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    Method and apparatus for invasively measuring cardiac output by detecting temperature differences of blood heated by radiation
    4.
    发明授权
    Method and apparatus for invasively measuring cardiac output by detecting temperature differences of blood heated by radiation 失效
    通过检测通过辐射加热的血液的温度差来入侵地测量心输出量的方法和装置

    公开(公告)号：US5954659A

    公开(公告)日：1999-09-21

    申请号：US602916

    申请日：1996-02-16

    申请人： Michael G. Curley ,  William H. Newman

    发明人： Michael G. Curley ,  William H. Newman

    IPC分类号： A61B5/028 ,  A61B5/027 ,  A61B5/026

    CPC分类号： A61B5/028

    摘要： A cardiac output measurement device volumetrically heating a predefined quantity of blood flowing through a heart by arbitrarily applying a containable energy field to the blood using a thermodilution catheter having an emitter that uniformly emits electromagnetic radiation. Blood temperature is measured at the pulmonary artery by a sensor that provides a signal representing the temperature of the mixed blood to a controller. The controller determines the flow rate, or cardiac output, by performing a heat balance analysis based upon the applied power and resultant blood temperature. The cardiac output measurement device includes a catheter having an emitter and, preferably, a temperature sensor located at its distal end. The catheter is coupled to a laser or other energy source capable of generating containable electromagnetic radiation, such as an ultraviolet or microwave energy source. Significantly, for the preferred laser source, the emitter is a diffuser that uniformly emits the laser-generated energy into a predetermined volume of flowing blood. A temperature measuring system of the controller receives temperature signals from the sensor and generates a resultant temporal temperature profile used by a flow estimator to determine the flow rate and generate a power excitation function to control the energy source. The resultant measured flow may also be presented though a user interface.

    摘要翻译： 心输出测量装置使用具有均匀发射电磁辐射的发射体的热稀释导管，通过任意地向血液施加可容纳的能量来体积地加热流过心脏的预定量的血液。 通过传感器在肺动脉处测量血液温度，该传感器将表示混合血液的温度的信号提供给控制器。 控制器通过基于所施加的功率和产生的血液温度执行热平衡分析来确定流速或心输出量。 心脏输出测量装置包括具有发射器的导管，并且优选地，位于其远端处的温度传感器。 导管耦合到能够产生可容纳的电磁辐射的激光器或其他能量源，例如紫外线或微波能量源。 重要的是，对于优选的激光源，发射器是将激光产生的能量均匀地发射到预定体积的流动血液中的漫射器。 控制器的温度测量系统接收来自传感器的温度信号，并产生由流量估计器使用的合成时间温度曲线，以确定流量并产生用于控制能量源的功率激励功能。 所得到的测量流也可以通过用户界面呈现。

    DEVICES AND METHODS FOR REMOTE TEMPERATURE MONITORING IN FLUID ENHANCED ABLATION THERAPY
    5.
    发明申请
    DEVICES AND METHODS FOR REMOTE TEMPERATURE MONITORING IN FLUID ENHANCED ABLATION THERAPY 审中-公开
    流体增强治疗远程温度监测装置及方法

    公开(公告)号：US20120277737A1

    公开(公告)日：2012-11-01

    申请号：US13445034

    申请日：2012-04-12

    申请人： Michael G. Curley

    发明人： Michael G. Curley

    IPC分类号： A61B18/18

    摘要： Devices and methods for monitoring the temperature of tissue at various locations in a treatment volume during fluid enhanced ablation therapy are provided. In one embodiment, an ablation device is provided having an elongate body, at least one ablation element, and at least one temperature sensor. The elongate body includes a proximal and distal end, an inner lumen, and at least one outlet port to allow fluid to be delivered to tissue surrounding the elongate body. The at least one ablation element is configured to heat tissue surrounding the at least one ablation element. The at least one temperature sensor can be positioned a distance away from the at least one ablation element and can be effective to output a measured temperature of tissue spaced a distance apart from the at least one ablation element such that the measured temperature indicates whether tissue is being heating to a therapeutic level.

