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16 条记录 (耗时 0.03 秒)

    Yeast-Based Therapeutic for Chronic Hepatitis C Infection
    4.
    发明申请
    Yeast-Based Therapeutic for Chronic Hepatitis C Infection 失效
    基于酵母的慢性丙型肝炎感染治疗

    公开(公告)号：US20100150963A1

    公开(公告)日：2010-06-17

    申请号：US12631039

    申请日：2009-12-04

    申请人： Richard C. Duke ,  Alex Franzusoff ,  Aurelia Haller ,  Thomas H. King

    发明人： Richard C. Duke ,  Alex Franzusoff ,  Aurelia Haller ,  Thomas H. King

    IPC分类号： A61K39/29 ,  A61P31/12

    CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/5252 ,  C07K14/005 ,  C07K2319/35 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.

    摘要翻译： 公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。 本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。 本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。

    Methods and devices for collecting and storing clinical samples for genetic analysis
    5.
    发明授权
    Methods and devices for collecting and storing clinical samples for genetic analysis 失效
    用于收集和存储用于遗传分析的临床样品的方法和装置

    公开(公告)号：US5939259A

    公开(公告)日：1999-08-17

    申请号：US835614

    申请日：1997-04-09

    申请人： Michael A. Harvey ,  Richard D. Kremer ,  Robert L. Burghoff ,  Thomas H. King

    发明人： Michael A. Harvey ,  Richard D. Kremer ,  Robert L. Burghoff ,  Thomas H. King

    IPC分类号： C12N15/10 ,  C12Q1/68 ,  C40B40/06 ,  C07H21/02 ,  C07K1/00 ,  C12N1/08

    CPC分类号： C12Q1/6806 ,  C12N15/1003 ,  B01J2219/00639 ,  B01J2219/00722 ,  C40B40/06

    摘要： The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization, primarily by conventional amplification methods. The present invention can be used to collect, store, or purify nucleic acids from a treated whole blood source that has naturally occurring nucleic acid amplification inhibitors present, as well as added blood stabilization components that also inhibit nucleic acid amplification. More importantly, these nucleic acids can be released after collection or storage in a manner that enables them to be amplified by conventional techniques such as polymerase chain reaction. In particular, an absorbent material that does not bind nucleic acids irreversibly is impregnated with a chaotropic salt. A biological source sample is contacted with the impregnated absorbent material. Any nucleic acids present in the biological source can be either eluted or resolubilized off the absorbent material.

    摘要翻译： 本发明涉及用于从流体样品中收集，储存和纯化来自流体样品的核酸的装置和方法，用于随后的遗传表征，主要通过常规的扩增方法。 本发明可用于从存在天然存在的核酸扩增抑制剂的经处理的全血源收集，储存或纯化核酸，以及还抑制核酸扩增的添加的血液稳定化成分。 更重要的是，这些核酸可以在收集或储存之后以能够通过常规技术如聚合酶链反应扩增的方式被释放。 特别地，不结合核酸的吸收材料不可逆地浸渍有离液盐。 生物源样品与浸渍的吸收材料接触。 存在于生物来源中的任何核酸都可以从吸收材料中洗脱或再溶解。

    Yeast-based therapeutic for chronic hepatitis C infection
    8.
    发明授权
    Yeast-based therapeutic for chronic hepatitis C infection 失效
    基于酵母的慢性丙型肝炎感染治疗

    公开(公告)号：US07439042B2

    公开(公告)日：2008-10-21

    申请号：US11254252

    申请日：2005-10-18

    申请人： Richard C. Duke ,  Alex Franzusoff ,  Aurelia Haller ,  Thomas H. King

    发明人： Richard C. Duke ,  Alex Franzusoff ,  Aurelia Haller ,  Thomas H. King

    IPC分类号： C12N15/33

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/523 ,  A61K2039/5252 ,  A61K2039/55516 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.

    摘要翻译： 公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。 本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。 本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。

    Methods and devices for collecting and storing clinical samples for genetic analysis
    9.
    发明授权
    Methods and devices for collecting and storing clinical samples for genetic analysis 失效
    用于收集和存储用于遗传分析的临床样品的方法和装置

    公开(公告)号：US06168922A

    公开(公告)日：2001-01-02

    申请号：US09255151

    申请日：1999-02-22

    申请人： Michael A. Harvey ,  Richard D. Kremer ,  Robert L. Burghoff ,  Thomas H. King

    发明人： Michael A. Harvey ,  Richard D. Kremer ,  Robert L. Burghoff ,  Thomas H. King

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6806 ,  B01J2219/00639 ,  B01J2219/00722 ,  C12N15/1003 ,  C40B40/06 ,  C12Q2565/625 ,  C12Q2527/127

    摘要： The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization, primarily by conventional amplification methods. The present invention can be used to collect, store, or purify nucleic acids either from a biological source other than untreated whole blood, the biological source having naturally occurring nucleic acid amplification inhibitors present, (including either a buccal swab, cerebrospinal fluid, feces, lymphatic fluid, a plasma sample, a saliva sample, a serum sample, urine, or a suspension of cells or viruses), or from a treated whole blood source that has naturally occurring nucleic acid amplification inhibitors present, as well as added blood stabilization components that also inhibit nucleic acid amplification. More importantly, these nucleic acids can be released after collection or storage in a manner that enables them to be amplified by conventional techniques such as polymerase chain reaction. In particular, an absorbent material that does not bind nucleic acids irreversibly is impregnated with a chaotropic salt. A biological source sample is contacted with the impregnated absorbent material. Any nucleic acids present in the biological source can be either eluted or resolubilized off the absorbent material.

    摘要翻译： 本发明涉及用于从流体样品中收集，储存和纯化来自流体样品的核酸的装置和方法，用于随后的遗传表征，主要通过常规的扩增方法。 本发明可用于从除未经处理的全血之外的生物来源收集，储存或纯化核酸，所述生物来源具有天然存在的核酸扩增抑制剂（包括颊拭子，脑脊液，粪便， 淋巴液，血浆样品，唾液样品，血清样品，尿液或细胞或病毒的悬浮液）或来自具有天然存在的核酸扩增抑制剂的处理的全血源，以及添加的血液稳定化成分 这也抑制核酸扩增。 更重要的是，这些核酸可以在收集或储存之后以能够通过常规技术如聚合酶链反应扩增的方式被释放。 特别地，不结合核酸的吸收材料不可逆地浸渍有离液盐。 生物源样品与浸渍的吸收材料接触。 存在于生物来源中的任何核酸都可以从吸收材料中洗脱或再溶解。