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    Methods for determining the coat color genotype of a pig
    4.
    发明授权
    Methods for determining the coat color genotype of a pig 失效
    确定猪的外套颜色基因型的方法

    公开(公告)号：US06183955B2

    公开(公告)日：2001-02-06

    申请号：US09014241

    申请日：1998-01-27

    申请人： Leif Andersson ,  Maria Johansson Moller ,  Richard Wales ,  Kenneth William Siggens ,  Graham Stuart Plastow

    发明人： Leif Andersson ,  Maria Johansson Moller ,  Richard Wales ,  Kenneth William Siggens ,  Graham Stuart Plastow

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6876 ,  C12Q1/6827 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/16 ,  Y10S435/81

    摘要： Coat color is important to the pig breeding industry for a number of reasons. It is therefore desirable to develop populations of pigs which will breed true for coat color. However, establishing such populations would be time-consuming and costly using traditional test mating programs. It is therefore desirable to determine the coat color genotype of individual pigs. The inventors have shown that the KIT gene in pigs is involved with coat color determination. Specifically, the inventors have discovered that the difference between the I, IP, and i alleles of the coat color determining gene is duplication of at least part of the KIT gene in the I and IP alleles. Further, the inventors have discovered that the difference between the I and IP alleles is that, although both I and IP have a duplication in the KIT gene, only I and not IP exhibits a deletion in one of the duplicated regions. These discoveries have allowed the inventors to develop methods for distinguishing between the alleles I, IP, and i, thereby determining the genotype of individual pigs with respect to coat color. In accordance with the present invention, there are provided methods for determining the genotype of individual pigs with respect to coat color and kits for use in carrying out such methods.

    摘要翻译： 由于种种原因，大衣颜色对养猪业很重要。 因此，需要开发出将种植真皮用于外套颜色的猪群。 然而，使用传统的测试交配程序，建立这样的人口将是耗时和昂贵的。 因此，需要确定个体猪的外套颜色基因型。 发明人已经表明，猪中的KIT基因涉及外壳颜色测定。 具体地，本发明人已经发现，外层颜色确定基因的I，IP和i等位基因之间的差异是I和IP等位基因中至少部分KIT基因的重复。 此外，发明人已经发现，I和IP等位基因之间的区别在于，虽然I和IP在KIT基因中都有重复，但只有I而不是IP在其中一个复制区域中表现出缺失。 这些发现允许发明人开发区分等位基因I，IP和i的方法，由此确定单个猪相对于衣服颜色的基因型。 根据本发明，提供了确定各种猪相对于外套颜色的基因型的方法和用于实施这些方法的试剂盒。

    Identification of canine leukocyte adhesion deficiency in dogs
    6.
    发明授权
    Identification of canine leukocyte adhesion deficiency in dogs 有权
    鉴定犬白细胞粘附缺陷

    公开(公告)号：US06210897B1

    公开(公告)日：2001-04-03

    申请号：US09393554

    申请日：1999-09-10

    申请人： Leif Andersson ,  James Kijas ,  Sophie Gafvert ,  Gunilla Wigh-Trowaldh ,  Ake Hedhammar

    发明人： Leif Andersson ,  James Kijas ,  Sophie Gafvert ,  Gunilla Wigh-Trowaldh ,  Ake Hedhammar

    IPC分类号： C12Q168

    CPC分类号： C07K14/70553 ,  C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/156

    摘要： The present invention relates to an isolated nucleic acid molecule encoding canine leukocyte integrin &bgr;-2 subunit having a Cys36Ser missense mutation, wherein the missense mutation is indicative of a carrier of canine leukocyte adhesion deficiency. The present invention also relates to a method for identifying dogs which are carriers of or are affected with canine leukocyte adhesion deficiency. This method includes obtaining a biological sample from a dog and testing the biological sample for a Cys36Ser missense mutation in a gene encoding leukocyte integrin &bgr;-2 subunit, wherein the missense mutation in one allele is indicative of a carrier of canine leukocyte adhesion deficiency and the missense mutation in both alleles is indicative of a dog affected with canine leukocyte adhesion deficiency.

