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公开(公告)号：US20090300779A1
公开(公告)日：2009-12-03
申请号：US11631247
申请日：2005-06-29
CPC分类号： A61K35/74 , A61K38/2013 , A61K38/51
摘要： Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.
摘要翻译： 在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗，标记试剂和针对感染的疫苗。 也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。
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公开(公告)号：US08822194B2
公开(公告)日：2014-09-02
申请号：US11631247
申请日：2005-06-29
CPC分类号： A61K35/74 , A61K38/2013 , A61K38/51
摘要： Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.
摘要翻译： 在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗，标记试剂和针对感染的疫苗。 也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。
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4.发明授权Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效使用巢蛋白表达干细胞来形成新生血管的血管生成模型公开(公告)号：US08778308B2
公开(公告)日：2014-07-15
申请号：US10977219
申请日：2004-10-28
申请人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
发明人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
CPC分类号： G01N33/5073
摘要： The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.
摘要翻译： 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物，特别是肿瘤相关血管发生。 具体来说，巢蛋白作为脑肿瘤如胶质瘤，血管母细胞瘤，神经鞘瘤，成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此，所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。
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公开(公告)号：US20130063482A1
公开(公告)日：2013-03-14
申请号：US13229810
申请日：2011-09-12
申请人： Silvana Moncayo , Leonardo Blanco , Reiner Fink , Imran Majid , Meng Yang , Jonathan Liperi , Daniel Rischar , Aleksandar Antonijevic , Joshua Priestley
发明人： Silvana Moncayo , Leonardo Blanco , Reiner Fink , Imran Majid , Meng Yang , Jonathan Liperi , Daniel Rischar , Aleksandar Antonijevic , Joshua Priestley
摘要： An application programming interface is provided by an operating system that includes a direct composition engine. The composition engine maintains a data structure that represents the display objects to be rendered on a desktop display. The application programming interface allows an application to write data to the data structure to update the display object, such as a window, for the application. Thus, multiple applications can update their respective display objects in this data structure. The direct composition engine is an operating system level process, presented to user-level processes as a service of the operating system. By having an operating system level process, performance standards can be maintained. The application programming interface also allows applications to provide display information that can be rendered more efficiently by the operating system than by the application.
摘要翻译： 应用编程接口由包括直接组合引擎的操作系统提供。 组合引擎维护表示在桌面显示器上呈现的显示对象的数据结构。 应用程序编程接口允许应用程序将数据写入数据结构，以更新应用程序的显示对象（如窗口）。 因此，多个应用可以在该数据结构中更新它们各自的显示对象。 直接组合引擎是操作系统级进程，作为操作系统的服务呈现给用户级进程。 通过操作系统级流程，可以保持性能标准。 应用程序编程接口还允许应用程序提供可由操作系统比应用程序更高效地呈现的显示信息。
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6.发明申请SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环丙基化合物，包含这些化合物的组合物和处理方法公开(公告)号：US20120142706A1
公开(公告)日：2012-06-07
申请号：US13390147
申请日：2010-08-03
申请人： Harold B. Wood , Alan D. Adams , Jason W. Szewczyk , Yong Zhang , Meng Yang
发明人： Harold B. Wood , Alan D. Adams , Jason W. Szewczyk , Yong Zhang , Meng Yang
IPC分类号： A61K31/506 , C07D401/04 , A61P3/10 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04 , C07D413/14
摘要： Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 式I的取代的环丙基化合物被公开用于治疗或预防2型糖尿病和类似病症。 也包括药学上可接受的盐。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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公开(公告)号：US07666675B2
公开(公告)日：2010-02-23
申请号：US10251657
申请日：2002-09-20
IPC分类号： A01N63/00 , A61K48/00 , A01K67/027 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0661 , A61K35/12 , C12N5/0619 , C12N5/0622 , C12N5/0628 , C12N2501/13 , C12N2501/135 , C12N2506/092
摘要： Hair follicle stem cells are isolated from mammals by isolating nestin-expressing cells. These hair follicle stem cells are a source of adult stem cells for autologous or heterologous stem cell therapy. The stem cells can be systemically implanted into the mammal or directly implanted into the organ. In addition, the stem cells may be further differentiated in vitro and then implanted systemically or directly into the mammal.
摘要翻译： 通过分离巢蛋白表达细胞从哺乳动物中分离毛囊干细胞。 这些毛囊干细胞是用于自体或异源干细胞治疗的成体干细胞的来源。 干细胞可全身植入哺乳动物或直接植入器官。 此外，干细胞可以在体外进一步分化，然后系统地或直接植入哺乳动物。
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8.发明申请Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效使用巢蛋白表达干细胞来形成新生血管的血管生成模型公开(公告)号：US20050170330A1
公开(公告)日：2005-08-04
申请号：US10977219
申请日：2004-10-28
申请人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
发明人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
IPC分类号： A01K67/027 , A01N63/00 , C12Q1/00 , G01N33/50
CPC分类号： G01N33/5073
摘要： The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.
摘要翻译： 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物，特别是肿瘤相关血管发生。 具体来说，巢蛋白作为脑肿瘤如胶质瘤，血管母细胞瘤，神经鞘瘤，成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此，所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。
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公开(公告)号：US06905831B2
公开(公告)日：2005-06-14
申请号：US10643785
申请日：2003-08-18
申请人： Ping Jiang , Mingxu Xu , Meng Yang
发明人： Ping Jiang , Mingxu Xu , Meng Yang
IPC分类号： G01N21/78 , C12N20060101 , C12N5/00 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/68
CPC分类号： G01N33/5088 , G01N33/5011 , G01N33/5017 , G01N33/5035 , G01N33/574 , G01N33/6875
摘要： Living cells can be stably modified to emit different colors from the cytoplasm and nucleus, thus permitting analysis of the status of said cells and the effect of agents on said cells either by visual or instrumentally-aided observation. These observations may be made, if desired, in real time. In addition, rates of proliferation and drug sensitivities can be determined in vitro in real time by the use of cells modified to express a single fluorescent protein and observing fluorescence intensity as a function of time.
摘要翻译： 可以稳定地修饰活细胞以从细胞质和细胞核发射不同的颜色，从而通过视觉或仪器辅助观察来分析所述细胞的状态和药剂对所述细胞的作用。 如果需要，可以实时地进行这些观察。 此外，通过使用修饰以表达单个荧光蛋白并观察作为时间的函数的荧光强度的细胞，可以体外测定体外增殖和药物敏感性的速率。
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公开(公告)号：US20050039220A1
公开(公告)日：2005-02-17
申请号：US10856529
申请日：2004-05-27
IPC分类号： A01K67/00 , C07H21/04 , C07K1/10 , C07K14/00 , C07K14/165 , C07K17/00 , C12N20060101 , C12Q1/70 , G01N33/50
CPC分类号： G01N33/5082 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0393 , C07K14/005 , C07K2319/60 , C12N2770/20022 , G01N33/5091 , G01N2333/165
摘要： Imaged animal models for coronavirus infection are described.
摘要翻译： 描述了冠状病毒感染的成像动物模型。
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