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公开(公告)号：US08597944B2
公开(公告)日：2013-12-03
申请号：US13172027
申请日：2011-06-29
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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2.发明申请Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof 审中-公开基因完整诱导多能细胞或转分化细胞及其生产方法公开(公告)号：US20110286978A1
公开(公告)日：2011-11-24
申请号：US12787175
申请日：2010-05-25
申请人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
发明人： Irina V. Klimanskaya , Shi-Jiang Lu , Robert Lanza , Michael D. West , Karen B. Chapman , Roy Geoffrey Sargent , Raymond Page , Tanja Dominko , Christopher Malcuit
CPC分类号： C12N5/0696 , C07K2319/10 , C07K2319/60 , C07K2319/71 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608
摘要： The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells.
摘要翻译： 本公开涉及用于去分化和转分化受体细胞，优选人体细胞的方法。 这些方法使不希望的基因组序列改变的风险最小化。 这些方法采用重编程因子，其可以单独使用或以某种组合使用。 这些方法特别适用于基于细胞的疗法，细胞系的建立以及转基因细胞的生产。
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公开(公告)号：US20110256622A1
公开(公告)日：2011-10-20
申请号：US13172027
申请日：2011-06-29
IPC分类号： C12N5/073 , C12N5/0735 , C12N5/02
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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公开(公告)号：US07910369B2
公开(公告)日：2011-03-22
申请号：US11211174
申请日：2005-08-24
CPC分类号： C12N5/0606 , C12N15/873 , C12N2502/04
摘要： The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
摘要翻译： 本发明提供了用于培养动物多能干细胞及其分化的后代细胞，组织和器官以及非人动物胚胎和胎儿的方法。
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5.发明申请Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy 有权用于鉴定分化诱导剂的筛选测定和用于细胞治疗的分化细胞的产生公开(公告)号：US20090253588A1
公开(公告)日：2009-10-08
申请号：US12322612
申请日：2009-02-03
申请人： Michael D. West , Raymond Page , Hans Scholer , Karen B. Chapman
发明人： Michael D. West , Raymond Page , Hans Scholer , Karen B. Chapman
CPC分类号： G01N33/5023 , C12N5/0652 , C12N5/0657 , C12N5/069 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/23 , C12N2501/998 , C12N2506/02 , C12N2506/03 , C12N2506/04 , C12Q1/6888 , C12Q2600/158 , G01N33/5011 , G01N33/5061 , G01N33/5073 , G01N33/5091 , G01N2333/475 , G01N2333/52
摘要： The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.
摘要翻译： 本发明涉及同时或临时地筛选生长因子，粘附分子，免疫刺激分子，细胞外基质组分和其它材料，用于诱导多能干细胞和多能干细胞的定向分化的能力。
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6.发明申请METHODS FOR IDENTIFYING LIGANDS FOR STEM CELLS AND CELLS DERIVED THEREFROM 审中-公开用于识别干细胞和其衍生细胞的配体的方法公开(公告)号：US20090215640A1
公开(公告)日：2009-08-27
申请号：US11915696
申请日：2006-05-26
申请人： Michael D. West , Karen B. Chapman , David Larocca
发明人： Michael D. West , Karen B. Chapman , David Larocca
CPC分类号： G01N33/56966
摘要： The present invention provides methods for the identification of novel ligands to pluripotent stem cells such as human embryonic stem cells, human embryo-derived cells, and from cells differentiated from such cells, and the use of such ligands in identifying differentiation conditions, purifying cells, and for eliminating such cells from mixtures of varied cell types. The invention also provides methods for the identification of target progenitor cells and cells identified thereby.
摘要翻译： 本发明提供用于鉴定多能干细胞（例如人胚胎干细胞，人胚胎源细胞）和从这些细胞分化的细胞的新配体的方法，以及这些配体在鉴定分化条件，纯化细胞， 并且用于从不同细胞类型的混合物中消除这种细胞。 本发明还提供用于鉴定由此鉴定的靶祖细胞和细胞的方法。
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公开(公告)号：US09334478B2
公开(公告)日：2016-05-10
申请号：US12322612
申请日：2009-02-03
CPC分类号： G01N33/5023 , C12N5/0652 , C12N5/0657 , C12N5/069 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/23 , C12N2501/998 , C12N2506/02 , C12N2506/03 , C12N2506/04 , C12Q1/6888 , C12Q2600/158 , G01N33/5011 , G01N33/5061 , G01N33/5073 , G01N33/5091 , G01N2333/475 , G01N2333/52
摘要： The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.