    摘要翻译： 提供了用于在液体增强消融治疗期间监测治疗体积中各个位置处的组织温度的装置和方法。 在一个实施例中，提供具有细长主体，至少一个消融元件和至少一个温度传感器的消融装置。 细长体包括近端和远端，内腔和至少一个出口端口，以允许流体被传送到围绕细长体的组织。 所述至少一个消融元件构造成加热围绕所述至少一个消融元件的组织。 所述至少一个温度传感器可以定位成离开所述至少一个消融元件一定距离，并且可以有效地输出与所述至少一个消融元件间隔开距离的组织的测量温度，使得所测量的温度指示组织是否为 被加热到治疗水平。

    Method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer
    7.
    发明授权
    Method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer 有权
    用于制造围绕导管安装的相控阵超声换能器的端部的方法

    公开(公告)号：US6149599A

    公开(公告)日：2000-11-21

    申请号：US206680

    申请日：1998-12-07

    申请人： Randall L. Schlesinger ,  Michael G. Curley ,  John W. Eaton

    发明人： Randall L. Schlesinger ,  Michael G. Curley ,  John W. Eaton

    IPC分类号： A61B1/005 ,  A61B8/12 ,  A61M25/01 ,  A61B8/00

    CPC分类号： A61B8/12 ,  A61B1/0052 ,  A61B8/4488 ,  A61M25/0133 ,  A61M25/0136 ,  A61B2018/00916 ,  A61B8/445

    摘要： The preferred embodiments include a method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer. The material used for the end portion can be altered to give the end portion focusing, defocusing, or non-focusing characteristics. In one preferred embodiment, a thermoplastic material is injection molded or insert molded around a phased-array ultrasound transducer carried at a distal end of a catheter. In another preferred embodiment, a thermoset material is used to form the end portion using a casting or transfer molding technique. In yet another preferred embodiment, the phased-array ultrasound transducer is placed into a pre-formed end portion. The pre-formed end portion can be adhesively-attached to the phased-array transducer and catheter. If the pre-formed end portion is made from a thermoplastic material, the end portion can be thermally melted to attach the end portion to the phased-array transducer and catheter.

    摘要翻译： 优选实施例包括用于制造围绕导管安装的相控阵超声换能器的端部的方法。 用于端部的材料可以改变以给出端部聚焦，散焦或非聚焦特性。 在一个优选实施例中，将热塑性材料注射模制或插入模制在围绕导管远端承载的相控阵超声换能器周围。 在另一个优选实施例中，使用热固性材料来使用铸造或传递模塑技术形成端部。 在另一优选实施例中，将相控阵超声波换能器放置在预先形成的端部。 预成形的端部可以粘附到相控阵换能器和导管上。 如果预先形成的端部由热塑性材料制成，则端部可以被热熔化以将端部附接到相控阵换能器和导管。

    Apparatus and method for reduction of motion artifact
    8.
    发明授权
    Apparatus and method for reduction of motion artifact 失效
    减少运动伪影的装置和方法

    公开(公告)号：US5978693A

    公开(公告)日：1999-11-02

    申请号：US17536

    申请日：1998-02-02

    申请人： Patrick S. Hamilton ,  Michael G. Curley ,  Roberto M. Aimi

    发明人： Patrick S. Hamilton ,  Michael G. Curley ,  Roberto M. Aimi

    IPC分类号： A61B5/0416 ,  A61B5/0424 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0492 ,  A61B5/0402 ,  A61B5/0448 ,  A61B5/0478

    CPC分类号： A61B5/0428 ,  A61B5/0416 ,  A61B5/0424 ,  A61B5/0476 ,  A61B5/0492 ,  A61B5/721

    摘要： A skin-mounted physiological recording electrode assembly has a foam pad having a front surface having a central recess and mounted to the skin, and a rear surface. A pad passage extends from the central recess to the rear surface. An electrode in the pad passage has a sensing end in the central recess and a connector end to which a clip attaches. The clip attaches to a lead wire connecting to a monitoring device. At least one deformation gauge is coupled to the rear surface of the foam pad, and may be a strain gauge, a bending sensor, or a combination of both. The electrode assembly may be used in a patient monitoring system having an electrode signal processor, sensor signal processors, a multiplexer, an A-to-D convertor, and a microprocessor programmed with an adaptive noise canceling algorithm. A method is taught of monitoring signals from at least two electrodes, generating and monitoring deformation signals which are correlated to the deformation of the foam pads, and making an adaptive noise canceling analysis of the electrode signals and the deformation signals to reduce or eliminate the noise component of the electrode signals.

