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公开(公告)号:US20120045511A1
公开(公告)日:2012-02-23
申请号:US12858305
申请日:2010-08-17
申请人: Mi-Hua Tao , Ho-Yuan Chou , Hsin-Hsin Shen , Tsai-Yu Lin
发明人: Mi-Hua Tao , Ho-Yuan Chou , Hsin-Hsin Shen , Tsai-Yu Lin
CPC分类号: A61K39/292 , A61K9/0024 , A61K39/12 , A61K47/34 , A61K2039/55522 , A61K2039/57 , C12N2730/10134
摘要: A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer; a surface antigen of hepatitis B virus (HBsAg); and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.
摘要翻译: 提供热敏乙肝疫苗。 热敏乙型肝炎疫苗包括含有可生物降解的热敏水凝胶共聚物的水相溶液; 乙型肝炎病毒(HBsAg)的表面抗原; 和生物活性物质。 本公开的热敏乙型肝炎疫苗特别适合于应用于对常规乙型肝炎疫苗具有低响应性或无反应性的患者,用于增强细胞介导的免疫应答的诱导并克服HBsAg无反应性。
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公开(公告)号:US08614190B2
公开(公告)日:2013-12-24
申请号:US13172776
申请日:2011-06-29
申请人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
发明人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
IPC分类号: A61P19/08 , A61K38/18 , A61K31/74 , C07K14/51 , C07K14/475
CPC分类号: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A Formula (I) B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II) wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
摘要翻译: 提供了用于治疗骨疾病的热应答组合物。 用于治疗骨疾病的热应答组合物包括骨生长因子和可生物降解的共聚物。 生物降解性共聚物具有式(I)或式(II)的结构:AB-BOX-B-AFormula(I)BAB-(BOX-BAB)n-BOX-BA-BFormula(II)其中,A包括亲水 聚乙二醇聚合物,B包括疏水性聚酯聚合物,BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段AB或BAB,并且n是整数并且相同或多于 0。
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公开(公告)号:US20120010139A1
公开(公告)日:2012-01-12
申请号:US13172776
申请日:2011-06-29
申请人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
发明人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
CPC分类号: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A (Formula I) and B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II), wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
摘要翻译: 提供了用于治疗骨疾病的热应答组合物。 用于治疗骨疾病的热应答组合物包括骨生长因子和可生物降解的共聚物。 生物降解性共聚物具有式(I)或式(II)的结构:AB-BOX-BA(式I)和BAB-(BOX-BAB)n-BOX-BAB式(II),其中,A包括亲水 聚乙二醇聚合物,B包括疏水性聚酯聚合物,BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段AB或BAB,并且n为整数并且相同或多于 0。
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公开(公告)号:US10180738B2
公开(公告)日:2019-01-15
申请号:US15922874
申请日:2018-03-15
申请人: Jyh-Chyang Tzou , Tsai-Yu Lin , Hsin Yeh , Wei-Hao Lan
发明人: Jyh-Chyang Tzou , Tsai-Yu Lin , Hsin Yeh , Wei-Hao Lan
IPC分类号: G06F3/03 , G06F3/0354 , G06F1/16
摘要: An electronic assembly including an electronic device and a stylus is provided. The electronic device includes a housing having a receiving groove and an opening, the opening communicating with the receiving groove, and a first connecting element disposed around the opening. The stylus includes a sleeve and a pen rod. The sleeve has a second connecting element and corresponds to the receiving groove. The second connecting element is combined with the first connecting element to fix the sleeve to the housing. The pen rod is slidably disposed in the sleeve and has a first end and a second end opposite to each other, and a third connecting element located at the first end.
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公开(公告)号:US20190278326A1
公开(公告)日:2019-09-12
申请号:US16276631
申请日:2019-02-15
申请人: Yuan-Ping Chu , Jyh-Chyang Tzou , Tsai-Yu Lin , Chun-Ping Li
发明人: Yuan-Ping Chu , Jyh-Chyang Tzou , Tsai-Yu Lin , Chun-Ping Li
摘要: An electronic device including a main body, a handle and a driven mechanism is provided. The main body includes a base and a button unit movably disposed on the base. The handle is movably connected to the main body. The handle is adapted to be rotated from a first position to a second position relative to the main body. The driven mechanism includes a first connection element and an ascending/descending assembly. A first section of the first connection element is fixed to the handle, and a second section of the first connection element is movably disposed in the base. The ascending/descending assembly is disposed in the base and located between the second section and a bottom of the button unit. When the handle is rotated from the first position to the second position, the first connection element moves with the handle, and the ascending/descending assembly is moved with the second section and lifts up the button unit.
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公开(公告)号:US09946301B2
公开(公告)日:2018-04-17
申请号:US15498489
申请日:2017-04-27
申请人: Wei-Hao Lan , Jyh-Chyang Tzou , Ching-Tai Chang , Chia-Chi Lin , Tsai-Yu Lin , Hsin Yeh , Che-Hsien Lin , Cheng-Shiue Jan
发明人: Wei-Hao Lan , Jyh-Chyang Tzou , Ching-Tai Chang , Chia-Chi Lin , Tsai-Yu Lin , Hsin Yeh , Che-Hsien Lin , Cheng-Shiue Jan
CPC分类号: G06F1/1633 , E05D3/18 , E05D11/082 , E05Y2900/606 , F16C11/04 , F16C11/10 , F16M13/005 , G06F1/1681
摘要: A pivot structure includes a base, a bracket, an elastic component, and a positioning assembly. The bracket is rotatably connected to the base. The elastic component is disposed on the base. The positioning assembly includes an elastic clip and a pillar. The elastic clip is pivoted to the base and has a first releasing segment and a first positioning segment. The pillar is connected to the bracket and has a second positioning segment. The pillar is rotatably clipped in the elastic clip. The bracket is adapted to be expanded to a first expanding state through an elastic force of the elastic component, so as to drive the second positioning segment to move along the first releasing segment. The bracket is adapted to receive an external force to be further expanded to a second expanding state, so as to drive the second positioning segment to move to the first positioning segment.
