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37 条记录 (耗时 0.034 秒)

    Aminoindan derivatives
    1.
    发明授权
    Aminoindan derivatives 有权
    氨基茚衍生物

    公开(公告)号：US06538025B2

    公开(公告)日：2003-03-25

    申请号：US09944912

    申请日：2001-08-31

    申请人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B.H. Youdim

    发明人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B.H. Youdim

    IPC分类号： A61K3127

    CPC分类号： C07C271/56 ,  C07C271/24 ,  C07C271/44 ,  C07C271/58 ,  C07C333/04 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10

    摘要： This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R3 and R4 are each independently hydrogen, C1-6 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及下式的化合物：其中当a为0时，b为1或2; 当a为1时，b为1，m为0-3，X为O或S，Y为卤素，R1为氢C1-4烷基，R2为氢，C1-4烷基或任选取代的炔丙基，R3和 R 4各自独立地为氢，C 1-6烷基，C 6-12芳基，各自任选取代的C 6-12芳烷基。本发明还涉及这些化合物用于治疗抑郁症，注意力缺陷（ADD），注意力缺陷和多动症 疾病（ADHD），Tourette综合征，阿尔茨海默病和其他痴呆症如老年性痴呆，帕金森氏型痴呆，血管性痴呆和路易体痴呆。本发明还涉及包含治疗有效量的上述定义的药物组合物 化合物和药学上可接受的载体。

    Phenylethylamine derivatives
    2.
    发明授权
    Phenylethylamine derivatives 失效
    苯乙胺衍生物

    公开(公告)号：US06251938B1

    公开(公告)日：2001-06-26

    申请号：US09335555

    申请日：1999-06-18

    申请人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    发明人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    IPC分类号： A61K3127

    CPC分类号： C07C271/42 ,  C07C271/56

    摘要： This invention is directed to compounds of the following formula: wherein m is from 0-4; X is O or S; Y is halogeno; R1 is hydrogen or C1-4 alkyl; R2 is hydrogen, C1-4 alkyl or optionally substituted propargyl; and R3 and R4 are each independently hydrogen, C1-8 alkyl, C6-12 aryl, C6-12 cycloalkyl or C6-12 aralkyl, R5 is hydrogen or C1-4 alkyl; and pharmaceutically acceptable salts thereof, provided that when X is O, R2 is optionally substituted propargyl. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及下式的化合物：其中m为0-4; X是O或S; Y为卤素; R1是氢或C1-4烷基; R2是氢，C1-4烷基或任选取代的炔丙基; 并且R 3和R 4各自独立地为氢，C 1-8烷基，C 6-12芳基，C 6-12环烷基或C 6-12芳烷基，R 5为氢或C 1-4烷基; 其中X为O时，R2为任选取代的炔丙基。本发明还涉及这些化合物用于治疗抑郁症，注意力缺陷症（ADD），注意力缺陷和多动症（ADHD）的用途， Tourette综合征，阿尔茨海默病和其他痴呆症如老年性痴呆，帕金森氏型痴呆，血管性痴呆和路易体痴呆。本发明还涉及一种药物组合物，其包含治疗有效量的上述化合物和药学上可接受的 载体

    Aminoindan derivatives
    3.
    发明授权
    Aminoindan derivatives 有权
    氨基茚衍生物

    公开(公告)号：US06462222B1

    公开(公告)日：2002-10-08

    申请号：US09944850

    申请日：2001-08-31

    申请人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    发明人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    IPC分类号： C07C26100

    CPC分类号： C07C271/56 ,  C07C271/24 ,  C07C271/44 ,  C07C271/58 ,  C07C333/04 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10

    摘要： This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is 0 or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R1 and R4 are each independently hydrogen, C1-6 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome. Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及下式的化合物：其中当a为0时，b为1或2; 当a为1时，b为1，m为0-3，X为0或S，Y为卤素，R1为氢C1-4烷基，R2为氢，C1-4烷基或任选取代的炔丙基，R1和 R 4各自独立地为氢，C 1-6烷基，C 6-12芳基，各自任选取代的C 6-12芳烷基。本发明还涉及这些化合物用于治疗抑郁症，注意力缺陷（ADD），注意力缺陷和多动症 多动症（ADHD），Tourette综合征。 阿尔茨海默病和其他痴呆症如老年性痴呆，帕金森氏型痴呆，血管性痴呆和路易体痴呆。本发明还涉及包含治疗有效量的上述化合物和药学上可接受的载体的药物组合物。

    Aminoindan derivatives
    4.
    发明授权
    Aminoindan derivatives 有权
    氨基茚衍生物

    公开(公告)号：US06303650B1

    公开(公告)日：2001-10-16

    申请号：US09336493

    申请日：1999-06-18

    申请人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    发明人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    IPC分类号： A61K3127

    CPC分类号： C07C271/56 ,  C07C271/24 ,  C07C271/44 ,  C07C271/58 ,  C07C333/04 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10