摘要翻译： 本发明涉及同时或临时地筛选生长因子，粘附分子，免疫刺激分子，细胞外基质组分和其它材料，用于诱导多能干细胞和多能干细胞的定向分化的能力。
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公开(公告)号：US08685386B2
公开(公告)日：2014-04-01
申请号：US13384289
申请日：2010-07-16
申请人： Michael D. West , Hal Sternberg , Karen B. Chapman
发明人： Michael D. West , Hal Sternberg , Karen B. Chapman
CPC分类号： A61K31/734 , A61K9/0024 , A61K31/722 , A61K31/728 , A61K31/729 , A61K31/737 , A61K35/32 , A61K38/363 , A61K38/39 , A61K47/36 , C12N5/0655 , C12N2506/02 , A61K2300/00
摘要： Aspects of the present invention include methods and compositions related to the production, identification and use of embryonic progenitor cell lines that are capable of undergoing chondrogenesis. A number of exemplary chondrogenic cell lines derived from primordial stem cells are disclosed. The chondrogenic cell lines described herein are robust, can expand for >40 passages, and have site-specific purity, thus providing for compositions and methods of producing diverse cartilage types with unique molecular compositions for use in research and therapy.
摘要翻译： 本发明的方面包括与能够进行软骨形成的胚胎祖细胞系的生产，鉴定和使用相关的方法和组合物。 公开了一些衍生自原始干细胞的示例性软骨形成细胞系。 本文描述的软骨形成细胞系是稳健的，可以扩增> 40代，并且具有位点特异性的纯度，从而提供用于研究和治疗的具有独特分子组成的多种软骨类型的组合物和方法。
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公开(公告)号：US20120171171A1
公开(公告)日：2012-07-05
申请号：US13384289
申请日：2010-07-16
申请人： Michael D. West , Hal Sternberg , Karen B. Chapman
发明人： Michael D. West , Hal Sternberg , Karen B. Chapman
CPC分类号： A61K31/734 , A61K9/0024 , A61K31/722 , A61K31/728 , A61K31/729 , A61K31/737 , A61K35/32 , A61K38/363 , A61K38/39 , A61K47/36 , C12N5/0655 , C12N2506/02 , A61K2300/00
摘要： Aspects of the present invention include methods and compositions related to the production, identification and use of embryonic progenitor cell lines that are capable of undergoing chondrogenesis. A number of exemplary chondrogenic cell lines derived from primordial stem cells are disclosed. The chondrogenic cell lines described herein are robust, can expand for >40 passages, and have site-specific purity, thus providing for compositions and methods of producing diverse cartilage types with unique molecular compositions for use in research and therapy.
摘要翻译： 本发明的方面包括与能够进行软骨形成的胚胎祖细胞系的生产，鉴定和使用相关的方法和组合物。 公开了一些衍生自原始干细胞的示例性软骨形成细胞系。 本文描述的软骨形成细胞系是稳健的，可以扩增> 40代，并且具有位点特异性的纯度，从而提供用于研究和治疗的具有独特分子组成的多种软骨类型的组合物和方法。
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公开(公告)号：US20110143441A1
公开(公告)日：2011-06-16
申请号：US12856043
申请日：2010-08-13
IPC分类号： C12N15/87 , C12N5/071 , C12N5/078 , C12N5/0793
CPC分类号： C12N5/0606 , A01K67/0271 , C12N5/0676 , C12N5/16 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/606 , C12N2501/72 , C12N2506/00 , C12N2506/11 , C12Q1/6881 , C12Q2600/158
摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
摘要翻译： 本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法，以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。 更具体地说，本发明涉及用于鉴定，扩增培养和配制哺乳动物多能干细胞和分化细胞的方法，所述哺乳动物多能干细胞和分化细胞在成年人的细胞基因表达模式中不同，因此提供独特的特征，其提供新颖的治疗策略 退行性疾病的治疗。
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