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公开(公告)号:US20180052487A1
公开(公告)日:2018-02-22
申请号:US15641305
申请日:2017-07-04
申请人: Chia-Chi Lin , Wei-Hao Lan , Tsai-Yu Lin , Jyh-Chyang Tzou , Hsin Yeh , Tzu-Fang Huang
发明人: Chia-Chi Lin , Wei-Hao Lan , Tsai-Yu Lin , Jyh-Chyang Tzou , Hsin Yeh , Tzu-Fang Huang
IPC分类号: G06F1/16
CPC分类号: G06F1/1615 , G06F1/1624 , G06F1/1626 , G06F1/1656 , G06F1/166
摘要: An electronic device includes a body, a stand and a sliding member. The stand is rotatably connected to the body. The sliding member is slidably disposed on the body and has at least one stopping portion and at least one pushing portion. When the sliding member is located at a first position, the stopping portion interferes with the stand to stop the stand from expanding from the body. When the sliding member slides relative to the body to be away from the first position, the stopping portion releases the stand and the pushing portion pushes the stand to drive the stand to rotate and expand from the body.
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公开(公告)号:US20170344067A1
公开(公告)日:2017-11-30
申请号:US15498489
申请日:2017-04-27
申请人: Wei-Hao Lan , Jyh-Chyang Tzou , Ching-Tai Chang , Chia-Chi Lin , Tsai-Yu Lin , Hsin Yeh , Che-Hsien Lin , Cheng-Shiue Jan
发明人: Wei-Hao Lan , Jyh-Chyang Tzou , Ching-Tai Chang , Chia-Chi Lin , Tsai-Yu Lin , Hsin Yeh , Che-Hsien Lin , Cheng-Shiue Jan
CPC分类号: G06F1/1633 , E05D3/18 , E05D11/082 , E05Y2900/606 , F16C11/04 , F16C11/10 , F16M13/005 , G06F1/1681
摘要: A pivot structure includes a base, a bracket, an elastic component, and a positioning assembly. The bracket is rotatably connected to the base. The elastic component is disposed on the base. The positioning assembly includes an elastic clip and a pillar. The elastic clip is pivoted to the base and has a first releasing segment and a first positioning segment. The pillar is connected to the bracket and has a second positioning segment. The pillar is rotatably clipped in the elastic clip. The bracket is adapted to be expanded to a first expanding state through an elastic force of the elastic component, so as to drive the second positioning segment to move along the first releasing segment. The bracket is adapted to receive an external force to be further expanded to a second expanding state, so as to drive the second positioning segment to move to the first positioning segment.
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9.
公开(公告)号:US08940333B2
公开(公告)日:2015-01-27
申请号:US12053327
申请日:2008-03-21
申请人: Ming-Fa Hsieh , Hsuen-Tseng Cha'ng , Chin-Fu Chen , Yuan-Chia Chang , Pei Kan , Tsai-Yu Lin
发明人: Ming-Fa Hsieh , Hsuen-Tseng Cha'ng , Chin-Fu Chen , Yuan-Chia Chang , Pei Kan , Tsai-Yu Lin
IPC分类号: A61K9/14 , A61K9/51 , A61K31/00 , C08G63/91 , C08G63/48 , A61K8/11 , A61K9/107 , A61K47/34 , C08G63/664 , C08G63/685 , C08G63/688 , C08G63/692 , A61K8/00 , A61K9/12
CPC分类号: A61K9/5153 , A61K9/1075 , A61K31/4745 , A61K47/34 , C08G63/664 , C08G63/6852 , C08G63/6882 , C08G63/6922 , Y10S977/906 , Y10S977/926
摘要: An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.
摘要翻译: 公开了两亲嵌段共聚物。 两亲性嵌段共聚物包括一种或多种亲水性聚合物,一种或多种疏水性聚合物和一种或多种两性离子。 本发明还提供了包含用于递送水不溶性药物,生长因子,基因或水不溶性化妆品物质的两亲嵌段共聚物的纳米颗粒和载体。
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10.
公开(公告)号:US08124128B2
公开(公告)日:2012-02-28
申请号:US11268544
申请日:2005-11-08
申请人: Ming-Fa Hsieh , Hsuen-Tseng Chang , Chin-Fu Chen , Yuan-Chia Chang , Pei Kan , Tsai-Yu Lin , Yuan-Hung Hsu
发明人: Ming-Fa Hsieh , Hsuen-Tseng Chang , Chin-Fu Chen , Yuan-Chia Chang , Pei Kan , Tsai-Yu Lin , Yuan-Hung Hsu
IPC分类号: A61K48/00 , A61K9/14 , A61K31/4745 , C08G63/91 , C08G63/48
CPC分类号: A61K9/5153 , A61K9/1075 , A61K31/4745 , A61K47/34 , C08G63/664 , C08G63/6852 , C08G63/6882 , C08G63/6922 , Y10S977/906 , Y10S977/926
摘要: An amphiphilic block copolymer. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nano particle and carrier comprising the amhpiphilic block copolymer for delivery of water-insoluble drugs, growth factors, genes, or cosmetic substances.
摘要翻译: 两亲嵌段共聚物。 两亲性嵌段共聚物包括一种或多种亲水性聚合物,一种或多种疏水性聚合物和一种或多种两性离子。 本发明还提供纳米颗粒和载体,其包含用于递送水不溶性药物,生长因子,基因或化妆品物质的亲脂性嵌段共聚物。
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