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1.发明申请BIOMATERIAL BASED ON ALIGNED FIBERS, ARRANGED IN A GRADIENT INTERFACE, WITH MECHANICAL REINFORCEMENT FOR TRACHEAL REGENERATION AND REPAIR 审中-公开基于对准纤维的生物材料，安装在梯度界面，机械加固用于河道再生和修复公开(公告)号：US20150230918A1
公开(公告)日：2015-08-20
申请号：US14239049
申请日：2012-08-15
申请人： Michael Detamore , Lindsey Ott , Robert Weatherly
发明人： Michael Detamore , Lindsey Ott , Robert Weatherly
CPC分类号： A61F2/20 , A61F2/04 , A61F2002/046 , A61F2210/0076 , A61F2250/0018 , A61F2250/0028 , A61L27/10 , A61L27/14 , A61L27/18 , A61L27/34 , A61L2300/414 , A61L2420/04 , A61L2420/08 , A61L2430/22 , C08L67/04
摘要： An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers.
摘要翻译： 植入物可以包括与纤维体相关联的多个聚合物纤维。 纤维体能够成形为适合气管缺损并且能够通过缝线或通过生物粘附固定在适当位置。 纤维体可以具有对准的纤维（例如，周向排列）或未对准的纤维。 纤维体可以电纺丝。 纤维体可以具有穿过纤维体的至少一部分的第一梯度分布的第一特征。 纤维体可以包括一个或多个可以嵌入多根纤维中的结构加强构件，例如带状结构增强构件。 纤维体可以包括一个或多个结合的增强部件，其结合到具有液体聚合物作为粘合剂的纤维上，该液体聚合物具有基本相似的纤维组成。
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公开(公告)号：US20090130755A1
公开(公告)日：2009-05-21
申请号：US11985707
申请日：2007-11-16
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（“PEG-DA”）和甲基丙烯酸2-羟乙酯（“HEMA”）。
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公开(公告)号：US08293510B2
公开(公告)日：2012-10-23
申请号：US11985707
申请日：2007-11-16
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（PEG-DA）和甲基丙烯酸2-羟乙酯（HEMA）。
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4.发明申请MICROSPHERE-BASED MATERIALS WITH PREDEFINED 3D SPATIAL AND TEMPORAL CONTROL OF BIOMATERIALS, POROSITY AND/OR BIOACTIVE SIGNALS 有权具有预测的生物材料，多孔性和/或生物信号的3D空间和时间控制的基于微孔的材料公开(公告)号：US20090098183A1
公开(公告)日：2009-04-16
申请号：US12248530
申请日：2008-10-09
申请人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
发明人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
CPC分类号： C12N5/0075 , C12N2533/10 , C12N2533/40
摘要： A tissue engineering scaffold for growing cells can include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
摘要翻译： 用于生长细胞的组织工程支架可以包括连接在一起以形成三维基质的多个生物相容性微球。 基质可以包括用于生长细胞的多个孔。 生物相容性微球可以包括第一组和第二组微球。 第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。 第二组微球可以具有不同于第一特性的第二特性，以及与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。 第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性， 刚度，颜色，辐射透明度，无线电等等。
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公开(公告)号：US20150307837A1
公开(公告)日：2015-10-29
申请号：US14698157
申请日：2015-04-28
IPC分类号： C12N5/0793 , C12N15/113 , A61K35/30 , C07K14/47
CPC分类号： C12N5/062 , A61K35/30 , C12N15/113 , C12N2310/14 , C12N2310/51 , C12N2506/025 , C12N2510/00 , C12N2533/90
摘要： A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells (hWJCs) to increase expression of or biological function of HATH1 so as to transform the hWJCs into MHCs. The method can include; administering a nucleic acid that encodes HATH1 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the hWJCs; administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the WJCs by administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5; nucleic acids are administered includes a sequence of SEQ ID NO: 2, SEQ ID NO: 3, and/or SEQ ID NO: 4.
