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    DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MANUFACTURING DEVICE
    3.
    发明申请
    DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MANUFACTURING DEVICE 有权
    用于测量细胞外潜能的装置和制造装置的方法

    公开(公告)号：US20090035846A1

    公开(公告)日：2009-02-05

    申请号：US12245091

    申请日：2008-10-03

    申请人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    发明人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    IPC分类号： C12M1/34

    CPC分类号： G01N33/48728 ,  G01N33/54353 ,  G01N33/552

    摘要： A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.

    摘要翻译： 用于测量测试电池的细胞外电位的装置包括在其第一表面中形成良好的衬底和形成在其中的第一陷阱。 井有一个底部。 第一陷阱包括形成在井的底部并朝向基板的第二面延伸的第一开口，经由第一连接部分与第一开口连通的第一中空部分，以及延伸到第二表面的第二开口， 通过第二连接部与第一中空部连通。 第一连接部分的直径小于第一中空部分的最大直径，大于第二连接部分的直径，并且小于测试电池的直径。 该装置可以牢固地保持测试电池，并容易接受化学品和测试电池放入设备中。

    Extracellular potential measuring device and its manufacturing method
    4.
    发明授权
    Extracellular potential measuring device and its manufacturing method 有权
    细胞外电位测定装置及其制造方法

    公开(公告)号：US08257962B2

    公开(公告)日：2012-09-04

    申请号：US10513392

    申请日：2004-03-08

    申请人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    发明人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    IPC分类号： C12M1/42 ,  C12M3/00 ,  C12N13/00

    CPC分类号： G01N33/48728

    摘要： An extracellular potential measuring device includes a plate portion having a first surface and a second surface opposite to the first surface, and an electrode provided on the second surface of the plate portion. In the plate portion, a pocket having an opening which opens to the first surface is formed, and a through-hole communicating to the second surface from the pocket. The through-hole communicates from a position which is closer to the opening than a deepest point of the first pocket. The electrode is provided around of the opening of the through-hole. In this device, even if a cell to be examined does not reach the deepest point of the pocket, a cell membrane of the cell can tightly attaches onto the through-hole securely without a clearance. Hence, culture solution inside the through-hole is isolated from culture solution over an upper surface of the plate portion, thereby allowing electrochemical changes caused by activities of the cell to be detected efficiently with a detector electrode.

    摘要翻译： 细胞外电位测量装置包括具有第一表面和与第一表面相对的第二表面的板部分，以及设置在板部分的第二表面上的电极。 在该板部分中，形成具有向第一表面开口的开口的口袋，以及从口袋连通到第二表面的通孔。 通孔从比第一口袋的最深点更靠近开口的位置连通。 电极设置在通孔的开口周围。 在该装置中，即使要检查的细胞未达到口袋的最深点，细胞的细胞膜可以牢固地紧贴在通孔上而没有间隙。 因此，通孔内部的培养液在培养液的上表面上与培养液分离，从而能够通过检测器电极有效地检测细胞活性引起的电化学变化。

    Device for measuring extracellular potential and method of manufacturing device
    5.
    发明授权
    Device for measuring extracellular potential and method of manufacturing device 有权
    用于测量细胞外电位的装置和制造装置的方法

    公开(公告)号：US08232084B2

    公开(公告)日：2012-07-31

    申请号：US12245091

    申请日：2008-10-03

    申请人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    发明人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    IPC分类号： C12N13/00 ,  C12M1/42 ,  C12M3/00

    CPC分类号： G01N33/48728 ,  G01N33/54353 ,  G01N33/552

    摘要： A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.

    摘要翻译： 用于测量测试电池的细胞外电位的装置包括在其第一表面中形成良好的衬底和形成在其中的第一陷阱。 井有一个底部。 第一陷阱包括形成在井的底部并朝向基板的第二面延伸的第一开口，经由第一连接部分与第一开口连通的第一中空部分和延伸到第二表面的第二开口， 通过第二连接部与第一中空部连通。 第一连接部分的直径小于第一中空部分的最大直径，大于第二连接部分的直径，并且小于测试电池的直径。 该装置可以牢固地保持测试电池，并容易接受化学品和测试电池放入设备中。

    Extracellular potential measuring device and method for fabricating the same
    6.
    发明授权
    Extracellular potential measuring device and method for fabricating the same 有权
    细胞外电位测定装置及其制造方法

    公开(公告)号：US07501278B2

    公开(公告)日：2009-03-10

    申请号：US10485644

    申请日：2003-06-02

    申请人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    发明人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    IPC分类号： C12M1/36 ,  C12M1/38 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00

    CPC分类号： G01N33/48728 ,  G01N33/54353 ,  G01N33/552

    摘要： A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.

