公开(公告)号：US07076433B2

公开(公告)日：2006-07-11

申请号：US10052309

申请日：2002-01-17

申请人： Masashi Ito ,  Hiroshi Tsujino

发明人： Masashi Ito ,  Hiroshi Tsujino

IPC分类号： G10L19/02

CPC分类号： G10L21/0272 ,  G10L19/10 ,  G10L21/0264 ,  G10L2021/02166

摘要： A sound separation apparatus for separating a target signal from a mixed input signal, wherein the mixed input signal includes the target signal and one or more sound signals emitted from different sound sources. The sound separation apparatus according comprises a frequency analyzer for performing a frequency analysis on the mixed input signal and calculating spectrum and frequency component candidate points at each time. The apparatus further comprises feature extraction means for extracting feature parameters which are estimated to correspond with the target signal, comprising a local layer for analyzing local feature parameters using the spectrum and the frequency component candidate points and one or more global layers for analyzing global feature parameters using the feature parameters extracted by the local layer. The apparatus further comprises a signal regenerator for regenerating a waveform of the target signal using the feature parameters extracted by the feature extraction means.Since both of local feature parameters and global feature parameters can be processed together in the feature extraction means, the separation accuracy of the target signal is improved without depending on the accuracy for extracting feature parameters from the input signal. Feature parameters to be extracted include frequencies and amplitudes and their variation rates for the frequency component candidate points, harmonic structure, pitch consistency, intonation, on-set/off-set information and/or sound source direction. The number of the layers provided in the feature extraction means may be changed according to the types of the feature parameters to be extracted.

摘要翻译： 一种用于从混合输入信号中分离目标信号的声音分离装置，其中混合输入信号包括目标信号和从不同声源发射的一个或多个声音信号。 声音分离装置包括频率分析器，用于对混合输入信号进行频率分析，并且每次计算频谱和频率分量候选点。 该装置还包括用于提取被估计为与目标信号相对应的特征参数的特征提取装置，包括用于使用频谱和频率分量候选点分析局部特征参数的局部层和用于分析全局特征参数的一个或多个全局层 使用本地层提取的特征参数。 该装置还包括信号再生器，用于使用由特征提取装置提取的特征参数再生目标信号的波形。 由于局部特征参数和全局特征参数可以在特征提取装置中一起处理，所以目标信号的分离精度提高，而不依赖于从输入信号提取特征参数的精度。 要提取的特征参数包括频率分量候选点的频率和幅度及其变化率，谐波结构，音调一致性，语调，定位/偏移信息和/或声源方向。 可以根据要提取的特征参数的类型来改变在特征提取装置中提供的层的数量。

公开(公告)号：US20140187115A1

公开(公告)日：2014-07-03

申请号：US14122114

申请日：2012-06-01

申请人： Yohei Nakano ,  Yoshikazu Yakake ,  Masashi Ito

发明人： Yohei Nakano ,  Yoshikazu Yakake ,  Masashi Ito

IPC分类号： D01F6/76 ,  D04H1/4326

CPC分类号： D01F6/765 ,  D01D5/08 ,  D04H1/4326 ,  D04H1/44 ,  D04H1/54 ,  Y10T442/60 ,  Y10T442/69

摘要： Provided are a polyphenylene sulfide fiber including a PPS resin as a main component and having both excellent heat resistance and excellent thermal bonding properties, and a nonwoven fabric including the fiber. The polyphenylene sulfide fiber includes polyphenylene sulfide as a main component and having the sum of the crystallinity and the rigid amorphous fraction of 30% to 90%. The crystallinity is preferably not less than 5% and less than 25%. The polyphenylene sulfide fiber is used to form a nonwoven fabric. The nonwoven fabric is preferably produced by consolidation by thermal bonding or mechanical entanglement.

摘要翻译： 提供以PPS树脂为主要成分，具有优异的耐热性和优异的热粘合性的聚苯硫醚纤维，以及包含该纤维的无纺布。 聚苯硫醚纤维包括聚苯硫醚作为主要成分，其结晶度和刚性非晶部分之和为30％至90％。 结晶度优选为5％以上且小于25％。 聚苯硫醚纤维用于形成无纺织物。 无纺布优选通过热粘合或机械缠结固结而制成。

公开(公告)号：US08735135B2

公开(公告)日：2014-05-27

申请号：US12449868

申请日：2008-02-28

申请人： Tadashi Fujii ,  Atsushi Ochiai ,  Masashi Ito ,  Hiroki Kabumoto ,  Yoshikazu Fujii ,  Kazuhiro Machida

