,  Chao Qiang Lai ,  Garrett J. Lee ,  Michael H. Luethy ,  Timothy J. Leland ,  Jingdong Liu ,  Bin Lu ,  Adrian A. Lund ,  Linda L. Madson ,  Kathleen P. Malloy ,  Marcus Paul McNabnay ,  Manchikanti Padmavati ,  Thomas Ruff ,  William Start ,  Daniel Tennessen ,  Carl P. Urwin ,  Gabriela Vaduva ,  K.R. Vidya ,  Steven Thomas Voss ,  Christine Voyles ,  Zhango Xin ,  Nanfei Xu ,  Qingzhang Xu ,  Qiang Zhang ,  Yajuan Zhao ,  Li Zhou

IPC分类号： A01H1/02 ,  A01D45/00 ,  A01H5/10 ,  C12N5/10 ,  A01H5/00

CPC分类号： C12N15/8279 ,  A01D45/00 ,  A01N25/34 ,  A01N31/16 ,  A01N41/10 ,  A01N43/40 ,  A01N43/653 ,  A01N43/78 ,  A01N43/80 ,  A01N55/02 ,  C07K14/415 ,  C12N9/0071 ,  C12N15/8241 ,  C12N15/8243 ,  C12N15/8247 ,  C12N15/8251 ,  C12N15/8261 ,  C12N15/8271 ,  C12N15/8273 ,  C12N15/8274 ,  C12N15/8275 ,  C12Y114/12017 ,  A01N25/10 ,  A01N25/02 ,  A01N2300/00

摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

摘要翻译： 本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。 本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率， 种子蛋白和增强种子油。 还公开了用于制备具有增强特征的转基因种子和植物的方法。

公开(公告)号：US07939703B2

公开(公告)日：2011-05-10

申请号：US12327596

申请日：2008-12-03

申请人： Li-Zhu Wu ,  Ming-Li Peng ,  Li Zhou ,  Deng-Hui Wang

发明人： Li-Zhu Wu ,  Ming-Li Peng ,  Li Zhou ,  Deng-Hui Wang

IPC分类号： C07C5/23

CPC分类号： B01J31/1815 ,  B01J31/183 ,  B01J35/004 ,  B01J2231/52 ,  B01J2531/0241 ,  B01J2531/0244 ,  B01J2531/828 ,  C07C5/2286 ,  C07C2531/22 ,  C07C15/52

摘要： The present invention relates to methods for accelerating the trans-cis isomerization of 1,2-diphenylethylene analogues by using photocatalyst. According to this invention, in the presence of polypyridyl platinum(II) complex with catalytic dosage, a solution containing trans-1,2-diphenylethylene analogues or mixture of cis- and trans-1,2-diphenylethylene analogues is irradiated by visible light to prepare product of cis-1,2-diphenylethylene analogues or product predominantly being cis-1,2-diphenylethylene analogues under inert gas atmosphere. This method has the advantages of fast reaction, high performance, easy separation of reaction system and recycle of the polypyridyl platinum (II) complexes.

摘要翻译： 本发明涉及通过使用光催化剂加速1,2-二苯基乙烯类似物的反式顺式异构化的方法。 根据本发明，在催化剂量的聚吡啶基铂（II）络合物的存在下，含有反式1,2-二苯基乙烯类似物或顺式 - 和反式-1,2-二苯基乙烯类似物的混合物的溶液被可见光照射到 在惰性气体气氛下制备顺式-1,2-二苯基乙烯类似物或主要为顺式1,2-二苯基乙烯类似物的产物。 该方法具有反应快，性能好，反应体系分离容易，聚吡啶铂（II）配合物循环利用等优点。

