公开(公告)号：US20100173307A1

公开(公告)日：2010-07-08

申请号：US12652395

申请日：2010-01-05

申请人： Li Lin ,  John Pang ,  Wen Wei ,  Edward G. Lakatta

发明人： Li Lin ,  John Pang ,  Wen Wei ,  Edward G. Lakatta

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N15/625 ,  C07K2319/02 ,  C07K2319/43 ,  C12N15/1086 ,  G01N33/542

摘要： Described herein are nucleic acid modules for cloning, expression and tagging of eukaryotic membrane proteins. The nucleic acid modules include a receptor for advanced glycation end products (RAGE) signal sequence, a nucleic acid sequence encoding a tag and a multiple cloning sequence (MCS). Any membrane protein of interest can be cloned into the MCS for expression in cells. The nucleic acid modules can encode any type of tag, such as an epitope tag or affinity tag. The nucleic acid modules disclosed herein can be used to express any type of membrane protein and are particularly suited to the expression and tagging of Type I and Type III membrane proteins.

摘要翻译： 本文描述了用于克隆，表达和标记真核细胞蛋白质的核酸模块。 核酸模块包括用于晚期糖基化终产物（RAGE）信号序列的受体，编码标签的核酸序列和多克隆序列（MCS）。 感兴趣的任何膜蛋白可以克隆到MCS中以在细胞中表达。 核酸模块可以编码任何类型的标签，例如表位标签或亲和标签。 本文公开的核酸模块可用于表达任何类型的膜蛋白，并且特别适用于I型和III型膜蛋白的表达和标记。

公开(公告)号：US08501925B2

公开(公告)日：2013-08-06

申请号：US12652395

申请日：2010-01-05

申请人： Li Lin ,  John Pang ,  Wen Wei ,  Edward G. Lakatta

发明人： Li Lin ,  John Pang ,  Wen Wei ,  Edward G. Lakatta

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12N15/625 ,  C07K2319/02 ,  C07K2319/43 ,  C12N15/1086 ,  G01N33/542

摘要： Described herein are nucleic acid modules for cloning, expression and tagging of eukaryotic membrane proteins. The nucleic acid modules include a receptor for advanced glycation end products (RAGE) signal sequence, a nucleic acid sequence encoding a tag and a multiple cloning sequence (MCS). Any membrane protein of interest can be cloned into the MCS for expression in cells. The nucleic acid modules can encode any type of tag, such as an epitope tag or affinity tag. The nucleic acid modules disclosed herein can be used to express any type of membrane protein and are particularly suited to the expression and tagging of Type I and Type III membrane proteins.

摘要翻译： 本文描述了用于克隆，表达和标记真核细胞蛋白质的核酸模块。 核酸模块包括用于晚期糖基化终产物（RAGE）信号序列的受体，编码标签的核酸序列和多克隆序列（MCS）。 感兴趣的任何膜蛋白可以克隆到MCS中以在细胞中表达。 核酸模块可以编码任何类型的标签，例如表位标签或亲和标签。 本文公开的核酸模块可用于表达任何类型的膜蛋白，并且特别适用于I型和III型膜蛋白的表达和标记。

公开(公告)号：US09410998B2

公开(公告)日：2016-08-09

申请号：US14090333

申请日：2013-11-26

申请人： Li Lin

发明人： Li Lin

IPC分类号： G01R31/26 ,  G01R27/26 ,  G01D5/241

CPC分类号： G01R27/2605 ,  G01D5/2415

摘要： A system for obtaining incremental and absolute displacement measurements using systems of electrodes that interact to form variable capacitors and systems that facilitate implementation of the method along with exemplary embodiments of these systems. The capacitors created by the disclosed method have known physical properties and corresponding known mathematical relationships. These laws are exploited in such a way by our method as to overcome inadequacies in existing systems and create superior systems. These superior systems improve upon the existing art by including economically and reliably made sensors based on the area varying principle which eliminate dead zone issues and increase accuracy through a reduction of the influence of gap variations on capacitive systems through the use of compensatory geometrical arrangements of multiple capacitive systems.

摘要翻译： 一种用于使用与可变电容器相互作用的电极系统以及便于该方法的实施以及这些系统的示例性实施例的系统来获得增量和绝对位移测量的系统。 由所公开的方法产生的电容器具有已知的物理性质和对应的已知数学关系。 这些法律以我们的方法被利用来克服现有系统的不足之处，创造出优越的系统。 这些优越的系统通过包括经济可靠地制造的传感器，通过使用区域变化原理包括经济地和可靠地制造的传感器来改进现有技术，该原理消除了死区问题，并且通过使用多重补偿几何排列来减小间隙变化对电容性系统的影响 电容系统。