    摘要： This invention is directed to compounds of the following formula wherein when a is O, b is 1 or 2; when a is 1, b is 1, m is from 0-3 X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R3 and R4 are each independently hydrogen, C1-8 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADC), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia. This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及当a是O，b是1或2时，下列化合物的化合物： 当a为1时，b为1，m为0-3 X为O或S，Y为卤素，R1为氢C1-4烷基，R2为氢，C1-4烷基或任选取代的炔丙基，R3和R4 各自独立地为氢，C 1-8烷基，C 6-12芳基，各自任选取代的C 6-12芳烷基。本发明还涉及这些化合物用于治疗抑郁症，注意力缺陷（ADC），注意力缺陷和多动障碍 （ADHD），Tourette综合征，阿尔茨海默氏病和其他痴呆症如老年性痴呆，帕金森氏型痴呆，血管性痴呆和路易体痴呆。本发明还涉及一种药物组合物，其包含治疗有效量的上述定义的化合物 和药学上可接受的载体。

    Aminoindan derivatives
    5.
    再颁专利
    Aminoindan derivatives 有权
    氨基茚衍生物

    公开(公告)号：USRE39616E1

    公开(公告)日：2007-05-08

    申请号：US11091008

    申请日：2005-03-25

    申请人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    发明人： Michael Chorev ,  Tamar Goren ,  Yacov Herzig ,  Jeffrey Sterling ,  Marta Weinstock-Rosin ,  Moussa B. H. Youdim

    IPC分类号： A61K31/27

    CPC分类号： C07C271/56 ,  C07C271/24 ,  C07C271/44 ,  C07C271/58 ,  C07C333/04 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10

    摘要： This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R3 and R4 are each independently hydrogen, C1-6 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted. This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome, Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia.This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及下式的化合物：其中当a为0时，b为1或2; 当a为1时，b为1，m为0-3，X为O或S，Y为卤素，R 1为氢，C 1-4烷基， R 2是氢，C 1-4烷基或任选取代的炔丙基，R 3和R 4是 各自独立地为氢，C 1-6烷基，C 6-12芳基，C 6-12芳烷基，各自任选取代。 本发明还涉及这些化合物用于治疗抑郁症，注意力缺陷症（ADD），注意力缺陷和多动障碍（ADHD），图雷特氏综合征，阿尔茨海默病和其他痴呆症如老年性痴呆，帕金森氏型痴呆， 血管性痴呆和路易体痴呆。 本发明进一步涉及包含治疗有效量的上述化合物和药学上可接受的载体的药物组合物。

    2-Adamantyl hydrazines and biocidal compositions thereof
    9.
    发明授权
    2-Adamantyl hydrazines and biocidal compositions thereof 失效
    2-金刚烷基肼及其杀生物组合物

    公开(公告)号：US4254128A

    公开(公告)日：1981-03-03

    申请号：US963113

    申请日：1978-11-22

    申请人： Ben-Zion Weiner ,  Raul Suchi ,  Jeffrey Sterling ,  Haim Yellin

    发明人： Ben-Zion Weiner ,  Raul Suchi ,  Jeffrey Sterling ,  Haim Yellin

    IPC分类号： A61K31/15 ,  A01N45/00 ,  A61K31/185 ,  A61K31/195 ,  A61K31/215 ,  A61K31/445 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C07C67/00 ,  C07C241/00 ,  C07C243/20 ,  C07C243/22 ,  C07D213/77 ,  C07D215/28 ,  C07D215/42 ,  C07D233/80 ,  C07D295/22 ,  C07D295/30 ,  C07D327/06 ,  A61K31/40

    CPC分类号： C07D213/77 ,  C07C243/00 ,  C07D215/42 ,  C07D233/80 ,  C07D295/30

    摘要： The invention provides novel 2-adamantyl hydrazine derivatives of the general formula A ##STR1## In this formula R.sub.1 is hydrogen or a lower alkyl group of 1-4 carbon atoms; R.sub.2 and R.sub.3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical.The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.Several methods of preparation of the new compounds are described.The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.

    摘要翻译： 本发明提供了通式为A的新型2-金刚烷基肼衍生物。在该式中，R 1是氢或1-4个碳原子的低级烷基; R2和R3相同或不同，各自为氢，未取代或取代的基团为1-4个碳原子的低级烷基，2-4个碳原子的低级链烷酸基团或其低级烷基酯，金刚烷基，芳基 ，其中烷基部分具有1-4个碳原子的芳烷基或芳族特征的未取代或取代的杂环基; 或R 2和R 3与它们所连接的氮原子一起形成未取代或取代的非芳族环状基团。 本发明进一步提供上述化合物的药学上可接受的酸加成盐。 描述了几种制备新化合物的方法。 根据本发明的新化合物具有有价值的抗真菌（人和植物），抗病毒，抗原虫和抗微生物特性。