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公开(公告)号：US08268548B2
公开(公告)日：2012-09-18
申请号：US11788379
申请日：2007-04-18
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danix Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danix Li , Roel P. Funke
IPC分类号： C12Q1/68
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2333/91215 , G01N2500/02
摘要： Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
摘要翻译： 人MAP3K基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MAP3K活性的试剂。
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公开(公告)号：US08153384B2
公开(公告)日：2012-04-10
申请号：US12802748
申请日：2010-06-10
申请人： Lori Friedman , Gregory D. Plowman , Helen Francis-Lang , Danxi Li , Roel P. Funke , Marcia Belvin , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Helen Francis-Lang , Danxi Li , Roel P. Funke , Marcia Belvin , Mario N. Lioubin
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/00
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的试剂。
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公开(公告)号：US20090068186A1
公开(公告)日：2009-03-12
申请号：US11788379
申请日：2007-04-18
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2333/91215 , G01N2500/02
摘要： Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
摘要翻译： 人MAP3K基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MAP3K活性的试剂。
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公开(公告)号：US07049088B2
公开(公告)日：2006-05-23
申请号：US10164278
申请日：2002-06-05
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Rolf Peter Ryseck , Lata Jayaraman , David K. Bol , Matthew Lorenzi
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Rolf Peter Ryseck , Lata Jayaraman , David K. Bol , Matthew Lorenzi
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2333/4739 , G01N2500/10
摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
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公开(公告)号：US20080166709A1
公开(公告)日：2008-07-10
申请号：US11627976
申请日：2007-01-28
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的试剂。
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公开(公告)号：US20110159508A1
公开(公告)日：2011-06-30
申请号：US12900340
申请日：2010-10-07
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
IPC分类号： C12Q1/68 , C12Q1/52 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/5011 , G01N2510/00
摘要： Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.
摘要翻译： 人GFAT基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节GFAT活性的试剂。
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公开(公告)号：US20100325743A1
公开(公告)日：2010-12-23
申请号：US12802748
申请日：2010-06-10
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的药剂。
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公开(公告)号：US07993829B2
公开(公告)日：2011-08-09
申请号：US11627831
申请日：2007-01-26
申请人： Lori Friedman , Gregory D. Plowman , Tak Hung , Helen Francis-Lang , Danix Li , Roel P. Funke , Michael Costa
发明人： Lori Friedman , Gregory D. Plowman , Tak Hung , Helen Francis-Lang , Danix Li , Roel P. Funke , Michael Costa
IPC分类号： C12Q1/68
CPC分类号： G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
摘要翻译： 人hPRP4基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节hPRP4活性的试剂。
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公开(公告)号：US06972179B2
公开(公告)日：2005-12-06
申请号：US10056790
申请日：2002-01-23
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/37 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/573 , G01N33/574 , G01N33/68 , A01N61/00 , C12Q1/70 , G01N33/48
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/914 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
摘要翻译： RRP基因被鉴定为p53或p21途径的调节剂，因此是与缺陷型p53或p21功能相关的病症的治疗靶点。 提供了鉴定p53或p21调节剂的方法，包括筛选调节RRP活性的试剂。 使用本发明方法鉴定的调节剂可用于特异性抑制过表达RRP蛋白的肿瘤细胞的生长。 还提供了mRRP1敲除小鼠。
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公开(公告)号：US20100159470A1
公开(公告)日：2010-06-24
申请号：US12714257
申请日：2010-02-26
IPC分类号： C12Q1/68
CPC分类号： G01N33/5011 , C12Q1/485 , C12Q1/527 , G01N33/5017 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/90212 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SCD are provided.
摘要翻译： 人类SCD基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节SCD活性的药剂。
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