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公开(公告)号：US5506128A
公开(公告)日：1996-04-09
申请号：US78873
申请日：1993-06-17
IPC分类号： A61K39/00 , A61K39/245 , A61K39/265 , C07K14/015 , C07K14/03 , C07K14/14 , C07K14/445 , C12N7/01 , C12N15/00 , C12N15/62 , C12N15/869 , C12Q1/70 , A61K39/155 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/265 , C07K14/005 , C07K14/445 , C12N15/00 , C12N15/62 , C12Q1/705 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2720/12322 , C12N2750/14322
摘要： The present invention provides a recombinant infectious bovine rhinotracheitis virus which is characterized by an insertion of an expressible foreign DNA sequence encoding a polypeptide into the BamHI C fragment of the infectious bovine rhinotracheitis virus genome.
摘要翻译： 本发明提供了重组感染性牛鼻气管炎病毒，其特征在于将编码多肽的可表达的外源DNA序列插入感染性牛鼻气管炎病毒基因组的BamHI C片段。
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2.发明授权Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence 失效减毒疱疹病毒和疱疹病毒，其中包括编码氨基酸序列的外来DNA
公开(公告)号：US5223424A
公开(公告)日：1993-06-29
申请号：US225032
申请日：1988-07-27
IPC分类号： A61K39/00 , A61K39/245 , A61K39/265 , C07K14/015 , C07K14/03 , C07K14/14 , C07K14/445 , C12N7/01 , C12N15/00 , C12N15/62 , C12N15/869 , C12Q1/70
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/265 , C07K14/005 , C07K14/445 , C12N15/00 , C12N15/62 , C12Q1/705 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2720/12322 , C12N2750/14322
摘要： The present invention provides a recombinant fusion protein comprising an antigenic amino acid sequence fused to at least a portion of the gpX glycoprotein from pseudorabies virus. Such a protein may be formulated into a vaccine and delivered to an animal using a live herpesvirus vector adapted to express the fusion protein.
摘要翻译： 本发明提供一种重组融合蛋白，其包含与来自伪狂犬病病毒的至少一部分gpX糖蛋白融合的抗原性氨基酸序列。 可以将这样的蛋白质配制成疫苗并使用适于表达融合蛋白的活疱疹病毒载体递送至动物。
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公开(公告)号：US20090274724A1
公开(公告)日：2009-11-05
申请号：US12490098
申请日：2009-06-23
CPC分类号： C12N15/86 , C12N2710/10343
摘要： The present invention provides novel viral vectors. In one embodiment, the present invention provides mutant and recombinant bovine adenoviruses having a deletion and/or insertion of DNA in the early gene region 4 (E4). In another embodiment, the present invention provides mutant and recombinant bovine adenovirus 1 viruses having a deletion and/or insertion of DNA in the early gene region 3 (E3). The present invention also contemplates the use of the viral vectors for vaccination, gene therapy or other applications as suitable.
摘要翻译： 本发明提供新的病毒载体。 在一个实施方案中，本发明提供在早期基因区域4（E4）中具有缺失和/或插入DNA的突变和重组牛腺病毒。 在另一个实施方案中，本发明提供在早期基因区域3（E3）中具有缺失和/或插入DNA的突变和重组牛腺病毒1病毒。 本发明还考虑使用病毒载体进行疫苗接种，基因治疗或其它适合的应用。
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公开(公告)号：US06451319B1
公开(公告)日：2002-09-17
申请号：US09545481
申请日：2000-04-07
IPC分类号： A61K3912
CPC分类号： C12N15/86 , C12N2710/10343
摘要： The present invention provides novel viral vectors. In one embodiment, the present invention provides mutant and recombinant bovine adenoviruses having a deletion and/or insertion of DNA in the early gene region 4 (E4). In another embodiment, the present invention provides mutant and recombinant bovine adenovirus 1 viruses having a deletion and/or insertion of DNA in the early gene region 3 (E3). The present invention also contemplates the use of the viral vectors for vaccination, gene therapy or other applications as suitable.
摘要翻译： 本发明提供新的病毒载体。 在一个实施方案中，本发明提供在早期基因区域4（E4）中具有缺失和/或插入DNA的突变和重组牛腺病毒。 在另一个实施方案中，本发明提供在早期基因区域3（E3）中具有缺失和/或插入DNA的突变和重组牛腺病毒1病毒。 本发明还考虑使用病毒载体进行疫苗接种，基因治疗或其它适合的应用。
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公开(公告)号：US5731188A
公开(公告)日：1998-03-24
申请号：US323531
申请日：1994-10-14
IPC分类号： A61K39/00 , A61K39/245 , A61K39/265 , C07K14/015 , C07K14/03 , C07K14/14 , C12N7/01 , C12N15/00 , C12N15/869 , C12Q1/70 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/245 , A61K39/265 , C07K14/005 , C12N15/00 , C12Q1/705 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/00 , C07K2319/02 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
