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公开(公告)号：US20090274724A1
公开(公告)日：2009-11-05
申请号：US12490098
申请日：2009-06-23
CPC分类号： C12N15/86 , C12N2710/10343
摘要： The present invention provides novel viral vectors. In one embodiment, the present invention provides mutant and recombinant bovine adenoviruses having a deletion and/or insertion of DNA in the early gene region 4 (E4). In another embodiment, the present invention provides mutant and recombinant bovine adenovirus 1 viruses having a deletion and/or insertion of DNA in the early gene region 3 (E3). The present invention also contemplates the use of the viral vectors for vaccination, gene therapy or other applications as suitable.
摘要翻译： 本发明提供新的病毒载体。 在一个实施方案中，本发明提供在早期基因区域4（E4）中具有缺失和/或插入DNA的突变和重组牛腺病毒。 在另一个实施方案中，本发明提供在早期基因区域3（E3）中具有缺失和/或插入DNA的突变和重组牛腺病毒1病毒。 本发明还考虑使用病毒载体进行疫苗接种，基因治疗或其它适合的应用。
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公开(公告)号：US5506128A
公开(公告)日：1996-04-09
申请号：US78873
申请日：1993-06-17
IPC分类号： A61K39/00 , A61K39/245 , A61K39/265 , C07K14/015 , C07K14/03 , C07K14/14 , C07K14/445 , C12N7/01 , C12N15/00 , C12N15/62 , C12N15/869 , C12Q1/70 , A61K39/155 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/265 , C07K14/005 , C07K14/445 , C12N15/00 , C12N15/62 , C12Q1/705 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2720/12322 , C12N2750/14322
摘要： The present invention provides a recombinant infectious bovine rhinotracheitis virus which is characterized by an insertion of an expressible foreign DNA sequence encoding a polypeptide into the BamHI C fragment of the infectious bovine rhinotracheitis virus genome.
摘要翻译： 本发明提供了重组感染性牛鼻气管炎病毒，其特征在于将编码多肽的可表达的外源DNA序列插入感染性牛鼻气管炎病毒基因组的BamHI C片段。
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公开(公告)号：US06451319B1
公开(公告)日：2002-09-17
申请号：US09545481
申请日：2000-04-07
IPC分类号： A61K3912
CPC分类号： C12N15/86 , C12N2710/10343
摘要： The present invention provides novel viral vectors. In one embodiment, the present invention provides mutant and recombinant bovine adenoviruses having a deletion and/or insertion of DNA in the early gene region 4 (E4). In another embodiment, the present invention provides mutant and recombinant bovine adenovirus 1 viruses having a deletion and/or insertion of DNA in the early gene region 3 (E3). The present invention also contemplates the use of the viral vectors for vaccination, gene therapy or other applications as suitable.
摘要翻译： 本发明提供新的病毒载体。 在一个实施方案中，本发明提供在早期基因区域4（E4）中具有缺失和/或插入DNA的突变和重组牛腺病毒。 在另一个实施方案中，本发明提供在早期基因区域3（E3）中具有缺失和/或插入DNA的突变和重组牛腺病毒1病毒。 本发明还考虑使用病毒载体进行疫苗接种，基因治疗或其它适合的应用。
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公开(公告)号：US5731188A
公开(公告)日：1998-03-24
申请号：US323531
申请日：1994-10-14
IPC分类号： A61K39/00 , A61K39/245 , A61K39/265 , C07K14/015 , C07K14/03 , C07K14/14 , C12N7/01 , C12N15/00 , C12N15/869 , C12Q1/70 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/265 , C07K14/005 , C12N15/00 , C12Q1/705 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/00 , C07K2319/02 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
摘要翻译： 本发明涉及非天然存在的重组马疱疹病毒。 本发明还涉及能够复制的重组马疱疹病毒，其包含来自马疱疹病毒和外来DNA的种类的病毒DNA，所述外来DNA被插入马疱疹病毒DNA中，所述位点对于马疱疹病毒的复制不是必需的。 本发明还涉及编码马疱疹病毒的US2蛋白的DNA。 本发明涉及用于产生重组马疱疹病毒的同源载体，其通过将外来DNA插入马疱疹病毒DNA而产生重组马疱疹病毒。 本发明还涉及一种产生胎儿安全的活重组马疱疹病毒的方法。
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公开(公告)号：US06225111B1
公开(公告)日：2001-05-01
申请号：US08107794
申请日：1995-08-03
IPC分类号： C12N1586
CPC分类号： A61K39/245 , A61K39/00 , A61K39/092 , A61K39/12 , A61K39/27 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
摘要翻译： 本发明涉及非天然存在的重组马疱疹病毒。 本发明还涉及能够复制的重组马疱疹病毒，其包含来自马疱疹病毒和外来DNA的种类的病毒DNA，所述外来DNA被插入马疱疹病毒DNA中，所述位点对于马疱疹病毒的复制不是必需的。 本发明还涉及编码马疱疹病毒的US2蛋白的DNA。 本发明涉及用于产生重组马疱疹病毒的同源载体，其通过将外来DNA插入马疱疹病毒DNA而产生重组马疱疹病毒。 本发明还涉及一种产生胎儿安全的活重组马疱疹病毒的方法。
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公开(公告)号：US5741696A
公开(公告)日：1998-04-21
申请号：US198094
申请日：1994-02-17
IPC分类号： A61K39/00 , A61K39/245 , A61K39/27 , C07K14/03 , C07K14/11 , C12N7/00 , C12N15/38 , C12N15/869 , C12N7/01 , C12N7/04 , C12N15/86
CPC分类号： C12N15/86 , A61K39/092 , A61K39/12 , A61K39/245 , A61K39/27 , C07K14/005 , C12N7/00 , A61K2039/552 , A61K39/00 , C12N2710/16422 , C12N2710/16443 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
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7.发明授权Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence 失效减毒疱疹病毒和疱疹病毒，其中包括编码氨基酸序列的外来DNA
公开(公告)号：US5223424A
公开(公告)日：1993-06-29
申请号：US225032
申请日：1988-07-27
IPC分类号： A61K39/00 , A61K39/245 , A61K39/265 , C07K14/015 , C07K14/03 , C07K14/14 , C07K14/445 , C12N7/01 , C12N15/00 , C12N15/62 , C12N15/869 , C12Q1/70
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/265 , C07K14/005 , C07K14/445 , C12N15/00 , C12N15/62 , C12Q1/705 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2720/12322 , C12N2750/14322
摘要： The present invention provides a recombinant fusion protein comprising an antigenic amino acid sequence fused to at least a portion of the gpX glycoprotein from pseudorabies virus. Such a protein may be formulated into a vaccine and delivered to an animal using a live herpesvirus vector adapted to express the fusion protein.
