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1.发明授权Controlled transfer biological sample collection devices and methods of using such devices 有权受控转移生物样品收集装置和使用这种装置的方法公开(公告)号：US08468901B2
公开(公告)日：2013-06-25
申请号：US12449603
申请日：2008-02-15
申请人： Michael A. Harvey , Breck O. Parker , Stevan Paul Tortorella , Elizabeth A. Moran , John Pipinias
发明人： Michael A. Harvey , Breck O. Parker , Stevan Paul Tortorella , Elizabeth A. Moran , John Pipinias
IPC分类号： B01L3/00
CPC分类号： B01L9/00 , B01L3/5023 , B01L3/505 , B01L2200/027 , B01L2300/069 , G01N1/02 , G01N2001/028 , G01N2035/00356
摘要： The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection cmember having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.
摘要翻译： 本发明的领域涉及使用干燥固体储存和转移介质的受控转移生物收集装置和用于以适于储存和/或随后分析的形式收集目的生物材料（遗传或蛋白质材料）的方法 。 具体地，本发明提供一种采样装置，其通过保持存储介质和具有分析物收集表面的可移动的样品收集组件来控制生物样品向存储介质的转移。 本发明还提供了不仅用于将生物分析物储存在该收集装置上的方法，而且还用于使用适合于自动分析系统的方法分析储存的生物分析物的方法。
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2.发明申请CONTROLLED TRANSFER BIOLOGICAL SAMPLE COLLECTION DEVICES AND METHODS OF USING SUCH DEVICES 有权控制转移生物样品采集装置和使用这种装置的方法公开(公告)号：US20100106057A1
公开(公告)日：2010-04-29
申请号：US12449603
申请日：2008-02-15
申请人： Michael A. Harvey , Breck O. Parker , Stevan Paul Tortorella , Elizabeth A. Moran , John Pipinias
发明人： Michael A. Harvey , Breck O. Parker , Stevan Paul Tortorella , Elizabeth A. Moran , John Pipinias
IPC分类号： A61B10/00
CPC分类号： B01L9/00 , B01L3/5023 , B01L3/505 , B01L2200/027 , B01L2300/069 , G01N1/02 , G01N2001/028 , G01N2035/00356
摘要： The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.
摘要翻译： 本发明的领域涉及使用干燥固体储存和转移介质的受控转移生物收集装置和用于以适于储存和/或随后分析的形式收集目的生物材料（遗传或蛋白质材料）的方法 。 具体地，本发明提供一种采样装置，其通过保持存储介质和具有分析物收集表面的可移动样品收集构件来控制生物样品向存储介质的转移。 本发明还提供了不仅用于将生物分析物储存在该收集装置上的方法，而且还用于使用适合于自动分析系统的方法分析储存的生物分析物的方法。
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3.发明授权Controlled transfer biological sample collection devices and methods of using such devices 有权受控转移生物样品收集装置和使用这种装置的方法公开(公告)号：US07748283B2
公开(公告)日：2010-07-06
申请号：US11707313
申请日：2007-02-16
IPC分类号： B01L3/00
CPC分类号： B01L9/00 , B01L3/5023 , B01L3/505 , B01L2200/027 , B01L2300/069 , G01N1/02 , G01N2001/028 , G01N2035/00356
摘要： The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.
摘要翻译： 本发明的领域涉及使用干燥固体储存和转移介质的受控转移生物收集装置和用于以适于储存和/或随后分析的形式收集目的生物材料（遗传或蛋白质材料）的方法 。 具体地，本发明提供一种采样装置，其通过保持存储介质和具有分析物收集表面的可移动样品收集构件来控制生物样品向存储介质的转移。 本发明还提供了不仅用于将生物分析物储存在该收集装置上的方法，而且还用于使用适合于自动分析系统的方法分析储存的生物分析物的方法。
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4.发明申请Controlled transfer biological sample collection devices and methods of using such devices 有权受控转移生物样品收集装置和使用这种装置的方法公开(公告)号：US20080196517A1
公开(公告)日：2008-08-21
申请号：US11707313
申请日：2007-02-16
申请人： Michael A. Harvey , Breck O. Parker , Stevan P. Tortorella , Elizabeth A. Moran , John Pipinias
发明人： Michael A. Harvey , Breck O. Parker , Stevan P. Tortorella , Elizabeth A. Moran , John Pipinias
CPC分类号： B01L9/00 , B01L3/5023 , B01L3/505 , B01L2200/027 , B01L2300/069 , G01N1/02 , G01N2001/028 , G01N2035/00356
摘要： The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.
