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公开(公告)号:US20100291182A1
公开(公告)日:2010-11-18
申请号:US12620334
申请日:2009-11-17
申请人: Maria Palasis , Upma Sharma , Quyhn Pham , John Marini
发明人: Maria Palasis , Upma Sharma , Quyhn Pham , John Marini
IPC分类号: A61F2/00 , A61K31/575 , A61K31/4535 , A61K31/4468 , A61K31/485 , A61K31/445 , A61K38/17 , A61P19/02 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号: A61K9/7007 , A61K9/0024 , A61K9/0051 , A61K9/0085 , A61K9/0092 , A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535 , A61K31/485 , A61K31/573 , A61K31/575 , A61K38/00 , A61K47/34
摘要: Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches.
摘要翻译: 公开了用于将治疗剂递送到患者体内的目标位置的植入物和方法。 植入物包括纤维,其包含聚合物材料并且具有直至约20微米的直径,以及纤维内的第一治疗剂。 治疗剂基本上是颗粒形式。 植入物具有各种构造,例如单独的纤维,纱线,绳索,管和贴片。
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公开(公告)号:US20140199364A1
公开(公告)日:2014-07-17
申请号:US14173099
申请日:2014-02-05
申请人: Maria Palasis , Upma Sharma , Quynh Pham , John Marini
发明人: Maria Palasis , Upma Sharma , Quynh Pham , John Marini
IPC分类号: A61K9/70 , A61K31/573
CPC分类号: A61K9/7007 , A61K9/0024 , A61K9/0051 , A61K9/0085 , A61K9/0092 , A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535 , A61K31/485 , A61K31/573 , A61K31/575 , A61K38/00 , A61K47/34
摘要: Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches.
摘要翻译: 公开了用于将治疗剂递送到患者体内的目标位置的植入物和方法。 植入物包括纤维,其包含聚合物材料并且具有直至约20微米的直径,以及纤维内的第一治疗剂。 治疗剂基本上是颗粒形式。 植入物具有各种构造,例如单独的纤维,纱线,绳索,管和贴片。
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公开(公告)号:US20130071463A1
公开(公告)日:2013-03-21
申请号:US13616386
申请日:2012-09-14
申请人: Maria Palasis , Upma Sharma , John Marini , Quynh Pham , Toby Freyman , Adam Rago
发明人: Maria Palasis , Upma Sharma , John Marini , Quynh Pham , Toby Freyman , Adam Rago
CPC分类号: A61K9/70 , A61K9/0024 , A61K9/0092 , A61K31/445 , A61K31/4468 , A61K31/4535 , A61K31/485 , A61K31/575 , A61K38/00 , A61K47/34
摘要: Medical implants and methods useful in treating postoperative pain are described. The implants comprise one or more electrospun drug-loaded fibers, which fibers comprise a drug useful in the treatment of pain. The implants are implanted at sites of interest including joint capsules, bones, and subcutaneous spaces, and are secured with tissue flaps or fasteners.
摘要翻译: 描述了可用于治疗术后疼痛的医疗植入物和方法。 植入物包含一种或多种电纺丝载药纤维,该纤维包含可用于治疗疼痛的药物。 将植入物植入感兴趣的部位,包括关节囊,骨骼和皮下空间,并用组织瓣或紧固件固定。
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公开(公告)号:US20120299223A1
公开(公告)日:2012-11-29
申请号:US13571545
申请日:2012-08-10
申请人: Maria Palasis , Upma Sharma , Quynh Pham , John Marini
发明人: Maria Palasis , Upma Sharma , Quynh Pham , John Marini
IPC分类号: D01D5/34
CPC分类号: A61K9/7007 , A61K9/0024 , A61K9/0051 , A61K9/0085 , A61K9/0092 , A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535 , A61K31/485 , A61K31/573 , A61K31/575 , A61K38/00 , A61K47/34
摘要: Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches.
