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公开(公告)号：US5232437A
公开(公告)日：1993-08-03
申请号：US496739
申请日：1990-03-21
申请人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger , Robert R. Stromberg , Leonard I. Friedman
发明人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger , Robert R. Stromberg , Leonard I. Friedman
CPC分类号： A61M5/1483 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M5/148 , A61M1/3643 , A61M2205/8225
摘要： Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood from a donor; forcing the collected blood unit through a plasma separator; accumulating the plasma in a container; and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.
摘要翻译： 提供了从供体收集血液成分（如血浆）的方法和系统。 一种方法包括从供体收集全血的单元的步骤; 通过等离子体分离器迫使收集的血液单元; 将等离子体积聚在容器中; 并将浓缩的细胞返回给供体。 一个系统包括一次性血液收集装置和可重复使用的固定装置，收集装置可安装在其上。 夹具由独立的能源操作，不需要外部电气连接或其他外部能源。
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公开(公告)号：US4911703A
公开(公告)日：1990-03-27
申请号：US296850
申请日：1989-01-12
申请人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger , Robert R. Stromberg , Leonard I. Friedman
发明人： Michael J. Lysaght , Daniel R. Boggs , Philip L. Ritger , Robert R. Stromberg , Leonard I. Friedman
CPC分类号： A61M5/1483 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M5/148 , A61M1/3643 , A61M2205/8225
摘要： Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood froma donor; forcing the collected blood unit through a plasma separator; accumulating the plasma in a container; and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.
摘要翻译： 提供了从供体收集血液成分（如血浆）的方法和系统。 一种方法包括从供体中收集全血的单位的步骤; 通过等离子体分离器迫使收集的血液单元; 将等离子体积聚在容器中; 并将浓缩的细胞返回给供体。 一个系统包括一次性血液收集装置和可重复使用的固定装置，收集装置可安装在其上。 夹具由独立的能源操作，不需要外部电气连接或其他外部能源。
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公开(公告)号：US4964976A
公开(公告)日：1990-10-23
申请号：US473142
申请日：1990-02-01
CPC分类号： B01D61/147 , A61M1/3496 , B01D61/22 , B01D63/02 , B01D63/021 , B01D2313/90
摘要： A method and apparatus for optimizing parameters of a hollow membrane filter results in a relatively small filter when a predetermined, substantially constant, driving pressure drop is applied between the inlet and the outlet of the filter. The method includes simultaneous solution of a set of equations to specify fiber length, number and internal diameter. A system including a computer can make optimized filters in response to the determined parameters.
摘要翻译： 当在过滤器的入口和出口之间施加预定的，基本恒定的驱动压降时，用于优化中空膜过滤器的参数的方法和装置导致相对较小的过滤器。 该方法包括同时求解一组方程式以指定纤维长度，数量和内径。 包括计算机的系统可以响应于确定的参数来制作优化的滤波器。
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公开(公告)号：US4842576A
公开(公告)日：1989-06-27
申请号：US919044
申请日：1986-10-15
CPC分类号： A61M1/3672 , A61M1/302 , A61M1/306 , A61M1/308 , A61M5/148 , A61M1/30 , A61M2205/50
摘要： A system for generating substantially constant fluid pressure is provided for forcing fluid from a variable volume container. The system includes a roller that rotates in response to a constant applied torque to force fluid from the flexible container under a substantially constant pressure. Two spaced apart parallel rollers can exert force on both sides of the container.
摘要翻译： 提供用于产生基本恒定流体压力的系统，用于迫使来自可变容积容器的流体。 该系统包括一个辊，其响应于恒定的施加扭矩而旋转，以在基本恒定的压力下迫使来自柔性容器的流体。 两个间隔开的平行辊可以在容器的两侧施加力。
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5.发明授权
公开(公告)号：US5073265A
公开(公告)日：1991-12-17
申请号：US347845
申请日：1989-05-04
CPC分类号： B01D67/0093 , A61M1/3679 , A61M1/3687 , B01D69/08 , A61M2202/0421
摘要： A material is formed into hollow fiber form, and the surface characteristics of the interior bore is selectively modified in a predetermined fashion by a reactive lumen fluid. Nucleophilic materials, such as regenerated cellulose, can be formed into hollow fibers and simultaneously modified to improve their biocompatibility in accordance with the invention.
