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公开(公告)号：US20080166709A1
公开(公告)日：2008-07-10
申请号：US11627976
申请日：2007-01-28
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的试剂。
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公开(公告)号：US20100325743A1
公开(公告)日：2010-12-23
申请号：US12802748
申请日：2010-06-10
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Mario N. Lioubin
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的药剂。
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公开(公告)号：US08153384B2
公开(公告)日：2012-04-10
申请号：US12802748
申请日：2010-06-10
申请人： Lori Friedman , Gregory D. Plowman , Helen Francis-Lang , Danxi Li , Roel P. Funke , Marcia Belvin , Mario N. Lioubin
发明人： Lori Friedman , Gregory D. Plowman , Helen Francis-Lang , Danxi Li , Roel P. Funke , Marcia Belvin , Mario N. Lioubin
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/00
CPC分类号： G01N33/57423 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/62 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译： 人MARK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MARK活性的试剂。
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公开(公告)号：US20110159508A1
公开(公告)日：2011-06-30
申请号：US12900340
申请日：2010-10-07
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
IPC分类号： C12Q1/68 , C12Q1/52 , G01N33/574
CPC分类号： G01N33/57484 , G01N33/5011 , G01N2510/00
摘要： Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.
摘要翻译： 人GFAT基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节GFAT活性的试剂。
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公开(公告)号：US20090068186A1
公开(公告)日：2009-03-12
申请号：US11788379
申请日：2007-04-18
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2333/91215 , G01N2500/02
摘要： Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
摘要翻译： 人MAP3K基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MAP3K活性的试剂。
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公开(公告)号：US07049088B2
公开(公告)日：2006-05-23
申请号：US10164278
申请日：2002-06-05
申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Rolf Peter Ryseck , Lata Jayaraman , David K. Bol , Matthew Lorenzi
发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Rolf Peter Ryseck , Lata Jayaraman , David K. Bol , Matthew Lorenzi
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2333/4739 , G01N2500/10
摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
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公开(公告)号：US20100275275A1
公开(公告)日：2010-10-28
申请号：US12536466
申请日：2009-08-05
申请人： Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
发明人： Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
CPC分类号： G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要： Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
摘要翻译： 人HADH基因被鉴定为p21途径的调节剂，因此是与缺陷型p21功能相关的病症的治疗靶点。 提供了鉴定p21调节剂的方法，包括筛选调节HADH活性的药剂。
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公开(公告)号：US06927022B2
公开(公告)日：2005-08-09
申请号：US10192353
申请日：2002-07-10
申请人： Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
发明人： Lori Friedman , Gregory D. Plowman , Roel P. Funke , Marcia Belvin , Danxi Li , Stephanie A. Robertson
CPC分类号： G01N33/5008 , A01K2227/706 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/5091 , G01N33/574 , G01N33/57419 , G01N33/57449 , G01N33/5748 , G01N33/57496 , G01N33/6872 , G01N2333/82 , G01N2333/914 , G01N2500/10
摘要： Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
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公开(公告)号：US06924117B2
公开(公告)日：2005-08-02
申请号：US09908419
申请日：2001-07-18
申请人： Mario N. Lioubin , Lori Friedman , Marcia Belvin , Jeffery S. Larson , Changyou Chen , Stephanie A. Robertson , Wen Shi , Jocelyn Chan , Danxi Li
发明人： Mario N. Lioubin , Lori Friedman , Marcia Belvin , Jeffery S. Larson , Changyou Chen , Stephanie A. Robertson , Wen Shi , Jocelyn Chan , Danxi Li
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , A01N37/18
CPC分类号： C07K14/705 , A61K38/00
摘要： Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.
摘要翻译： 提供参与EGFR信号通路的菱形相关蛋白（RRPs）。 含有编码RRP多肽的转基因或影响RRP多肽表达的基因的转基因非人类哺乳动物以及调节RRP蛋白与其通路成员的相互作用的方法以及筛选调节RRP相互作用的试剂的方法 还提供了具有RRP结合靶的多肽，例如RRP特异性抗体和在高通量筛选中鉴定的小分子。 使用本发明方法鉴定的调节剂可用于特异性抑制过表达RRP蛋白的肿瘤细胞的生长。
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公开(公告)号：US20050227228A1
公开(公告)日：2005-10-13
申请号：US10479871
申请日：2002-06-03
申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号： C12Q1/48 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2333/91215 , G01N2500/02
摘要： Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
摘要翻译： 人MAP3K基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法，包括筛选调节MAP3K活性的试剂。
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