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公开(公告)号：US20110183098A1
公开(公告)日：2011-07-28
申请号：US13119272
申请日：2009-09-15
申请人： Manuel Hidalgo , Fubien Debaud
发明人： Manuel Hidalgo , Fubien Debaud
IPC分类号： B32B1/08 , C08F8/30 , C09D133/10 , A43B13/04
CPC分类号： C08F22/10 , C08C19/22 , C08F8/30 , C08J3/243 , C08J2323/08 , Y10T428/139
摘要： The invention relates to an elastomer material including flexible polymer chains containing crosslinking bridges having covalent bonds and crosslinking bridges having noncovalent bonds. The invention also relates to a method for preparing such elastomer material.
摘要翻译： 本发明涉及弹性体材料，其包括含有具有共价键的交联桥和具有非共价键的交联桥的柔性聚合物链。 本发明还涉及制备这种弹性体材料的方法。
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公开(公告)号：US09017473B2
公开(公告)日：2015-04-28
申请号：US13121307
申请日：2009-09-25
IPC分类号： C09D7/12 , C09D5/16 , C08K5/3467 , C07D233/36 , C09D5/02 , C09D17/00 , C08K5/17 , C08K5/34
CPC分类号： C09D7/1233 , C08K5/17 , C08K5/34 , C09D7/63 , C09D17/003
摘要： The invention relates to a method of neutralizing paints, that includes adding at least one associative neutralizing agent to a formulation such as a pigment concentrate, a white paint base or paint. The associative neutralizing agent includes at least one neutralizing group N and at least one nitrogenous associative group A bonded together by at least one “spacer” group Sp. The invention also relates to pigment concentrates and to paints containing at least one such associative neutralizing agent.
摘要翻译： 本发明涉及一种中和涂料的方法，其包括向制剂如颜料浓缩物，白漆基料或涂料中加入至少一种缔合中和剂。 缔合中和剂包括至少一个中和基团N和至少一个通过至少一个“间隔基”基团Sp连接在一起的含氮缔合基团A. 本发明还涉及颜料浓缩物和含有至少一种这种缔合中和剂的油漆。
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公开(公告)号：US20130211057A1
公开(公告)日：2013-08-15
申请号：US13809767
申请日：2011-07-12
IPC分类号： C07D233/36
CPC分类号： C07D233/36 , C07D233/32 , C07D403/12
摘要： The present invention relates to nitrogenous associative molecules comprising at least one unit rendering them capable of associating with one another or with a filler by noncovalent bonds, and comprising a function capable of reacting with a polymer containing unsaturations so as to form a covalent bond with said polymer.
摘要翻译： 本发明涉及包含至少一个单元的含氮缔合分子，使得它们能够通过非共价键彼此缔合或与填料缔合，并且包含能够与含有不饱和基团的聚合物反应以便与所述的共价键形成共价键的功能 聚合物。
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公开(公告)号：US20120034318A1
公开(公告)日：2012-02-09
申请号：US13254610
申请日：2010-03-05
申请人： Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Sian Jones , Scott Kern , Ralph Hruban , James R. Eshleman , Michael Goggins , Alison Klein , Manuel Hidalgo , Victor E. Velculescu
发明人： Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Sian Jones , Scott Kern , Ralph Hruban , James R. Eshleman , Michael Goggins , Alison Klein , Manuel Hidalgo , Victor E. Velculescu
IPC分类号： A61K33/24 , A61P35/00 , C40B20/08 , G01N33/577 , G01N33/566 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/407 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/57438 , G01N2333/47
摘要： The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.
摘要翻译： 本发明提供了一种检测胰腺癌患者和具有胰腺癌家族史的个体中PALB2基因突变的方法。 还提供了用于诊断患有胰腺癌的倾向，用于预测患者对胰腺癌治疗的反应以及用于治疗患者胰腺癌的方法，其基于在患者体内PALB2突变或异常PALB2基因表达的存在。
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5.发明申请Use, as a Shock Absorber, of a Material Formed from Branched Molecules Containing Associative Groups 有权作为减震器使用由含有相关组的支链分子形成的材料公开(公告)号：US20120022221A1
公开(公告)日：2012-01-26
申请号：US13254282
申请日：2010-03-29
IPC分类号： C08G65/333
CPC分类号： C08G63/12 , C08G83/005 , C08G83/008
摘要： The present invention relates to the use, as a shock absorber, of a material formed from branched molecules comprising associative groups. Said branched molecules are each constituted of fragments that are at least bifunctional and of fragments that are at least trifunctional joined together by ester or thioester bridges, alone or in combination with amide or urea bridges.
摘要翻译： 本发明涉及作为减震器的由包含缔合基团的支链分子形成的材料的用途。 所述支链分子各自由至少双功能的片段和至少三官能的片段组成，所述片段通过酯或硫酯桥连接在一起，单独或与酰胺或脲桥组合。
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公开(公告)号：US20110144264A1
公开(公告)日：2011-06-16
申请号：US12161447
申请日：2007-01-09
申请人： Manuel Hidalgo
发明人： Manuel Hidalgo
IPC分类号： C08L33/14
CPC分类号： C08F2/24 , C08F220/14 , C08F220/18 , C08F220/26 , C08F299/00 , C08F299/06 , C08F299/065
摘要： The invention relates to the use of poly(ethylene-co-propylene) glycol monoalkyl ether or polyethylene glycol monoalkyl ether or poly(ethylene-co-propylene) glycol or polyethylene glycol (meth)acrylic amide or ester monomers capable of contributing to stabilization in the course of a latex preparation process by emulsion polymerization of at least one polymerizable monomer in the presence of an ionizable polymerization initiator.
