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公开(公告)号：US08293510B2
公开(公告)日：2012-10-23
申请号：US11985707
申请日：2007-11-16
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（PEG-DA）和甲基丙烯酸2-羟乙酯（HEMA）。
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公开(公告)号：US20090130755A1
公开(公告)日：2009-05-21
申请号：US11985707
申请日：2007-11-16
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（“PEG-DA”）和甲基丙烯酸2-羟乙酯（“HEMA”）。
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公开(公告)号：US20120328678A1
公开(公告)日：2012-12-27
申请号：US13603611
申请日：2012-09-05
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（PEG-DA）和甲基丙烯酸2-羟乙酯（HEMA）。
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4.发明授权Hudrogel network comprising thermally gelling polysaccharide or protein gel encapsulating living cells 有权水凝胶网络包括热胶凝多糖或包封活细胞的蛋白质凝胶公开(公告)号：US08715983B2
公开(公告)日：2014-05-06
申请号：US13603611
申请日：2012-09-05
申请人： Michael Detamore , Stevin H. Gehrke
发明人： Michael Detamore , Stevin H. Gehrke
CPC分类号： C12N5/0012 , A61L27/18 , A61L27/38 , A61L27/3817 , A61L27/52 , C12N2533/30 , C12N2533/76 , C08L71/02
摘要： The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
摘要翻译： 本发明涉及由物理交联的聚合物和包含活性细胞（例如软骨细胞）的化学交联聚合物或物理缠结共聚物组成的水凝胶网络。 在优选的方面，物理交联的聚合物选自热胶凝多糖和蛋白质，例如琼脂糖或明胶，并且化学交联或物理缠结聚合物由水溶性乙烯基单体合成， 作为均聚物或共聚物，例如聚乙二醇二丙烯酸酯（“PEG-DA”）和甲基丙烯酸2-羟乙酯（“HEMA”）。
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公开(公告)号：US6030442A
公开(公告)日：2000-02-29
申请号：US737404
申请日：1996-11-08
CPC分类号： C08J3/075 , C08L1/284 , C08J2301/28
摘要： A microporous, cross-linked, reversibly responsive gel obtainable from a polymeric precursor is disclosed. The microporous gels exhibit a volume change response on the order of seconds, many times faster than nonporous volume change gels of similar dimension. A method of making a microporous, fast response and reversibly responsive gel having a defined pore size and defined strut thickness is also disclosed. The method comprises preparing a polymer solution having a certain initial concentration of polymer precursor, initiating phase separation of the polymer to produce a phase separated state; cross-linking the polymer in its phase separated state or cross-linking the polymer prior in its phase separated state, or both prior to and during its phase separated state, for a certain cross-linking reaction time; and allowing gelation to be completed. Particular uses of the fast response gels are also described. In one embodiment, a method for purifying and concentrating a solute from a solution is described. The method includes the steps of contacting a solution containing the solute with the microporous gel of the invention. Next, the gel is swollen to absorb a portion of the solution and exclude the solute by initiating expansion. This results in a concentrated solution of solute and microporous gel swollen primarily with solution lacking solute.
