MULTIPLEX (+/-) STRANDED ARRAYS AND ASSAYS FOR DETECTING CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH CANCER AND OTHER DISEASES
    1.
    发明申请
    MULTIPLEX (+/-) STRANDED ARRAYS AND ASSAYS FOR DETECTING CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH CANCER AND OTHER DISEASES 审中-公开
    用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)条带阵列和测定

    公开(公告)号:US20110086772A1

    公开(公告)日:2011-04-14

    申请号:US12891623

    申请日:2010-09-27

    IPC分类号: C40B30/04 C40B40/08

    摘要: Multiplex (+/−) stranded analyses, such as array comparative genomic hybridization (aCGH), are provided for detecting chromosomal rearrangements associated with cancer and other diseases. For example, an illustrative multiplex array for CGH includes discrete plus (+) strand and minus (−) strand DNA probes, complementary to each other but separable on the CGH array. The minus (−) strand DNA probes recover diagnostic information lost to conventional microarrays, since many genes transcribe from the minus (−) strand. In an illustrative system, patient and control DNA samples are prepared for CGH by amplification and labeling using comprehensive primers that generate both plus (+) strands and minus (−) strands of DNA in the samples. The breakpoints of a translocated chromosome may be detected on a multiplex microarray by DNA probes of one polarity, while DNA copy number changes associated with the translocation region may be detected by corresponding DNA probes of the complementary polarity. Related methods for identifying translocation partner genes are also provided.

    摘要翻译: 提供多重(+/-)链分析,如阵列比较基因组杂交(aCGH),用于检测与癌症和其他疾病相关的染色体重排。 例如,用于CGH的说明性多重阵列包括彼此互补但在CGH阵列上可分离的离散加(+)链和负( - )链DNA探针。 负( - )链DNA探针恢复常规微阵列损失的诊断信息,因为许多基因从负( - )链转录。 在说明性系统中,通过使用在样品中产生加(+)链和负( - )链DNA的综合引物进行扩增和标记来制备用于CGH的患者和对照DNA样品。 可以通过一个极性的DNA探针在多重微阵列上检测易位染色体的断点,而与易位区相关的DNA拷贝数变化可以通过互补极性的相应DNA探针检测。 还提供了用于鉴定易位配偶体基因的相关方法。

    Downhole Telemetry System Using an Optically Transmissive Fluid Media and Method for Use of Same
    2.
    发明申请
    Downhole Telemetry System Using an Optically Transmissive Fluid Media and Method for Use of Same 审中-公开
    使用光学透射流体介质的井下遥测系统及其使用方法

    公开(公告)号:US20120218119A1

    公开(公告)日:2012-08-30

    申请号:US13463661

    申请日:2012-05-03

    IPC分类号: G01V3/00

    CPC分类号: G01V11/002

    摘要: A multi-channel downhole telemetry system for enabling communication in a wellbore. The system includes a downhole transmitter operable to optically transmit a first data stream on a first optical channel and a second data stream on a second optical channel. A downhole receiver is operable to receive the first data stream and the second data stream. An optically transmissive fluid disposed in the wellbore provides a medium for the optical transmission of the first data stream and the second data stream between the downhole transmitter and the downhole receiver. The optically transmissive fluid contains suspended solids having refraction surfaces that scatter the optically transmitted data streams in the wellbore.

    摘要翻译: 一种用于实现井筒通信的多通道井下遥测系统。 该系统包括井下发射器,其可操作以在第二光学信道上光学地发送第一光信道上的第一数据流和第二数据流。 井下接收器可操作以接收第一数据流和第二数据流。 布置在井眼中的透光流体提供用于第一数据流的光传输和井下发射器与井下接收器之间的第二数据流的介质。 光学透射流体包含具有将光学传输的数据流分散在井眼中的折射表面的悬浮固体。

    High-temperature devices on insulator substrates
    3.
    发明申请
    High-temperature devices on insulator substrates 审中-公开
    绝缘体基板上的高温器件

