Implantable drug infusion device having a flow regulator
    1.
    发明授权
    Implantable drug infusion device having a flow regulator 失效
    具有流量调节器的可植入药物输注装置

    公开(公告)号:US06203523B1

    公开(公告)日:2001-03-20

    申请号:US09017194

    申请日:1998-02-02

    IPC分类号: A61M1100

    摘要: An implantable drug infusion device which features an improved flow regulator which permits the flow rate to be independent of reservoir pressure within a given pressure range. The flow regulator features a membrane having a hole, the membrane itself positioned above a bottom layer such that sufficient deflection of the membrane causes the membrane to engage against the bottom layer. As liquid flows through the hole a drag force is applied to the edge of the hole resulting in a deflection of the membrane. Once contact is made between the membrane and the bottom layer, then flow reduced. In a further embodiment the bottom layer features a variable flow channel such that upon membrane deflection flow may only proceed through the hole and through the flow channel. By tailoring the shape and length of the variable flow channel the flow characteristics of the regulator versus pressure may be adjusted. In a further embodiment the flow regulator also features a flow sensor integrated therewith. This integrated sensor provides a measurement of flow and may be coupled to the flow regulator to provide feedback thereto.

    摘要翻译: 一种可植入药物输注装置,其具有改进的流量调节器,其允许流量独立于给定压力范围内的储层压力。 流动调节器具有具有孔的膜,膜本身定位在底层上方,使得膜的足够偏转导致膜与底层接合。 当液体流过孔时,阻力被施加到孔的边缘,导致膜的偏转。 一旦在膜和底层之间进行接触,则流动减少。 在另一个实施方案中,底层具有可变流动通道,使得在膜偏转时,流动可以仅通过孔并通过流动通道。 通过调节可变流动通道的形状和长度,可以调整调节器与压力的流动特性。 在另一实施例中,流量调节器还具有与其集成的流量传感器。 该集成传感器提供流量测量并且可以耦合到流量调节器以向其提供反馈。

    Implantable drug infusion device having a flow regulator
    2.
    发明授权
    Implantable drug infusion device having a flow regulator 有权
    具有流量调节器的可植入药物输注装置

    公开(公告)号:US06878135B1

    公开(公告)日:2005-04-12

    申请号:US09712237

    申请日:2000-11-15

    摘要: An implantable drug infusion device which features an improved flow regulator which permits the flow rate to be independent of reservoir pressure within a given pressure range. The flow regulator features a membrane having a hole, the membrane itself positioned above a bottom layer such that sufficient deflection of the membrane causes the membrane to engage against the bottom layer. As liquid flows through the hole a drag force is applied to the edge of the hole resulting in a deflection of the membrane. Once contact is made between the membrane and the bottom layer, then flow reduced. In a further embodiment the bottom layer features a variable flow channel such that upon membrane deflection flow may only proceed through the hole and through the flow channel. By tailoring the shape and length of the variable flow channel the flow characteristics of the regulator versus pressure may be adjusted. In a further embodiment the flow regulator also features a flow sensor integrated therewith. This integrated sensor provides a measurement of flow and may be coupled to the flow regulator to provide feedback thereto.

    摘要翻译: 一种可植入药物输注装置,其具有改进的流量调节器,其允许流量独立于给定压力范围内的储层压力。 流动调节器具有具有孔的膜,膜本身定位在底层上方,使得膜的足够偏转导致膜与底层接合。 当液体流过孔时,阻力被施加到孔的边缘,导致膜的偏转。 一旦在膜和底层之间进行接触,则流动减少。 在另一个实施方案中,底层具有可变流动通道,使得在膜偏转时,流动可以仅通过孔并通过流动通道。 通过调节可变流动通道的形状和长度,可以调整调节器与压力的流动特性。 在另一实施例中,流量调节器还具有与其集成的流量传感器。 该集成传感器提供流量测量并且可以耦合到流量调节器以向其提供反馈。

    Over-current protection device
    5.
    发明授权

    公开(公告)号:US09787079B2

    公开(公告)日:2017-10-10

    申请号:US14372608

    申请日:2012-01-20

    IPC分类号: H02H3/02 H02H3/08

    CPC分类号: H02H3/02 H02H3/08

    摘要: An over-current protection circuit including, a current supply switch with a first terminal coupled to a supply current input and with a second terminal coupled to a supply current output. The current supply switch is switchable at least between an on-state, in which the current supply switch provides a conductive connection between the first terminal and the second terminal, and an off-state, in which the current supply switch interrupts the conductive connection between the first terminal and the second terminal. The over-current protection circuit receives a supply current via the supply current input and provides the supply current via the supply current output if the switch is in the on-state. The current supply switch includes a High Electron Mobility Transistor.

    Assay device and method for performing biological assays
    7.
    发明授权
    Assay device and method for performing biological assays 有权
    用于进行生物测定的测定装置和方法

    公开(公告)号:US09040463B2

    公开(公告)日:2015-05-26

    申请号:US13141570

    申请日:2009-12-23

    IPC分类号: G01N33/543 B01L3/00

    摘要: The invention provides a multiplexed assay device comprising a reaction chamber and several sets of encoded microcarriers 2 wherein the reaction chamber is a microchannel 1 and wherein the longitudinal movement of the microcarriers 2 is restricted and wherein the microcarriers 2 have a shape in relation to the geometry of the microchannel 1 such that at least two can stand side by side in the microchannel 1 without touching each other and without touching the perimeter of the microchannel 1 and are preferably observable in the reaction chamber. Moreover, the invention provides a method for performing multiplexed assay based on microcarriers 2 that improves mass transfer, simplifies the preparation and the execution of the assay and facilitates readout of biological reactions and identity of microcarriers 2.

