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1.发明申请Human cDNA Clones Comprising Polynucleotides Encoding Polypeptides and Methods of Their Use 审中-公开包含编码多肽的多核苷酸的人cDNA克隆及其使用方法公开(公告)号：US20090286954A1
公开(公告)日：2009-11-19
申请号：US12424373
申请日：2009-04-15
申请人： Lewis T. Williams , Keting Chu , Ernestine Lee , Kevin Hestir , Justin Wong , Stephen K. Doberstein
发明人： Lewis T. Williams , Keting Chu , Ernestine Lee , Kevin Hestir , Justin Wong , Stephen K. Doberstein
IPC分类号： C07K14/00 , C07K14/765 , C07K16/00
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705
摘要： The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译： 本发明提供新型人全长cDNA克隆，新型多核苷酸，相关多肽，相关核酸和多肽组合物以及相关调节剂，例如抗体和小分子调节剂。 本发明还提供了制备和使用这些cDNA克隆，多核苷酸，多肽，相关组合物和调节剂的方法。 这些方法包括诊断，预防和治疗应用。 本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。
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2.发明申请Human cDNA clones comprising polynucleotides encoding polypeptides and methods of their use 审中-公开包含编码多肽的多核苷酸的人cDNA克隆及其使用方法公开(公告)号：US20080182974A1
公开(公告)日：2008-07-31
申请号：US11983397
申请日：2007-11-07
申请人： Lewis T. Williams , Keting Chu , Ernestine Lee , Kevin Hestir , Justin Wong , Stephen K. Doberstein
发明人： Lewis T. Williams , Keting Chu , Ernestine Lee , Kevin Hestir , Justin Wong , Stephen K. Doberstein
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705
摘要： The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译： 本发明提供新型人全长cDNA克隆，新型多核苷酸，相关多肽，相关核酸和多肽组合物以及相关调节剂，例如抗体和小分子调节剂。 本发明还提供了制备和使用这些cDNA克隆，多核苷酸，多肽，相关组合物和调节剂的方法。 这些方法包括诊断，预防和治疗应用。 本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。
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公开(公告)号：US20110003384A1
公开(公告)日：2011-01-06
申请号：US12370559
申请日：2009-02-12
申请人： Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： C12N5/071
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US08575312B2
公开(公告)日：2013-11-05
申请号：US13446254
申请日：2012-04-13
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： C07K14/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US20120258071A1
公开(公告)日：2012-10-11
申请号：US13446254
申请日：2012-04-13
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文鉴定为单核细胞，粒细胞和树突细胞集落刺激因子（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US08178109B2
公开(公告)日：2012-05-15
申请号：US12370559
申请日：2009-02-12
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： A61K39/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译： 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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7.发明申请STROMAL CELL-DERIVED FACTOR-1 POLYPEPTIDES, POLYNUCLEOTIDES, MODULATORS THEREOF AND METHODS OF USE 有权结晶细胞衍生因子-1多肽，多核苷酸，调节剂及其使用方法公开(公告)号：US20110020375A1
公开(公告)日：2011-01-27
申请号：US12752936
申请日：2010-04-01
申请人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
发明人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
IPC分类号： A61K38/17 , C12N15/12 , C07K14/435 , C12N15/00 , C07K1/00 , C07K16/18 , G01N33/48 , G01N33/53 , A61K35/12 , A61K39/00 , C12N5/00 , A61P7/02 , A61P3/10 , A61P9/00 , A61P37/00 , A61P31/00 , A61P9/10 , A61P35/00 , A61P37/08 , A61P17/00 , A61P11/00
CPC分类号： C07K14/522 , Y10T436/143333
摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。
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公开(公告)号：US08058403B2
公开(公告)日：2011-11-15
申请号：US12752936
申请日：2010-04-01
申请人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
发明人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
IPC分类号： C07K16/24
CPC分类号： C07K14/522 , Y10T436/143333
摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。
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9.发明申请Novel Stromal Cell-Derived Factor-1 Polypeptides, Polynucleotides, Modulators Thereof and Methods of Use 有权新型基质细胞衍生因子-1多肽，多核苷酸，调节剂及其使用方法公开(公告)号：US20090010946A1
公开(公告)日：2009-01-08
申请号：US11587651
申请日：2005-04-29
申请人： Keting Chu , Lewis T. Williams , Justin G.P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
发明人： Keting Chu , Lewis T. Williams , Justin G.P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
IPC分类号： A61K39/00 , C12N15/11 , C07K14/00 , C12N15/87 , C12P21/04 , A61P31/00 , C12N5/06 , G01N33/566 , A61K38/00 , A61K35/12
CPC分类号： C07K14/522 , Y10T436/143333
摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。
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10.发明授权Stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof and methods of use 有权基质细胞衍生因子-1多肽，多核苷酸，其调节剂和使用方法公开(公告)号：US07776564B2
公开(公告)日：2010-08-17
申请号：US11587651
申请日：2005-04-29
申请人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
发明人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
CPC分类号： C07K14/522 , Y10T436/143333
摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。
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