摘要翻译: 公开了用于将治疗剂递送到患者体内的目标位置的植入物和方法。 植入物包括纤维,其包含聚合物材料并且具有直至约20微米的直径,以及纤维内的第一治疗剂。 治疗剂基本上是颗粒形式。 植入物具有各种构造,例如单独的纤维,纱线,绳索,管和贴片。
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公开(公告)号:US20130317600A1
公开(公告)日:2013-11-28
申请号:US13863632
申请日:2013-04-16
申请人: Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
发明人: Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
IPC分类号: A61F2/06
CPC分类号: A61F2/06 , A61F2/90 , A61F2230/0054 , A61F2250/0067 , A61K47/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08 , C08L67/04 , C08L75/04
摘要: Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译: 公开了用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构,并且被设计为低轮廓,使得它们可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号:US20130158652A1
公开(公告)日:2013-06-20
申请号:US13766294
申请日:2013-02-13
申请人: Maria Palasis , Changcheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
发明人: Maria Palasis , Changcheng You , Daniel Concagh , Lee Core , Kicherl Ho , Upma Sharma , Greg Zugates
IPC分类号: A61F2/82
CPC分类号: A61F2/82 , A61F2/90 , A61F2230/0054 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/06 , C08L67/04 , C08L75/04
摘要: Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译: 公开了用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构,并且被设计为低轮廓,使得它们可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号:US20100298952A1
公开(公告)日:2010-11-25
申请号:US12783261
申请日:2010-05-19
申请人: Rany Busold , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
发明人: Rany Busold , Chang Cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
IPC分类号: A61F2/04
CPC分类号: A61F2/86 , A61F2/90 , A61F2/95 , A61F2230/0054 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , D04C1/06 , D10B2403/0112 , D10B2509/06 , C08L67/04
摘要: Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译: 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构,并且被设计为低轮廓,使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号:US20160128850A1
公开(公告)日:2016-05-12
申请号:US15000605
申请日:2016-01-19
申请人: Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Gregory T. Zugates
发明人: Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Gregory T. Zugates
CPC分类号: A61L31/16 , A61F2/04 , A61F2/86 , A61F2/90 , A61F2210/0004 , A61F2210/0057 , A61F2230/0054 , A61F2250/0067 , A61K9/0024 , A61K31/337 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/216 , A61L2300/416 , A61L2420/06 , A61L2420/08 , C08L67/04 , D04C1/06 , D10B2403/0112 , D10B2509/06
摘要: Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译: 公开了用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构,并且被设计为低轮廓,使得它们可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号:US08137396B2
公开(公告)日:2012-03-20
申请号:US12783261
申请日:2010-05-19
申请人: Rany Busold , Chang cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
发明人: Rany Busold , Chang cheng You , Daniel Concagh , Lee Core , Kicherl Ho , Maria Palasis , Upma Sharma , Greg Zugates
IPC分类号: A61F2/06
CPC分类号: A61F2/86 , A61F2/90 , A61F2/95 , A61F2230/0054 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , D04C1/06 , D10B2403/0112 , D10B2509/06 , C08L67/04
摘要: Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.
摘要翻译: 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构,并且被设计为低轮廓,使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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公开(公告)号:US20120040137A1
公开(公告)日:2012-02-16
申请号:US13185550
申请日:2011-07-19
申请人: Maria Palasis , Upma Sharma , Greg Zugates , Daniel Concagh , Toby Freyman , Quynh Pham
发明人: Maria Palasis , Upma Sharma , Greg Zugates , Daniel Concagh , Toby Freyman , Quynh Pham
CPC分类号: A61L27/48 , A61L27/54 , A61L27/58 , A61L31/129 , A61L31/148 , A61L31/16 , Y10T428/24479 , Y10T428/249924
摘要: Disclosed are fiber composite structures comprising a matrix material and at least one polymeric fiber in contact with the matrix material. The fiber(s) are preferably characterized by a diameter of up to about 20 microns. In certain embodiments, the fiber(s) comprise a therapeutic agent in an amount that exceeds the solubility limit of the therapeutic agent in the fiber polymer. In some embodiments, the fiber(s) comprise an inner radial portion and an outer radial portion.
摘要翻译: 公开了包含基质材料和至少一种与基质材料接触的聚合物纤维的纤维复合结构。 优选的纤维的特征在于直径至多约20微米。 在某些实施方案中,纤维包含超过纤维聚合物中治疗剂的溶解度极限的量的治疗剂。 在一些实施例中,纤维包括内径向部分和外径向部分。
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