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公开(公告)号：US06458530B1
公开(公告)日：2002-10-01
申请号：US08626285
申请日：1996-04-04
IPC分类号： C12Q168
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00529 , B01J2219/0054 , B01J2219/00542 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00695 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00
摘要： Methods of selecting tag nucleic acids and VLSIPS™ arrays and the arrays made by the methods are used to label and track compositions, including cells and viruses, e.g., in libraries of cells or viruses. In addition to providing a way of tracking compositions in mixtures, the tags facilitate analysis of cell and viral phenotypes.
摘要翻译： 选择标签核酸和VLSIPS TM阵列的方法以及通过该方法制备的阵列用于标记和跟踪组合物，包括细胞和病毒，例如在细胞或病毒的文库中。 除了提供跟踪混合物中组合物的方式之外，标签有助于细胞和病毒表型的分析。
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公开(公告)号：US06600996B2
公开(公告)日：2003-07-29
申请号：US08828952
申请日：1997-03-28
申请人： Teresa A. Webster , MacDonald S. Morris , Michael P. Mittmann , David J. Lockhart , Ming-Hsiu Ho , Derek Bernhart , Luis C. Jevons
发明人： Teresa A. Webster , MacDonald S. Morris , Michael P. Mittmann , David J. Lockhart , Ming-Hsiu Ho , Derek Bernhart , Luis C. Jevons
IPC分类号： G01N3348
CPC分类号： C12Q1/6816 , G01N15/1475 , G06F19/20
摘要： Computer-aided techniques for analyzing biological sequences like nucleic acids are provided. The computer system may analyze hybridization intensities indicating hybridization affinity between nucleic acid probes and a sample nucleic acid sequence in order to call bases in the sample sequence. Multiple base calls may be combined to form a single base call. Additionally, the computer system may analyze hybridization intensities in order to monitor gene expression or the change in gene expression as compared to a baseline.
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公开(公告)号：US08697334B2
公开(公告)日：2014-04-15
申请号：US13337024
申请日：2011-12-23
CPC分类号： B82Y25/00 , B82Y20/00 , G01N33/54326 , G01N33/585 , G09F3/00 , G11B5/66 , H01F1/0072
摘要： An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.
摘要翻译： 提供具有空间码的编码微粒; 以及一组编码的微粒，其具有各自具有可区分的空间码的子集，其中所述码符合预定编码方案。 还提出了在各种生物测定中使用编码的微粒的方法，例如各种多重测定，并通过产生编码的微粒的数字图像并确定是否存在假阳性来使其可视化。 还提供了使用旋涂玻璃技术应用铁磁性纳米粒子的编码微粒的制造方法。
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公开(公告)号：US20120196381A1
公开(公告)日：2012-08-02
申请号：US13337024
申请日：2011-12-23
CPC分类号： B82Y25/00 , B82Y20/00 , G01N33/54326 , G01N33/585 , G09F3/00 , G11B5/66 , H01F1/0072
摘要： An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.
摘要翻译： 提供具有空间码的编码微粒; 以及一组编码的微粒，其具有各自具有可区分的空间码的子集，其中所述码符合预定编码方案。 还提出了在各种生物测定中使用编码的微粒的方法，例如各种多重测定，并通过产生编码的微粒的数字图像并确定是否存在假阳性来使其可视化。 还提供了使用旋涂玻璃技术应用铁磁性纳米粒子的编码微粒的制造方法。
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公开(公告)号：US06826296B2
公开(公告)日：2004-11-30
申请号：US09737838
申请日：2000-12-14
IPC分类号： G06K900
CPC分类号： G06F19/28 , G06F19/20 , Y10S707/99933
摘要： Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.
