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公开(公告)号：US08273302B2
公开(公告)日：2012-09-25
申请号：US12532908
申请日：2008-05-14
IPC分类号： B01D21/28
CPC分类号： B01D21/283 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0436
摘要： A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate.
摘要翻译： 元件分离装置包括流路，用于在流路中产生声波的声波发生器，用于将含有固体粒子的第一溶液引入流路的第一入口通道，用于引入第二溶液的第二入口通道， 以及用于从流动通道排出溶液的出口通道。 在第一入口通道处设置密度级发生器，用于形成固体颗粒的密度等级。 该组分分离装置以高收集速率将固体颗粒提取成高纯度溶液。
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公开(公告)号：US20100219488A1
公开(公告)日：2010-09-02
申请号：US12676826
申请日：2008-09-04
CPC分类号： G01N33/48728 , B81B2201/0214 , B81B2201/052 , B81C1/00206 , Y10T428/23943
摘要： A silicon structure of the present invention is provided with a silicon substrate (1) to become a base, and a plurality of fibrous projections (2) made of silicon dioxide and directly joined to a silicon-made surface (1a) of the silicon substrate (1). By arbitrarily constructing an area where these fibrous projections (2) are formed in a predetermined area, it is possible to render the area to have at least either hydrophilicity or water retentivity, so as to provide a silicon structure useful for a variety of devices.
摘要翻译： 本发明的硅结构设置有成为基底的硅基板（1）和由二氧化硅制成的直接接合到硅基板的硅制表面（1a）的多个纤维突起（2） （1）。 通过任意构造这些纤维状突起（2）形成在预定区域的区域，可以使该区域具有至少亲水性或保水性，以提供可用于各种装置的硅结构。
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3.发明申请DEVICE FOR CELLULAR ELECTROPHYSIOLOGY SENSOR, CELLULAR ELECTROPHYSIOLOGY SENSOR USING THE DEVICE, AND METHOD FOR MANUFACTURING THE CELLULAR ELECTROPHYSIOLOGY SENSOR DEVICE 有权用于细胞电生理学传感器的装置，使用该装置的细胞电生理学传感器以及用于制造细胞电生理学传感器装置的方法公开(公告)号：US20090281410A1
公开(公告)日：2009-11-12
申请号：US12301307
申请日：2007-06-27
IPC分类号： A61B5/04
CPC分类号： G01N33/48728
摘要： A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced.
摘要翻译： 细胞电生理传感器的传感器芯片的侧表面的漏电流减少。 为了这样做，提供了具有连续孔的传感器芯片和覆盖传感器芯片的侧表面的芯片保持部分。 传感器芯片包括硅作为主要部件，芯片保持部分由玻璃制成。 通过玻璃焊接将芯片保持部粘合到传感器芯片的侧面。 因此，在本发明的细胞电生理传感器装置中，传感器芯片的侧面与芯片保持部之间的气密性提高，能够降低漏电流。
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公开(公告)号：US08314466B2
公开(公告)日：2012-11-20
申请号：US12676826
申请日：2008-09-04
CPC分类号： G01N33/48728 , B81B2201/0214 , B81B2201/052 , B81C1/00206 , Y10T428/23943
摘要： A silicon structure of the present invention is provided with a silicon substrate (1) to become a base, and a plurality of fibrous projections (2) made of silicon dioxide and directly joined to a silicon-made surface (1a) of the silicon substrate (1). By arbitrarily constructing an area where these fibrous projections (2) are formed in a predetermined area, it is possible to render the area to have at least either hydrophilicity or water retentivity, so as to provide a silicon structure useful for a variety of devices.
摘要翻译： 本发明的硅结构设置有成为基底的硅基板（1）和由二氧化硅制成的直接接合到硅基板的硅制表面（1a）的多个纤维突起（2） （1）。 通过任意构造这些纤维状突起（2）形成在预定区域的区域，可以使该区域具有至少亲水性或保水性，以提供可用于各种装置的硅结构。
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5.发明授权Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device 有权用于细胞电生理学传感器的装置，使用该装置的细胞电生理学传感器以及用于制造细胞电生理学传感器装置的方法公开(公告)号：US08445263B2
公开(公告)日：2013-05-21
申请号：US12301307
申请日：2007-06-27
IPC分类号： C12M1/34
CPC分类号： G01N33/48728
摘要： A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced.
