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公开(公告)号：US20050084850A1
公开(公告)日：2005-04-21
申请号：US10347669
申请日：2003-01-16
Applicant: Li Cao , Haishan Lin
Inventor： Li Cao , Haishan Lin
IPC: C12N15/09 , A61K38/00 , A61P43/00 , C07K14/47 , C07K14/495 , C07K16/18 , C12N5/10 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N9/64
CPC classification number: C07K14/47 , C07K14/495 , C07K2319/00 , Y02A90/26
Abstract: Novel polynucleotides and secreted proteins encoded thereby are disclosed. The proteins can be used as therapeutics, for example, to stimulate blood cell generation in patients receiving cancer chemotherapy, to treat bone marrow transplantation patients, and to heal fractured bones. Polynucleotides of the invention can be used therapeutically, to provide proteins of the invention. Polynucleotides of the invention can also be used diagnostically, such as on polynucleotide arrays, to detect differential gene expression in diseased tissue compared with gene expression in normal tissue.
Abstract translation: 公开了由此编码的新型多核苷酸和分泌蛋白质。 蛋白质可以用作治疗剂，例如刺激接受癌症化学疗法的患者的血细胞生成，治疗骨髓移植患者，并且治愈骨折骨。 本发明的多核苷酸可用于治疗性地提供本发明的蛋白质。 与正常组织中的基因表达相比，本发明的多核苷酸也可以在诊断上使用，例如在多核苷酸阵列上检测患病组织中的差异基因表达。
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公开(公告)号：US20110003384A1
公开(公告)日：2011-01-06
申请号：US12370559
申请日：2009-02-12
Applicant: Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
Inventor： Dirk BEHRENS , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC: C12N5/071
CPC classification number: C07K16/243 , A61K38/00 , C07K14/53
Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US08575312B2
公开(公告)日：2013-11-05
申请号：US13446254
申请日：2012-04-13
Applicant: Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
Inventor： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC: C07K14/00
CPC classification number: C07K16/243 , A61K38/00 , C07K14/53
Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US20120258071A1
公开(公告)日：2012-10-11
申请号：US13446254
申请日：2012-04-13
Applicant: Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
Inventor： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
CPC classification number: C07K16/243 , A61K38/00 , C07K14/53
Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
Abstract translation: 公开了一种新鉴定的分泌型分子，本文鉴定为单核细胞，粒细胞和树突细胞集落刺激因子（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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Patent Agency Ranking
5.发明授权Colony stimulating factor 1 receptor (CSF1R) extracellular domain fusion molecules 有权集落刺激因子1受体（CSF1R）细胞外结构域融合分子公开(公告)号：US08080246B2
公开(公告)日：2011-12-20
申请号：US12626598
申请日：2009-11-25
Applicant: Haishan Lin , Li Long
Inventor： Haishan Lin , Li Long
CPC classification number: C07K14/7153 , A61K38/00 , C07K2319/30
Abstract: The present invention relates to specific CSF1R ECD fusion molecules that exhibit improved therapeutic properties. The invention also relates to polypeptide and polynucleotide sequences, vectors, host cells, and compositions comprising or encoding such molecules. The invention also relates to methods of making and using the CSF1R ECD fusion molecules. The invention further relates to methods of treatment using the CSF1R ECD fusion molecules. For example, certain CSF1R ECDs of the invention may be used to treat rheumatoid arthritis (RA) or multiple sclerosis (MS).
Abstract translation: 本发明涉及具有改善的治疗性质的特异性CSF1R ECD融合分子。 本发明还涉及包含或编码这种分子的多肽和多核苷酸序列，载体，宿主细胞和组合物。 本发明还涉及制备和使用CSF1R ECD融合分子的方法。 本发明还涉及使用CSF1R ECD融合分子的治疗方法。 例如，本发明的某些CSF1R ECD可用于治疗类风湿性关节炎（RA）或多发性硬化症（MS）。
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公开(公告)号：US07795404B1
公开(公告)日：2010-09-14
申请号：US11985863
申请日：2007-11-15
Applicant: Haishan Lin , Minmei Huang , Lewis T. Williams
Inventor： Haishan Lin , Minmei Huang , Lewis T. Williams
IPC: C07K14/435
CPC classification number: C07K14/705 , C07K14/47
Abstract: Novel soluble Notch receptor ligands and polynucleotides encoding such are disclosed, as well as methods for producing and using these novel nucleotides and polypeptides. These novel polypeptides or agonists or antagonists thereto modulate cellular activity, regulate the growth and division of cell, including stem cells, progenitor and precursor cells, are involved in cell fate decisions, and provide prophylactic or therapeutic benefits for treatment of human diseases. Expression systems are provided that facilitate the production, secretion, and purification of these molecules.
Abstract translation: 公开了新型可溶性Notch受体配体和编码这些配体的多核苷酸，以及生产和使用这些新型核苷酸和多肽的方法。 这些新型多肽或其拮抗剂调节细胞活性，调节细胞（包括干细胞，祖细胞和前体细胞）的生长和分裂参与细胞命运决定，并且为治疗人类疾病提供预防或治疗益处。 提供了促进这些分子的生产，分泌和纯化的表达系统。
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7.发明授权Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules 有权使用CSF1R细胞外结构域融合分子治疗溶骨性疾病和癌症公开(公告)号：US08183207B2
公开(公告)日：2012-05-22
申请号：US12626583
申请日：2009-11-25
Applicant: Haishan Lin , Li Long
Inventor： Haishan Lin , Li Long
CPC classification number: C07K14/70567 , A61K38/1793 , A61K47/60 , A61K47/643 , C07K2319/30
Abstract: Methods of using colony stimulating factor receptor (CSF1R) extracellular domain (ECD) fusion molecules for treating osteolytic bone loss, cancer metastasis, cancer metastasis-induced osteolytic bone loss, and tumor growth are provided. CSF1R ECD fusion molecules, polynucleotides encoding CSF1R ECD fusion molecules, and methods of making CSF1R ECD fusion molecules are also provided.
Abstract translation: 提供了使用集落刺激因子受体（CSF1R）胞外域（ECD）融合分子治疗溶骨性骨丢失，癌转移，癌转移诱导的溶骨性骨丢失和肿瘤生长的方法。 还提供了CSF1R ECD融合分子，编码CSF1R ECD融合分子的多核苷酸，以及制备CSF1R ECD融合分子的方法。
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公开(公告)号：US08178109B2
公开(公告)日：2012-05-15
申请号：US12370559
申请日：2009-02-12
Applicant: Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
Inventor： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC: A61K39/00
CPC classification number: C07K16/243 , A61K38/00 , C07K14/53
Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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公开(公告)号：US20070264277A1
公开(公告)日：2007-11-15
申请号：US11632319
申请日：2005-07-21
Applicant: Dirk Behrens , Elizabeth Bosch , Stephen Doberstein , Robert Halenbeck , Kevin Hestir , Min Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin Wong , Ge Wu , Aileen Zhou
Inventor： Dirk Behrens , Elizabeth Bosch , Stephen Doberstein , Robert Halenbeck , Kevin Hestir , Min Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin Wong , Ge Wu , Aileen Zhou
IPC: A61K39/00 , A61K38/00 , C07H21/00 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/87 , C12N5/06 , C12P1/00 , G01N33/53
CPC classification number: C07K16/243 , A61K38/00 , C07K14/53
Abstract: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
Abstract translation: 公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。 另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。 还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。
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