公开(公告)号：US08908396B2

公开(公告)日：2014-12-09

申请号：US13611091

申请日：2012-09-12

申请人： Ta-Yung Yang ,  Li Lin ,  Yue-Hong Tang ,  Jung-Sheng Chen

发明人： Ta-Yung Yang ,  Li Lin ,  Yue-Hong Tang ,  Jung-Sheng Chen

IPC分类号： H02M3/335 ,  H02M1/00

CPC分类号： H02M3/33507 ,  H02M2001/0003

摘要： A control circuit of the power converter according to the present invention comprises a feedback circuit, an output circuit and an adaptive clamping circuit. The feedback circuit generates a feedback signal in accordance with an output of the power converter. The output circuit generates a switching signal in accordance with the feedback signal for regulating the output of the power converter. The adaptive clamping circuit limits the level of the feedback signal under a first level for a first load condition. The feedback circuit determines a slew rate of the feedback signal for increasing the level of the feedback signal from the first level to a second level. The adaptive clamping circuit is disabled and the level of the feedback signal can be increased to the second level for a second load condition.

摘要翻译： 根据本发明的功率转换器的控制电路包括反馈电路，输出电路和自适应钳位电路。 反馈电路根据功率转换器的输出产生反馈信号。 输出电路根据用于调节功率转换器的输出的反馈信号产生开关信号。 自适应钳位电路在第一负载条件下将反馈信号的电平限制在第一电平。 反馈电路确定用于将反馈信号的电平从第一电平增加到第二电平的反馈信号的转换速率。 自适应钳位电路被禁用，并且反馈信号的电平可以在第二负载条件下增加到第二电平。

公开(公告)号：US08722613B2

公开(公告)日：2014-05-13

申请号：US10569884

申请日：2004-08-27

申请人： Li Lin

发明人： Li Lin

IPC分类号： A61K31/00 ,  A61K39/395

CPC分类号： C07K14/4703

摘要： A series of p105-based NF-κB super repressors, designated p-105(sr), have been designed. The p105(sr), no longer generates p50 and undergoes signal-induced degradation, effectively inhibiting all NF-κB activities. Additionally, p105(sr) significantly enhances tumor necrosis factor alpha (TNF-α)-mediated killing of MT1/2 skin papilloma cells when p50 homodimer activity is elevated. p105(sr) is an effective NF-κB super repressor with a broader range than other currently available IkBα super repressors. The novel repressor can be used in cells where a noncanical NF-κB activity is dominant or multiple NF-κB activities are activated.

摘要翻译： 已经设计了一系列基于p105的NF-κB超级阻遏物，指定为p-105（sr）。 p105（sr）不再产生p50并发生信号诱导的降解，有效抑制了所有的NF-和κB活性。 此外，当p50同型二聚体活性升高时，p105（sr）显着增强肿瘤坏死因子α（TNF-α）介导的杀死MT1 / 2皮肤乳头状瘤细胞。 p105（sr）是一种有效的NF-κB超级阻遏物，其范围比其他目前可用的IkBα超阻抑素更广泛。 该新型阻遏物可用于非科学的NF-κB活性占优势或多个NF-κB活性被激活的细胞中。

公开(公告)号：US08711583B2

公开(公告)日：2014-04-29

申请号：US13182291

申请日：2011-07-13

申请人： Ta-Yung Yang ,  Jhih-Da Hsu ,  Ying-Chieh Su ,  Li Lin

发明人： Ta-Yung Yang ,  Jhih-Da Hsu ,  Ying-Chieh Su ,  Li Lin

IPC分类号： H02M3/335

CPC分类号： H02M1/4258 ,  H02M2001/0006 ,  Y02B70/126

摘要： An exemplary embodiment of a power converter is provided. The power converter includes a transformer, a power device, a switching controller, and a capacitor. The power device is coupled to the transformer for switching the transformer to product output of the power converter. The switching controller receives a feedback signal for generating a switching signal coupled to drive the power device. An input circuit of the switching controller is coupled to the transformer to sample an input signal for generating the feedback signal, and the input signal is correlated to the output of the power converter. The capacitor is coupled to the switching controller to provide frequency compensation for a feedback loop of the power converter. Input of the power converter is without an electrolytic capacitor, and a maximum output current of the power converter is a constant current.

摘要翻译： 提供了功率转换器的示例性实施例。 功率转换器包括变压器，功率器件，开关控制器和电容器。 功率器件耦合到变压器，用于将变压器切换到功率转换器的产品输出。 开关控制器接收用于产生耦合以驱动功率器件的开关信号的反馈信号。 开关控制器的输入电路耦合到变压器以对输入信号进行采样以产生反馈信号，并且输入信号与功率转换器的输出相关。 电容器耦合到开关控制器以为功率转换器的反馈回路提供频率补偿。 功率转换器的输入没有电解电容器，功率转换器的最大输出电流为恒定电流。

公开(公告)号：US08585611B1

公开(公告)日：2013-11-19

申请号：US13566257

申请日：2012-08-03

申请人： Allen J. Raymond ,  Li Lin ,  Cai Long

发明人： Allen J. Raymond ,  Li Lin ,  Cai Long

IPC分类号： A61B5/00 ,  B65D81/00 ,  A61M5/32

CPC分类号： A61B5/150732 ,  A61B5/15003 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150587 ,  A61B5/150717 ,  A61B5/150908 ,  A61B5/154

摘要： A housing has upper, lower, and central sections having a common axis and forming an interior chamber. An opening in the intermediate section has upper, lower, and sides edges. A flap has one edge coupled with the opening and covers the opening. A support is slidable between extended and retracted orientations. The support has central, upper, and lower extents. A cylindrical bore extends through the support. The support has legs, including a short leg, extending downwardly and outwardly and adapted to be radially contracted with the short leg within the opening restrained from downward movement. The flap is adapted to be depressed to move the short leg from contact with the opening and spring the legs outwardly to move the support from the extended orientation to the retracted orientation. Upper and lower needles extend from the upper and lower extents of the support for movement therewith.

