Growth Hormone Conjugates
    3.
    发明申请
    Growth Hormone Conjugates 审中-公开
    生长激素共轭体

    公开(公告)号:US20080182783A1

    公开(公告)日:2008-07-31

    申请号:US11577238

    申请日:2005-10-18

    CPC分类号: C07K14/61 A61K38/00 A61K47/60

    摘要: Compounds of formula (I) wherein GH represent a radical derived from a growth hormone compound by removal of one hydrogen atom from the N-terminal amino group; X represents oxygen or two hydrogen atoms; Z represents a bond, alkylene, arylene, heteroarylene, —CH2—O—(CH2)1-10—, —CH2—O—(C6H4)—, or combinations thereof; and Y represents a radical selected from are provided together with methods for making said compounds. The compounds are useful in therapy.

    摘要翻译: 其中GH代表通过从N-末端氨基除去一个氢原子而衍生自生长激素化合物的基团的式(I)化合物; X表示氧或两个氢原子; Z表示键,亚烷基,亚芳基,亚杂芳基,-CH 2 - (CH 2)2 - , - 或其组合;或其组合;和/或其组合;和/或其组合; 和Y代表选自的基团与制备所述化合物的方法一起提供。 这些化合物可用于治疗。