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公开(公告)号：US06413722B1
公开(公告)日：2002-07-02
申请号：US09532419
申请日：2000-03-22
申请人： Lyle J. Arnold , Samuel P. Sawan , Paul H. Lee
发明人： Lyle J. Arnold , Samuel P. Sawan , Paul H. Lee
IPC分类号： C12Q168
CPC分类号： G01N33/552 , B01J2219/00497 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C03C17/30 , C03C17/3405 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , G01N33/54353
摘要： Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H2N—(CH2)n—SiX3 where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.
摘要翻译： 提供了通过用具有式H2N-（CH2）n-SiX3的试剂进行甲硅烷化（其中n在1和10之间），X独立地选自OMe，OEt，Cl ，Br或I，然后用交联剂活化，随后与含胺聚合物反应。 载体可任选地与交联剂再次反应。 如此修改的支架可用于制造阵列和微阵列，其中多个靶与支撑件稳定地相关联并以限定的方式布置。
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公开(公告)号：US06387631B1
公开(公告)日：2002-05-14
申请号：US09775319
申请日：2001-02-01
申请人： Lyle J. Arnold , Samuel P. Sawan , Paul H. Lee
发明人： Lyle J. Arnold , Samuel P. Sawan , Paul H. Lee
IPC分类号： C12Q168
CPC分类号： G01N33/552 , B01J2219/00497 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C03C17/30 , C03C17/3405 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , G01N33/54353
摘要： Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H2N—(CH2)n—SiX3 where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.
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公开(公告)号：US6030632A
公开(公告)日：2000-02-29
申请号：US151866
申请日：1998-09-11
IPC分类号： B65D83/00 , A01N25/24 , A01N25/34 , A01N47/44 , A01N59/16 , A61J1/05 , A61J1/14 , A61J1/20 , A61L2/16 , B01D39/00 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/12 , B01D71/02 , A01N25/08
CPC分类号： B01D67/0088 , A01N25/24 , A01N25/34 , A01N47/44 , A01N59/16 , A61L2/16 , B01D39/00 , B01D39/16 , B01D39/1623 , B01D39/1692 , B01D67/0069 , B01D67/0072 , B01D67/0079 , B01D67/009 , B01D69/02 , B01D69/12 , B01D69/148 , B01D71/022 , B82Y30/00 , A61J1/145 , A61J1/1456 , A61J1/1468 , B01D2239/0442 , B01D2239/0471 , B01D2239/0478 , B01D2323/02 , B01D2323/04 , B01D2325/38 , B01D2325/48
摘要： An antimicrobial material comprising an antimicrobial metallic material and a biguanide polymer reacted with a crosslinker to form an adduct is described. Both freestanding antimicrobial materials and antimicrobial films are provided. The antimicrobial material does not release biocidal levels of leachables into a contacting solution.
摘要翻译： 描述了包含抗微生物金属材料和与交联剂反应形成加合物的双胍聚合物的抗微生物材料。 提供了独立的抗菌材料和抗微生物膜。 抗微生物材料不会将杀生物等级的可浸出物释放到接触溶液中。
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公开(公告)号：US5817325A
公开(公告)日：1998-10-06
申请号：US742580
申请日：1996-10-28
CPC分类号： A01N47/44 , A01N25/34 , A01N59/16 , B01D39/2037 , B01D2239/0442 , B01D2239/0471 , B01D2239/0478 , B01D2239/086
摘要： Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocidal metallic materials non-leachably associated with the matrix. The antimicrobial material may used to form an antimicrobial coating or layer on a surface of the article or device, or may be dispersed in a vehicle or carrier to form a topical antiseptic or disinfectant, or solid shape having contact killing antimicrobial properties. When a microorganism contacts the article, device, or formulation, the biocidal metallic material is transferred to the microorganism in amounts sufficient to kill it.