摘要翻译： 将人类细胞转化为机械感染毛细胞（MHC）的方法，例如耳蜗和前庭器官内部听到的毛细胞，可以包括：引起人类沃顿的果冻细胞（hWJCs）增加HATH1的表达或生物学功能，以便 将hWJCs转化为MHC。 该方法可以包括 向hWJCs施用编码HATH1的核酸; 导致hWJCs中HES1和/或HES5的表达或生物学功能受到抑制; 施用抑制HES1的核酸和/或对hWJC抑制HES5的核酸; 通过施用抑制HES1的核酸和/或抑制HES5的核酸来抑制WJCs中HES1和/或HES5的表达或生物学功能; 核酸被给予包括SEQ ID NO：2，SEQ ID NO：3和/或SEQ ID NO：4的序列。
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6.发明授权Hudrogel network comprising thermally gelling polysaccharide or protein gel encapsulating living cells 有权水凝胶网络包括热胶凝多糖或包封活细胞的蛋白质凝胶公开(公告)号：US08715983B2
公开(公告)日：2014-05-06
申请号：US13603611
申请日：2012-09-05
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（“PEG-DA”）和甲基丙烯酸2-羟乙酯（“HEMA”）。
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7.发明授权公开(公告)号：US09512400B2
公开(公告)日：2016-12-06
申请号：US14698157
申请日：2015-04-28
IPC分类号： A61K35/30 , C12N15/113 , C12N5/0793
CPC分类号： C12N5/062 , A61K35/30 , C12N15/113 , C12N2310/14 , C12N2310/51 , C12N2506/025 , C12N2510/00 , C12N2533/90
摘要： A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells (hWJCs) to increase expression of or biological function of HATH1 so as to transform the hWJCs into MHCs. The method can include; administering a nucleic acid that encodes HATH1 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the hWJCs; administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the WJCs by administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5; nucleic acids are administered includes a sequence of SEQ ID NO: 2, SEQ ID NO: 3, and/or SEQ ID NO: 4.
摘要翻译： 将人类细胞转化为机械感染毛细胞（MHC）的方法，例如耳蜗和前庭器官内部听到的毛细胞，可以包括：引起人类沃顿的果冻细胞（hWJCs）增加HATH1的表达或生物学功能，以便 将hWJCs转化为MHC。 该方法可以包括 向hWJCs施用编码HATH1的核酸; 导致hWJCs中HES1和/或HES5的表达或生物学功能受到抑制; 施用抑制HES1的核酸和/或对hWJC抑制HES5的核酸; 通过施用抑制HES1的核酸和/或抑制HES5的核酸来抑制WJCs中HES1和/或HES5的表达或生物学功能; 核酸被给予包括SEQ ID NO：2，SEQ ID NO：3和/或SEQ ID NO：4的序列。
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8.发明申请公开(公告)号：US20140200678A1
公开(公告)日：2014-07-17
申请号：US14202379
申请日：2014-03-10
申请人： Michael Detamore , Vineet Gupta , Neethu Mohan , Cory Berkland
发明人： Michael Detamore , Vineet Gupta , Neethu Mohan , Cory Berkland
CPC分类号： A61L27/56 , A61L27/10 , A61L27/14 , A61L27/38 , A61L27/40 , A61L27/54 , C12N5/0075 , C12N2533/10 , C12N2533/40
摘要： Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
摘要翻译： 方法可以制备组织工程支架，其包括连接在一起的多个生物相容性核/壳微球形成三维基质。 基质可以包括用于生长细胞的多个孔。 生物相容性微球可以包括第一组和第二组微球。 第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。 第二组微球可以具有不同于第一特性的第二特性，以及与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。 第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性， 刚度，颜色，辐射透明度，无线电等等。
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9.发明授权Method of preparing a tissue engineering scaffold comprising a plurality of microspheres linked together 有权制备包含连接在一起的多个微球的组织工程支架的方法公开(公告)号：US08669107B2
公开(公告)日：2014-03-11
申请号：US13591087
申请日：2012-08-21
申请人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
发明人： Michael Detamore , Milind Singh , Aaron M. Scurto , Cory Berkland
CPC分类号： C12N5/0075 , C12N2533/10 , C12N2533/40
摘要： Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency, radiopaqueness, or the like.
摘要翻译： 方法可以制备组织工程支架，其包括连接在一起的多个生物相容性微球体以形成三维基质。 基质可以包括用于生长细胞的多个孔。 生物相容性微球可以包括第一组和第二组微球。 第一组微球可以具有第一特性，并且相对于三维矩阵具有第一预定空间分布。 第二组微球可以具有不同于第一特性的第二特性，以及与第一预定空间分布相对于三维矩阵不同的第二预定空间分布。 第一和第二特征可以选择组合物，聚合物，粒度，粒度分布，生物活性剂的类型，生物活性剂组合的类型，生物活性剂浓度，生物活性剂的量，生物活性剂释放速率，机械强度，柔韧性， 刚度，颜色，辐射透明度，无线电等等。
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公开(公告)号：US20120328678A1
公开(公告)日：2012-12-27
申请号：US13603611
申请日：2012-09-05
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（PEG-DA）和甲基丙烯酸2-羟乙酯（HEMA）。
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