-
公开(公告)号:US11740236B2
公开(公告)日:2023-08-29
申请号:US16158506
申请日:2018-10-12
Applicant: Massachusetts Institute of Technology
Inventor: Hadley Sikes Johnson , Eric Alexander Miller , Ki-Joo Sung
IPC: G01N33/566 , C07K14/33 , G01N33/569 , C07K14/195 , C07K16/06 , C07K16/28
CPC classification number: G01N33/566 , C07K14/195 , C07K14/33 , C07K16/065 , C07K16/28 , G01N33/56911 , C07K2319/20 , C07K2319/24 , C07K2319/60 , G01N2400/26
Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.
-
公开(公告)号:US20190113512A1
公开(公告)日:2019-04-18
申请号:US16158506
申请日:2018-10-12
Applicant: Massachusetts Institute of Technology
Inventor: Hadley Sikes Johnson , Eric Alexander Miller , Ki-Joo Sung
IPC: G01N33/566 , G01N33/569 , C07K14/33 , C07K16/06 , C07K16/28
Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.
-
公开(公告)号:US12287336B2
公开(公告)日:2025-04-29
申请号:US18330411
申请日:2023-06-07
Applicant: Massachusetts Institute of Technology
Inventor: Hadley Sikes Johnson , Eric Alexander Miller , Ki-Joo Sung
IPC: G01N33/566 , C07K14/195 , C07K14/33 , C07K16/06 , C07K16/28 , G01N33/569
Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.
-
公开(公告)号:US20230305002A1
公开(公告)日:2023-09-28
申请号:US18330411
申请日:2023-06-07
Applicant: Massachusetts Institute of Technology
Inventor: Hadley Sikes Johnson , Eric Alexander Miller , Ki-Joo Sung
IPC: G01N33/566 , C07K14/195 , C07K14/33 , C07K16/06 , C07K16/28 , G01N33/569
CPC classification number: G01N33/566 , C07K14/195 , C07K14/33 , C07K16/065 , C07K16/28 , G01N33/56911 , C07K2319/20 , G01N2400/26 , C07K2319/24 , C07K2319/60
Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.
-
公开(公告)号:US11598769B2
公开(公告)日:2023-03-07
申请号:US16523209
申请日:2019-07-26
Applicant: Massachusetts Institute of Technology
Inventor: Bradley David Olsen , Hadley Sikes Johnson , Eric Alexander Miller , Justin Paloni
IPC: G01N33/543
Abstract: The present disclosure relates to protein-polymer conjugates comprising an engineered binding oligomer protein and a polymer for detection of a ligand of interest, methods, compositions and kits thereof.
-
公开(公告)号:US20200057058A1
公开(公告)日:2020-02-20
申请号:US16523209
申请日:2019-07-26
Applicant: Massachusetts Institute of Technology
Inventor: Bradley David Olsen , Hadley Sikes Johnson , Eric Alexander Miller , Justin Paloni
IPC: G01N33/543
Abstract: The present disclosure relates to protein-polymer conjugates comprising an engineered binding oligomer protein and a polymer for detection of a ligand of interest, methods, compositions and kits thereof.
-
7.
公开(公告)号:US12061194B2
公开(公告)日:2024-08-13
申请号:US17545979
申请日:2021-12-08
Applicant: Massachusetts Institute of Technology
Inventor: Timothy Manning Swager , Hadley Sikes Johnson , Qifan Zhang , Eric Alexander Miller , Lukas Zeininger , Ki-Joo Sung , Kosuke Yoshinaga
IPC: G01N21/77 , C12Q1/6834 , C12Q1/70 , G01N21/59 , G01N33/543 , G01N33/569 , G01N21/78
CPC classification number: G01N33/5432 , C12Q1/6834 , C12Q1/701 , G01N21/59 , G01N21/77 , G01N33/54366 , G01N33/56983 , G01N2021/7783 , G01N21/78 , G01N2201/0221 , C12Q1/701 , C12Q2563/159
Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria).
-
公开(公告)号:US20230408515A1
公开(公告)日:2023-12-21
申请号:US18035809
申请日:2021-11-10
Applicant: Massachusetts Institute of Technology
Inventor: Hadley Sikes Johnson , Eric Alexander Miller , Seunghyeon Kim
IPC: G01N33/569 , G01N33/58 , C07K14/005
CPC classification number: G01N33/56983 , G01N33/581 , C07K14/005 , G01N2333/165 , G01N2469/20 , G01N2400/26 , C12N2770/20022 , C07K2319/20
Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of anti-SARS-CoV-2 antibodies, methods, compositions and kits thereof.
-
公开(公告)号:US20220205989A1
公开(公告)日:2022-06-30
申请号:US17545979
申请日:2021-12-08
Applicant: Massachusetts Institute of Technology
Inventor: Timothy Manning Swager , Hadley Sikes Johnson , Qifan Zhang , Eric Alexander Miller , Lukas Zeininger , Ki-Joo Sung , Kosuke Yoshinaga
IPC: G01N33/543 , G01N21/59 , G01N21/77 , C12Q1/6834 , C12Q1/70 , G01N33/569
Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria).
-
公开(公告)号:US20190170737A1
公开(公告)日:2019-06-06
申请号:US16202007
申请日:2018-11-27
Applicant: Massachusetts Institute of Technology
Inventor: Timothy M. Swager , Hadley Sikes Johnson , Qifan Zhang , Eric Alexander Miller , Lukas Zeininger , Ki-Joo Sung , Kosuke Yoshinaga
IPC: G01N33/543 , G01N21/59 , C12Q1/6834 , G01N21/77
Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria).
-
-
-
-
-
-
-
-
-