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公开(公告)号：US10968446B2
公开(公告)日：2021-04-06
申请号：US14440183
申请日：2013-11-01
Applicant: Massachusetts Institute of Technology
Inventor： Dehua Zhao , Christopher Voigt , Michael Joseph Smanski
IPC: C40B40/08 , C12N15/10 , C12N15/66 , G16B35/00 , G16C20/60 , G16B50/00 , C40B40/06 , G16B20/00 , G16B40/00
Abstract: The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof.
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公开(公告)号：US10030320B2
公开(公告)日：2018-07-24
申请号：US14388030
申请日：2013-03-15
Inventor： Virgil A. Rhodius , Christopher Voigt , Carol A. Gross
Abstract: The invention relates to anti-sigma factors (“anti-sigmas”) that bind to sigma factors and block activation of transcription. Anti-sigmas and their cognate sigma factors provide a highly effective mechanism for regulating gene expression in genetic circuits.
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3.发明申请COMPOSABILITY AND DESIGN OF PARTS FOR LARGE-SCALE PATHWAY ENGINEERING IN YEAST 审中-公开YEAST大规模路面工程部件的组合性和设计公开(公告)号：US20160083722A1
公开(公告)日：2016-03-24
申请号：US14838409
申请日：2015-08-28
Applicant: Massachusetts Institute of Technology
Inventor： Eric M. Young , David Benjamin Gordon , Christopher Voigt
IPC: C12N15/10 , C12N15/113
CPC classification number: C12N15/1082 , C12N15/1093 , C12N15/113 , C12N15/81 , C40B40/06 , C40B40/08
Abstract: Expression cassettes comprising promoter and terminator combinations are provided and can be used to tune gene expression. Synthetic yeast promoters and methods of making them also are provided.
Abstract translation: 提供了包含启动子和终止子组合的表达盒，可用于调节基因表达。 还提供合成酵母启动子及其制备方法。
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公开(公告)号：US20150315576A1
公开(公告)日：2015-11-05
申请号：US14440166
申请日：2013-11-01
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Brian Caliando , Christopher Voigt
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N15/63 , C12N2310/10 , C12N2310/14 , C12N2310/20 , C12N2310/3519
Abstract: The invention relates to DNA destruction devices and related methods reagents and kits. The DNA destruction devices are useful for achieving target specific DNA destruction in vivo using a system that involves an actuator element and a CRISPR array, under specific regulatory control.
Abstract translation: 本发明涉及DNA破坏装置和相关方法试剂和试剂盒。 DNA破坏装置对于在特定的调节控制下使用涉及致动器元件和CRISPR阵列的系统在体内实现目标特异性DNA破坏是有用的。
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公开(公告)号：US11591604B2
公开(公告)日：2023-02-28
申请号：US15580859
申请日：2016-06-10
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Mark K. Mimee , Christopher Voigt , Alex C. Tucker
IPC: A61K35/741 , C12N15/74 , A61K48/00 , C12N9/12 , C12N9/22 , C12N9/96 , C12N15/11 , C12N15/67 , C12N15/90
Abstract: Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
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Patent Agency Ranking
公开(公告)号：US09970040B2
公开(公告)日：2018-05-15
申请号：US14498116
申请日：2014-09-26
Applicant: Massachusetts Institute of Technology
Inventor： Johann Elbaz , Christopher Voigt
CPC classification number: C12P19/34 , C07H21/00 , C12N9/1276 , C12N15/1096
Abstract: Cells that can synthesize oligonucleotides in vivo to produce a nucleic acid nanostructure are described. Methods for producing oligonucleotide nanostructures for use in regulating gene expression and altering biological pathways are provided. Methods of performing multiplex automated genome editing (MAGE) are also provided.
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公开(公告)号：US20180073031A1
公开(公告)日：2018-03-15
申请号：US15701498
申请日：2017-09-12
Applicant: Massachusetts Institute of Technology
Inventor： Christopher Voigt , Mao Taketani
CPC classification number: C12N15/74 , A61K38/00 , A61K49/0097 , C07K14/28 , C12N15/635 , C12Q1/6897
Abstract: The present disclosure relates, in some aspects, to bile acid sensors.
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公开(公告)号：US20150051112A1
公开(公告)日：2015-02-19
申请号：US14388030
申请日：2013-03-15
Inventor： Virgil A. Rhodius , Christopher Voigt , Carol A. Gross
CPC classification number: C40B30/02 , B82Y10/00 , C07K14/195 , C12N15/63 , C12N15/635 , G06N3/123
Abstract: The invention relates to anti-sigma factors (“anti-sigmas”) that bind to sigma factors and block activation of transcription. Anti-sigmas and their cognate sigma factors provide a highly effective mechanism for regulating gene expression in genetic circuits.
Abstract translation: 本发明涉及与σ因子结合并阻断转录激活的抗σ因子（“抗信号”）。 抗丝印及其相关因素为基因表达调控提供了高效的机制。
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公开(公告)号：US11898141B2
公开(公告)日：2024-02-13
申请号：US15313863
申请日：2015-05-27
Inventor： Robert Nicol , Lauren Andrews , Tarjei Mikkelsen , Christopher Voigt
CPC classification number: C12N15/1065 , C12N15/1082 , C12N15/1093 , C12N15/66 , C40B40/06 , G16B20/00 , G16B20/20 , G16B30/00 , G16B30/20
Abstract: Disclosed is a method of generating a set of sequence-verified nucleic acid elements for the combinatorial construction of genetic elements. The method includes: providing a plurality of nucleic acid parts; assembling nucleic acid parts to form a one or more nucleic acid elements, wherein the nucleic acid elements include at least two sequences selected from the plurality of parts; and determining the sequence of the nucleic acid elements. Further disclosed is a pool of higher-order nucleic acid constructs or amplification products thereof, comprising one or more nucleic acid elements as well as kits including a pool of sequence-verified nucleic acid elements of claims and/or a pool of higher-order nucleic acid constructs; and a plurality of primers for retrieving one or more sequence-verified nucleic acid elements and/or higher-order nucleic acid constructs.
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公开(公告)号：US11208664B2
公开(公告)日：2021-12-28
申请号：US15701498
申请日：2017-09-12
Applicant: Massachusetts Institute of Technology
Inventor： Christopher Voigt , Mao Taketani
IPC: C12N15/74 , A01N63/00 , C12Q1/00 , C12Q1/6897 , C12N15/63 , A61K49/00 , C07K14/28 , C07K14/00 , A61K38/00
Abstract: The present disclosure relates, in some aspects, to bile acid sensors.
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