    摘要翻译： 皮肤安装的生理记录电极组件具有泡沫垫，其具有前表面，其具有中心凹部并且安装到皮肤和后表面。 衬垫通道从中心凹部延伸到后表面。 衬垫通道中的电极在中央凹部中具有感测端和夹子附接到的连接器端。 夹子连接到连接到监控设备的引线。 至少一个变形计耦合到泡沫垫的后表面，并且可以是应变计，弯曲传感​​器或两者的组合。 电极组件可以用在具有电极信号处理器，传感器信号处理器，多路复用器，A到D转换器和用自适应噪声消除算法编程的微处理器的患者监视系统中。 教导了一种监测来自至少两个电极的信号的方法，产生和监测与泡沫垫的变形相关的变形信号，并且对电极信号和变形信号进行自适应噪声消除分析以减少或消除噪声 电极信号的分量。

    Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue
    9.
    发明授权
    Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue 失效
    用于形成组织的超声图像同时消融组织的方法和系统

    公开(公告)号：US5788636A

    公开(公告)日：1998-08-04

    申请号：US805473

    申请日：1997-02-25

    申请人： Michael G. Curley

    发明人： Michael G. Curley

    IPC分类号： A61B19/00 ,  A61B8/00 ,  A61B18/12

    CPC分类号： A61B18/1206 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2090/3782

    摘要： A method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue in which the application of therapy current is sequenced with at least the ultrasonic detection phase of the ultrasonic visualization process. In this way, no ultrasonic detection takes place while therapy current passes, and no therapy current passes while ultrasonic detection takes place. The sequencing can take place using a communication protocol between a therapy system controlling the application of therapy current and an ultrasonic imaging system controlling the ultrasonic visualization process. Depending on the communication protocol used, the therapy system and the ultrasonic imaging system can handoff control to one another or one system can have exclusive control over the other.

    摘要翻译： 一种用于形成组织的超声波图像的方法和系统，同时使至少超声波可视化过程的超声波检测阶段消融施用治疗电流的组织。 以这种方式，当治疗电流通过时，不进行超声波检测，并且在超声波检测发生时没有治疗电流通过。 可以使用控制治疗电流的治疗系统和控制超声可视化过程的超声成像系统之间的通信协议进行测序。 根据所使用的通信协议，治疗系统和超声波成像系统可以将控制权切换到彼此，或者一个系统可以相互独占控制。

    Low profile fluid enhanced ablation therapy devices and methods
    10.
    发明授权
    Low profile fluid enhanced ablation therapy devices and methods 有权

    公开(公告)号：US10022176B2

    公开(公告)日：2018-07-17

    申请号：US13586559

    申请日：2012-08-15

    申请人： Michael G. Curley

    发明人： Michael G. Curley

    IPC分类号： A61B18/04 ,  A61B18/00 ,  A61B90/00

    摘要： Low profile devices and methods for delivering fluid enhanced ablation therapy are provided herein. In one embodiment, an ablation device is provided that includes an elongate body having proximal and distal ends, an inner lumen extending therethrough and at least one outlet port formed therein and configured to deliver fluid to surrounding tissue. The device can also include at least one ablation element disposed along a length of the body adjacent to the at least one outlet port and configured to deliver energy to surrounding tissue, as well as at least one heating element disposed within the inner lumen of the elongate body. The device further includes a handle having proximal and distal ends, the distal end of the handle being coupled to the proximal end of the elongate body. Further, a longitudinal axis of the elongate body extends at an angle to a longitudinal axis of the handle.