摘要翻译： 本发明提供一种重组融合蛋白，其包含与来自伪狂犬病病毒的至少一部分gpX糖蛋白融合的抗原性氨基酸序列。 可以将这样的蛋白质配制成疫苗并使用适于表达融合蛋白的活疱疹病毒载体递送至动物。
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公开(公告)号：US07892564B2
公开(公告)日：2011-02-22
申请号：US12363134
申请日：2009-01-30
申请人： Martha A. Wild , Mark D. Cochran
发明人： Martha A. Wild , Mark D. Cochran
IPC分类号： A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2710/16022 , C12N2710/16034 , C12N2710/16043 , C12N2710/16062 , C12N2770/20034 , C12Q1/705
摘要： The present invention provides a recombinant, attenuated infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the glycoprotein gG gene. This attenuated virus is useful as a vaccine against infectious laryngotracheitis virus.The present invention also provides a recombinant, attenuated infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the US2 gene, UL47-like gene, ORF4 gene or glycoprotein g60 gene.The present invention also provides a method for distinguishing chickens or other poultry vaccinated with a recombinant infectious laryngotracheitis virus which produces no glycoprotein gG from those infected with a naturally-occurring infectious laryngotracheitis virus.
摘要翻译： 本发明提供了包含在糖蛋白gG基因中含有缺失的感染性喉气管炎病毒基因组的重组减毒感染性喉气管炎病毒。 这种减毒病毒可用作针对感染性喉气管炎病毒的疫苗。 本发明还提供了包含感染性喉气管炎病毒基因组的重组减毒感染性喉气管炎病毒，其在US2基因，UL47样基因，ORF4基因或糖蛋白g60基因中含有缺失。 本发明还提供了用从天然感染性喉气管炎病毒感染的重组感染性喉气管炎病毒接种的鸡或其他禽类不产生糖蛋白gG的方法。
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公开(公告)号：US20100166800A1
公开(公告)日：2010-07-01
申请号：US12640645
申请日：2009-12-17
IPC分类号： A61K39/08 , C07H21/04 , A61P31/04 , A61P31/00 , G01N33/53 , C12N1/20 , C07K14/33 , C12N1/21 , C07K16/12
CPC分类号： A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/33
摘要： The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
摘要翻译： 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基，包括His68。 本发明还公开了编码突变蛋白的减毒生物，以及这些减毒生物体作为疫苗的用途。
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公开(公告)号：US07745593B2
公开(公告)日：2010-06-29
申请号：US11414707
申请日：2006-04-27
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/39 , A61K2039/55516
摘要： The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a host cells transformed with CD80-encoding vectors, CD86-encoding vectors, CD28-encoding vectors, or CTLA-4-encoding vectors. The invention provides polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a vaccine comprising an effective amount of polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention also provides vaccines which further comprise immunogens derived from pathogens. The invention provides for vaccines capable of enhancing an immune response. The invention also provides for vaccines capable of suppressing and immune response.
摘要翻译： 本发明提供编码猫科动物CD80（B7-1）配体，猫科动物CD86（B7-2）配体，猫科动物CD28受体或猫科动物CTLA-4（CD152）受体的分离和纯化的DNA，以及包含编码猫科动物的核酸的载体 CD80，猫科动物CD86，猫科动物CD28或猫科CTLA-4。 本发明提供用CD80编码载体，CD86编码载体，CD28编码载体或CTLA-4编码载体转化的宿主细胞。 本发明提供由猫科动物CD80，猫科动物CD86，猫科动物CD28或猫科动物CTLA-4的核酸编码的多肽。 本发明提供了包含有效量的由猫科动物CD80，猫科动物CD86，猫科动物CD28或猫科动物CTLA-4的核酸编码的多肽的疫苗。 本发明还提供了进一步包含衍生自病原体的免疫原的疫苗。 本发明提供能够增强免疫应答的疫苗。 本发明还提供能够抑制和免疫反应的疫苗。
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