    摘要翻译： 用于测量测试电池的细胞外电位的装置包括在其第一表面中形成良好的衬底和形成在其中的第一陷阱。 井有一个底部。 第一陷阱包括形成在井的底部并朝向基板的第二面延伸的第一开口，经由第一连接部分与第一开口连通的第一中空部分和延伸到第二表面的第二开口， 通过第二连接部与第一中空部连通。 第一连接部分的直径小于第一中空部分的最大直径，大于第二连接部分的直径，并且小于测试电池的直径。 该装置可以牢固地保持测试电池，并容易接受化学品和测试电池放入设备中。

    Extracellular potential measuring device and its manufacturing method
    7.
    发明申请
    Extracellular potential measuring device and its manufacturing method 有权
    细胞外电位测定装置及其制造方法

    公开(公告)号：US20050221469A1

    公开(公告)日：2005-10-06

    申请号：US10513392

    申请日：2004-03-08

    申请人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    发明人： Masaya Nakatani ,  Hiroaki Oka ,  Fumiaki Emoto

    IPC分类号： G01N33/487 ,  C12M1/34

    CPC分类号： G01N33/48728

    摘要： An extracellular potential measuring device includes a plate portion having a first surface and a second surface opposite to the first surface, and an electrode provided on the second surface of the plate portion. In the plate portion, a pocket having an opening which opens to the first surface is formed, and a through-hole communicating to the second surface from the pocket. The through-hole communicates from a position which is closer to the opening than a deepest point of the first pocket. The electrode is provided around of the opening of the through-hole. In this device, even if a cell to be examined does not reach the deepest point of the pocket, a cell membrane of the cell can tightly attaches onto the through-hole securely without a clearance. Hence, culture solution inside the through-hole is isolated from culture solution over an upper surface of the plate portion, thereby allowing electrochemical changes caused by activities of the cell to be detected efficiently with a detector electrode.

    摘要翻译： 细胞外电位测量装置包括具有第一表面和与第一表面相对的第二表面的板部分，以及设置在板部分的第二表面上的电极。 在该板部分中，形成具有向第一表面开口的开口的口袋，以及从口袋连通到第二表面的通孔。 通孔从比第一口袋的最深点更靠近开口的位置连通。 电极设置在通孔的开口周围。 在该装置中，即使要检查的细胞未达到口袋的最深点，细胞的细胞膜可以牢固地紧贴在通孔上而没有间隙。 因此，通孔内部的培养液在培养液的上表面上与培养液分离，从而能够通过检测器电极有效地检测细胞活性引起的电化学变化。

    VISION RECOVERY TRAINING DEVICE
    9.
    发明申请
    VISION RECOVERY TRAINING DEVICE 审中-公开
    视觉恢复训练装置

    公开(公告)号：US20090168016A1

    公开(公告)日：2009-07-02

    申请号：US11571302

    申请日：2005-07-11

    申请人： Eiichi Ohkawa ,  Hisashi Hagiwara ,  Fumiaki Emoto ,  Saho Yamada

    发明人： Eiichi Ohkawa ,  Hisashi Hagiwara ,  Fumiaki Emoto ,  Saho Yamada

    IPC分类号： A61B3/00

    CPC分类号： A61H5/00

    摘要： An object of the present invention is to provide a visual training apparatus in which a trainee can make accommodation of the trainee's eye easily when the trainee is training. The visual training apparatus includes a display member 1, an optical system 2, a base 3 and a housing 4. The display member 1 displays a training image, and is fixed to the base 3 so as to cross an optic axis 51 of a trainee 5 substantially perpendicularly thereto. The optical system 2 includes a lens 21, a feed screw 22 and a motor 23. When the motor 23 is driven, the lens 21 moves along the optic axis 51 with the aid of the feed screw 22. Thus, the optical characteristic of the optical system 2 is changed so that the optical distance between the eye position of the trainee 5 and the display member 1 can be changed. The display member 1 displays a training image having dimensions proportional to the optical distance between the eye position of the trainee and the display member 1.

    摘要翻译： 本发明的目的是提供一种视觉训练装置，其中受训者可以在受训者训练时容易地容纳受训者的眼睛的容纳。 视觉训练装置包括显示构件1，光学系统2，基座3和壳体4.显示构件1显示训练图像，并且固定到基部3以穿过受训者的光轴51 基本垂直于其。 光学系统2包括透镜21，进给螺杆22和马达23.当马达23被驱动时，透镜21借助于进给螺杆22沿着光轴51移动。因此，光学特性 改变光学系​​统2，使得可以改变实习者5的眼睛位置与显示构件1之间的光学距离。 显示构件1显示具有与受训者的眼睛位置和显示构件1之间的光学距离成比例的尺寸的训练图像。

    Fluorescence detecting device with integrated circuit and photodiode, and detection method
    10.
    发明授权
    Fluorescence detecting device with integrated circuit and photodiode, and detection method 失效
    具有集成电路和光电二极管的荧光检测装置及检测方法

    公开(公告)号：US06995386B2

    公开(公告)日：2006-02-07

    申请号：US10962239

    申请日：2004-10-08

    申请人： Fumiaki Emoto

    发明人： Fumiaki Emoto

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  B01L3/50851 ,  G01N21/6454

    摘要： A fluorescence detecting device is configured so that a semiconductor integrated circuit substrate includes a photodiode and a signal detecting circuit for detecting charges obtained as a result of photoelectric conversion by the photodiode, and a fluorescence reaction vessel where a fluorescence reaction occurs is arranged above the foregoing photodiode. Furthermore, in the device, an excitation-light-entry preventing layer is provided at one or more of a surface portion of the photodiode and a position between the photodiode and the fluorescence reaction vessel.

    摘要翻译： 荧光检测装置被配置为使得半导体集成电路基板包括光电二极管和用于检测作为光电二极管的光电转换的结果而获得的电荷的信号检测电路，并且发生荧光反应的荧光反应容器设置在上述 光电二极管 此外，在该器件中，在光电二极管的表面部分和光电二极管与荧光反应容器之间的位置的一个或多个处提供激发光入射防止层。