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    METHOD, APPARATUS AND SYSTEM FOR USE IN PROCESSING WAFERS
    4.
    发明申请
    METHOD, APPARATUS AND SYSTEM FOR USE IN PROCESSING WAFERS 有权
    用于处理波形的方法，装置和系统

    公开(公告)号：US20120046781A1

    公开(公告)日：2012-02-23

    申请号：US13290900

    申请日：2011-11-07

    申请人： William J. Kalenian ,  Thomas Walsh ,  Dave Halley

    发明人： William J. Kalenian ,  Thomas Walsh ,  Dave Halley

    IPC分类号： G06F19/00

    CPC分类号： B24B37/345 ,  B24B37/30 ,  H01L21/67161 ,  H01L21/67219 ,  H01L21/68785

    摘要： The present embodiment provides for methods and systems for use in processing objects such as wafers, including polishing and/or grinding wafers. Some embodiments provide systems that include a front-end module and a processing module. The front end module couples with a storage device that stores objects for processing. The front-end module can comprise a single robot, a transfer station, and a plurality of end effectors. The processing module is coupled with the front-end module such that the single robot delivers objects from the storage device to the processing module. The processing module comprising a rotating table, and a spindle with a carrier configured to retrieve the delivered object and process the object on the rotating table.

    摘要翻译： 本实施例提供了用于处理诸如晶片的物体的方法和系统，包括抛光和/或研磨晶片。 一些实施例提供了包括前端模块和处理模块的系统。 前端模块与存储用于处理的对象的存储设备耦合。 前端模块可以包括单个机器人，传送站和多个端部执行器。 处理模块与前端模块耦合，使得单个机器人将物体从存储装置传送到处理模块。 所述处理模块包括旋转台和具有承载件的主轴，所述托架被配置为检索所递送的物体并且处理所述旋转台上的物体。

    Grinding apparatus and method
    5.
    发明申请
    Grinding apparatus and method 有权
    研磨设备和方法

    公开(公告)号：US20070128983A1

    公开(公告)日：2007-06-07

    申请号：US11548213

    申请日：2006-10-10

    申请人： Thomas Walsh ,  Salman Kassir

    发明人： Thomas Walsh ,  Salman Kassir

    IPC分类号： B24B51/00 ,  B24B1/00

    CPC分类号： B24B49/16 ,  B24B7/22

    摘要： The present embodiments provide methods, systems and apparatuses for use in grinding work pieces, such as wafers. Some embodiments provide methods that position a grind spindle to contact a first grinding spindle to a face of a work piece, remove a portion of the face, and control the removing of the portion of the face according to a control algorithm. This control algorithm can comprise determining a force applied to the work piece during the removing of the portion of the face, adjusting a feed rate of the first grind spindle when the force applied to the work piece has a predefined relationship with a first threshold level; and dressing a portion of the first grinding portion when the force applied to the work piece has a predefined relationship with a second threshold level that is greater than the first threshold.

    摘要翻译： 本实施例提供了用于研磨诸如晶片的工件的方法，系统和装置。 一些实施例提供了一种方法，其定位研磨主轴以使第一研磨主轴接触工件的表面，去除面部的一部分，并且根据控制算法控制面部的部分的移除。 该控制算法可以包括确定在去除面部的部分期间施加到工件的力，当施加到工件的力具有与第一阈值水平的预定关系时，调节第一研磨主轴的进给速度; 以及当施加到所述工件上的力具有与大于所述第一阈值的第二阈值水平的预定关系时，修整所述第一研磨部的一部分。

    Wafer Carrier Pivot Mechanism
    6.
    发明申请
    Wafer Carrier Pivot Mechanism 审中-公开
    晶圆托架枢轴机构

    公开(公告)号：US20070105491A1

    公开(公告)日：2007-05-10

    申请号：US11619088

    申请日：2007-01-02

    申请人： Thomas Walsh ,  William Kalenian

    发明人： Thomas Walsh ,  William Kalenian

    IPC分类号： B24B47/02

    CPC分类号： B24B37/30

    摘要： A pivoting wafer carrier having a minimum of internal friction and a smooth, continuous pivoting motion. The pivot mechanism includes a lower ring mounted on a pressure plate, an upper ring mounted on a housing upper plate and ball transfer units disposed on the lower ring. Corresponding bearing wedges depend downwardly from the upper ring. As the pressure plate tilts during the polishing process, the load balls of the ball transfer units roll against the corresponding wedges, thus producing a smooth, continuous pivoting motion. A universal joint may be provided to the carrier to effect the rotation of the carrier and to aid the smooth, continuous pivoting motion of the wafer carrier.

    摘要翻译： 具有最小内摩擦和平滑，连续的枢转运动的枢转晶片载体。 枢转机构包括安装在压板上的下环，安装在壳体上板上的上环和设置在下环上的球传递单元。 相应的轴承楔块从上环向下取向。 当在抛光过程中压板倾斜时，球传送装置的载荷球相对于相应的楔形物滚动，从而产生平滑，连续的旋转运动。 可以向载体提供万向接头以实现载体的旋转并且有助于晶片载体的平滑，连续的枢转运动。

    Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology
    9.
    发明申请
    Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology 失效
    肾上腺髓质素（AM）和基因相关产物（PAMP）在人类病理和生理学中的功能作用

    公开(公告)号：US20070004630A1

    公开(公告)日：2007-01-04

    申请号：US11517599

    申请日：2006-09-05

    申请人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Miller ,  Edward Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

    发明人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Miller ,  Edward Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

    IPC分类号： A61K39/395 ,  A61K38/22

    CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/51 ,  C07K14/575 ,  C07K2317/34 ,  C07K2317/73

    摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.

    摘要翻译： 本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。 本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。 本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。 本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。 与大鼠分离的胰岛有关的方法表明，AM以剂量依赖的方式抑制胰岛素分泌。 中和AM生物活性的单克隆抗体MoAb-G6通过本发明的方法显示出增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。

    Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology
    10.
    发明授权
    Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology 有权
    肾上腺髓质素（AM）和基因相关产物（PAMP）在人类病理和生理学中的功能作用

    公开(公告)号：US07101548B2

    公开(公告)日：2006-09-05

    申请号：US09931700

    申请日：2001-08-16

    申请人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Jean Miller ,  Edward J. Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

    发明人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Jean Miller ,  Edward J. Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

    IPC分类号： A61K39/395

    CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/51 ,  C07K14/575 ,  C07K2317/34 ,  C07K2317/73

    摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have shown that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was shown by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.

    摘要翻译： 本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。 本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。 本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。 本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。 与大鼠分离的胰岛相关的方法已经表明AM以剂量依赖的方式抑制胰岛素分泌。 通过本发明的方法显示了中和AM生物活性的单克隆抗体MoAb-G6，以增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。