摘要翻译： PCT No.PCT / US94 / 05400 Sec。 371日期：1996年11月8日 102（e）日期1996年11月8日PCT 1994年5月13日PCT PCT。 公开号WO95 / 31498 日期1995年11月23日公开了一种由聚合物前体获得的微孔，交联，可逆响应的凝胶。 微孔凝胶表现出几秒的体积变化响应，比类似尺寸的无孔体积变化凝胶快许多倍。 还公开了制备具有限定的孔径和限定的支柱厚度的微孔，快速响应和可逆响应性凝胶的方法。 该方法包括制备具有一定初始浓度的聚合物前体的聚合物溶液，引发聚合物的相分离以产生相分离状态; 在相分离状态下交联聚合物或在其相分离状态之前交联聚合物，或在其相分离状态之前和期间将聚合物交联，以获得某些交联反应时间; 并允许凝胶化完成。 还描述了快速反应凝胶的特殊用途。 在一个实施方案中，描述了用于从溶液中提纯和浓缩溶质的方法。 该方法包括使含有溶质的溶液与本发明的微孔凝胶接触的步骤。 接下来，凝胶膨胀以吸收溶液的一部分并通过引发膨胀排除溶质。 这导致溶质和微孔凝胶的浓缩溶液主要溶于不溶于溶液的溶液中。
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公开(公告)号：US6027795A
公开(公告)日：2000-02-22
申请号：US823897
申请日：1997-03-17
CPC分类号： A61L15/32 , A61L15/26 , A61L15/28 , A61L15/425 , C08J9/28 , Y10S264/16 , Y10S264/18 , Y10S502/514 , Y10S521/905 , Y10T428/249954 , Y10T428/249979 , Y10T428/249995
摘要： An absorbent, microporous foam comprising a crosslinked polymer having interconnected fluid cells distributed throughout its mass, wherein the fluid cells have a diameter of between about 0.1 and about 100 .mu.m, and wherein the foam can rapidly absorb at least about twice its dry weight in fluid, is disclosed. Also disclosed is a method for producing such microporous, absorbent foams. In this method: (a) a crosslinkable polymer and a first solvent are mixed to form a stable solution which can be induced to phase separate; (b) the stable solution is induced to phase separate into a polymer concentrated phase and a polymer dilute phase; (c) the polymer is induced to crosslink in the polymer concentrated phase for a predetermined period of time thereby forming a microporous material; and (d) the microporous material is dried to produce the absorbent foam.
摘要翻译： 一种吸收性微孔泡沫，其包含交联的聚合物，其具有分布在其整个质量块中的相互连接的流体细胞，其中流体细胞的直径为约0.1至约100μm，并且其中泡沫可以快速吸收其干重至少约两倍的干重 流体。 还公开了一种生产这种微孔吸收泡沫的方法。 在该方法中：（a）可交联聚合物和第一溶剂混合形成可诱导相分离的稳定溶液; （b）将稳定的溶液诱导相分离成聚合物浓缩相和聚合物稀释相; （c）将聚合物在聚合物浓缩相中诱导交联预定的时间，从而形成微孔材料; 和（d）将微孔材料干燥以产生吸收性泡沫体。
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公开(公告)号：US5603955A
公开(公告)日：1997-02-18
申请号：US276462
申请日：1994-07-18
CPC分类号： A61K9/2054 , A61K9/205 , A61K9/2095 , A61L15/60 , Y10S514/944
摘要： A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting of a biologically active solute (i.e., drug) with:(i) a gel network; (ii) a second protectant polymer that is somewhat immiscible with the gel; and (iii) a protectant salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the protectants to be entrained in the gel. Most preferably, the gel network is a crosslinked gel responsive to a change in an environmental condition to which the gel is exposed.
摘要翻译： 描述了将药物装载到交联聚合物网络中并保护药物免受灭活效果的方法。 该方法包括使生物活性溶质（即药物）与（i）凝胶网络接触的步骤; （ii）与凝胶有些不混溶的第二保护剂聚合物; 和（iii）保护剂盐，在足以使生物活性溶质选择性分配到凝胶中的条件下，保护剂被夹带在凝胶中。 最优选地，凝胶网络是响应凝胶暴露的环境条件的变化的交联凝胶。
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公开(公告)号：US07407671B2
公开(公告)日：2008-08-05
申请号：US10787233
申请日：2004-02-27
CPC分类号： A61K9/0024 , A61K47/38 , A61L29/06 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/00 , A61L2300/258 , C08L1/00 , C08L1/26 , Y10S514/944
摘要： A system for delivering solute to a target location within a mammalian body, the system including a medical device, a thermosensitive cellulose gel structure over the medical device, and a biologically active solute within said gel structure. The gel structure deswells and expels the biologically active solute with an increase in gel temperature. The invention includes a method of delivering solute to a target location, where the method includes the steps of providing a thermosensitive cellulose gel structure, wherein the gel structure is loaded with a solute; positioning the loaded gel structure to the target location; and increasing the temperature of the loaded gel structure.