发明人： Tadashi Fujii ,  Atsushi Ochiai ,  Masashi Ito ,  Hiroki Kabumoto ,  Yoshikazu Fujii ,  Kazuhiro Machida

IPC分类号： C12N1/21 ,  C12P1/04

CPC分类号： C12P1/04 ,  C07K14/195 ,  C12P7/02 ,  C12P7/62 ,  C12P13/08 ,  C12P17/10 ,  C12P33/06

摘要： Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion system using a transformant which is given by introducing a gene originated from xerogenic organisms. A transformant is prepared by using a host which is defective in a gene encoding a multidrug efflux protein and introducing a gene originated from xerogenic organisms. Use of the transformant results in much effective microbial conversion of a hydrophobic or amphipathic substrate compound into a desired compound. In case, an Escherichia coli is used as the host, the gene encoding a multidrug efflux protein to be defective may be tolC, acrA, acrB and the like.

摘要翻译： 公开了一种改善常规生物转化系统中转化效率差的方法，该方法是使用通过引入源自干细胞生物体的基因而给出的转化体。 通过使用在编码多药外排蛋白的基因中有缺陷的宿主并引入源自干细胞生物的基因来制备转化体。 转化体的使用导致将疏水性或两亲性底物化合物转化为所需化合物的有效微生物转化。 如果使用大肠杆菌作为宿主，编码有缺陷的多药外排蛋白的基因可以是toC，acrA，acrB等。

公开(公告)号：US20130001859A1

公开(公告)日：2013-01-03

申请号：US13529229

申请日：2012-06-21

申请人： Noriyuki Sugiyama ,  Hiroyuki Saito ,  Atsushi Ikeda ,  Yasuyuki Hirai ,  Noriko Sato ,  Masashi Ito ,  Fumie Kameyama

发明人： Noriyuki Sugiyama ,  Hiroyuki Saito ,  Atsushi Ikeda ,  Yasuyuki Hirai ,  Noriko Sato ,  Masashi Ito ,  Fumie Kameyama

IPC分类号： B65H5/00 ,  B65H3/06

CPC分类号： B65H3/0684 ,  B65H3/34 ,  B65H3/56 ,  B65H3/66 ,  B65H2301/4222 ,  B65H2403/512 ,  B65H2405/1134 ,  B65H2405/1136 ,  B65H2511/214 ,  B65H2511/416 ,  B65H2515/81 ,  B65H2220/01 ,  B65H2220/02 ,  B65H2220/11

摘要： Even in printing apparatus that make use of a plurality of kinds of sheets, the degradation of image quality is reduced. A sheet conveying apparatus includes: a sheet stacking unit; a sheet conveying unit being in contact with the sheet stacked on an uppermost portion, of the stacked sheets, and conveying the sheet; a separation unit separating the sheets into only one sheet of the uppermost portion by a separation slope that abuts a tip portion of the sheet conveyed by the sheet conveying unit; and a guide unit connected to the separation unit and guiding the sheet, in which an angle between the sheet stacking unit and the separation slope is switched to a first angle and a second angle smaller than the first angle by a rotation center of the separation unit provided in a vicinity of a connection portion of the separation unit and the guide unit.

摘要翻译： 即使在使用多种片材的打印装置中，也降低了图像质量的劣化。 片材输送装置包括：片材堆积单元; 片材输送单元与层叠在最上部的片材接触，并且输送片材; 分离单元，其通过与由所述片材输送单元输送的所述片材的前端部抵接的分离斜面将所述片材分离成仅一片最上部; 以及引导单元，其连接到分离单元并引导片材，其中片材积累单元和分离斜面之间的角度通过分离单元的旋转中心切换到第一角度和小于第一角度的第二角度 设置在分离单元和引导单元的连接部分附近。

公开(公告)号：US08142955B2

公开(公告)日：2012-03-27

申请号：US12084637

申请日：2006-11-22

申请人： Masashi Ito

发明人： Masashi Ito

IPC分类号： H01M8/22

CPC分类号： H01M8/04089 ,  B60L11/1883 ,  B60L11/1892 ,  B60L11/1898 ,  H01M4/8647 ,  H01M8/04126 ,  H01M8/1023 ,  H01M8/1032 ,  H01M8/1039 ,  H01M2250/20 ,  Y02E60/521 ,  Y02T90/32 ,  Y02T90/34

摘要： A utility supply system supplies a fluid containing an antioxidant of a gaseous phase to a stack of proton-exchange membrane fuel cells, for efficient removal of hydroxyl radicals.