    摘要翻译： 本发明涉及编码具有Cys36Ser错义突变的犬白细胞整合素β-2亚基的分离的核酸分子，其中所述错义突变指示犬白细胞粘附缺陷的载体。 本发明还涉及用于鉴定作为犬白细胞粘附缺陷的载体或受其影响的狗的方法。 该方法包括从狗获得生物样品，并测试生物样品中编码白细胞整合素β-2亚基的基因中的Cys36Ser错义突变，其中一个等位基因中的错义突变指示犬白细胞粘附缺陷的载体， 两个等位基因中的错义突变表明狗受到白细胞粘附不足的影响。

    Methods and materials related to hair pigmentation and cancer
    8.
    发明授权
    Methods and materials related to hair pigmentation and cancer 有权
    与头发色素沉着和癌症相关的方法和材料

    公开(公告)号：US09096901B2

    公开(公告)日：2015-08-04

    申请号：US13603109

    申请日：2012-09-04

    申请人： Leif Andersson ,  Gerli Rosengren Pielberg ,  Anna Olegovna Golovko ,  Kjell Robert Johan Lennartsson ,  Carl-Henrik Heldin

    发明人： Leif Andersson ,  Gerli Rosengren Pielberg ,  Anna Olegovna Golovko ,  Kjell Robert Johan Lennartsson ,  Carl-Henrik Heldin

    IPC分类号： C12N15/11 ,  C12Q1/68

    CPC分类号： C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/124 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and materials such as nucleic acid probes and primer pairs that can be used to determine whether or not a horse contains a duplication in intron 6 of STX17 nucleic acid are provided. This document also relates to methods and materials for treating a mammal having or being likely to develop cancer (e.g., benign, malignant, or metastatic cancer). For example, methods and materials for treating cancer in a mammal by administering an agent having the ability to reduce expression of an STX17 polypeptide and/or an NR4A polypeptide (e.g., an NR4A1, NR4A2, or NR4A3 polypeptide) in the mammal are provided.

    摘要翻译： 本文件涉及用于确定马是否包含Gray等位基因的方法和材料。 例如，提供诊断方法，例如基于核酸的检测方法和诸如核酸探针和引物对的材料，其可用于确定马是否含有STX17核酸的内含子6中的重复。 本文件还涉及用于治疗具有或可能发展为癌症（例如良性，恶性或转移性癌症）的哺乳动物的方法和材料。 例如，提供了通过在哺乳动物中施用具有降低STX17多肽和/或NR4A多肽（例如NR4A1，NR4A2或NR4A3多肽）的表达能力的药剂来治疗哺乳动物癌症的方法和材料。

    METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES
    9.
    发明申请
    METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES 审中-公开
    预测马氏体位置图的方法

    公开(公告)号：US20150044681A1

    公开(公告)日：2015-02-12

    申请号：US14467594

    申请日：2014-08-25

    申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

    发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  A01K29/00 ,  C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N33/6872 ,  G01N33/6875 ,  G01N2333/4703

    摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

    摘要翻译： 本发明提供了一种用于预测马中运动模式的方法，其中包括马匹使用不同步态的能力和快速跑步的能力。 所述方法包括在样品中确定从马获得的DNA是否存在至少一种遗传标记，其中所述至少一种遗传标记位于马染色体23上，所述标记与使用不同步态的能力相关联。 本发明还提供了扩增与使用不同步态和杂交探针的能力相关联的标记的引物，以检测与使用不同步态的能力相关联的标记和以快速速度跑步的能力。

    METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES
    10.
    发明申请
    METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES 审中-公开
    预测马氏体位置图的方法

    公开(公告)号：US20140057253A1

    公开(公告)日：2014-02-27

    申请号：US13696128

    申请日：2012-05-04

    申请人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

    发明人： Lisa S. Andersson ,  Leif Andersson ,  Gabriella Lindgren

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  A01K29/00 ,  C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N33/6872 ,  G01N33/6875 ,  G01N2333/4703

    摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

    摘要翻译： 本发明提供了一种用于预测马中运动模式的方法，其中包括马匹使用不同步态的能力和快速跑步的能力。 所述方法包括在样品中确定从马获得的DNA是否存在至少一种遗传标记，其中所述至少一种遗传标记位于马染色体23上，所述标记与使用不同步态的能力相关联。 本发明还提供了扩增与使用不同步态和杂交探针的能力相关联的标记的引物，以检测与使用不同步态的能力相关联的标记和以快速速度跑步的能力。