摘要翻译： 本发明的领域涉及使用干燥固体储存和转移介质的受控转移生物收集装置和用于以适于储存和/或随后分析的形式收集目的生物材料（遗传或蛋白质材料）的方法 。 具体地，本发明提供一种采样装置，其通过保持存储介质和具有分析物收集表面的可移动样品收集构件来控制生物样品向存储介质的转移。 本发明还提供了不仅用于将生物分析物储存在该收集装置上的方法，而且还用于使用适合于自动分析系统的方法分析储存的生物分析物的方法。
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5.发明授权Methods and devices for collecting and storing clinical samples for genetic analysis 失效用于收集和存储用于遗传分析的临床样品的方法和装置公开(公告)号：US06168922A
公开(公告)日：2001-01-02
申请号：US09255151
申请日：1999-02-22
IPC分类号： C12Q168
CPC分类号： C12Q1/6806 , B01J2219/00639 , B01J2219/00722 , C12N15/1003 , C40B40/06 , C12Q2565/625 , C12Q2527/127
摘要： The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization, primarily by conventional amplification methods. The present invention can be used to collect, store, or purify nucleic acids either from a biological source other than untreated whole blood, the biological source having naturally occurring nucleic acid amplification inhibitors present, (including either a buccal swab, cerebrospinal fluid, feces, lymphatic fluid, a plasma sample, a saliva sample, a serum sample, urine, or a suspension of cells or viruses), or from a treated whole blood source that has naturally occurring nucleic acid amplification inhibitors present, as well as added blood stabilization components that also inhibit nucleic acid amplification. More importantly, these nucleic acids can be released after collection or storage in a manner that enables them to be amplified by conventional techniques such as polymerase chain reaction. In particular, an absorbent material that does not bind nucleic acids irreversibly is impregnated with a chaotropic salt. A biological source sample is contacted with the impregnated absorbent material. Any nucleic acids present in the biological source can be either eluted or resolubilized off the absorbent material.
摘要翻译： 本发明涉及用于从流体样品中收集，储存和纯化来自流体样品的核酸的装置和方法，用于随后的遗传表征，主要通过常规的扩增方法。 本发明可用于从除未经处理的全血之外的生物来源收集，储存或纯化核酸，所述生物来源具有天然存在的核酸扩增抑制剂（包括颊拭子，脑脊液，粪便， 淋巴液，血浆样品，唾液样品，血清样品，尿液或细胞或病毒的悬浮液）或来自具有天然存在的核酸扩增抑制剂的处理的全血源，以及添加的血液稳定化成分 这也抑制核酸扩增。 更重要的是，这些核酸可以在收集或储存之后以能够通过常规技术如聚合酶链反应扩增的方式被释放。 特别地，不结合核酸的吸收材料不可逆地浸渍有离液盐。 生物源样品与浸渍的吸收材料接触。 存在于生物来源中的任何核酸都可以从吸收材料中洗脱或再溶解。
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6.发明授权Methods and devices for collecting and storing clinical samples for genetic analysis 失效用于收集和存储用于遗传分析的临床样品的方法和装置
公开(公告)号：US5939259A
公开(公告)日：1999-08-17
申请号：US835614
申请日：1997-04-09
CPC分类号： C12Q1/6806 , C12N15/1003 , B01J2219/00639 , B01J2219/00722 , C40B40/06
摘要： The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization, primarily by conventional amplification methods. The present invention can be used to collect, store, or purify nucleic acids from a treated whole blood source that has naturally occurring nucleic acid amplification inhibitors present, as well as added blood stabilization components that also inhibit nucleic acid amplification. More importantly, these nucleic acids can be released after collection or storage in a manner that enables them to be amplified by conventional techniques such as polymerase chain reaction. In particular, an absorbent material that does not bind nucleic acids irreversibly is impregnated with a chaotropic salt. A biological source sample is contacted with the impregnated absorbent material. Any nucleic acids present in the biological source can be either eluted or resolubilized off the absorbent material.
摘要翻译： 本发明涉及用于从流体样品中收集，储存和纯化来自流体样品的核酸的装置和方法，用于随后的遗传表征，主要通过常规的扩增方法。 本发明可用于从存在天然存在的核酸扩增抑制剂的经处理的全血源收集，储存或纯化核酸，以及还抑制核酸扩增的添加的血液稳定化成分。 更重要的是，这些核酸可以在收集或储存之后以能够通过常规技术如聚合酶链反应扩增的方式被释放。 特别地，不结合核酸的吸收材料不可逆地浸渍有离液盐。 生物源样品与浸渍的吸收材料接触。 存在于生物来源中的任何核酸都可以从吸收材料中洗脱或再溶解。
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7.发明授权Method and devices for delivery of substrate for the detection of enzyme-linked, membrane-based binding assays 失效用于检测酶连接的基于膜的结合测定的底物的递送方法和装置
公开(公告)号：US5382516A
公开(公告)日：1995-01-17
申请号：US945097
申请日：1992-09-15
IPC分类号： C12P1/00 , G01N33/545 , G01N33/548 , C12Q1/26 , C12Q1/34 , G01N21/77
CPC分类号： C12P1/00 , G01N33/545 , G01N33/548 , Y10S436/807
摘要： The invention provides a method for supplying an enzyme substrate to a membrane-based, enzyme-linked reaction, comprising providing an open pore, high liquid retention capacity material impregnated with a predetermined amount of a substrate for the enzyme; and contacting the material with a membrane containing the enzyme-linked reaction under conditions which permit diffusion of the enzyme substrate to sites on the membrane containing the enzyme linked reaction. The invention further provides devices for membrane-based enzyme-linked reactions comprising a porous material impregnated with a predetermined amount of a substrate for the enzyme, wherein the porous material is paper, glass fiber paper, stainless steel mesh, woven and nonwoven nylon, polyester, polyethylene, polypropylene, or fluorocarbon polymers having a porosity ranging from about 5 microns to 5000 microns; and a microporous membrane of cellulose or a cellulose derivative, nylon, polysulfone, polypropylene, PTFE, or PVDF having a porosity ranging from about 0.05 microns to about 12 microns.