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公开(公告)号：US5681468A
公开(公告)日：1997-10-28
申请号：US599810
申请日：1996-02-12
IPC分类号： A01N25/24 , A01N25/34 , A01N47/44 , A01N59/16 , A61J1/14 , A61J1/20 , A61L2/16 , B01D39/00 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/12 , B01D71/02
CPC分类号： B01D67/0088 , A01N25/24 , A01N25/34 , A01N47/44 , A01N59/16 , A61L2/16 , B01D39/00 , B01D39/16 , B01D39/2027 , B01D67/0069 , B01D67/0072 , B01D67/009 , B01D69/02 , B01D69/12 , B01D71/022 , B05B11/047 , B65D47/18 , A61J1/145 , A61J1/1456 , A61J1/1468 , B01D2239/0442 , B01D2239/0478 , B01D2323/02 , B01D2325/48 , B65D81/24
摘要： A liquid dispenser for dispensing sterile liquid comprising a container for storing the sterile liquid, a nozzle assembly mounted on the container, and a filter which has at least one surface and a plurality of its pores coated with a metallic material, e.g., a metal or metal oxide or metal salt, that is bacteriostatic or bacteriocidal, is described. The metal coated filter, methods for coating the filter, and methods for using the liquid dispenser are also provided.
摘要翻译： 一种用于分配无菌液体的液体分配器，其包括用于存储无菌液体的容器，安装在容器上的喷嘴组件和具有至少一个表面和多个其孔的涂层的过滤器，所述金属材料例如金属或 描述了抑菌或杀菌的金属氧化物或金属盐。 还提供了金属涂层过滤器，涂覆过滤器的方法和使用液体分配器的方法。
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6.发明授权公开(公告)号：US06180584B2
公开(公告)日：2001-01-30
申请号：US09248861
申请日：1999-02-11
IPC分类号： C11D348
CPC分类号： A01N47/44 , A01N25/10 , A01N25/24 , A01N59/16 , C02F1/505 , C02F2209/001 , A01N2300/00 , A01N25/02
摘要： The present invention relates to a composition that, when applied to a substrate, forms an adherent, transparent, water insoluble polymeric film on the substrate surface that provides sustained antimicrobial disinfecting action for prolonged periods, without the necessity for reapplication. The coating provides surface disinfecting action by a contact-killing mechanism, and does not release its components into contacting solutions at levels that would result in solution disinfection. The polymeric film formed by the composition of the invention can be removed by treatment with dilute alcoholic base.
摘要翻译： 本发明涉及一种组合物，当应用于基材时，在基材表面上形成粘附的，透明的水不溶性聚合物膜，其提供持续的抗微生物消毒作用，延长时间，而不需要重新施用。 涂层通过接触杀伤机制提供表面消毒作用，并且不会将其组分以导致溶液消毒的水平释放到接触溶液中。 通过本发明的组合物形成的聚合物膜可以通过用稀醇基处理除去。
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公开(公告)号：US5490938A
公开(公告)日：1996-02-13
申请号：US170510
申请日：1993-12-20
IPC分类号： A01N25/24 , A01N25/34 , A01N47/44 , A01N59/16 , A61J1/14 , A61J1/20 , A61L2/16 , B01D39/00 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/12 , B01D71/02 , B01D61/00 , A61B19/00 , B67D5/58
CPC分类号： B01D67/0088 , A01N25/24 , A01N25/34 , A01N47/44 , A01N59/16 , A61L2/16 , B01D39/00 , B01D39/16 , B01D39/2027 , B01D67/0069 , B01D67/0072 , B01D67/009 , B01D69/02 , B01D69/12 , B01D71/022 , B05B11/047 , B65D47/18 , A61J1/145 , A61J1/1456 , A61J1/1468 , B01D2239/0442 , B01D2239/0478 , B01D2323/02 , B01D2325/48 , B65D81/24
摘要： A liquid dispenser for dispensing sterile liquid comprising a container for storing the sterile liquid, a nozzle assembly mounted on the container, and a filter which has at least one surface and a plurality of its pores coated with a metallic material, e.g., a metal or metal oxide or metal salt, that is bacteriostatic or bacteriocidal, is described. The metal coated filter, methods for coating the filter, and methods for using the liquid dispenser are also provided.