摘要翻译： 本发明涉及非天然存在的重组马疱疹病毒。 本发明还涉及能够复制的重组马疱疹病毒，其包含来自马疱疹病毒和外来DNA的种类的病毒DNA，所述外来DNA被插入马疱疹病毒DNA中，所述位点对于马疱疹病毒的复制不是必需的。 本发明还涉及编码马疱疹病毒的US2蛋白的DNA。 本发明涉及用于产生重组马疱疹病毒的同源载体，其通过将外来DNA插入马疱疹病毒DNA而产生重组马疱疹病毒。 本发明还涉及一种产生胎儿安全的活重组马疱疹病毒的方法。
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公开(公告)号：US06225111B1
公开(公告)日：2001-05-01
申请号：US08107794
申请日：1995-08-03
IPC分类号： C12N1586
CPC分类号： A61K39/245 , A61K39/00 , A61K39/092 , A61K39/12 , A61K39/27 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
摘要翻译： 本发明涉及非天然存在的重组马疱疹病毒。 本发明还涉及能够复制的重组马疱疹病毒，其包含来自马疱疹病毒和外来DNA的种类的病毒DNA，所述外来DNA被插入马疱疹病毒DNA中，所述位点对于马疱疹病毒的复制不是必需的。 本发明还涉及编码马疱疹病毒的US2蛋白的DNA。 本发明涉及用于产生重组马疱疹病毒的同源载体，其通过将外来DNA插入马疱疹病毒DNA而产生重组马疱疹病毒。 本发明还涉及一种产生胎儿安全的活重组马疱疹病毒的方法。
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公开(公告)号：US5741696A
公开(公告)日：1998-04-21
申请号：US198094
申请日：1994-02-17
IPC分类号： A61K39/00 , A61K39/245 , A61K39/27 , C07K14/03 , C07K14/11 , C12N7/00 , C12N15/38 , C12N15/869 , C12N7/01 , C12N7/04 , C12N15/86
CPC分类号： C12N15/86 , A61K39/092 , A61K39/12 , A61K39/245 , A61K39/27 , C07K14/005 , C12N7/00 , A61K2039/552 , A61K39/00 , C12N2710/16422 , C12N2710/16443 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
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公开(公告)号：US5273876A
公开(公告)日：1993-12-28
申请号：US599270
申请日：1990-10-16
IPC分类号： A61K48/00 , C07K14/16 , C12N7/01 , C12N7/08 , C12N15/113 , C12N15/869 , C12N9/38 , C12N15/86 , C12P21/00
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/86 , C12N7/00 , A61K48/00 , C12N2710/16143 , C12N2740/16022 , C12N2740/16064
摘要： The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen.Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.
摘要翻译： 本发明提供了包含对人巨细胞病毒复制必需的DNA序列和适于在宿主中表达的至少一种外来DNA序列的病毒。 外源DNA序列可以编码人免疫缺陷病毒反义mRNA序列或抗原性多肽，例如疟疾表面抗原。 还提供了包含本发明的新病毒的治疗组合物和疫苗。
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9.发明授权Recombinant infectious bovine rhinotracheitis virus comprising foreign DNA inserted into a non-essential region of a infectious bovine rhinotracheitis virus genome 失效重组感染性牛鼻气管炎病毒，其包含插入感染性牛鼻气管炎病毒基因组非必需区域的外来DNA公开(公告)号：US06210961B1
公开(公告)日：2001-04-03
申请号：US08912803
申请日：1997-08-18
IPC分类号： C12N1586
CPC分类号： A61K39/12 , A61K39/0258 , A61K39/155 , A61K39/17 , A61K39/215 , A61K39/225 , A61K39/23 , A61K39/245 , A61K39/255 , A61K39/265 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2710/16334 , C12N2710/16343 , C12N2710/16362 , C12N2710/16643 , C12N2710/16662 , C12N2710/16734 , C12N2710/16743 , C12N2710/16762 , C12N2720/10022 , C12N2720/12322 , C12N2750/14322 , C12N2760/18122 , C12N2760/18622 , C12N2760/18634 , C12N2770/20022 , C12N2770/24322 , C12N2770/24334 , Y02A50/474 , Y10S977/803 , Y10S977/917 , Y10S977/924
摘要： The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.
摘要翻译： 本发明提供了一种杂合非疱疹病毒，其包含DNA，其包含杂合体病毒复制所必需的序列，非疱疹病毒，其至少一部分以天然存在的非疱疹病毒的复制必需的序列存在，并且至少 一个外来DNA序列。 还提供了减毒的非疱疹病毒，其包含DNA，其包括对减毒的非疱疹病毒的病毒复制必需的序列，其至少一部分以天然存在的非疱疹病毒的复制必需的序列存在， 重复序列的至少一部分已被删除。 还提供了包含本发明病毒的疫苗和针对各种疾病免疫动物的方法。
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10.发明授权Recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a non-essential region of the herpesvirus of turkeys genome 失效火鸡重组疱疹病毒包含插入火鸡基因组疱疹病毒非必需区域的外源DNA
公开(公告)号：US6121043A
公开(公告)日：2000-09-19
申请号：US915520
申请日：1997-08-15
IPC分类号： C12N15/86 , C12N15/869
CPC分类号： A61K39/12 , A61K39/15 , A61K39/155 , A61K39/17 , A61K39/215 , A61K39/225 , A61K39/23 , A61K39/245 , A61K39/255 , A61K39/265 , C12N15/86 , C12N7/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K39/0258 , C12N2710/16334 , C12N2710/16343 , C12N2710/16362 , C12N2710/16643 , C12N2710/16662 , C12N2710/16734 , C12N2710/16743 , C12N2710/16762 , C12N2720/10022 , C12N2720/12322 , C12N2750/14322 , C12N2760/18122 , C12N2760/18622 , C12N2760/18634 , C12N2770/20022 , C12N2770/24322 , C12N2770/24334 , Y10S977/803 , Y10S977/917 , Y10S977/924
摘要： The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.
摘要翻译： 本发明提供了一种杂合非疱疹病毒，其包含DNA，其包含杂合体病毒复制所必需的序列，非疱疹病毒，其至少一部分以天然存在的非疱疹病毒的复制必需的序列存在，并且至少 一个外来DNA序列。 还提供了减毒的非疱疹病毒，其包含DNA，其包括对减毒的非疱疹病毒的病毒复制必需的序列，其至少一部分以天然存在的非疱疹病毒的复制必需的序列存在， 重复序列的至少一部分已被删除。 还提供了包含本发明病毒的疫苗和针对各种疾病免疫动物的方法。
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