摘要翻译： 一种用于将溶质输送到哺乳动物体内的目标位置的系统，所述系统包括医疗装置，医疗装置上的热敏纤维素凝胶结构以及所述凝胶结构内的生物活性溶质。 凝胶结构随着凝胶温度的升高而溶解并排出生物活性溶质。 本发明包括将溶质输送到目标位置的方法，其中所述方法包括提供热敏纤维素凝胶结构的步骤，其中所述凝胶结构装载有溶质; 将加载的凝胶结构定位到目标位置; 并增加加载的凝胶结构的温度。
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公开(公告)号：US06733788B2
公开(公告)日：2004-05-11
申请号：US09576714
申请日：2000-05-23
IPC分类号： A61K914
CPC分类号： A61K9/0024 , A61K47/38 , A61L29/06 , A61L29/08 , A61L29/145 , A61L29/16 , A61L2300/00 , A61L2300/258 , C08L1/00 , C08L1/26 , Y10S514/944
摘要： A system for delivering solute to a target location within a mammalian body, the system including a medical device, a thermosensitive cellulose gel structure over the medical device, and a biologically active solute within said gel structure. The gel structure deswells and expels the biologically active solute with an increase in gel temperature. The invention includes a method of delivering solute to a target location, where the method includes the steps of providing a thermosensitive cellulose gel structure, wherein the gel structure is loaded with a solute; positioning the loaded gel structure to the target location; and increasing the temperature of the loaded gel structure.
摘要翻译： 一种用于将溶质输送到哺乳动物体内的目标位置的系统，所述系统包括医疗装置，医疗装置上的热敏纤维素凝胶结构以及所述凝胶结构内的生物活性溶质。 凝胶结构随着凝胶温度的升高而溶解并排出生物活性溶质。 本发明包括将溶质输送到目标位置的方法，其中所述方法包括提供热敏纤维素凝胶结构的步骤，其中所述凝胶结构装载有溶质; 将加载的凝胶结构定位到目标位置; 并增加加载的凝胶结构的温度。
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公开(公告)号：US5573994A
公开(公告)日：1996-11-12
申请号：US242548
申请日：1994-05-13
CPC分类号： A61L15/32 , A61L15/26 , A61L15/28 , A61L15/425 , C08J9/28 , Y10S264/16 , Y10S264/18 , Y10S502/514 , Y10S521/905 , Y10T428/249954 , Y10T428/249979 , Y10T428/249995
摘要： An absorbent, microporous foam comprising a crosslinked polymer having interconnected fluid cells distributed throughout its mass, wherein the fluid cells have a diameter of between about 0.1 and about 100 .mu.m, and wherein the foam can rapidly absorb at least about twice its dry weight in fluid, is disclosed.A method for producing a microporous, absorbent foam is also disclosed. This method comprises the steps of:(a) mixing a cross-linkable polymer and a first solvent to form a stable solution, wherein the stable solution can be induced to phase separate;(b) inducing the stable solution to phase separate into a polymer-concentrated phase and a polymer-dilute phase after a predetermined period of time;(c) inducing crosslinking of said polymer, so that the polymer will crosslink in said concentrated phase for a predetermined period of time during phase separation to thereby form a microporous material; and(d) drying the microporous material to produce the absorbent foam.
摘要翻译： 一种吸收性微孔泡沫，其包含交联的聚合物，其具有分布在其整个质量块中的相互连接的流体细胞，其中流体细胞的直径为约0.1至约100μm，并且其中泡沫可以快速吸收其干重至少约两倍的干重 流体。 还公开了一种用于生产微孔吸收泡沫的方法。 该方法包括以下步骤：（a）将可交联聚合物和第一溶剂混合以形成稳定溶液，其中稳定溶液可诱导相分离; （b）在预定时间段之后诱导稳定的溶液相分离成聚合物浓缩相和聚合物稀释相; （c）诱导所述聚合物的交联，使得聚合物在相分离期间在所述浓缩相中交联预定的时间段，从而形成微孔材料; 和（d）干燥微孔材料以产生吸收性泡沫体。
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