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    Pyrrolidine compounds useful in the treatment of diabetes
    3.
    发明授权
    Pyrrolidine compounds useful in the treatment of diabetes 失效
    可用于治疗糖尿病的吡咯烷类化合物

    公开(公告)号：US5952363A

    公开(公告)日：1999-09-14

    申请号：US35494

    申请日：1998-03-05

    申请人： Marit Kristiansen ,  Palle Jakobsen ,  Jane Marie Lundbeck

    发明人： Marit Kristiansen ,  Palle Jakobsen ,  Jane Marie Lundbeck

    IPC分类号： C07D207/12 ,  A61K31/40 ,  C07D207/09 ,  C07D207/14

    CPC分类号： C07D207/12

    摘要： The present invention relates to novel pyrrolidine compounds having the general formula I ##STR1## and pharmaceutically acceptable acid addition salts or hydrates or prodrugs thereof, wherein R.sup.1 is straight or branched C.sub.1-14 -alkyl optionally substituted with C.sub.3-7 -cycloalkyl, C.sub.1-6 -alkoxy, phenoxy, perhalomethyl, halogen, optionally substituted phenyl;CR.sup.2 is optionally C.dbd.R.sup.2 or C--R.sup.2R.sup.2 is oxygen, hydroxy, halogen, amino or mercapto,R.sup.3 and R.sup.4 independently are hydroxy, halogen, amino or mercapto, the use of these compounds as medicament, the use of these medicaments in the treatment of diabetes, pharmaceutical compositions containing these compounds and methods of preparing the compounds.

    摘要翻译： 本发明涉及具有通式I的新型吡咯烷化合物及其药学上可接受的酸加成盐或水合物或前药，其中R 1为任选被C 3-7 - 环烷基，C 1-6 - 烷氧基取代的直链或支链C 1-14 - 烷基 ，苯氧基，全卤代甲基，卤素，任选取代的苯基; C + Z R2任选是C = R 2或C-R 2 R 2是氧，羟基，卤素，氨基或巯基，R 3和R 4独立地是羟基，卤素，氨基或巯基，使用这些化合物作为药物， 用于治疗糖尿病的药物，含有这些化合物的药物组合物和制备化合物的方法。