摘要翻译： 本发明提供了一种将酶底物提供给基于膜的酶联反应的方法，包括提供用预定量的酶底物浸渍的开孔，高液体保持能力的材料; 并在允许酶底物扩散到含有酶连接反应的膜上的位点的条件下使材料与含有酶联反应的膜接触。 本发明还提供了用于基于膜的酶联反应的装置，其包括浸渍有预定量的用于酶的底物的多孔材料，其中多孔材料是纸，玻璃纤维纸，不锈钢网，编织和非织造尼龙，聚酯 ，聚乙烯，聚丙烯或氟碳聚合物，其孔隙率范围为约5微米至5000微米; 以及孔隙率为约0.05微米至约12微米的纤维素或纤维素衍生物的微多孔膜，尼龙，聚砜，聚丙烯，PTFE或PVDF。
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8.发明授权Method for the rapid detection of analytes involving specific binding reactions and the use of light attenuating magnetic particles 失效用于快速检测涉及特异性结合反应的分析物和使用光衰减磁性颗粒的方法
公开(公告)号：US5242837A
公开(公告)日：1993-09-07
申请号：US632991
申请日：1990-12-24
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , Y10S436/80 , Y10S436/805
摘要： The present invention relates to an optical apparatus and a uniaxial method for rapidly measuring spectroscopically labelled specific binding analytes in a reaction assay mixture that contains unbound label without requiring the physical separation of the unbound label from the reaction mixture or sequential reagant additions and incubations. Moreover, the technique is equally applicable to measurements in either serum or whole blood.
摘要翻译： 本发明涉及用于在反应测定混合物中快速测量光谱标记的特异性结合分析物的光学装置和单轴方法，所述反应测定混合物含有未结合的标记而不需要将未结合的标记与反应混合物物理分离或连续的反应物添加和温育。 此外，该技术同样适用于血清或全血中的测量。
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9.发明授权Monoclonal antibodies specific for 330 KD breast tumor antigen and assay using said monoclonal antibodies 失效对330 KD乳腺肿瘤抗原特异性的单克隆抗体和使用所述单克隆抗体的测定
公开(公告)号：US4960716A
公开(公告)日：1990-10-02
申请号：US290852
申请日：1988-12-28
申请人： Michael A. Harvey , Brenda D. Manning , Mary L. Nicholson , Karen L. Travis , Albert A. Luderer
发明人： Michael A. Harvey , Brenda D. Manning , Mary L. Nicholson , Karen L. Travis , Albert A. Luderer
IPC分类号： C07K16/30
CPC分类号： C07K16/3015 , Y10S436/813 , Y10S530/828
摘要： A substantially pure antigen found on normal and benign breast epithelial cell membranes and in breast cancer cells, fused cell hybrids which produce antibodies specific for such antigen, the monoclonal antibodies produced by such fused cell hybrids, a method for detecting the presence of breast cancer in a patient which is based on measuring the concentrations of one or more determinants of such antigen in a patient sample, and a method for either identifying those breast cancer patients whose tumors would respond to estrogen manipulation or determining prognosis based on the degree of differentiation, which method is based on measuring the concentration of an estrogen-modulated determinant of such antigen.
摘要翻译： 在正常和良性乳腺上皮细胞膜和乳腺癌细胞中发现的基本上纯的抗原，产生对这种抗原特异性的抗体的融合细胞杂交体，由这样的融合细胞杂交产生的单克隆抗体，用于检测乳腺癌存在的方法 基于测量患者样品中这样的抗原的一种或多种决定簇的浓度的患者，以及用于鉴定肿瘤将根据分化程度对其进行雌激素操作或确定预后的那些乳腺癌患者的方法，其中 方法是基于测量这种抗原的雌激素调节决定簇的浓度。
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