摘要翻译： 细胞电生理传感器的传感器芯片的侧表面的漏电流减少。 为了这样做，提供了具有连续孔的传感器芯片和覆盖传感器芯片的侧表面的芯片保持部分。 传感器芯片包括硅作为主要部件，芯片保持部分由玻璃制成。 通过玻璃焊接将芯片保持部粘合到传感器芯片的侧面。 因此，在本发明的细胞电生理传感器装置中，传感器芯片的侧面与芯片保持部之间的气密性提高，能够降低漏电流。
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公开(公告)号：US20100126922A1
公开(公告)日：2010-05-27
申请号：US12532908
申请日：2008-05-14
IPC分类号： B01D21/28
CPC分类号： B01D21/283 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0436
摘要： A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate.
摘要翻译： 元件分离装置包括流路，用于在流路中产生声波的声波发生器，用于将含有固体粒子的第一溶液引入流路的第一入口通道，用于引入第二溶液的第二入口通道， 以及用于从流动通道排出溶液的出口通道。 在第一入口通道处设置密度级发生器，用于形成固体颗粒的密度等级。 该组分分离装置以高收集速率将固体颗粒提取成高纯度溶液。
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公开(公告)号：US08329451B2
公开(公告)日：2012-12-11
申请号：US11914685
申请日：2007-04-12
CPC分类号： G01N33/48728
摘要： In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through fusion with a portion of the outer shape of a first electrode in a ring shape intervening in a portion of the interface. In this configuration, a cell electrophysiological sensor which allows for measurement with high precision can be attained, and a manufacturing method which is excellent in terms of mass production can be provided.
摘要翻译： 在具有带有通孔的薄板的细胞电生理传感器中，具有通孔的支撑板和具有粘附在该支撑板的上部的通孔的容器板，支撑板和容器板粘附到每个 另一个通过与介于界面的一部分中的环形的第一电极的外部形状的一部分融合。 在该结构中，可以实现能够高精度地进行测定的细胞电生理学传感器，并且可以提供在批量生产方面优异的制造方法。
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8.发明授权Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm 有权膜片和用于测量细胞电位的装置使用相同的膜片的制造方法公开(公告)号：US08202439B2
公开(公告)日：2012-06-19
申请号：US12359426
申请日：2009-01-26
申请人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
IPC分类号： B44C1/22 , H01L21/302
CPC分类号： G01N33/48728 , Y10T428/24322
摘要： A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape.
摘要翻译： 通过蚀刻基板形成隔膜。 该基板具有通过各向同性干蚀刻设置有凹部的第一表面和与第一表面相对的第二表面。 此外，通过各向异性干蚀刻从凹陷形成通孔到第二表面。 通过使用一个抗蚀剂掩模形成凹陷和通孔。 凹陷具有半球形或半椭圆形球形。
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公开(公告)号：US20090081765A1
公开(公告)日：2009-03-26
申请号：US11914685
申请日：2007-04-12
CPC分类号： G01N33/48728
摘要： In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through fusion with a portion of the outer shape of a first electrode in a ring shape intervening in a portion of the interface. In this configuration, a cell electrophysiological sensor which allows for measurement with high precision can be attained, and a manufacturing method which is excellent in terms of mass production can be provided.
摘要翻译： 在具有带有通孔的薄板的细胞电生理传感器中，具有通孔的支撑板和具有粘附在该支撑板的上部的通孔的容器板，支撑板和容器板粘附到每个 另一个通过与介于界面的一部分中的环形的第一电极的外部形状的一部分融合。 在该结构中，可以实现能够高精度地进行测定的细胞电生理学传感器，并且可以提供在批量生产方面优异的制造方法。
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10.发明申请公开(公告)号：US20090239033A1
公开(公告)日：2009-09-24
申请号：US12359426
申请日：2009-01-26
申请人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Soichiro Hiraoka , Hiroshi Ushio , Akiyoshi Oshima , Hiroaki Oka , Fumiaki Emoto
CPC分类号： G01N33/48728 , Y10T428/24322
摘要： A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape.
摘要翻译： 通过蚀刻基板形成隔膜。 该基板具有通过各向同性干蚀刻设置有凹部的第一表面和与第一表面相对的第二表面。 此外，通过各向异性干蚀刻从凹陷形成通孔到第二表面。 通过使用一个抗蚀剂掩模形成凹陷和通孔。 凹陷具有半球形或半椭圆形球形。
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