摘要翻译： 公用设施供应系统将含有气相抗氧化剂的流体提供给质子交换膜燃料电池堆，以有效地除去羟基。

公开(公告)号：US08071085B2

公开(公告)日：2011-12-06

申请号：US12175186

申请日：2008-07-17

申请人： Masashi Ito ,  Yasushi Saito

发明人： Masashi Ito ,  Yasushi Saito

IPC分类号： A61K48/00 ,  C12P21/00 ,  C12P21/02

CPC分类号： C12N5/0653 ,  A61K35/12 ,  C12N2510/00 ,  C12N2510/02

摘要： The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells. This invention provides cells suitable for gene therapy, which can replace bone marrow cells and liver cells used for conventional ex vivo gene therapy. The present invention established methods for transferring foreign genes into primary cultured adipocytes, which are suitable for ex vivo gene therapy; can be easily collected and implanted; and can be removed after implantation. Specifically, the present invention established these methods that use retroviral vectors. The present invention also established primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells.

摘要翻译： 本发明涉及用于基因治疗的原代培养的脂肪细胞，其中脂肪细胞稳定地维持编码在细胞外分泌的蛋白质的外源基因。 本发明提供适用于基因治疗的细胞，其可代替用于常规体外基因治疗的骨髓细胞和肝细胞。 本发明建立了将外源基因转移到适合离体基因治疗的原代培养脂肪细胞中的方法; 可以轻松收集和植入; 并且可以在植入后去除。 具体地，本发明建立了使用逆转录病毒载体的这些方法。 本发明还建立了用于基因治疗的原代培养的脂肪细胞，其中脂肪细胞稳定地保持编码在细胞外分泌的蛋白质的外源基因。

公开(公告)号：US08045155B2

公开(公告)日：2011-10-25

申请号：US12377343

申请日：2008-06-05

申请人： Tomofumi Suzuki ,  Katsumi Shibayama ,  Takafumi Yokino ,  Masashi Ito ,  Helmut Teichmann ,  Dietmar Hiller ,  Ulrich Starker

发明人： Tomofumi Suzuki ,  Katsumi Shibayama ,  Takafumi Yokino ,  Masashi Ito ,  Helmut Teichmann ,  Dietmar Hiller ,  Ulrich Starker

IPC分类号： G01J3/26

CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0243 ,  G01J3/0259 ,  G01J3/04

摘要： The spectroscopy module is provided with a body portion for transmitting light, a spectroscopic portion for dispersing light made incident from the front plane of the body portion into the body portion to reflect the light on the front plane, a light detecting element having a light detecting portion for detecting the light dispersed and reflected by the spectroscopic portion and electrically connected to a wiring formed on the front plane of the body portion by face-down bonding, and an underfill material filled in the body portion side of the light detecting element to transmit the light. The light detecting element is provided with a light-passing hole through which the light advancing into the spectroscopic portion passes, and a reservoir portion is formed on a rear plane of the body portion side in the light detecting element so as to enclose a light outgoing opening of the light-passing hole.

摘要翻译： 光谱模块设置有用于透射光的主体部分，用于将从主体部分的前平面入射的光分散到主体部分中以将光反射到前平面上的光谱部分，具有光检测的光检测元件 用于检测由分光部分分散和反射的光并通过面朝下接合与形成在主体部分的前平面上的布线电连接的光;以及填充在光检测元件的主体部分侧的底部填充材料， 光。 光检测元件设置有通向分光部分的光通过的通光孔，并且在光检测元件中的主体部分侧的后平面上形成储存部分，以便包围光出射 打开通光孔。

公开(公告)号：US07799485B2

公开(公告)日：2010-09-21

申请号：US11571865

申请日：2005-07-07

申请人： Masashi Ito ,  Takao Maruyama

发明人： Masashi Ito ,  Takao Maruyama

IPC分类号： H01M4/02 ,  B01D19/00 ,  C10L1/24 ,  C10L1/00

CPC分类号： H01M8/1039 ,  B60L11/1883 ,  B60L11/1898 ,  B60L2240/36 ,  H01M8/04 ,  H01M8/1023 ,  H01M2250/20 ,  Y02E60/521 ,  Y02E60/528 ,  Y02T90/32 ,  Y02T90/34

摘要： According to the invention, a fuel cell system features a fuel cell (1) having an electrode (5, 6), and an antioxidant residing in or contacting the electrode (5, 6), for inactivating active oxygen.