摘要翻译： 用于组织与包括寡核苷酸阵列芯片的聚合物探针阵列芯片的设计有关的信息的系统和方法。 提供了一种数据库模型，其组织芯片上的信息相关探针，由芯片研究的基因组项目以及与芯片设计有关的序列信息。 该模型很容易翻译成数据库语言，如SQL。 数据库模型可以存储关于大量具有复杂设计的芯片的信息。
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6.发明申请Apparatuses, Systems and Methods for the Attachment of Substrates to Supports with Light Curable Adhesives 审中-公开用光固化粘合剂支撑底物的装置，系统和方法公开(公告)号：US20120151746A1
公开(公告)日：2012-06-21
申请号：US13329170
申请日：2011-12-16
申请人： John Mundaden , Chi Sou Yu , Michael P. Mittmann
发明人： John Mundaden , Chi Sou Yu , Michael P. Mittmann
IPC分类号： B23P17/04
CPC分类号： B01L3/50853 , B01J2219/00529 , B01J2219/00531 , B01J2219/00554 , B01J2219/00596 , B01J2219/00608 , B01J2219/00662 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01L3/0244 , B01L3/0258 , B01L2200/12 , B01L2300/046 , B01L2300/0819 , B01L2300/0829 , F16B11/006 , Y10T29/4998 , Y10T29/53961
摘要： Disclosed are apparatuses, systems and methods for attachment of substrates to supports. Disclosed are integrated pick-and-place curing apparatuses and systems and methods for using them. Integration of pick-and-place and curing functionalities provides higher efficiency and effectiveness compared to approaches which separate the two functions. Also disclosed are systems and methods for simultaneous attachment of a plurality of substrates to a support. Substrates include, within certain embodiments, arrays of biological polymers which are unaffected by the disclosed pick-and-place curing approaches.
摘要翻译： 公开了用于将衬底附接到支撑件的装置，系统和方法。 公开了集成拾取和固化固化设备及其使用的系统和方法。 与分离两种功能的方法相比，拾取和固化功能的集成提供了更高的效率和有效性。 还公开了用于将多个基板同时附接到支撑件的系统和方法。 在某些实施方案中，底物包括不受所公开的拾取和固化固化方法影响的生物聚合物阵列。
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公开(公告)号：US06949638B2
公开(公告)日：2005-09-27
申请号：US09824931
申请日：2001-04-03
IPC分类号： B01J19/00 , C40B40/06 , C40B60/14 , G01N33/543 , G03F1/00 , G06F19/20 , C07H21/00 , C07H17/00 , C12Q1/68 , G01N33/52
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N33/54366 , G06F19/20
摘要： Systems, methods, and products are described for synthesizing probe arrays of polymers. A mask is used that includes reticle areas, each of which includes a number of reticles associated with a same synthesis area on a substrate. A method includes (a) aligning the mask with respect to the substrate so that a first reticle of a first reticle area is aligned with a first synthesis area and so that a second reticle of the first reticle area is aligned with a first discard area on the substrate; (b) coupling monomers on the first synthesis area at locations determined by the first reticle; (c) re-aligning the mask with respect to the substrate so that the second reticle is aligned with the first synthesis area; and (d) coupling monomers on the first synthesis area at locations determined by the second reticle. The monomers may be, for example, nucleotides, amino acids or saccharides.
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公开(公告)号：US06188783B1
公开(公告)日：2001-02-13
申请号：US09122304
申请日：1998-07-24
IPC分类号： G06K900
CPC分类号： H04M1/006 , C12Q1/6809 , G06F19/20 , G06F19/28 , H04M1/72519 , H04M3/46 , H04M3/54 , H04M2207/206 , Y10S128/922 , Y10S707/925 , Y10S707/955 , Y10S707/99933 , Y10S707/99934 , Y10S707/99945
摘要： Systems and method for organizing information relating to the design of polymer probe array chips including oligonucleotide array chips. A database model is provided which organizes information interrelating probes on a chip, genomic items investigated by the chip, and sequence information relating to the design of the chip. The model is readily translatable into database languages such as SQL. The database model scales to permit storage of information about large numbers of chips having complex designs.
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