摘要翻译： 壳体具有上部，下部和中心部分，具有共同的轴线并形成内部腔室。 中间部分的开口具有上，下和侧边。 翼片具有与开口连接并且覆盖开口的一个边缘。 支撑件可在延伸和缩进方向之间滑动。 支持中心，上限和下限。 圆柱形孔延伸穿过支撑件。 支撑件具有腿部，包括一个向下和向外延伸的短腿，并适于与限制在向下运动的开口内的短腿径向收缩。 翼片适于被压下以使短腿与开口接触移动，并向外弹弹腿，以将支撑件从延伸方向移动到缩回方向。 上针和下针从支撑件的上部和下部延伸以与其一起运动。

公开(公告)号：US08570887B2

公开(公告)日：2013-10-29

申请号：US12944031

申请日：2010-11-11

申请人： Thomas B. Cho ,  Li Lin ,  Mao Yu ,  Atul Salhotra

发明人： Thomas B. Cho ,  Li Lin ,  Mao Yu ,  Atul Salhotra

IPC分类号： G01R31/08

CPC分类号： H04L27/0002 ,  H03F1/0272 ,  H03G3/3068

摘要： Apparatus having corresponding methods and non-transitory computer-readable media comprise an amplifier configured to amplify signals according to a bias current, wherein the signals represent packets of data; a packet module configured to recover the packets of data from the signals amplified by the amplifier; and a control module configured to control the bias current according to one or more characteristics of the packets of data.

摘要翻译： 具有相应方法和非瞬时计算机可读介质的装置包括放大器，其经配置以根据偏置电流放大信号，其中所述信号表示数据分组; 分组模块，被配置为从放大器放大的信号中恢复数据分组; 以及控制模块，被配置为根据所述数据分组的一个或多个特性来控制所述偏置电流。

公开(公告)号：US08564471B1

公开(公告)日：2013-10-22

申请号：US13333058

申请日：2011-12-21

申请人： Xiang Gao ,  Chih-Wei Yao ,  Chi-Hung Lin ,  Li Lin

发明人： Xiang Gao ,  Chih-Wei Yao ,  Chi-Hung Lin ,  Li Lin

IPC分类号： H03M1/50

CPC分类号： H03M1/50 ,  G04F10/005 ,  H03K5/13 ,  H03L7/0814 ,  H03L7/0891 ,  H03M1/00 ,  H03M1/0641 ,  H03M1/0695 ,  H03M1/12 ,  H03M2201/4233

摘要： Disclosed is a time-to-digital (TDC) converter comprising an analog voltage source. An analog-to-digital converter quantizes two voltage samples in response to receiving a first input signal at a first time t1 and a second input signal at a second time t2. The first and second digital signals are combined to produce a digital signal that represents the difference (t2−t1).

摘要翻译： 公开了一种包括模拟电压源的时间数字（TDC）转换器。 响应于在第一时间t1接收第一输入信号和第二时间t2的第二输入信号，模数转换器量化两个电压采样。 第一和第二数字信号被组合以产生表示差的数字信号（t2-t1）。

公开(公告)号：US20120276857A1

公开(公告)日：2012-11-01

申请号：US13449468

申请日：2012-04-18

申请人： Xiang Gao ,  Chi-Hung Lin ,  Li Lin

发明人： Xiang Gao ,  Chi-Hung Lin ,  Li Lin

IPC分类号： H04B1/38 ,  H03K21/00 ,  H03B19/14

CPC分类号： H03B19/00

摘要： Frequency multipliers having corresponding methods and multifunction radios comprise: N multipliers, wherein N is an integer greater than one; wherein the multipliers are connected in series such that each of the multipliers, except for a first one of the multipliers, is configured to mix a periodic input signal with an output of another respective one of the multipliers; wherein the first one of the multipliers is configured to mix the periodic input signal with the periodic input signal.

摘要翻译： 具有相应方法和多功能无线电的频率乘法器包括：N个乘法器，其中N是大于1的整数; 其中所述乘法器串联连接，使得除所述乘法器中的第一乘法器之外的每个乘法器被配置为将周期性输入信号与所述乘法器中的另一相应乘法器的输出混合; 其中所述乘法器中的所述第一乘法器被配置为将所述周期性输入信号与所述周期性输入信号混合。