公开(公告)号：US20070032890A1

公开(公告)日：2007-02-08

申请号：US11385065

申请日：2006-03-21

申请人： Li Zhou ,  Eduardo Misawa

发明人： Li Zhou ,  Eduardo Misawa

IPC分类号： G05B19/04

CPC分类号： G05B19/416 ,  G05B2219/41144 ,  G05B2219/41337 ,  G11B5/5582 ,  G11B5/596 ,  G11B19/042

摘要： According to a preferred aspect of the instant invention, there is provided a system and method of robust vibration suppression which might be used in many subject matters, but which is preferably used in connection with computer controlled electromechanical devices such as disk drive arms. In a first preferred embodiment, a Gaussian waveform is selected as a velocity profile, with its integral and derivatives providing position and acceleration/jerk profiles respectively. According to another preferred embodiment, the movement velocity profile will be selected to be a member of the prolate spheroid family of waveforms. This family of functions has certain optimal properties with respect to the frequency domain concentration of energy for a given time-domain length time series. The movement of a flexible arm that is performed according to the invention will be one that has minimal or reduced residual vibration after it has reached its destination.

摘要翻译： 根据本发明的优选方面，提供了可用于许多主题的鲁棒振动抑制系统和方法，但是优选地与计算机控制的机电装置如磁盘驱动臂结合使用。 在第一优选实施例中，选择高斯波形作为速度分布，其积分和导数分别提供位置和加速度/加加曲线​​。 根据另一个优选实施例，移动速度分布将被选择为波形的长椭球系列的成员。 对于给定的时域长度时间序列，这个函数族对于能量的频域浓度具有一定的最佳性质。 根据本发明执行的柔性臂的运动将是在到达目的地之后具有最小或减小的残余振动的运动。

公开(公告)号：US20200234244A1

公开(公告)日：2020-07-23

申请号：US16255195

申请日：2019-01-23

申请人： Li Zhou ,  Chong Zhang ,  Andrew Walter Chimka ,  Kevin Chuang ,  Kumaresh Pattabiraman ,  Yixiao Lu ,  Chen Qian ,  George Pearman

发明人： Li Zhou ,  Chong Zhang ,  Andrew Walter Chimka ,  Kevin Chuang ,  Kumaresh Pattabiraman ,  Yixiao Lu ,  Chen Qian ,  George Pearman

IPC分类号： G06Q10/10

摘要： Disclosed are systems, methods, and non-transitory computer-readable media for providing profiles with limited permission level functionality in the network. In response to receiving a request to post the new employment listing, a collaboration system updates a permission list of the employment listing to provide a first user account with an administrator permission level in relation to the employment listing. The administrator permission level provides a first function and a second function in relation to the employment listing. The collaboration system receives a request to tag a second user account to the employment listing and updates the permission list to provide the second user account with a limited permission level in relation to the employment listing. The limited permission level provides the second user account with permission to perform the first function in relation to the employment listing but does not provide permission to perform the second function.

公开(公告)号：US20170081411A1

公开(公告)日：2017-03-23

申请号：US15126037

申请日：2015-03-13

申请人： Boris Engels ,  Andreas Loew ,  Michael C. Milone ,  Li Zhou ,  Novartis AG ,  The Trustees of the University of Pennsylvania

发明人： Boris Engels ,  Andreas Loew ,  Michael C. Milone ,  Li Zhou

IPC分类号： C07K16/28 ,  C12N15/62 ,  A61K38/17 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725

CPC分类号： C07K16/2863 ,  A61K38/00 ,  A61K38/177 ,  A61K38/1774 ,  A61K39/0011 ,  A61K39/3955 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/55561 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70575 ,  C07K16/00 ,  C07K16/28 ,  C07K16/2803 ,  C07K2317/22 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/10 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/70 ,  C07K2319/73 ,  C12N15/62

摘要： Provided are compositions and methods relating to regulatable chimeric antigen receptors (RCARs), natural killer cell receptor CARs (NKR-CARs), and regulatable NKR-CARs (RNKR-CARs), where the intracellular signaling or proliferation of the RCAR or RNKR-CAR can be controlled to optimize the use of an RCAR/NKR-CAR- or RNKR-CAR-expressing cell to provide an immune response. Cells can be engineered to express a RNKR-CAR or to express a RCAR and a NKR-CAR (e.g., inhibitory NKR-CAR). For example, a RCAR or RNKR-CAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR or RNKR-CAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.