摘要翻译： 一种用于分配无菌液体的液体分配器，其包括用于存储无菌液体的容器，安装在容器上的喷嘴组件和具有至少一个表面和多个其孔的涂层的过滤器，所述金属材料例如金属或 描述了抑菌或杀菌的金属氧化物或金属盐。 还提供了金属涂层过滤器，涂覆过滤器的方法和使用液体分配器的方法。
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公开(公告)号：US08920843B2
公开(公告)日：2014-12-30
申请号：US12734520
申请日：2008-11-07
申请人： Samuel P. Sawan , Daniel Jacobs , Tadmor Shalon
发明人： Samuel P. Sawan , Daniel Jacobs , Tadmor Shalon
IPC分类号： A61K9/14 , A61K31/445 , A61P17/02 , A61P23/02 , A61K9/10 , A61L26/00 , A61K9/06 , A61K9/00 , A61K31/167 , A61K9/12
CPC分类号： A61L26/0066 , A61K9/0014 , A61K9/0024 , A61K9/06 , A61K9/10 , A61K9/12 , A61K31/167 , A61K31/445 , A61L26/0076 , A61L2300/21 , A61L2300/402 , A61L2300/622
摘要： Particles of an organic acid salt of an amino acid amide or ester local anesthetic are employed as agents for the improved alleviation of pain. Particularly, the particles find use with surgically created wounds, where the particles may be administered directly into the bed of the wound or topically for transdermal transport.
摘要翻译： 使用氨基酸酰胺或酯局部麻醉剂的有机酸盐的颗粒作为改善疼痛缓解的药剂。 特别地，颗粒用外科手术创建的伤口，其中颗粒可以直接施用于伤口的床或局部用于经皮转运。
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公开(公告)号：US20110184057A1
公开(公告)日：2011-07-28
申请号：US13014170
申请日：2011-01-26
申请人： Gregory R. Mundy , Helen Mundy , Tadmor Shalon , Samuel P. Sawan
发明人： Gregory R. Mundy , Helen Mundy , Tadmor Shalon , Samuel P. Sawan
IPC分类号： A61K31/351 , A61K31/222 , A61P35/00 , A61P25/28
CPC分类号： A61K9/0019 , A61K31/35 , A61K45/06 , A61K2300/00
摘要： Cancer patients, patients with cognitive dysfunction, or patients with pulmonary hypertension are treated with parenterally administered therapeutic doses of statins. Particularly, transdermal, injection employing liquid infusion or particles are employed. For cancer, the statins may be used by themselves or in conjunction with a chemotherapeutic regimen. Liver cancer is treated orally with super doses of statins.
摘要翻译： 癌症患者，认知功能障碍患者或肺动脉高压患者用胃肠外给药的治疗剂量的他汀类药物治疗。 特别地，采用使用液体输注或颗粒的透皮，注射剂。 对于癌症，他汀可以自己使用或与化疗方案联合使用。 用超级剂量的他汀类药物口服治疗肝癌。
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公开(公告)号：US20100233271A1
公开(公告)日：2010-09-16
申请号：US12734520
申请日：2008-11-07
申请人： Samuel P. Sawan , Daniel Jacobs , Tadmor Shalon
发明人： Samuel P. Sawan , Daniel Jacobs , Tadmor Shalon
IPC分类号： A61K9/14 , A61K31/445 , A61P17/02 , A61P23/02
CPC分类号： A61L26/0066 , A61K9/0014 , A61K9/0024 , A61K9/06 , A61K9/10 , A61K9/12 , A61K31/167 , A61K31/445 , A61L26/0076 , A61L2300/21 , A61L2300/402 , A61L2300/622
摘要： Particles of an organic acid salt of an amino acid amide or ester local anesthetic are employed as agents for the improved alleviation of pain. Particularly, the particles find use with surgically created wounds, where the particles may be administered directly into the bed of the wound or topically for transdermal transport.
摘要翻译： 使用氨基酸酰胺或酯局部麻醉剂的有机酸盐的颗粒作为改善疼痛缓解的药剂。 特别地，颗粒用外科手术创建的伤口，其中颗粒可以直接施用于伤口的床或局部用于经皮转运。
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