摘要翻译： 根据本发明，燃料电池系统具有燃料电池（1），其具有电极（5,6）以及驻留在电极（5,6）中或与电极接触的抗氧化剂，用于使活性氧失活。

公开(公告)号：US20080050787A1

公开(公告)日：2008-02-28

申请号：US10581366

申请日：2004-12-01

申请人： Hazuki Nagai ,  Kaname Konuki ,  Masashi Ito ,  Tomohiro Sameshima

发明人： Hazuki Nagai ,  Kaname Konuki ,  Masashi Ito ,  Tomohiro Sameshima

IPC分类号： C12P17/00 ,  C07D333/32

CPC分类号： C12P17/167

摘要： A method for manufacturing (R)-tetrahydrothiophene-3-ol denoted by formula (II): by bioconversion of tetrahydrothiophene-3-one denoted by formula (I): to (R)-tetrahydrothiophene-3-ol denoted by formula (II). It comprises the steps of: (A) incubating the tetrahydrothiophene-3-one denoted by formula (I) in the presence of a strain, or a preparation of a cultured cell thereof, belonging to Penicillium, Aspergillus, or Streptomyces that is capable of said bioconversion; and (B) collecting the (R)-tetrahydrothiophene-3-ol denoted by formula (II) from incubated solution. A method for crystallization of optically active tetrahydrothiophene-3-ol of improved optical purity, characterized by maintaining a solution comprising optically active tetrahydrothiophene-3-ol and organic solvent at equal to or lower than 1° C. to cause optically active tetrahydrothiophene-3-ol to crystallize from said solution, or characterized by adding optically active tetrahydrothiophene-3-ol dropwise to organic solvent at a solution temperature of equal to or lower than 1° C. to cause optically active tetrahydro thiophene-3-ol to crystallize.

摘要翻译： 由式（II）表示的（R） - 四氢噻吩-3-醇的制造方法：通过式（I）表示的四氢噻吩-3-酮的生物转化：式（II）表示的（R） - 四氢噻吩-3-醇 ）。 其包括以下步骤：（A）在菌株存在下将式（I）表示的四氢噻吩-3-酮或其培养细胞的制剂，属于青霉属，曲霉属或链霉菌属，其能够 说生物转化 和（B）从温育溶液中收集由式（II）表示的（R） - 四氢噻吩-3-醇。 一种提高光学纯度的光学活性四氢噻吩-3-醇的结晶方法，其特征在于将含有光学活性四氢噻吩-3-醇和有机溶剂的溶液保持在等于或低于1℃，使光学活性的四氢噻吩-3 - 醇从所述溶液中结晶，或者特征在于在等于或低于1℃的溶液温度下将光学活性的四氢噻吩-3-醇滴加到有机溶剂中，使光学活性的四氢噻吩-3-醇结晶。

公开(公告)号：US20060121008A1

公开(公告)日：2006-06-08

申请号：US10518472

申请日：2003-06-18

申请人： Masashi Ito ,  Yasushi Saito

发明人： Masashi Ito ,  Yasushi Saito

IPC分类号： A61K48/00 ,  C12N5/08 ,  C12N15/867 ,  C12N15/861

CPC分类号： C12N5/0653 ,  A61K35/12 ,  C12N2510/00 ,  C12N2510/02

摘要： The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells. This invention provides cells suitable for gene therapy, which can replace bone marrow cells and liver cells used for conventional ex vivo gene therapy. The present invention established methods for transferring foreign genes into primary cultured adipocytes, which are suitable for ex vivo gene therapy; can be easily collected and implanted; and can be removed after implantation. Specifically, the present invention established these methods that use retroviral vectors. The present invention also established primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells.

摘要翻译： 本发明涉及用于基因治疗的原代培养的脂肪细胞，其中脂肪细胞稳定地维持编码在细胞外分泌的蛋白质的外源基因。 本发明提供适用于基因治疗的细胞，其可代替用于常规体外基因治疗的骨髓细胞和肝细胞。 本发明建立了将外源基因转移到适合离体基因治疗的原代培养脂肪细胞中的方法; 可以轻松收集和植入; 并且可以在植入后去除。 具体地，本发明建立了使用逆转录病毒载体的这些方法。 本发明还建立了用于基因治疗的原代培养的脂肪细胞，其中脂肪细胞稳定地保持编码在细胞外分泌的蛋白质的外源基因。