    公开(公告)号:US20060091379A1

    公开(公告)日:2006-05-04

    申请号:US10992067

    申请日:2004-11-18

    IPC分类号: H01L29/08 H01L35/24

    摘要: Semiconductor devices, logic devices, libraries to represent logic devices, and methods for designing and fabricating the same are disclosed. The semiconductor devices include a substrate comprising sapphire or diamond, an active layer disposed on the substrate, the active layer having a thickness tSi and comprising a channel region having a length L, where L/tSi is above 7 and an oxide layer disposed on the active layer

    摘要翻译: 公开了用于表示逻辑器件的半导体器件,逻辑器件,库,以及用于设计和制造它们的方法。 半导体器件包括包括蓝宝石或金刚石的衬底,设置在衬底上的有源层,有源层具有厚度tSi并且包括具有长度L的沟道区,其中L / tSi高于7,并且氧化层位于 活动层

    Method and apparatus for high temperature operation of electronics
    4.
    发明申请
    Method and apparatus for high temperature operation of electronics 有权
    电子元件高温运行的方法和装置

    公开(公告)号:US20060060964A1

    公开(公告)日:2006-03-23

    申请号:US10946813

    申请日:2004-09-22

    IPC分类号: H01L21/44 H01L23/34

    摘要: Embodiments of methods and apparatus for high temperature operation of electronics according to the invention are disclosed. One embodiment of the invention generally includes an integrated circuit package having a substrate. A plurality of integrated circuits are coupled to a surface of the substrate. A lid is positioned above the substrate facing the surface. One or more pieces of compliant and thermally conductive material are compressed between at least one of the integrated circuits and the lid. The lid defines in part an enclosed volume containing the compliant and thermally conductive material.

    摘要翻译: 公开了用于根据本发明的电子设备的高温操作的方法和装置的实施例。 本发明的一个实施例通常包括具有基板的集成电路封装。 多个集成电路耦合到衬底的表面。 盖子位于面向表面的基板上。 一个或多个顺应性和导热材料在至少一个集成电路和盖子之间被压缩。 盖子部分地限定包含顺从性和导热材料的封闭容积。

    Shape memory alloy for erosion control of downhole tools
    5.
    发明申请
    Shape memory alloy for erosion control of downhole tools 审中-公开
    形状记忆合金,用于井下工具的侵蚀控制

    公开(公告)号:US20060048936A1

    公开(公告)日:2006-03-09

    申请号:US10936279

    申请日:2004-09-07

    IPC分类号: E21B34/00

    CPC分类号: E21B34/066 E21B43/12

    摘要: A downhole fluid flow control device (188) and method for minimizing erosion are disclosed. The downhole fluid flow control device (188) includes a downhole surface (190) subjectable to an erosive stress (196, 198) which may be a moving fluid or an erosive agent, for example. A shape memory alloy (192) is integrated with the downhole surface (190) in order to provide erosion resistance by reversibly transforming from an austenitic phase (194) to a martensitic phase (200) in response to the application of the erosive stress (196, 198). Further, the shape memory alloy (192) reversibly transforms from the martensitic phase (200) to the austenitic phase (192) in response to the presence of sufficient heat.

    摘要翻译: 公开了一种用于最小化侵蚀的井下流体流量控制装置(188)和方法。 井下流体流量控制装置(188)包括例如能够受到侵蚀应力(196,198)的井下表面(190),其可以是移动流体或侵蚀剂。 形状记忆合金(192)与井下表面(190)一体化,以便通过可逆地从奥氏体相(194)转变为马氏体相(200),以应对侵蚀应力(196) ,198)。 此外,形状记忆合金(192)响应于存在足够的热而可逆地从马氏体相(200)转变为奥氏体相(192)。

    Downhole oil and water separator and method
    6.
    发明申请
    Downhole oil and water separator and method 有权
    井下油水分离器及方法

    公开(公告)号:US20060037746A1

    公开(公告)日:2006-02-23

    申请号:US10924161

    申请日:2004-08-23

    IPC分类号: E21B43/00 E21B43/34

    CPC分类号: E21B43/385

    摘要: A downhole oil and water separator for an oil well includes a water-selective membrane disposed in a production flowpath of the well. The water-selective membrane is operable to selectively pass water from the production flowpath to a disposal zone to increase the concentration of oil in the production flowpath at the surface.