    摘要翻译: 本发明提供了一种多重测定装置,其包括反应室和若干组编码的微载体2,其中反应室是微通道1,并且其中微载体2的纵向运动受到限制,并且其中微载体2具有相对于几何形状的形状 使得至少两个可以在微通道1中并排放置而不彼此接触并且不接触微通道1的周边,并且优选在反应室中可观察到。 此外,本发明提供了一种用于进行基于微载体2的多重测定的方法,其提高了质量传递,简化了测定的准备和执行,并且促进了微载体的生物学反应和身份的读出。

    Semiconductor structure, an integrated circuit including a semiconductor structure and a method for manufacturing a semiconductor structure
    8.
    发明授权
    Semiconductor structure, an integrated circuit including a semiconductor structure and a method for manufacturing a semiconductor structure 有权
    半导体结构,包括半导体结构的集成电路和半导体结构的制造方法

    公开(公告)号:US08390091B2

    公开(公告)日:2013-03-05

    申请号:US13143548

    申请日:2009-02-03

    申请人: Philippe Renaud

    发明人: Philippe Renaud

    IPC分类号: H01L29/47

    摘要: A monolithic semiconductor structure includes a stack of layers. The stack includes a substrate; a first layer made from a first semiconductor material; and a second layer made from a second semiconductor material. The first layer is situated between the substrate and the second layer and at least one of the first semiconductor material and the second semiconductor material contains a III-nitride material. The structure includes a power transistor, including a body formed in the stack of layers; a first power terminal at a side of the first layer facing the second layer; a second power terminal at least partly formed in the substrate; and a gate structure for controlling the propagation through the body of electric signals between the first power terminal and the second power terminal. The structure further includes a vertical Schottky diode, including: an anode; a cathode including the substrate, and a Schottky barrier between the cathode and the anode, the Schottky barrier being situated between the substrate and a anode layer in the stack of layers.

    摘要翻译: 单片半导体结构包括一叠层。 堆叠包括基板; 由第一半导体材料制成的第一层; 以及由第二半导体材料制成的第二层。 第一层位于衬底和第二层之间,并且第一半导体材料和第二半导体材料中的至少一个含有III族氮化物材料。 该结构包括功率晶体管,其包括形成在层叠层中的主体; 位于所述第一层的面向所述第二层的一侧的第一电源端子; 至少部分地形成在所述基板中的第二电源端子; 以及栅极结构,用于控制在第一电力端子和第二电力端子之间通过主体的电信号的传播。 该结构还包括垂直肖特基二极管,包括:阳极; 包括衬底的阴极和在阴极和阳极之间的肖特基势垒,肖特基势垒位于衬底和堆叠层中的阳极层之间。

    ASSAY DEVICE AND METHOD FOR PERFORMING BIOLOGICAL ASSAYS
    9.
    发明申请
    ASSAY DEVICE AND METHOD FOR PERFORMING BIOLOGICAL ASSAYS 有权
    用于进行生物测定的测定装置和方法

    公开(公告)号:US20110306506A1

    公开(公告)日:2011-12-15

    申请号:US13141570

    申请日:2009-12-23

    IPC分类号: C40B30/00 C40B60/12

    摘要: The invention provides a multiplexed assay device comprising a reaction chamber and several sets of encoded microcarriers 2 wherein the reaction chamber is a microchannel 1 and wherein the longitudinal movement of the microcarriers 2 is restricted and wherein the microcarriers 2 have a shape in relation to the geometry of the microchannel 1 such that at least two can stand side by side in the microchannel 1 without touching each other and without touching the perimeter of the microchannel 1 and are preferably observable in the reaction chamber. Moreover, the invention provides a method for performing multiplexed assay based on microcarriers 2 that improves mass transfer, simplifies the preparation and the execution of the assay and facilitates readout of biological reactions and identity of microcarriers 2.

    摘要翻译: 本发明提供了一种多重测定装置,其包括反应室和若干组编码的微载体2,其中反应室是微通道1,并且其中微载体2的纵向运动受到限制,并且其中微载体2具有相对于几何形状的形状 使得至少两个可以在微通道1中并排放置而不彼此接触并且不接触微通道1的周边,并且优选在反应室中可观察到。 此外,本发明提供了一种用于进行基于微载体2的多重测定的方法,其提高了质量传递,简化了测定的准备和执行,并且促进了微载体的生物学反应和身份的读出。

    MICROFABRICATED NEUROSTIMULATION DEVICE
    10.
    发明申请
    MICROFABRICATED NEUROSTIMULATION DEVICE 有权
    微波神经元装置

    公开(公告)号:US20110301665A1

    公开(公告)日:2011-12-08

    申请号:US13128821

    申请日:2009-11-12

    IPC分类号: A61N1/05

    摘要: Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.

    摘要翻译: 本文描述的是微电极阵列器件及其制造和使用方法,以提供对神经靶标的高度局部化和有效的电刺激。 该装置包括沿细长探针轴布置的多个微电极元件。 微电极元件的尺寸和形状被设计成针对可能位于动物神经系统中的单个神经元,神经元组和神经组织,例如人类脑内深处。 有利地,神经学探针可用于促进神经系统靶的定位并保持植入用于长期监测和/或刺激。