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公开(公告)号：US20130184456A1
公开(公告)日：2013-07-18
申请号：US13528136
申请日：2012-06-20
申请人： Michael John ZAWOROTKO , Zhenjie Zhang , Randy W. Larsen , Mohamed Eddaoudi , Linping Zhang , Lukasz Wojtas
发明人： Michael John ZAWOROTKO , Zhenjie Zhang , Randy W. Larsen , Mohamed Eddaoudi , Linping Zhang , Lukasz Wojtas
CPC分类号： C07F15/065 , C07F3/003 , C07F3/02 , C07F3/06 , C07F3/08 , C07F13/005 , C07F15/025 , C07F15/045
摘要： A process for the preparation of a heterocyclic macrocycle-templated supramolecular metal organic material, the process comprising preparing a reaction mixture containing a metal, a heterocyclic macrocycle, and organic ligands and forming, in the reaction mixture, a heterocyclic macrocycle-templated metal organic material comprising the metal, the heterocyclic macrocycle and the ligands by template-directed synthesis with the heterocyclic macrocycle serving as the template and being encapsulated within a cage of the template metal organic material.
摘要翻译： 一种用于制备杂环大环化合物模板的超分子金属有机材料的方法，该方法包括制备含有金属，杂环大环化合物和有机配体的反应混合物，并在反应混合物中形成杂环大环化合物模板化的金属有机材料 通过与作为模板的杂环大环化合物进行模板指导合成并将其包封在模板金属有机材料的笼中，包含金属，杂环大环化合物和配体。
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2.发明授权Compounds and methods for inhibiting the interaction of BCL proteins with binding partners 有权抑制BCL蛋白与结合配偶体相互作用的化合物和方法公开(公告)号：US07851637B2
公开(公告)日：2010-12-14
申请号：US11156364
申请日：2005-06-17
申请人： Alfredo C. Castro , Wei Deng , Kristopher M. Depew , Michael A. Foley , Christian C. Fritz , Asimina T. Georges Evangelinos , Michael J. Grogan , Nafeeza Hafeez , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Tao Liu , David A. Mann , Lisa A. Marcaurelle , Daniel A. Snyder , Dennis J. Underwood , Andrew A. Wylie , Lin-Chen Yu , Linping Zhang
发明人： Alfredo C. Castro , Wei Deng , Kristopher M. Depew , Michael A. Foley , Christian C. Fritz , Asimina T. Georges Evangelinos , Michael J. Grogan , Nafeeza Hafeez , Edward B. Holson , Brian T. Hopkins , Nii O. Koney , Tao Liu , David A. Mann , Lisa A. Marcaurelle , Daniel A. Snyder , Dennis J. Underwood , Andrew A. Wylie , Lin-Chen Yu , Linping Zhang
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要： One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译： 本发明的一个方面涉及结合bcl蛋白并抑制Bcl功能的杂环化合物。 本发明的另一方面涉及包含本发明的杂环化合物的组合物。 本发明提供了治疗和调节与过度增生相关的疾病如癌症的方法。
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3.发明申请公开(公告)号：US20060025460A1
公开(公告)日：2006-02-02
申请号：US11156364
申请日：2005-06-17
申请人： Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
发明人： Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要： One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
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公开(公告)号：US20060020004A1
公开(公告)日：2006-01-26
申请号：US11155314
申请日：2005-06-17
申请人： Burton Christensen , Michael Foley , Asimina Georges Evangelinos , Tao Liu , James Porter , Amy Ripka , Linping Zhang
发明人： Burton Christensen , Michael Foley , Asimina Georges Evangelinos , Tao Liu , James Porter , Amy Ripka , Linping Zhang
IPC分类号： A61K31/42 , C07D261/10 , C07D261/12 , C07D413/02
CPC分类号： C07D261/02 , C07D413/12
摘要： The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.
摘要翻译： 本发明涉及可用于其制备的抗生素化合物和中间体。 许多抗生素化合物含有取代的异恶唑烷环。 本发明还涉及含有本发明化合物的药物组合物。 本发明还提供了制备本发明化合物的方法及其用作治疗剂的方法。
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