    摘要翻译: 用于油井的井下油水分离器包括设置在井的生产流路中的水选择性膜。 水选择性膜可操作以选择性地将水从生产流程传递到处理区域,以增加在表面处的生产流程中的油的浓度。

    Methods of heating energy storage devices that power downhole tools
    7.
    发明申请
    Methods of heating energy storage devices that power downhole tools 有权
    为井下工具供电的储能装置的加热方法

    公开(公告)号:US20050211436A1

    公开(公告)日:2005-09-29

    申请号:US10806913

    申请日:2004-03-23

    IPC分类号: E21B36/00 E21B41/00 E21B43/24

    CPC分类号: E21B36/00 E21B41/0085

    摘要: An energy storage device for powering a downhole tool may be heated to an effective temperature to improve the operability of the energy storage device. The energy storage device may comprise, for example, a primary battery, a secondary battery, a fuel cell, a capacitor, or combinations thereof. The effective temperature to which the energy storage device is heated may be greater than an ambient temperature in the wellbore near the energy storage device. The energy storage device may be heated using various heat sources such as an ohmic resistive heater, a heat pump, an exothermic reaction, a power generator, a heat transfer medium, the energy storage device itself, a downhole tool, or combinations thereof. A thermal conductor may extend between the heat source and the energy storage device. Further, a thermal insulator may at least partially surround the heat source and the energy storage device.

    摘要翻译: 用于为井下工具供电的能量存储装置可以被加热到有效温度以提高储能装置的可操作性。 能量存储装置可以包括例如一次电池,二次电池,燃料电池,电容器或其组合。 能量储存装置被加热到的有效温度可能大于能量存储装置附近的井眼中的环境温度。 可以使用诸如欧姆电阻加热器,热泵,放热反应,发电机,传热介质,能量存储装置本身,井下工具或其组合的各种热源来加热能量存储装置。 热导体可以在热源和能量存储装置之间延伸。 此外,绝热体可以至少部分地围绕热源和能量存储装置。

    High temperature memory device
    10.
    发明申请
    High temperature memory device 审中-公开
    高温记忆装置

    公开(公告)号:US20050104104A1

    公开(公告)日:2005-05-19

    申请号:US10992144

    申请日:2004-11-18

    摘要: Disclosed herein are various nonvolatile integrated device embodiments suitable for use at high temperatures. In some embodiments, a high temperature nonvolatile integrated device comprises a sapphire or spinel substrate having multiple ferroelectric memory cells disposed upon it. In other embodiments, a high temperature nonvolatile integrated device comprises a silicon on insulator substrate or a large bandgap semiconductor substrate having multiple ferroelectric or magnetic memory cells disposed on it. In yet other embodiments, a high temperature nonvolatile integrated device comprises a sapphire, silicon on insulator, or a large bandgap substrate having programmable read only memory (PROM) cells or electrically erasable PROM (EEPROM) cells disposed on it.

    摘要翻译: 本文公开了适用于在高温下使用的各种非易失性集成器件实施例。 在一些实施例中,高温非易失性集成器件包括具有设置在其上的多个铁电存储器单元的蓝宝石或尖晶石衬底。 在其他实施例中,高温非易失性集成器件包括绝缘体上硅衬底或具有设置在其上的多个铁电或磁存储单元的大带隙半导体衬底。 在其他实施例中,高温非易失性集成器件包括蓝宝石,绝缘体上硅或具有可编程只读存储器(PROM)单元或设置在其上的电可擦除PROM(EEPROM)单元)的大带隙衬底。