摘要翻译： 材料形成为中空纤维形式，并且内部孔的表面特性通过反应性流体流体以预定方式选择性地修改。 亲核材料，例如再生纤维素，可以形成中空纤维，并且根据本发明同时进行改性以提高其生物相容性。
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6.发明授权
公开(公告)号：US4882106A
公开(公告)日：1989-11-21
申请号：US24652
申请日：1987-03-11
IPC分类号： A61M1/18 , A61M1/36 , B01D67/00 , B01D69/08 , B01D71/10 , B01D71/82 , D01D5/24 , D01F2/04 , D01F2/28
CPC分类号： B01D67/0093 , A61M1/3679 , A61M1/3687 , B01D69/08 , A61M2202/0421
摘要： A material is formed into hollow fiber form, and the surface characteristics of the interior bore is selectively modified in a predetermined fashion by a reactive lumen fluid. Nucleophilic materials, such as regenerated cellulose, can be formed into hollow fibers and simultaneously modified to improve their biocompatibility in accordance with the invention.
摘要翻译： 材料形成为中空纤维形式，并且内部孔的表面特性通过反应性流体流体以预定方式选择性地修改。 亲核材料，例如再生纤维素，可以形成中空纤维，并且根据本发明同时进行改性以提高其生物相容性。
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7.发明授权Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products 有权用于递送选定治疗产品的可植入生物相容性免疫佐剂
公开(公告)号：US6083523A
公开(公告)日：2000-07-04
申请号：US148671
申请日：1998-09-04
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual.
摘要翻译： 用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。 载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送， 个人
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8.发明授权Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products 失效用于递送选定治疗产品的植入式生物相容性免疫佐剂公开(公告)号：US06960351B2
公开(公告)日：2005-11-01
申请号：US10624081
申请日：2003-07-21
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61F13/00 , A61F2/00 , A61F9/14 , A61F9/16 , A61F9/22
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/4816 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K2035/126 , A61K2035/128 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.
摘要翻译： 用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。 载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送， 个人 该载体特别适合于从朗格汉斯的免疫隔离胰岛递送胰岛素，并且还可有利地用于递送高分子量产物，例如大于IgG的产物。 在共挤出方法的第一实施方案中和在逐步方法的第二实施方案中制备生物相容的免疫隔离可植入载体的方法。 一种用于分离生物相容的免疫隔离可植入载体中的细胞的方法，其保护分离的细胞免受被植入其中的个体的免疫系统的攻击。 向个体提供所需的生物制品或代谢功能的方法，包括向个体植入包含产生产物或提供代谢功能的分离细胞的免疫隔离载体。
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9.发明授权Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic products 失效用于递送选定治疗产品的植入式生物相容性免疫佐剂公开(公告)号：US06322804B1
公开(公告)日：2001-11-27
申请号：US09563248
申请日：2000-05-02
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61K950
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/4816 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K2035/126 , A61K2035/128 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual.
摘要翻译： 用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。 载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送， 个人
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10.发明授权Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core 失效制备具有生物相容性护套和生物相容性基质芯的免疫隔离植入式车辆的方法
公开(公告)号：US5834001A
公开(公告)日：1998-11-10
申请号：US449214
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Sharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Sharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61K9/14
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells capable of secreting a biocompatible matrix comprising a hydrogel or extracellular matrix, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product or said function.
摘要翻译： 公开了一种形成可植入和可回收的免疫隔离载体的方法，所述方法包括以下步骤：首先形成生物相容性热塑性或水凝胶的护套，然后用包含至少1μl体积和至少104 能够分泌包含水凝胶或细胞外基质的生物相容性基质的细胞，所述护套具有分子量截留允许分子跨越其通过以提供所述生物活性产物或所述功能。
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