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公开(公告)号：US09303002B2
公开(公告)日：2016-04-05
申请号：US14085947
申请日：2013-11-21
申请人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07D285/135 , C07D417/14 , C07D285/12 , C07D417/12 , C07D471/04
CPC分类号： C07D285/135 , C07D285/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号：US20140142146A1
公开(公告)日：2014-05-22
申请号：US14085947
申请日：2013-11-21
申请人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07D285/135 , C07D417/14
CPC分类号： C07D285/135 , C07D285/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号：US09662327B2
公开(公告)日：2017-05-30
申请号：US14126791
申请日：2012-06-18
申请人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
发明人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
IPC分类号： C07D491/052 , C07D401/04 , C07D519/00 , C07D217/22 , C07D471/04 , C07D405/12 , A61K31/496 , A61K31/519 , C07D217/26 , C07D413/04 , A61K31/551
CPC分类号： C07D491/052 , A61K31/496 , A61K31/519 , A61K31/551 , C07D217/22 , C07D217/26 , C07D401/04 , C07D405/12 , C07D413/04 , C07D471/04 , C07D519/00
摘要： Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
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公开(公告)号：US20140213580A1
公开(公告)日：2014-07-31
申请号：US14126763
申请日：2012-06-18
申请人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
发明人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
IPC分类号： C07D401/04 , A61K31/496 , C07D401/14 , C07D413/14 , C07D213/85 , C07D471/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , A61K31/4985 , A61K31/517 , A61K31/501 , A61K31/506 , A61K31/502 , A61K31/498
CPC分类号： C07F9/650952 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/675 , C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07F9/65583
摘要： Provided are compounds with the following structure, formula (I) pharmaceutically acceptable salts thereof, use of those compounds for treating cancer and pharmaceutical compositions comprising those compounds.
摘要翻译： 提供具有以下结构的化合物，式（I）其药学上可接受的盐，这些化合物用于治疗癌症的用途和包含那些化合物的药物组合物。
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公开(公告)号：US20140206673A1
公开(公告)日：2014-07-24
申请号：US14126791
申请日：2012-06-18
申请人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
发明人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
IPC分类号： C07D491/052 , C07D401/04 , C07D519/00 , C07D217/22 , A61K31/551 , C07D471/04 , C07D405/12 , A61K31/496 , A61K31/519
CPC分类号： C07D491/052 , A61K31/496 , A61K31/519 , A61K31/551 , C07D217/22 , C07D217/26 , C07D401/04 , C07D405/12 , C07D413/04 , C07D471/04 , C07D519/00
摘要： Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
摘要翻译： 提供式（I）化合物，其中X，Y，Z，W，V，R 2，R 3和m如描述中所定义。 还提供了它们的药物组合物及其用于治疗癌症的用途。
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公开(公告)号：US20130184222A1
公开(公告)日：2013-07-18
申请号：US13810410
申请日：2011-07-15
申请人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey Saunders , Jeremy Travins , Shunqi Yan
发明人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07C237/22 , C07D333/24 , C07D409/12 , C07D319/20 , C07C271/58 , C07D237/14 , C07D241/12 , C07D233/64 , C07C311/13 , C07K5/065 , C07D317/68
CPC分类号： C07K5/06078 , A61K38/00 , C07C237/22 , C07C271/22 , C07C271/44 , C07C271/58 , C07C311/06 , C07C311/13 , C07C311/19 , C07C317/36 , C07C335/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/10 , C07D207/16 , C07D209/08 , C07D209/14 , C07D209/26 , C07D209/42 , C07D209/44 , C07D211/14 , C07D211/38 , C07D211/54 , C07D211/60 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/74 , C07D217/04 , C07D221/18 , C07D231/12 , C07D231/42 , C07D231/56 , C07D233/61 , C07D233/64 , C07D233/70 , C07D233/88 , C07D235/04 , C07D237/14 , C07D239/26 , C07D241/12 , C07D249/04 , C07D249/18 , C07D253/06 , C07D257/04 , C07D261/18 , C07D265/36 , C07D271/06 , C07D271/10 , C07D277/28 , C07D277/30 , C07D277/56 , C07D295/04 , C07D295/205 , C07D305/08 , C07D307/20 , C07D307/22 , C07D309/12 , C07D309/14 , C07D317/68 , C07D319/20 , C07D333/24 , C07D333/38 , C07D409/12 , C07D471/04
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
摘要翻译： 提供治疗以IDH1突变等位基因存在为特征的癌症的方法，其包括向有需要的受试者施用本文所述的化合物。
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公开(公告)号：US20150087600A1
公开(公告)日：2015-03-26
申请号：US14373154
申请日：2013-01-21
申请人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Zhenwei Cai , Shunqi Yan , Ding Zhou
发明人： Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Zhenwei Cai , Shunqi Yan , Ding Zhou
CPC分类号： C07K5/06078 , A61K38/05 , A61K45/06 , C07D205/04 , C07D207/16 , C07D207/48 , C07D209/42 , C07D213/56 , C07D213/74 , C07D215/48 , C07D233/61 , C07D233/64 , C07D233/68 , C07D233/90 , C07D241/04 , C07D249/04 , C07D249/08 , C07D257/04 , C07D263/04 , C07D263/06 , C07D263/24 , C07D265/30 , C07D401/04 , C07D403/04 , C07D403/12 , C07D413/12 , C07D471/04 , C07K5/0202 , C07K5/06026 , C07K5/0606 , C07K5/06069 , C07K5/06139 , C07K5/06165 , C07K5/06191
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
摘要翻译： 提供治疗特征在于存在IDH1 / 2的突变等位基因的癌症的方法，包括向有需要的受试者施用本文所述的化合物。
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8.发明授权N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators 有权丙酮酸激酶M2（PMK2）调节剂N-（4-（氮杂环丁烷-1-羰基）苯基） - （异 - ）芳基磺酰胺衍生物公开(公告)号：US09221792B2
公开(公告)日：2015-12-29
申请号：US13994398
申请日：2011-12-16
IPC分类号： A61K31/397 , A61K31/00 , C07D205/00 , C07D215/36 , C07D401/12 , C07D401/14 , A61K31/4709
CPC分类号： C07D401/12 , A61K31/4709 , C07D215/36 , C07D401/14
摘要： Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译： 本文描述了通式（I）的化合物和包含调节丙酮酸激酶M2（PKM2）的通式I化合物的组合物。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
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公开(公告)号：US08785450B2
公开(公告)日：2014-07-22
申请号：US12826630
申请日：2010-06-29
IPC分类号： A61K31/496 , A61K31/4709 , C07D215/36 , C07D401/12 , C07D401/14 , C07D405/06 , C07D471/00
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US20100331307A1
公开(公告)日：2010-12-30
申请号：US12826630
申请日：2010-06-29
IPC分类号： A61K31/5513 , A61P35/00 , A61K31/497 , C07D401/12 , C07D417/14 , C07D405/14 , C07D401/14
CPC分类号： C07D215/36 , A61K31/497 , A61K31/5513 , C07D215/40 , C07D239/42 , C07D241/20 , C07D243/08 , C07D271/12 , C07D277/64 , C07D277/68 , C07D295/192 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , Y02P20/582
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译： 包含调节丙酮酸激酶M2（PKM2）的化合物的化合物和组合物在本文中描述。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
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