摘要翻译： 本发明涉及能够有助于稳定化的聚（乙烯 - 共 - 丙烯）二醇单烷基醚或聚乙二醇单烷基醚或聚（乙烯 - 共 - 丙烯）二醇或聚乙二醇（甲基）丙烯酰胺或酯单体的用途 通过在可电离聚合引发剂的存在下通过至少一种可聚合单体的乳液聚合的胶乳制备过程的过程。
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7.发明申请Composition containing a halogenated vinyl polymer and a copolymer bearing associative groups 审中-公开含有卤代乙烯基聚合物和带有缔合基团的共聚物的组合物公开(公告)号：US20110065866A1
公开(公告)日：2011-03-17
申请号：US12991218
申请日：2009-05-05
IPC分类号： C08L39/04 , C09D139/04 , C09J139/04
CPC分类号： C09D127/00 , C08L27/00 , C08L33/00 , C08L2666/04 , C09J127/00
摘要： The present invention relates to a composition comprising: (a) at least one halogenated vinyl polymer and (b) at least one copolymer containing (i) units derived from a first monomer (A) rendering said copolymer compatible with said halogenated vinyl polymer and (ii) units derived from a second monomer (B) bearing at least one given associative group. The present invention also relates to the use of such a copolymer bearing associative groups, for improving certain properties of a halogenated vinyl polymer. The invention finally relates to the uses of the aforementioned composition.
摘要翻译： 本发明涉及一种组合物，其包含：（a）至少一种卤代乙烯基聚合物和（b）至少一种共聚物，其包含（i）衍生自第一单体（A）的单元，使所述共聚物与所述卤代乙烯基聚合物相容和（ ii）衍生自具有至少一个给定缔合基团的第二单体（B）的单元。 本发明还涉及这种共聚物支持缔合基团用于改进卤代乙烯基聚合物的某些性能的用途。 本发明最终涉及上述组合物的用途。
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公开(公告)号：US20100135940A1
公开(公告)日：2010-06-03
申请号：US12440308
申请日：2007-09-07
申请人： Sandra Grimaldi , Jean-Philippe Gillet , Manuel Hidalgo , Francois-Genes Tournilhac , Philippe Cordier , Ludwik Leibler
发明人： Sandra Grimaldi , Jean-Philippe Gillet , Manuel Hidalgo , Francois-Genes Tournilhac , Philippe Cordier , Ludwik Leibler
CPC分类号： A61K8/84 , A61K2800/54 , A61Q19/00 , C08G69/00 , C09D177/00
摘要： The invention relates to a supramolecular polymer derived from the reaction between (i) an amine bearing a nitrogen-containing heterocyclic group: imidazolidone, trimethyleneurea or triazine, capable of joining together via hydrogen bonds with (ii) at least one fatty acid monomer comprising at least one reactive functional group, a dimer of identical or different fatty acids and/or a trimer of identical or different fatty acids, or a derivative of said fatty acid(s) chosen from a fatty acid ester, and a fatty acid chloride.
摘要翻译： 本发明涉及一种超分子聚合物，其衍生自（i）带有含氮杂环基的胺：咪唑烷酮，三亚甲基脲或三嗪，其能够通过氢键与（ii）至少一种含有 至少一个反应性官能团，相同或不同脂肪酸的二聚物和/或相同或不同脂肪酸的三聚体，或所述脂肪酸的衍生物，选自脂肪酸酯和脂肪酰氯。
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9.发明授权Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (BPU) sulfur analogs 失效新型微管蛋白聚合抑制剂的合成：苯甲酰基苯脲（BPU）硫类似物公开(公告)号：US07595326B2
公开(公告)日：2009-09-29
申请号：US11673519
申请日：2007-02-09
IPC分类号： C07D239/38 , A61K31/505 , A61P35/00
CPC分类号： A61K31/38 , A61K31/404 , A61K31/4152 , A61K31/427 , A61K31/428 , A61K31/505 , C07D239/34 , C07D239/38
摘要： A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 μM.
摘要翻译： 合成了一系列新的BPU类似物，并评价其抗肿瘤活性。 特别地，与化合物1相比，BPU硫类似物6n和7d显示与癌细胞系相比具有高达10倍的效力。 6n比化合物1更有效地引起MCF-7细胞凋亡。 与具有相似作用机制的其他药物相比，6n保留显着的抑制微管蛋白装配能力，IC50为2.1μM。
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10.发明申请USE OF PARTICULAR POLYMERS OR COPOLYMERS AS SURFACTANTS FOR STABILIZING LATICES 审中-公开使用特殊聚合物或共聚物作为表面活性剂稳定化公开(公告)号：US20090170958A1
公开(公告)日：2009-07-02
申请号：US12281353
申请日：2007-03-02
申请人： Jean-Luc Couturier , Manuel Hidalgo
发明人： Jean-Luc Couturier , Manuel Hidalgo
IPC分类号： C08L13/02 , A61K47/32 , C09D11/02 , C09D133/08
摘要： The invention relates to a composition comprising a latex and at least one copolymer that may be obtained via a monomer polymerization process, comprising a step of placing in contact, in a medium comprising water, the said monomer(s) with at least one initiator corresponding, for example, to the formula:
摘要翻译： 本发明涉及一种包含胶乳和至少一种可通过单体聚合方法获得的共聚物的组合物，其包括在包含水的介质中使所述单体与至少一种引发剂对应地接触的步骤 ，例如，以下公式：
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