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公开(公告)号：US10322835B1
公开(公告)日：2019-06-18
申请号：US14836508
申请日：2015-08-26
申请人： LifeCell Corporation
发明人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick T. Owens
IPC分类号： B65B55/02 , B65B55/22 , B65B55/08 , B65B55/16 , A61L2/08 , A61L2/18 , A61L2/00 , A61L27/36 , B65B31/02
摘要： The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.
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公开(公告)号：US20180311410A1
公开(公告)日：2018-11-01
申请号：US16028870
申请日：2018-07-06
申请人： LifeCell Corporation
发明人： Wendell Sun
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/362 , F01C21/06 , F03C2/08
摘要： A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.
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公开(公告)号：US20170100509A1
公开(公告)日：2017-04-13
申请号：US15378447
申请日：2016-12-14
申请人： LifeCell Corporation
发明人： Wendell Sun , Gary Monteiro
CPC分类号： A61L27/24 , A61F2/12 , A61F2/186 , A61L27/3604 , A61L27/362 , A61L27/3641 , A61L27/3691 , A61L27/50 , A61L2430/04 , A61L2430/40 , C12N5/0081
摘要： Methods for shaping tissue matrices are provided. The methods can be used to produce shaped tissue products that retain desired biologic properties without using chemical crosslinking agents.
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公开(公告)号：US10406260B2
公开(公告)日：2019-09-10
申请号：US15176863
申请日：2016-06-08
申请人： LifeCell Corporation
发明人： Rick T. Owens , Wendell Sun
摘要： The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions.
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公开(公告)号：US20160030487A1
公开(公告)日：2016-02-04
申请号：US14805728
申请日：2015-07-22
申请人： LifeCell Corporation
发明人： Nathaniel Bachrach , Hui Xu , Wendell Sun
IPC分类号： A61K35/36
CPC分类号： A61K35/36 , A61L27/24 , A61L27/26 , A61L27/3604 , A61L27/362 , A61L27/3633 , A61L27/3695
摘要： Methods of producing tissue matrices are provided. The methods can comprise selection of collagen-based tissues from animals based on desired mechanical and/or biologic properties relating to the age of a source animal. Furthermore, tissue matrices produced from animals including pigs selected at various ages to control mechanical properties are provided.
摘要翻译： 提供生产组织基质的方法。 该方法可以包括基于与源动物的年龄相关的期望的机械和/或生物学特性从动物中选择基于胶原的组织。 此外，提供了由包括在各种年龄选择的猪的动物产生的组织基质以控制机械性能。
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公开(公告)号：US20240207488A1
公开(公告)日：2024-06-27
申请号：US18386832
申请日：2023-11-03
申请人： LifeCell Corporation
发明人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick T. Owens
CPC分类号： A61L27/505 , A01N1/0226 , A61L2/08 , A61L27/36 , A61L27/362 , A61L27/3683 , A61L2430/40
摘要： The present disclosure provides a variety of methods and compositions e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).
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公开(公告)号：US20160317707A1
公开(公告)日：2016-11-03
申请号：US15176863
申请日：2016-06-08
申请人： LifeCell Corporation
发明人： Rick T. Owens , Wendell Sun
CPC分类号： A61L27/362 , A61L27/16 , A61L27/18 , A61L27/36 , A61L27/3633 , A61L31/005 , A61L2400/18 , A61L2420/02 , C08L89/06 , C08L23/12 , C08L67/04
摘要： The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions.
摘要翻译： 本发明提供组织修复组合物和制备组织修复组合物的方法。 还特征在于使用包括组织修复组合物的组织修复组合物和制品的治疗方法。
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公开(公告)号：US20160114080A1
公开(公告)日：2016-04-28
申请号：US14989301
申请日：2016-01-06
申请人： LifeCell Corporation
发明人： Wendell Sun
IPC分类号： A61L27/36
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/362 , F01C21/06 , F03C2/08
摘要： A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.
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公开(公告)号：US20140296623A1
公开(公告)日：2014-10-02
申请号：US14303489
申请日：2014-06-12
申请人： LifeCell Corporation
发明人： Rick T. Owens , Wendell Sun , Mike Liu , Yong Mao
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61L27/3633 , A61L27/48
摘要： Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
摘要翻译： 提供了用于治疗或修复组织或器官缺损或损伤的装置和方法。 该装置可以包括由无细胞组织基质和聚合物产生的组织支架，其具有稳定的三维形状并且引起有限的免疫学或炎症反应。
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公开(公告)号：US10906679B1
公开(公告)日：2021-02-02
申请号：US16410319
申请日：2019-05-13
申请人： LifeCell Corporation
发明人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick T. Owens
摘要： The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.
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